BACKGROUND Respiratory viruses are increasingly detected in children with communityacquired pneumonia.Further strategies to limit antibiotic use in children with viral pneumonia are warranted.AIM To explore clinical e...BACKGROUND Respiratory viruses are increasingly detected in children with communityacquired pneumonia.Further strategies to limit antibiotic use in children with viral pneumonia are warranted.AIM To explore clinical efficacy of budesonide/formoterol inhalation powder for viral pneumonia in children and its impact on cellular immunity and inflammatory factor production.METHODS A total of 60 children with viral pneumonia were recruited:30 receiving budesonide/formoterol inhalation powder and 30 conventional symptomatic treatment.Outcome measures included peripheral blood levels of inflammatory cytokines,CD4^(+),CD8^(+),Th1,Th2,Th17 and Treg,clinical efficacy,and incidence of adverse reactions.RESULTS Compared with the control group,the observation group showed a significant reduction in interleukin-6 and high-sensitivity C-reactive protein levels after treatment.Compared with the control group,the observation group showed a significant increase in CD4^(+)/CD8^(+)and Th1/Th2 levels,and a decrease in Th17/Treg levels after treatment.The total effective rates in the observation group and the control group were 93.75%and 85.00%,respectively,which was a significant difference(P=0.003).CONCLUSION Budesonide/formoterol inhalation powder significantly improved therapeutic efficacy for viral pneumonia in children.The mechanism of action may be related to downregulation of the inflammatory response and improved cellular immune function.展开更多
目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的8...目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的80例慢阻肺急性加重期患者作为研究对象,按照随机数字表分为对照组和观察组,各40例。对照组使用布地格福进行治疗,观察组在对照组的基础上联合K5压力阈值吸气肌训练治疗,两组均治疗30d。分别比较患者治疗前后的圣乔治评分(St.George's Respiratory Questionnaire,SGRQ)、6分钟步行试验(6-minute walk test,6MWT)、最大吸气压(Maximum inspiratory pressure,MIP),并通过测量第1秒呼气量(Forced Expiratory Volume in the first second,FEV1)、用力肺活量(Forced Vital Capacity,FVC)、弥散功能血氧饱和度(Oxygen saturation of blood,SaO_(2))、动脉氧分压(Arterial Oxygen Partial Pressure,PO_(2))、动脉二氧化碳分压(Partial pressure of arterial carbon dioxide,PCO_(2))对肺功能和血气指标进行比较分析,对其进行比较分析。结果:观察组的SGRQ三项评分均低于对照组(P<0.05);治疗后观察组的6MWT和MIP两项都比对照组高(P<0.05);观察组的FEV1、FVC和弥散功能三项指标都高于对照组(P<0.05);观察组的SaO_(2)和PO_(2)明显高于对照组,PCO_(2)明显低于对照组(P<0.05)。结论:布地格福吸入气雾剂联合K5压力阈值吸气肌训练能有效减轻患者的症状,改善呼吸力学参数并提高生命质量,延长患者生存时间。展开更多
基金the Wenzhou Basic Medical and Health Science and Technology Project,No.Y20210307.
文摘BACKGROUND Respiratory viruses are increasingly detected in children with communityacquired pneumonia.Further strategies to limit antibiotic use in children with viral pneumonia are warranted.AIM To explore clinical efficacy of budesonide/formoterol inhalation powder for viral pneumonia in children and its impact on cellular immunity and inflammatory factor production.METHODS A total of 60 children with viral pneumonia were recruited:30 receiving budesonide/formoterol inhalation powder and 30 conventional symptomatic treatment.Outcome measures included peripheral blood levels of inflammatory cytokines,CD4^(+),CD8^(+),Th1,Th2,Th17 and Treg,clinical efficacy,and incidence of adverse reactions.RESULTS Compared with the control group,the observation group showed a significant reduction in interleukin-6 and high-sensitivity C-reactive protein levels after treatment.Compared with the control group,the observation group showed a significant increase in CD4^(+)/CD8^(+)and Th1/Th2 levels,and a decrease in Th17/Treg levels after treatment.The total effective rates in the observation group and the control group were 93.75%and 85.00%,respectively,which was a significant difference(P=0.003).CONCLUSION Budesonide/formoterol inhalation powder significantly improved therapeutic efficacy for viral pneumonia in children.The mechanism of action may be related to downregulation of the inflammatory response and improved cellular immune function.
文摘目的:研究布地格福联合K5压力阈值吸气肌训练对慢阻肺急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者呼吸力学参数及生命质量的影响。方法:选取2022年1月至2024年1月在赣州市第五人民医院就诊的80例慢阻肺急性加重期患者作为研究对象,按照随机数字表分为对照组和观察组,各40例。对照组使用布地格福进行治疗,观察组在对照组的基础上联合K5压力阈值吸气肌训练治疗,两组均治疗30d。分别比较患者治疗前后的圣乔治评分(St.George's Respiratory Questionnaire,SGRQ)、6分钟步行试验(6-minute walk test,6MWT)、最大吸气压(Maximum inspiratory pressure,MIP),并通过测量第1秒呼气量(Forced Expiratory Volume in the first second,FEV1)、用力肺活量(Forced Vital Capacity,FVC)、弥散功能血氧饱和度(Oxygen saturation of blood,SaO_(2))、动脉氧分压(Arterial Oxygen Partial Pressure,PO_(2))、动脉二氧化碳分压(Partial pressure of arterial carbon dioxide,PCO_(2))对肺功能和血气指标进行比较分析,对其进行比较分析。结果:观察组的SGRQ三项评分均低于对照组(P<0.05);治疗后观察组的6MWT和MIP两项都比对照组高(P<0.05);观察组的FEV1、FVC和弥散功能三项指标都高于对照组(P<0.05);观察组的SaO_(2)和PO_(2)明显高于对照组,PCO_(2)明显低于对照组(P<0.05)。结论:布地格福吸入气雾剂联合K5压力阈值吸气肌训练能有效减轻患者的症状,改善呼吸力学参数并提高生命质量,延长患者生存时间。
