Chronic lung allograft dysfunction(CLAD)following lung transplantation limits long-term survival considerably.The main reason for this is a lack of knowledge regarding the pathological condition and the establishment ...Chronic lung allograft dysfunction(CLAD)following lung transplantation limits long-term survival considerably.The main reason for this is a lack of knowledge regarding the pathological condition and the establishment of treatment.The consensus statement from the International Society for Heart and Lung Transplantation on CLAD in 2019 classified CLAD into two main phenotypes:Bronchiolitis obliterans syndrome and restrictive allograft syndrome.Along with this clear classification,further exploration of the mechanisms and the development of appropriate prevention and treatment strategies for each phenotype are desired.In this review,we summarize the new definition of CLAD and update and summarize the existing knowledge on the underlying mechanisms of bronchiolitis obliterans syndrome and restrictive allograft syndrome,which have been elucidated from clinicopathological observations and animal experiments worldwide.展开更多
目的系统评价儿童腺病毒肺炎后发生闭塞性细支气管炎的危险因素。方法计算机检索PubMed、Embase、Web of Science、中国知网、维普数据库、万方医学数据库和中国生物医学文献数据库,搜集有关儿童腺病毒肺炎后发生闭塞性细支气管炎危险...目的系统评价儿童腺病毒肺炎后发生闭塞性细支气管炎的危险因素。方法计算机检索PubMed、Embase、Web of Science、中国知网、维普数据库、万方医学数据库和中国生物医学文献数据库,搜集有关儿童腺病毒肺炎后发生闭塞性细支气管炎危险因素的病例对照研究和队列研究,检索时限均为建库至2022年7月。由2名研究员独立完成文献筛选、数据提取和质量评价后,使用RevMan5.4软件进行Meta分析。结果共纳入11个研究,共1672名患儿,病例组350例,对照组1322例。Meta分析结果显示:年龄[WMD=-4.22,95%CI[-5.86,-2.59],P<0.0001]、住院天数[WMD=4.39,95%CI(1.73,7.04),P<0.001]、热程[WMD=2.60,95%CI(0.96,4.23),P<0.01]、呼吸机使用时间[WMD=3.55,95%CI(0.53,6.56),P=0.02]、机械通气[OR=11.85,95%CI(6.70,20.96),P<0.0001]、喘息[OR=2.40,95%CI(2.01,2.88),P<0.0001]、呼吸困难[OR=11.70,95%CI(6.93,19.77),P<0.0001]、合并细菌感染[OR=2.02,95%CI(1.32,3.10),P<0.01]均是儿童腺病毒肺炎后发生闭塞性细支气管炎的危险因素。结论当前证据表明,年龄小、住院天数、热程及呼吸机使用时间长、急性期喘息与呼吸困难症状、合并细菌感染及使用机械通气辅助治疗是儿童腺病毒肺炎后发生感染后闭塞性细支气管炎的危险因素。展开更多
文摘Chronic lung allograft dysfunction(CLAD)following lung transplantation limits long-term survival considerably.The main reason for this is a lack of knowledge regarding the pathological condition and the establishment of treatment.The consensus statement from the International Society for Heart and Lung Transplantation on CLAD in 2019 classified CLAD into two main phenotypes:Bronchiolitis obliterans syndrome and restrictive allograft syndrome.Along with this clear classification,further exploration of the mechanisms and the development of appropriate prevention and treatment strategies for each phenotype are desired.In this review,we summarize the new definition of CLAD and update and summarize the existing knowledge on the underlying mechanisms of bronchiolitis obliterans syndrome and restrictive allograft syndrome,which have been elucidated from clinicopathological observations and animal experiments worldwide.
文摘目的系统评价儿童腺病毒肺炎后发生闭塞性细支气管炎的危险因素。方法计算机检索PubMed、Embase、Web of Science、中国知网、维普数据库、万方医学数据库和中国生物医学文献数据库,搜集有关儿童腺病毒肺炎后发生闭塞性细支气管炎危险因素的病例对照研究和队列研究,检索时限均为建库至2022年7月。由2名研究员独立完成文献筛选、数据提取和质量评价后,使用RevMan5.4软件进行Meta分析。结果共纳入11个研究,共1672名患儿,病例组350例,对照组1322例。Meta分析结果显示:年龄[WMD=-4.22,95%CI[-5.86,-2.59],P<0.0001]、住院天数[WMD=4.39,95%CI(1.73,7.04),P<0.001]、热程[WMD=2.60,95%CI(0.96,4.23),P<0.01]、呼吸机使用时间[WMD=3.55,95%CI(0.53,6.56),P=0.02]、机械通气[OR=11.85,95%CI(6.70,20.96),P<0.0001]、喘息[OR=2.40,95%CI(2.01,2.88),P<0.0001]、呼吸困难[OR=11.70,95%CI(6.93,19.77),P<0.0001]、合并细菌感染[OR=2.02,95%CI(1.32,3.10),P<0.01]均是儿童腺病毒肺炎后发生闭塞性细支气管炎的危险因素。结论当前证据表明,年龄小、住院天数、热程及呼吸机使用时间长、急性期喘息与呼吸困难症状、合并细菌感染及使用机械通气辅助治疗是儿童腺病毒肺炎后发生感染后闭塞性细支气管炎的危险因素。
