Wind plays an important role in hydrodynamic processes such as the expansion of Changjiang （Yangtze） River Diluted Water （CDW）, and shelf circulation in the Changjiang estuary. Thus, it is essential to include win...Wind plays an important role in hydrodynamic processes such as the expansion of Changjiang （Yangtze） River Diluted Water （CDW）, and shelf circulation in the Changjiang estuary. Thus, it is essential to include wind in the numerical simulation of these phenomena. Synthetic aperture radar （SAR） with high resolution and wide spatial coverage is valuable for measuring spatially inhomogeneous ocean surface wind fields. We have collected 87 ERS-2 SAR images with wind-induced streaks that cover the Cbangjiang coastal area, to verify and improve the validity of wind direction retrieval using the 2D fast Fourier transform method. We then used these wind directions as inputs to derive SAR wind speeds using the C-band model. To demonstrate the applicability of the algorithms, we validated the SAR-retrieved wind fields using QuikSCAT measurements and the atmospheric Weather Research Forecasting model. In general, we found good agreement between the datasets, indicating the reliability and applicability of SAR- retrieved algorithms under different atmospheric conditions. We investigated the main error sources of this process, and conducted sensitivity analyses to estimate the wind speed errors caused by the effect of speckle, uncertainties in wind direction, and inaccuracies in the normalized radar cross section. Finally, we used the SAR-retrieved wind fields to simulate the salinity distribution off the Changjiang estuary. The findings of this study will be valuable for wind resource assessment and the development of future numerical ocean models based on SAR images.展开更多
The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis ...The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis C. Since the benefit of these treatments takes place after years, simulation models are needed to predict long-term outcomes. In simulation models, the choice of different values of yearly discount rates (e.g., 6%, 3.5%, 2%, 1.5% or 0%) influences the results, but no studies have specifically addressed this issue. We examined this point by determining the long-term benefits under different conditions on the basis of standard modelling and using quality-adjusted life years (QALYs) to quantify the benefits. In our base case scenario, we compared the long-term benefit between patients given a treatment with a 40% sustained virologic response (SVR) (dual therapy) and patients given a treatment with a 70% SVR (triple therapy), and we then examined how these specific yearly discount rates influenced the incremental benefit. The gain between a 70% SVR and a 40% SVR decreased from 0.45 QA-LYs with a 0% discount rate to 0.22 QALYs with a 6% discount rate (ratio between the two values = 2.04).Testing the other discounting assumptions confirmed that the discount rate has a marked impact on the magnitude of the model-estimated incremental benefit. In conclusion, the results of our analysis can be helpful to better interpret cost-effectiveness studies evaluating new treatment for hepatitis C.展开更多
基金Supported by the National Basic Research Program of China(973 Program)(No.2010CB951204)the State Key Laboratory of Estuarine and Coastal Research grant(No.SKLEC-2012KYYW02)
文摘Wind plays an important role in hydrodynamic processes such as the expansion of Changjiang （Yangtze） River Diluted Water （CDW）, and shelf circulation in the Changjiang estuary. Thus, it is essential to include wind in the numerical simulation of these phenomena. Synthetic aperture radar （SAR） with high resolution and wide spatial coverage is valuable for measuring spatially inhomogeneous ocean surface wind fields. We have collected 87 ERS-2 SAR images with wind-induced streaks that cover the Cbangjiang coastal area, to verify and improve the validity of wind direction retrieval using the 2D fast Fourier transform method. We then used these wind directions as inputs to derive SAR wind speeds using the C-band model. To demonstrate the applicability of the algorithms, we validated the SAR-retrieved wind fields using QuikSCAT measurements and the atmospheric Weather Research Forecasting model. In general, we found good agreement between the datasets, indicating the reliability and applicability of SAR- retrieved algorithms under different atmospheric conditions. We investigated the main error sources of this process, and conducted sensitivity analyses to estimate the wind speed errors caused by the effect of speckle, uncertainties in wind direction, and inaccuracies in the normalized radar cross section. Finally, we used the SAR-retrieved wind fields to simulate the salinity distribution off the Changjiang estuary. The findings of this study will be valuable for wind resource assessment and the development of future numerical ocean models based on SAR images.
文摘The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis C. Since the benefit of these treatments takes place after years, simulation models are needed to predict long-term outcomes. In simulation models, the choice of different values of yearly discount rates (e.g., 6%, 3.5%, 2%, 1.5% or 0%) influences the results, but no studies have specifically addressed this issue. We examined this point by determining the long-term benefits under different conditions on the basis of standard modelling and using quality-adjusted life years (QALYs) to quantify the benefits. In our base case scenario, we compared the long-term benefit between patients given a treatment with a 40% sustained virologic response (SVR) (dual therapy) and patients given a treatment with a 70% SVR (triple therapy), and we then examined how these specific yearly discount rates influenced the incremental benefit. The gain between a 70% SVR and a 40% SVR decreased from 0.45 QA-LYs with a 0% discount rate to 0.22 QALYs with a 6% discount rate (ratio between the two values = 2.04).Testing the other discounting assumptions confirmed that the discount rate has a marked impact on the magnitude of the model-estimated incremental benefit. In conclusion, the results of our analysis can be helpful to better interpret cost-effectiveness studies evaluating new treatment for hepatitis C.
