The study aimed to test if Briganti’s 2012 nomogram could be associated with the risk of prostate cancer (PCa) progression in European Association of Urology (EAU) intermediate-risk patients treated with robotic surg...The study aimed to test if Briganti’s 2012 nomogram could be associated with the risk of prostate cancer (PCa) progression in European Association of Urology (EAU) intermediate-risk patients treated with robotic surgery. From January 2013 to December 2021, 527 consecutive patients belonging to the EAU intermediate-risk class were selected. Briganti’s 2012 nomogram, which predicts the risk of pelvic lymph node invasion (PLNI), was assessed as a continuous and dichotomous variable that categorized up to the median of 3.0%. Disease progression defined as biochemical recurrence and/or metastatic progression was evaluated by Cox proportional hazards (univariate and multivariate analysis). After a median follow-up of 95.0 months (95% confidence interval [CI]: 78.5–111.4), PCa progression occurred in 108 (20.5%) patients who were more likely to present with an unfavorable nomogram risk score, independently by the occurrence of unfavorable pathology including tumor upgrading and upstaging as well as PLNI. Accordingly, as Briganti’s 2012 risk score increased, patients were more likely to experience disease progression (hazard ratio [HR] = 1.060;95% CI: 1.021–1.100;P = 0.002);moreover, it also remained significant when dichotomized above a risk score of 3.0% (HR = 2.052;95% CI: 1.298–3.243;P < 0.0001) after adjustment for clinical factors. In the studied risk population, PCa progression was independently predicted by Briganti’s 2012 nomogram. Specifically, we found that patients were more likely to experience disease progression as their risk score increased. Because of the significant association between risk score and tumor behavior, the nomogram can further stratify intermediate-risk PCa patients, who represent a heterogeneous risk category for which different treatment paradigms exist.展开更多
智慧交通行业具有综合性、系统性、数据驱动、服务智能化、安全性和环保性等特点,对相关企业进行价值评估可以为投资决策提供参考、为资产配置提供依据、为相关企业的并购重组提供指导、明确业务发展的方向等。在进行企业价值评估时,重...智慧交通行业具有综合性、系统性、数据驱动、服务智能化、安全性和环保性等特点,对相关企业进行价值评估可以为投资决策提供参考、为资产配置提供依据、为相关企业的并购重组提供指导、明确业务发展的方向等。在进行企业价值评估时,重要的是考虑当前实际情况,相应地调整使用的参数,选择恰当的评估方法,确保评估数据反映最新的市场动态和企业经营状况。文章以qf科技为例,使用灰色预测模型GM(1,1)对qf科技企业的未来自由现金流加以预测,通过DCF模型和经过蒙特卡洛模拟(Monte Carlo Simulation)改进后的DCF模型对qf科技企业价值进行评估,最终结果显示:通过蒙特卡洛模拟(Monte Carlo Simulation)改进后的模型评估企业价值更加合理。展开更多
文摘The study aimed to test if Briganti’s 2012 nomogram could be associated with the risk of prostate cancer (PCa) progression in European Association of Urology (EAU) intermediate-risk patients treated with robotic surgery. From January 2013 to December 2021, 527 consecutive patients belonging to the EAU intermediate-risk class were selected. Briganti’s 2012 nomogram, which predicts the risk of pelvic lymph node invasion (PLNI), was assessed as a continuous and dichotomous variable that categorized up to the median of 3.0%. Disease progression defined as biochemical recurrence and/or metastatic progression was evaluated by Cox proportional hazards (univariate and multivariate analysis). After a median follow-up of 95.0 months (95% confidence interval [CI]: 78.5–111.4), PCa progression occurred in 108 (20.5%) patients who were more likely to present with an unfavorable nomogram risk score, independently by the occurrence of unfavorable pathology including tumor upgrading and upstaging as well as PLNI. Accordingly, as Briganti’s 2012 risk score increased, patients were more likely to experience disease progression (hazard ratio [HR] = 1.060;95% CI: 1.021–1.100;P = 0.002);moreover, it also remained significant when dichotomized above a risk score of 3.0% (HR = 2.052;95% CI: 1.298–3.243;P < 0.0001) after adjustment for clinical factors. In the studied risk population, PCa progression was independently predicted by Briganti’s 2012 nomogram. Specifically, we found that patients were more likely to experience disease progression as their risk score increased. Because of the significant association between risk score and tumor behavior, the nomogram can further stratify intermediate-risk PCa patients, who represent a heterogeneous risk category for which different treatment paradigms exist.
文摘智慧交通行业具有综合性、系统性、数据驱动、服务智能化、安全性和环保性等特点,对相关企业进行价值评估可以为投资决策提供参考、为资产配置提供依据、为相关企业的并购重组提供指导、明确业务发展的方向等。在进行企业价值评估时,重要的是考虑当前实际情况,相应地调整使用的参数,选择恰当的评估方法,确保评估数据反映最新的市场动态和企业经营状况。文章以qf科技为例,使用灰色预测模型GM(1,1)对qf科技企业的未来自由现金流加以预测,通过DCF模型和经过蒙特卡洛模拟(Monte Carlo Simulation)改进后的DCF模型对qf科技企业价值进行评估,最终结果显示:通过蒙特卡洛模拟(Monte Carlo Simulation)改进后的模型评估企业价值更加合理。
