4,6-O-Benzylidenation of D-galactal with PhCH（OCH3）2 catalyzed by bromodimethylsulfonium bromide leads to methyl 2-dexoy-4,6-O-benzylidene galactopyranoside efficiently, which serves as a key intermediate to the rea...4,6-O-Benzylidenation of D-galactal with PhCH（OCH3）2 catalyzed by bromodimethylsulfonium bromide leads to methyl 2-dexoy-4,6-O-benzylidene galactopyranoside efficiently, which serves as a key intermediate to the ready preparation of 2,3- and 2,6-dideoxy galactopyranosides.展开更多
Bromodimethylsulfonium bromide （BDMS） was used as an efficient brominating reagent for the synthesis of 9,10-dibromoanthracene in dichloromethane. The desired products were obtained in excellent yields.
Herein,a mild and simple method to synthesize methylthiomethyl(MTM)esters with commercially available bromodimethylsulfonium bromide is described.The developed procedure allows the methylthiomethylation of a vast scop...Herein,a mild and simple method to synthesize methylthiomethyl(MTM)esters with commercially available bromodimethylsulfonium bromide is described.The developed procedure allows the methylthiomethylation of a vast scope of carboxylic acids,including alkyl,(hetero)aryl and unsaturated acids,with the tolerance of various functionalities.Several drug or bioactive molecules and amino acids have been successfully converted to their MTM ester analogues as well.展开更多
基金This work is sponsored by National Natural Science Foundation of China （No. 21002014） and the Startup Foundation for Young Teachers, School of Pharmacy,Fudan University.
文摘4,6-O-Benzylidenation of D-galactal with PhCH（OCH3）2 catalyzed by bromodimethylsulfonium bromide leads to methyl 2-dexoy-4,6-O-benzylidene galactopyranoside efficiently, which serves as a key intermediate to the ready preparation of 2,3- and 2,6-dideoxy galactopyranosides.
基金supported financially by the Natural Science Foundation of Tianjin (Nos. 12JCZDJC34300, 11JCYBJC03600)Young Scientist Fund (No. 21001080)
文摘Bromodimethylsulfonium bromide （BDMS） was used as an efficient brominating reagent for the synthesis of 9,10-dibromoanthracene in dichloromethane. The desired products were obtained in excellent yields.
基金the National Key Research and Development Project(No.2021YFC2100100)the National Natural Science Foundation of China(No.21901123)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20190694)the Jiangsu Specially Appointed Professor Plan.
文摘Herein,a mild and simple method to synthesize methylthiomethyl(MTM)esters with commercially available bromodimethylsulfonium bromide is described.The developed procedure allows the methylthiomethylation of a vast scope of carboxylic acids,including alkyl,(hetero)aryl and unsaturated acids,with the tolerance of various functionalities.Several drug or bioactive molecules and amino acids have been successfully converted to their MTM ester analogues as well.
