Objectives: To identify local resource use such as pharmaceutical treatment, medical follow-up, and patient hospitalization and estimate the budget impact of simeprevir (SMV) plus pegylated interferon (P)/ribavirin (R...Objectives: To identify local resource use such as pharmaceutical treatment, medical follow-up, and patient hospitalization and estimate the budget impact of simeprevir (SMV) plus pegylated interferon (P)/ribavirin (R) as a treatment option in the early stages of the disease in Greece. Methods: A budget impact tool was developed with a two-year time horizon, which estimated the impact on the Social Insurance Funds (SIFs) of introducing SMV + PR in the management of the early disease stages. Total direct and indirect costs were estimated for each of the following health states: non-cirrhotic chronic Hepatitis C (and within that by fibrosis stage), compensated cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma. Data gaps on treatment algorithms, resource use and productivity losses were covered via an expert panel of eight leading hepatologists. Epidemiology data were taken from the published literature. Unit costs were obtained from the Ministry of Health and SIFs. The perspective was that of the SIF and the cost base year was 2015. Results: The total (direct and indirect) cost per patient per year (excluding cost of antiviral treatment) was estimated at €647, €703, €5,753, €16,313 and €37,237 for non-cirrhotic CHC, compensated cirrhosis, decompensated cirrhosis, HCC and liver transplantation, respectively. The budget impact analysis showed that adding SMV to PR in the early stages of the disease would lead to an increase in the cost of antiviral treatment by €2.03 million. Conclusions: Costs of managing CHC increase dramatically with disease severity. SMV + PR for naive patients at early disease stages has a significant but manageable budget impact, and could prevent high costs in advanced stages.展开更多
目的通过评估我国公开发表的医保预算影响分析(BIA)研究文献,探讨我国医保BIA研究预测的准确性,并分析其影响因素,以期为我国医保决策提供参考。方法通过PubMed、Web of Science、CNKI、万方和维普等数据库检索BIA研究的相关文献,使用...目的通过评估我国公开发表的医保预算影响分析(BIA)研究文献,探讨我国医保BIA研究预测的准确性,并分析其影响因素,以期为我国医保决策提供参考。方法通过PubMed、Web of Science、CNKI、万方和维普等数据库检索BIA研究的相关文献,使用医保预算影响分析质量评估量表对纳入研究的文献质量进行定量评估,准确性分析指标为药品销售金额预测值与其实际值的比值,使用t检验进行单因素分析、多重线性回归进行多因素分析。结果最终纳入11篇文献,文献评估得分为0.7503±0.0309。共有24项数据纳入分析,单因素分析结果显示文献评分对BIA预测准确性差异有统计学意义(P<0.05),多因素分析显示BIA预测准确性受到文献评分、年均/疗程药品成本的影响(F=7.844,P<0.05)。结论我国医保BIA相关文献质量总体较好,但在数据引用、分析内容与结果呈现等方面仍存在一定问题;研究预测结果的准确性存在欠缺,预测值普遍高于实际值。建议提高对医保BIA研究质量的重视程度,加强医保BIA准确性的相关研究。展开更多
文摘Objectives: To identify local resource use such as pharmaceutical treatment, medical follow-up, and patient hospitalization and estimate the budget impact of simeprevir (SMV) plus pegylated interferon (P)/ribavirin (R) as a treatment option in the early stages of the disease in Greece. Methods: A budget impact tool was developed with a two-year time horizon, which estimated the impact on the Social Insurance Funds (SIFs) of introducing SMV + PR in the management of the early disease stages. Total direct and indirect costs were estimated for each of the following health states: non-cirrhotic chronic Hepatitis C (and within that by fibrosis stage), compensated cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma. Data gaps on treatment algorithms, resource use and productivity losses were covered via an expert panel of eight leading hepatologists. Epidemiology data were taken from the published literature. Unit costs were obtained from the Ministry of Health and SIFs. The perspective was that of the SIF and the cost base year was 2015. Results: The total (direct and indirect) cost per patient per year (excluding cost of antiviral treatment) was estimated at €647, €703, €5,753, €16,313 and €37,237 for non-cirrhotic CHC, compensated cirrhosis, decompensated cirrhosis, HCC and liver transplantation, respectively. The budget impact analysis showed that adding SMV to PR in the early stages of the disease would lead to an increase in the cost of antiviral treatment by €2.03 million. Conclusions: Costs of managing CHC increase dramatically with disease severity. SMV + PR for naive patients at early disease stages has a significant but manageable budget impact, and could prevent high costs in advanced stages.
文摘目的通过评估我国公开发表的医保预算影响分析(BIA)研究文献,探讨我国医保BIA研究预测的准确性,并分析其影响因素,以期为我国医保决策提供参考。方法通过PubMed、Web of Science、CNKI、万方和维普等数据库检索BIA研究的相关文献,使用医保预算影响分析质量评估量表对纳入研究的文献质量进行定量评估,准确性分析指标为药品销售金额预测值与其实际值的比值,使用t检验进行单因素分析、多重线性回归进行多因素分析。结果最终纳入11篇文献,文献评估得分为0.7503±0.0309。共有24项数据纳入分析,单因素分析结果显示文献评分对BIA预测准确性差异有统计学意义(P<0.05),多因素分析显示BIA预测准确性受到文献评分、年均/疗程药品成本的影响(F=7.844,P<0.05)。结论我国医保BIA相关文献质量总体较好,但在数据引用、分析内容与结果呈现等方面仍存在一定问题;研究预测结果的准确性存在欠缺,预测值普遍高于实际值。建议提高对医保BIA研究质量的重视程度,加强医保BIA准确性的相关研究。
