Preliminary Results of Assessing the Mixing of Wave Transport Flux Residualin the Upper Ocean with ROMS

The effects of the mixing of wave transport flux residual(Bvl) on the upper ocean is studied through carrying out the control run(CR) and a series of sensitive runs(SR) with ROMS model.In this study,the important role of Bvl is revealed by comparing the ocean temperature,statistical analysis of errors and evaluating the mixed layer depth.It is shown that the overestimated SST is improved effectively when the wave-induced mixing is incorporated to the vertical mixing scheme.As can be seen from the vertical structure of temperature 28℃ isotherm changes from 20 min CR to 35 m in SR3,which is more close to the observation.Statistic analysis shows that the root-mean-square errors of the temperature in 10 m are reduced and the correlation between model results and observation data are increased after considering the effect of Bvl.The numerical results of the ocean temperature show improvement in summer and in tropical zones in winter,especially in the strong current regions in summer.In August the mixed layer depth(MLD) which is defined as the depth that the temperature has changed 0.5℃ from the reference depth of 10 m is further analyzed.The simulation results have a close relationship with undetermined coefficient of Bvl,sensitivity studies show that a coefficient about 0.1 is reasonable value in the model.

I期非小细胞肺癌的分子预后

目的 联合检测I期非小细胞肺癌（NSCLC）的细胞增殖、凋亡和血管生成，探讨I期非小细胞肺癌预后分层。方法应用免疫组织化学方法检测118例I期非小细胞肺癌、30例肺良性组织和30例正常肺组织血管内皮生长因子（VEGF）的表达，应用比Ki67标记检测细胞增殖指数（PI）。TUNEL法检测70例I期非小细胞肺癌，30例正常肺组织凋亡指数（AI）。结果单因素分析结果表明，肿瘤血管浸润、VEGF高表达、高PI、低AI为I期非小细胞肺癌的不良预后因素。多因素分析结果显示，肿瘤血管浸润（BVI、VEGF及PI可以作为影响I期非小细胞肺癌预后的独立因素。根据免疫组化综合评分（IRS）IRS=VEGF＋PI＋AI，将患者分为低危组及高危组，5年总体生存率分别为82．22％、23．33％，有显著性差异（P=0．0056）。综合评分可作为独立预后因素（RR=4．878，95％CI：1．379～17．258，P=O．014）。结论联合检测肿瘤的细胞增殖、凋亡和血管生成，可能实现对I期非小细胞肺癌的预后分层，判断预后以及指导治疗。