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Evolution of the Etiologies of Purulent Meningitis in Children over a Period of 24 Months in Conflict-Affected Rural Areas of the Central African Republic after the Introduction of 2 New Vaccines in the Expanded Vaccination Program
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作者 Rostand Kombaya Marie Colette Nganda Bangue +6 位作者 Irenee Galendji Honorat Nouzoukem Edgar Tchoumateu Brice Olivier Bogning Mejiozem Freddy Samuel Ngbonga Konzapa Voulou Henri Saint Clavaire Diemer Christian Diamant Mossoro-Kpindé 《Open Journal of Medical Microbiology》 2023年第3期183-194,共12页
Background and Objective: Purulent meningitis is a therapeutic emergency and remains a real public health problem in the world, particularly in limited resources countries. The study aimed to describe the epidemiologi... Background and Objective: Purulent meningitis is a therapeutic emergency and remains a real public health problem in the world, particularly in limited resources countries. The study aimed to describe the epidemiological clinical, etiological and scalable features of purulent meningitis in children in Bria. Methods: A cross-sectional descriptive study was conducted from January 1, 2018 to December 31, 2019 (24 months). It included all suspected cases of purulent meningitis in children aged 0 to 15 years, confirmed by agglutination with Pastorex meningitis. A standard sheet was used to collect the data which was entered and analyzed on Epi Info 7 software. Results: A total of 37 cases of purulent meningitis were confirmed among 90 suspected cases. The female gender predominated (59.5%), with a sex ratio of 0.7. The age group from 0 to 11 months was majority (48.6%). Nearly 2 thirds of children were not vaccinated (64.8%). The most frequent functional signs were fever (83.8%), and convulsion (51.4%). The etiologies were Streptococcus (51.4%), Neisseria meningitidis (35.1%) and Haemophilus influenzae (13.5%). Therapeutic success under 3rd generation cephalosporin treatment was obtained in 86.5% including 8.1% with sequelae;13.5% of death was observed. Streptococcus was the most lethal bacterium at 21.1%. Conclusion: The results of these studies show that pediatric purulent meningitis is still common despite the availability of free vaccination. They require early therapeutic management to limit the occurrence of sequelae and death. Hence, it is important to strengthen prevention strategies. 展开更多
关键词 Purulent Meningitis CHILDREN EPIDEMIOLOGY ETIOLOGIES bria Central African Republic
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刺五加苷E对穹窿-海马伞损伤大鼠学习记忆能力及海马神经元可塑性的影响 被引量:6
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作者 徐娅丽 杜万雪 黄德斌 《中成药》 CAS CSCD 北大核心 2018年第11期2368-2373,共6页
目的探索刺五加苷E对穹窿-海马伞损伤大鼠学习记忆能力及海马神经元可塑性的影响。方法 120只大鼠随机分为对照组、模型组、假手术组及刺五加苷E低、中、高剂量组(100、200、500 mg/kg),每组20只。第7、21天分别测定寻找平台潜伏期和错... 目的探索刺五加苷E对穹窿-海马伞损伤大鼠学习记忆能力及海马神经元可塑性的影响。方法 120只大鼠随机分为对照组、模型组、假手术组及刺五加苷E低、中、高剂量组(100、200、500 mg/kg),每组20只。第7、21天分别测定寻找平台潜伏期和错误次数后,RT-PCR、ELISA检测锥体细胞凋亡率、c-fos基因表达、Na+-K+-ATP酶活性。结果与模型组比较,刺五加苷E组寻找平台潜伏期、错误次数显著减少(P <0. 05),Na+-K+-ATP酶活性、正常锥体细胞数量显著增加(P <0. 05),锥体细胞密集度和排列方式、神经纤维缠结、胶质细胞增生、核固缩明显改善(P <0. 05),第7天c-fos相对灰度值显著增加(P <0. 05),第21天恰好相反(P <0. 05)。结论刺五加苷E可剂量依赖性地改善穹窿-海马伞损伤大鼠学习记忆能力,其机制可能与增强Na+-K+-ATP酶活性、调控c-fos基因表达、阻止海马神经元损伤并促进其可塑性有关。 展开更多
关键词 刺五加苷E 学习记忆能力 海马神经元 可塑性 穹窿-海马伞损伤
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