Four new triterpenoid alkaloid derivatives,buxrugulines A-D(1-4),together with four known ones(5-8),were isolated from the leaves and stems of Buxus rugulosa.The structures of compounds 1-4 were elucidated by NMR and ...Four new triterpenoid alkaloid derivatives,buxrugulines A-D(1-4),together with four known ones(5-8),were isolated from the leaves and stems of Buxus rugulosa.The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis.All compounds were assayed for their cytotoxicities against HL-60,SMMC-7721,A549,MCF-7,and SW480 cells lines.展开更多
Buxrugulosides A–E,four lignan glycosides(1–4)and a protocatechuate derivative(5)featuring a rare(N,Ndiethyl)methyl amino group at aromatic rings,were obtained from the aerial parts of Buxus rugulosa,which is famous...Buxrugulosides A–E,four lignan glycosides(1–4)and a protocatechuate derivative(5)featuring a rare(N,Ndiethyl)methyl amino group at aromatic rings,were obtained from the aerial parts of Buxus rugulosa,which is famous for treating coronary heart disease.Their structures including absolute configurations were elucidated by HRMS,1 D and 2 D NMR,and by comparing their CD data with previous reports.Compound 1 was a rare sesquilignan,and all of these compounds were the first example of lignans with(N,N-diethyl)methyl amino group.展开更多
基金The project was financially supported by the Knowledge Innovation Program of the CAS(Grant No.KSCX2-YW-G-038,KSCX2-YW-R-194,KSCX2-EW-R-15,and KZCX2-XB2-15-03)as well as Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2008-ZZ05 and P2010-ZZ14).
文摘Four new triterpenoid alkaloid derivatives,buxrugulines A-D(1-4),together with four known ones(5-8),were isolated from the leaves and stems of Buxus rugulosa.The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis.All compounds were assayed for their cytotoxicities against HL-60,SMMC-7721,A549,MCF-7,and SW480 cells lines.
基金supported by the“Double FirstClass”University Project(No.CPU2018GY08)the Drug Innovation Major Project(No.2018ZX09711-001-007)。
文摘Buxrugulosides A–E,four lignan glycosides(1–4)and a protocatechuate derivative(5)featuring a rare(N,Ndiethyl)methyl amino group at aromatic rings,were obtained from the aerial parts of Buxus rugulosa,which is famous for treating coronary heart disease.Their structures including absolute configurations were elucidated by HRMS,1 D and 2 D NMR,and by comparing their CD data with previous reports.Compound 1 was a rare sesquilignan,and all of these compounds were the first example of lignans with(N,N-diethyl)methyl amino group.
