AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new ant...AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats. METHODS: The effect of B. coccineus extract(100–800 mg·kg–1, p.o.) on blood glucose levels in normal and glucose loaded rats, and alloxan-induced diabetic rats was determined. After 10 days of treatment, blood samples were collected from rats for lipid and insulin profiling. Animals were thereafter sacrificed and the kidneys, heart, and liver were harvested for antioxidant indices assay. RESULTS: In normal rats, B. coccineus did not cause significant reduction in blood glucose. At the dose of 800 mg·kg–1, significant increase in blood glucose level was not observed 30 min. after glucose load. B. coccineus administered acutely did not generally produce significant reduction in blood glucose level in diabetic rats. Administered subacutely, the extract significantly reduced blood glucose level in diabetic rats from the 3rdday with peak effect observed at the dose of 800 mg·kg–1on the 10thday. The extract generally preserved in vivo antioxidant levels in the kidneys, heart, and liver, increased the level of high density lipoprotein and insulin, and reduced the level of triglycerides and low density lipoprotein compared to diabetic control. CONCLUSION: The findings in this study suggest that the hydroethanolic leaf extract Byrsocarpus coccineus possesses antidiabetic activity possibly mediated through inhibition of intestinal glucose absorption, in vivo antioxidant activity, and enhancement of regeneration of beta cells of the pancreas and insulin secretion.展开更多
Objective:To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus,a plant used in herbal medicine for the management of various diseases in Nigeria.Methods:Ethanol-,acetylsalicylic acid-,...Objective:To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus,a plant used in herbal medicine for the management of various diseases in Nigeria.Methods:Ethanol-,acetylsalicylic acid-,histamine-and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf extract.Acute toxicity studies were also carried out.Results:The ethanolic leaf extract significantly(P<0.05)reduced the ulcer index in all assays used with the maximal antiulcer activity recorded at 400 mg/kg.The LD_(50)values obtained were greater than 5000 mg/kg in rats.Conclusions:The implication of this finding is that Byrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents.展开更多
文摘AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats. METHODS: The effect of B. coccineus extract(100–800 mg·kg–1, p.o.) on blood glucose levels in normal and glucose loaded rats, and alloxan-induced diabetic rats was determined. After 10 days of treatment, blood samples were collected from rats for lipid and insulin profiling. Animals were thereafter sacrificed and the kidneys, heart, and liver were harvested for antioxidant indices assay. RESULTS: In normal rats, B. coccineus did not cause significant reduction in blood glucose. At the dose of 800 mg·kg–1, significant increase in blood glucose level was not observed 30 min. after glucose load. B. coccineus administered acutely did not generally produce significant reduction in blood glucose level in diabetic rats. Administered subacutely, the extract significantly reduced blood glucose level in diabetic rats from the 3rdday with peak effect observed at the dose of 800 mg·kg–1on the 10thday. The extract generally preserved in vivo antioxidant levels in the kidneys, heart, and liver, increased the level of high density lipoprotein and insulin, and reduced the level of triglycerides and low density lipoprotein compared to diabetic control. CONCLUSION: The findings in this study suggest that the hydroethanolic leaf extract Byrsocarpus coccineus possesses antidiabetic activity possibly mediated through inhibition of intestinal glucose absorption, in vivo antioxidant activity, and enhancement of regeneration of beta cells of the pancreas and insulin secretion.
文摘Objective:To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus,a plant used in herbal medicine for the management of various diseases in Nigeria.Methods:Ethanol-,acetylsalicylic acid-,histamine-and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf extract.Acute toxicity studies were also carried out.Results:The ethanolic leaf extract significantly(P<0.05)reduced the ulcer index in all assays used with the maximal antiulcer activity recorded at 400 mg/kg.The LD_(50)values obtained were greater than 5000 mg/kg in rats.Conclusions:The implication of this finding is that Byrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents.
