A STUDY OF LECTINS IN HUMAN BREAST CANCER AND PRECANCEROUS LESIONS

This paper report the binding pattern of 12 different kinds of lectin in human breast lesions. Of the 12 kinds of lectins, WGA showed the highest binding activity to the cells of the breast tissue derived; the binding of BSL, SBA and DBA were localized to membrane or cytoplasm of cancer cells and to the lumina membrane border of the normal and benign lesions; PNA receptor is related with the differentiation of the breast; cancer; we didn't find any relationship between the lectin receptor and the tendency of metastasis of breast cancer.

乳腺上皮不典型增生时DNA含量、超微结构及肿瘤相关抗原变化的意义

观测正常乳腺、乳腺囊性增生病和乳腺癌细胞核ＤＮＡ含量、细胞超微结构、Ｙ抗原及免疫抑制性酸性蛋白（ＩＡＰ２）表达。结果：上皮增生Ⅰ级细胞与正常乳腺细胞相似；不典型增生细胞ＤＮＡ含量增加，细胞膜和细胞核超微结构出现发育不良及去分化现象，部分不典型增生细胞见异常抗原表达；部分Ⅲ级不典型增生细胞ＤＮＡ含量和超微结构与乳腺癌组织分化Ⅰ级细胞相似。提示在不典型增生阶段，这些细胞的生物学异常和程度与其细胞分化程度。