Brucellosis is an important zoonosis that results in substantial economic losses to the livestock industry through abortions and reduced milk yield.This study investigated an abortion outbreak in a dairy herd and then...Brucellosis is an important zoonosis that results in substantial economic losses to the livestock industry through abortions and reduced milk yield.This study investigated an abortion outbreak in a dairy herd and then explored the efects of emergency vaccination with Brucella abortus A19 vaccine on the incidence of abortion and milk yield.A full dose of vaccine(6×10^(10)—12×10^(10)colony forming units,CFU)was administered subcutaneously to calves and non-pregnant heifers,and a reduced dose(6×10^(8)—12×10^(8)CFU)to adult cows and pregnant replacement heifers.Rose Bengal Test was used to screen Brucella infection status and then positive samples were tested with a C-ELISA.Animals that tested positive for both tests were considered positive to Brucella spp.The animal-level seroprevalence of brucellosis was 23.1%(95%CI:17.0,30.2),and the attributable fraction of abortions in seropositive animals was 89.1%(95%CI:64.3,96.7).The odds of seropositivity were signifcantly higher in cows that aborted compared to cows that calved normally(OR=21.4,95%CI:4.4,168.4).Cows in sheds A2 and C1 were 10.2(95%CI:1.4,128.0)and 17.0(95%CI:2.8,190.3)times more likely to be seropositive than cows in shed B1.Antibodies were not detectable in most heifers 12 months post-vaccination.The efectiveness of the vaccine in preventing abortions was estimated to be 56.8%(95%CI:15.8,77.8)for the entire herd,but increased to 86.7%(95%CI:4.4,98.1)when only primiparous heifers were considered.Furthermore,a signifcant increase in the average herd 305-day milk yield one-year after vaccination was also observed relative to that in the previous three years.It is concluded that emergency vaccination of a dairy herd undergoing an abortion outbreak with the A19 vaccine efectively reduced the incidence of abortion and indirectly increased milk yield one-year after vaccination.展开更多
时下,越来越多的品牌电脑向着更居家、更节省空间和更大的显示面积三个方向发展。恒星视界迎合消费者的需求,推出了恒星视界PC-TV all in one系列液晶多媒体一体机。我是一个不折不扣的游戏迷,虽然平常工作比较繁忙,但是从小就喜欢玩游...时下,越来越多的品牌电脑向着更居家、更节省空间和更大的显示面积三个方向发展。恒星视界迎合消费者的需求,推出了恒星视界PC-TV all in one系列液晶多媒体一体机。我是一个不折不扣的游戏迷,虽然平常工作比较繁忙,但是从小就喜欢玩游戏的我,却总是在下班后,一个人在屋子里玩上几个小时的游戏,缓解一天来工作的疲劳。然而。展开更多
AIM: To investigate the feasibility and efficacy of the combination of S-1 with gemcitabine followed by oral S-1 with concurrent radiotherapy (intensity modulated radiotherapy, IMRT) and maintenance therapy with S-1 f...AIM: To investigate the feasibility and efficacy of the combination of S-1 with gemcitabine followed by oral S-1 with concurrent radiotherapy (intensity modulated radiotherapy, IMRT) and maintenance therapy with S-1 for locally advanced pancreatic cancer.展开更多
基金supported by the earmarked fund for China Agriculture Research System(Beef/Yaks)(#CARS-37)National Science Foundation of Hubei Province(#2021CFA016).
文摘Brucellosis is an important zoonosis that results in substantial economic losses to the livestock industry through abortions and reduced milk yield.This study investigated an abortion outbreak in a dairy herd and then explored the efects of emergency vaccination with Brucella abortus A19 vaccine on the incidence of abortion and milk yield.A full dose of vaccine(6×10^(10)—12×10^(10)colony forming units,CFU)was administered subcutaneously to calves and non-pregnant heifers,and a reduced dose(6×10^(8)—12×10^(8)CFU)to adult cows and pregnant replacement heifers.Rose Bengal Test was used to screen Brucella infection status and then positive samples were tested with a C-ELISA.Animals that tested positive for both tests were considered positive to Brucella spp.The animal-level seroprevalence of brucellosis was 23.1%(95%CI:17.0,30.2),and the attributable fraction of abortions in seropositive animals was 89.1%(95%CI:64.3,96.7).The odds of seropositivity were signifcantly higher in cows that aborted compared to cows that calved normally(OR=21.4,95%CI:4.4,168.4).Cows in sheds A2 and C1 were 10.2(95%CI:1.4,128.0)and 17.0(95%CI:2.8,190.3)times more likely to be seropositive than cows in shed B1.Antibodies were not detectable in most heifers 12 months post-vaccination.The efectiveness of the vaccine in preventing abortions was estimated to be 56.8%(95%CI:15.8,77.8)for the entire herd,but increased to 86.7%(95%CI:4.4,98.1)when only primiparous heifers were considered.Furthermore,a signifcant increase in the average herd 305-day milk yield one-year after vaccination was also observed relative to that in the previous three years.It is concluded that emergency vaccination of a dairy herd undergoing an abortion outbreak with the A19 vaccine efectively reduced the incidence of abortion and indirectly increased milk yield one-year after vaccination.
文摘时下,越来越多的品牌电脑向着更居家、更节省空间和更大的显示面积三个方向发展。恒星视界迎合消费者的需求,推出了恒星视界PC-TV all in one系列液晶多媒体一体机。我是一个不折不扣的游戏迷,虽然平常工作比较繁忙,但是从小就喜欢玩游戏的我,却总是在下班后,一个人在屋子里玩上几个小时的游戏,缓解一天来工作的疲劳。然而。
文摘AIM: To investigate the feasibility and efficacy of the combination of S-1 with gemcitabine followed by oral S-1 with concurrent radiotherapy (intensity modulated radiotherapy, IMRT) and maintenance therapy with S-1 for locally advanced pancreatic cancer.
