Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing.We now report a radical-polar crossover(RPC)-enabled three-component cyclization of bromodiflu...Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing.We now report a radical-polar crossover(RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino cyclization.The reaction exhibited a broad substrate scope(>40 examples)including complex molecules,which highlighted the utility of this strategy for the construction of a library of bioactive analogs.展开更多
基金the National Natural Science Foundation of China(22071171)the Natural Science Foundation of Zhejiang Province(LZ22B020003)for financial support of this work.
文摘Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing.We now report a radical-polar crossover(RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino cyclization.The reaction exhibited a broad substrate scope(>40 examples)including complex molecules,which highlighted the utility of this strategy for the construction of a library of bioactive analogs.
