The electric field of the microtubule is calculated according to its dipole distribution. The conformational change of a molecular motor is described by the rotation of a dipole which interacts with the microtubule. T...The electric field of the microtubule is calculated according to its dipole distribution. The conformational change of a molecular motor is described by the rotation of a dipole which interacts with the microtubule. The numerical simulation for the particle current shows that this interaction helps to produce a directional motion along the microtubule. And the average displacement executes step changes that resemble the experimental result for kinesin motors.展开更多
The directional drifting of particles/molecules with broken symmetry has received increasing attention. Through molecular dynamics simulations, we investigate the effects of various solvents on the time-dependent dire...The directional drifting of particles/molecules with broken symmetry has received increasing attention. Through molecular dynamics simulations, we investigate the effects of various solvents on the time-dependent directional drifting of a particle with broken symmetry. Our simulations show that the distance of directional drift of the asymmetrical particle is reduced while the ratio of the drift to the mean displacement of the particle is enhanced with increasing mass, size, and interaction strength of the solvent atoms in a short time range. Among the parameters considered, solvent atom size is a particularly influential factor for enhancing the directional drift of asymmetrical particles, while the effects of the interaction strength and the mass of the solvent atoms are relatively weaker. These findings are of great importance to the understanding and control of the Brownian motion of particles in various physical, chemical, and biological processes within finite time spans.展开更多
Transport of an underdamped Brownian particle in a one-dimensional asymmetric deformable potential is investigated in the presence of both an ac force and a static force,respectively.From numerical simulations,we obta...Transport of an underdamped Brownian particle in a one-dimensional asymmetric deformable potential is investigated in the presence of both an ac force and a static force,respectively.From numerical simulations,we obtain the current average velocity.The current reversals and the absolute negative mobility are presented.The increasing of the deformation of the potential can cause the absolute negative mobility to be suppressed and even disappear.When the static force is small,the increase of the potential deformation suppresses the absolute negative mobility.When the force is large,the absolute negative mobility disappears.In particular,when the potential deformation is equal to0.015,the two current reversals present with the increasing of the force.Remarkably,when the potential deformation is small,there are three current reversals with the increasing of the friction coefficient and the average velocity presents a oscillation behavior.展开更多
文摘The electric field of the microtubule is calculated according to its dipole distribution. The conformational change of a molecular motor is described by the rotation of a dipole which interacts with the microtubule. The numerical simulation for the particle current shows that this interaction helps to produce a directional motion along the microtubule. And the average displacement executes step changes that resemble the experimental result for kinesin motors.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11175230 and 11474299)Innovation Program of the Shanghai Municipality Education Commission, China (Grant No. 14ZZ095)Shanghai Supercomputer Center and Supercomputing Center of the Chinese Academy of Sciences
文摘The directional drifting of particles/molecules with broken symmetry has received increasing attention. Through molecular dynamics simulations, we investigate the effects of various solvents on the time-dependent directional drifting of a particle with broken symmetry. Our simulations show that the distance of directional drift of the asymmetrical particle is reduced while the ratio of the drift to the mean displacement of the particle is enhanced with increasing mass, size, and interaction strength of the solvent atoms in a short time range. Among the parameters considered, solvent atom size is a particularly influential factor for enhancing the directional drift of asymmetrical particles, while the effects of the interaction strength and the mass of the solvent atoms are relatively weaker. These findings are of great importance to the understanding and control of the Brownian motion of particles in various physical, chemical, and biological processes within finite time spans.
基金Supported in part by the National Natural Science Foundation of China under Grant Nos.11575064 and 11175067the Natural Science Foundation of Guangdong Province under Grant No.2016A030313433
文摘Transport of an underdamped Brownian particle in a one-dimensional asymmetric deformable potential is investigated in the presence of both an ac force and a static force,respectively.From numerical simulations,we obtain the current average velocity.The current reversals and the absolute negative mobility are presented.The increasing of the deformation of the potential can cause the absolute negative mobility to be suppressed and even disappear.When the static force is small,the increase of the potential deformation suppresses the absolute negative mobility.When the force is large,the absolute negative mobility disappears.In particular,when the potential deformation is equal to0.015,the two current reversals present with the increasing of the force.Remarkably,when the potential deformation is small,there are three current reversals with the increasing of the friction coefficient and the average velocity presents a oscillation behavior.
