Fenofibrate is mainly used to reduce cholesterol level in patients at risk of cardiovascular disease. Thermal transition study with the help of differential scanning calorimetry （DSC） shows that the aforesaid active...Fenofibrate is mainly used to reduce cholesterol level in patients at risk of cardiovascular disease. Thermal transition study with the help of differential scanning calorimetry （DSC） shows that the aforesaid active pharmaceutical ingredient （API） is a good glass former. Based on our DSC study, the molecular dynamics of this API has been carried out by broadband dielectric spectroscopy （BDS） covering wide temperature and frequency ranges. Dielectric measurements of amorphous fenofibrate were per- formed after its vitrification by fast cooling from a few degrees above the melting point （Tm=354.11 K） to deep glassy state. The sample does not show any crystallization tendency during cooling and reaches the glassy state. The temperature dependence of the structural relaxation has been fitted by single Vogel- Fulcher-Tamman （VFT） equation. From VFT fit, glass transition temperature （Tg） was estimated as 250.56 K and fragility （m） was determined as 94.02. This drug is classified as a fragile glass former. Deviations of experimental data from Kohlrausch-Williams-Watts （KWW） fits on high-frequency flank of α-peak indicate the presence of an excess wing in fenofibrate. Based on Ngai＇s coupling model, we identified the excess wing as true Johari-Goldstein （JG） process. Below the glass transition temperature one can clearly see a secondary relaxation （γ） with an activation energy of 32.67 kJ/mol.展开更多
Composite materials, by nature, are universally dielectric. The distribution of the phases, including voids and cracks, has a major influence on the dielectric properties of the composite materials. The dielectric rel...Composite materials, by nature, are universally dielectric. The distribution of the phases, including voids and cracks, has a major influence on the dielectric properties of the composite materials. The dielectric relaxation behavior measured by Broadband Dielectric Spectroscopy (BbDS) is often caused by interfacial polarization, which is known as Maxwell-Wagner-Sillars polarization that develops because of the heterogeneity of the composite materials. A prominent mechanism in the low frequency range is driven by charge accumulation at the interphases between different constituent phases. In our previous work, we observed in-situ changes in dielectric behavior during static tensile testing, and also studied the effects of applied mechanical and ambient environments on composite material damage states based on the evaluation of dielectric spectral analysis parameters. In the present work, a two dimensional conformal computational model was developed using a COMSOL™multi-physics module to interpret the effective dielectric behavior of the resulting composite as a function of applied frequency spectra, especially the effects of volume fraction, the distribution of the defects inside of the material volume, and the influence of the permittivity and Ohmic conductivity of the host materials and defects.展开更多
The long-term properties of continuous fiber reinforced composite materials are increasingly important as applications in airplanes, cars, and other safety critical structures are growing rapidly. Although a clear und...The long-term properties of continuous fiber reinforced composite materials are increasingly important as applications in airplanes, cars, and other safety critical structures are growing rapidly. Although a clear understanding has been established for initiation, growth and accumulation of damage, it is still unclear when and how the interactions of these local events lead to the development of a “critical” fracture path resulting in a sudden change of global properties and possible rupture. In the present paper, we simulate damage development in a neat polymeric resin using X-FEM analysis, and conduct concomitant dielectric response analysis with a COMSOLTM simulation model to study the collective defect structure as it develops in a model system. Our studies reveal inflection points in the predicted global dielectric response vs. strain that are related to changes in local damage growth rates and modes that clearly indicate impending fracture and capture the progressive change in material state.展开更多
基金University Grants Commission (No. F.FIP/ 11th Plan/KLCA046TF, dated 12. May, 2009),Government of India for the award of a research fellowship under the Faculty Improvement Program (FIP)
文摘Fenofibrate is mainly used to reduce cholesterol level in patients at risk of cardiovascular disease. Thermal transition study with the help of differential scanning calorimetry （DSC） shows that the aforesaid active pharmaceutical ingredient （API） is a good glass former. Based on our DSC study, the molecular dynamics of this API has been carried out by broadband dielectric spectroscopy （BDS） covering wide temperature and frequency ranges. Dielectric measurements of amorphous fenofibrate were per- formed after its vitrification by fast cooling from a few degrees above the melting point （Tm=354.11 K） to deep glassy state. The sample does not show any crystallization tendency during cooling and reaches the glassy state. The temperature dependence of the structural relaxation has been fitted by single Vogel- Fulcher-Tamman （VFT） equation. From VFT fit, glass transition temperature （Tg） was estimated as 250.56 K and fragility （m） was determined as 94.02. This drug is classified as a fragile glass former. Deviations of experimental data from Kohlrausch-Williams-Watts （KWW） fits on high-frequency flank of α-peak indicate the presence of an excess wing in fenofibrate. Based on Ngai＇s coupling model, we identified the excess wing as true Johari-Goldstein （JG） process. Below the glass transition temperature one can clearly see a secondary relaxation （γ） with an activation energy of 32.67 kJ/mol.
文摘Composite materials, by nature, are universally dielectric. The distribution of the phases, including voids and cracks, has a major influence on the dielectric properties of the composite materials. The dielectric relaxation behavior measured by Broadband Dielectric Spectroscopy (BbDS) is often caused by interfacial polarization, which is known as Maxwell-Wagner-Sillars polarization that develops because of the heterogeneity of the composite materials. A prominent mechanism in the low frequency range is driven by charge accumulation at the interphases between different constituent phases. In our previous work, we observed in-situ changes in dielectric behavior during static tensile testing, and also studied the effects of applied mechanical and ambient environments on composite material damage states based on the evaluation of dielectric spectral analysis parameters. In the present work, a two dimensional conformal computational model was developed using a COMSOL™multi-physics module to interpret the effective dielectric behavior of the resulting composite as a function of applied frequency spectra, especially the effects of volume fraction, the distribution of the defects inside of the material volume, and the influence of the permittivity and Ohmic conductivity of the host materials and defects.
文摘The long-term properties of continuous fiber reinforced composite materials are increasingly important as applications in airplanes, cars, and other safety critical structures are growing rapidly. Although a clear understanding has been established for initiation, growth and accumulation of damage, it is still unclear when and how the interactions of these local events lead to the development of a “critical” fracture path resulting in a sudden change of global properties and possible rupture. In the present paper, we simulate damage development in a neat polymeric resin using X-FEM analysis, and conduct concomitant dielectric response analysis with a COMSOLTM simulation model to study the collective defect structure as it develops in a model system. Our studies reveal inflection points in the predicted global dielectric response vs. strain that are related to changes in local damage growth rates and modes that clearly indicate impending fracture and capture the progressive change in material state.
