Banxia Xiexin Decoction(半夏泻心汤)Combined with Afatinib in Treatment of Advanced Gallbladder Cancer:Case Report and Literature Review

Gallbladder cancer(GBC)is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developingCurrently,GBC has a low early diagnosis rate and an extremely poor prognosis,leading to major problems for treatment of GBC.Liver invasion and metastasis one of the main causes of its poor prognosis,with its average overall survival of 6 months.

半夏泻心汤对糖尿病胃轻瘫大鼠胰岛素抵抗中GLUT4和GSK-3表达的影响

目的：观察半夏泻心汤对糖尿病胃轻瘫（Diabetic gastroparesis,DGP）胰岛素抵抗中葡萄糖转运蛋白4（glucose transport4,GLUT4）和糖原合成酶激酶-3（glycogen synthetase kinase-3,GSK-3）表达的影响,分析其治疗糖尿病胃轻瘫的作用机制。方法：将120只大鼠随机分为空白组和造模组,造模组链脲佐菌素（sreptozotocin,STZ）腹腔注射后采用高脂高糖饲料连续喂养15天,选择大鼠空腹血糖（fasting plasma glucose,FGB）在11.1-30.0mmol/L的大鼠作为糖尿病胃轻瘫大鼠模型,按照血糖分层随机分为模型组、二甲双胍组（1.80g/kg）、半夏泻心汤组（10.20g/kg）、半夏泻心汤组（5.10g/kg）、半夏泻心汤组（2.55g/kg）,再按被试因素施加方法连续灌胃7d。实验结束后禁食不禁水12h后取材检测。结果：与模型组相比,空白组、半夏泻心汤组（2.55-10.20g/kg）与二甲双胍组（（1.80g/kg）实验组大鼠GLUT4表达明显增加;与模型组相比,半夏泻心汤组（5.10-10.20g/kg）与二甲双胍组（1.80g/kg）组大鼠GSK-3明显降低。结论：半夏泻心汤对糖尿病胃轻瘫大鼠胰岛素抵抗时有增加GLUT4的表达、降低GSK-3的表达的作用。