目的探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)的临床特点和预后情况。方法收集癌症和肿瘤基因图谱(The Cancer Genome Atlas,TCGA)数据库700例乳腺癌患者资料。根据分子标志物和激素受体状态,将其分为多种亚型。对三阴性...目的探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)的临床特点和预后情况。方法收集癌症和肿瘤基因图谱(The Cancer Genome Atlas,TCGA)数据库700例乳腺癌患者资料。根据分子标志物和激素受体状态,将其分为多种亚型。对三阴性和非三阴性乳腺癌临床数据进行Kaplan-Meier生存分析及χ2检验,预后影响因素采用单因素和多因素分析。结果生存曲线显示,TNBC患者(n=85)与非三阴性乳腺癌(non triple-negative breast cancer,non TNBC)患者(n=615)的10年总生存率(overall survival,OS)比较差异具有统计学意义(P=0.005),并低于luminal A型乳腺癌患者(P=0.001),与其他亚型患者比较差异均无统计学意义(均P>0.05)。TNBC与non TNBC患者在绝经状态、组织类型、AJCC肿瘤病理状态、AJCC淋巴结病理状态和年龄方面比较差异均具有统计学意义(均P<0.05)。综合单因素及多因素分析发现,淋巴结转移是TNBC重要的独立预后因素(P=0.021)。伴随肿瘤患者生存时间也短于无肿瘤患者(P=0.009)。结论 TNBC临床病理特征与其他类型的乳腺癌差异较大。手术完全清除肿瘤对TNBC患者意义重大。展开更多
AIM:To investigate the relationship between the mast cell density(MCD)and the context of clinicopathological parameters and expression of p185,estrogen receptor(ER), and proliferating cell nuclear antigen(PCNA)in gast...AIM:To investigate the relationship between the mast cell density(MCD)and the context of clinicopathological parameters and expression of p185,estrogen receptor(ER), and proliferating cell nuclear antigen(PCNA)in gastric carcinoma. METHODS:Mast cell,p185,ER,and PCNA were detected using immunohistochemical S-P labeling method.Mast cell was counted in tissue of gastric carcinoma and regional lymph nodes respectively,and involved lymph nodes(ILN)were examined as usual. RESULTS:MCD was significantly related to both age and depth of penetration(x^2=4.688,P<0.05 for age and x^2=9.350, P<0.01 for depth of penetration)between MCD>21/0.03 mm^2 and MCD≤21/0.03 mm^2 in 100 patients;MCD in 1-6 ILN group patients was significantly higher than that in 7-15 ILN or>15 ILN group patients(u=6.881,8.055,P<0.01); There were significant differences intergroup in positive expression rate of p185,ER and PCNA between MCD>21/ 0.03 mm^2 and MCD≤21/0.03 mm^2 in 100 patients. CONCLUSION:Mast cell may have effect on inhibiting invasive growth of tumor,especially in the aged patients; The number of mast cells,in certain degree,may predicate the number of involved lymph nodes,which is valuable for assessment of prognosis;MCD was related to the expression of p185,ER,and PCNA in gastric carcinoma.It suggests that mast cell accumulation may inhibit the proliferation and the dissemination of the gastric carcinoma. INTRODUCTION Recently,many studies have reported on the association of mast cell with various tumorst.In several malignancies,mast cell has been found to correlate with growth,penetration and prognosis of tumor.Therefore,our study was undertaken to investigate the relationship between the mast cell density (MCD)and the context of clinicopathological parameters and expression of p 185,estrogen receptor(ER),and proliferating cell nuclear antigen(PCNA)in gastric carcinoma.展开更多
文摘目的探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)的临床特点和预后情况。方法收集癌症和肿瘤基因图谱(The Cancer Genome Atlas,TCGA)数据库700例乳腺癌患者资料。根据分子标志物和激素受体状态,将其分为多种亚型。对三阴性和非三阴性乳腺癌临床数据进行Kaplan-Meier生存分析及χ2检验,预后影响因素采用单因素和多因素分析。结果生存曲线显示,TNBC患者(n=85)与非三阴性乳腺癌(non triple-negative breast cancer,non TNBC)患者(n=615)的10年总生存率(overall survival,OS)比较差异具有统计学意义(P=0.005),并低于luminal A型乳腺癌患者(P=0.001),与其他亚型患者比较差异均无统计学意义(均P>0.05)。TNBC与non TNBC患者在绝经状态、组织类型、AJCC肿瘤病理状态、AJCC淋巴结病理状态和年龄方面比较差异均具有统计学意义(均P<0.05)。综合单因素及多因素分析发现,淋巴结转移是TNBC重要的独立预后因素(P=0.021)。伴随肿瘤患者生存时间也短于无肿瘤患者(P=0.009)。结论 TNBC临床病理特征与其他类型的乳腺癌差异较大。手术完全清除肿瘤对TNBC患者意义重大。
文摘AIM:To investigate the relationship between the mast cell density(MCD)and the context of clinicopathological parameters and expression of p185,estrogen receptor(ER), and proliferating cell nuclear antigen(PCNA)in gastric carcinoma. METHODS:Mast cell,p185,ER,and PCNA were detected using immunohistochemical S-P labeling method.Mast cell was counted in tissue of gastric carcinoma and regional lymph nodes respectively,and involved lymph nodes(ILN)were examined as usual. RESULTS:MCD was significantly related to both age and depth of penetration(x^2=4.688,P<0.05 for age and x^2=9.350, P<0.01 for depth of penetration)between MCD>21/0.03 mm^2 and MCD≤21/0.03 mm^2 in 100 patients;MCD in 1-6 ILN group patients was significantly higher than that in 7-15 ILN or>15 ILN group patients(u=6.881,8.055,P<0.01); There were significant differences intergroup in positive expression rate of p185,ER and PCNA between MCD>21/ 0.03 mm^2 and MCD≤21/0.03 mm^2 in 100 patients. CONCLUSION:Mast cell may have effect on inhibiting invasive growth of tumor,especially in the aged patients; The number of mast cells,in certain degree,may predicate the number of involved lymph nodes,which is valuable for assessment of prognosis;MCD was related to the expression of p185,ER,and PCNA in gastric carcinoma.It suggests that mast cell accumulation may inhibit the proliferation and the dissemination of the gastric carcinoma. INTRODUCTION Recently,many studies have reported on the association of mast cell with various tumorst.In several malignancies,mast cell has been found to correlate with growth,penetration and prognosis of tumor.Therefore,our study was undertaken to investigate the relationship between the mast cell density (MCD)and the context of clinicopathological parameters and expression of p 185,estrogen receptor(ER),and proliferating cell nuclear antigen(PCNA)in gastric carcinoma.
