组织文化分类的演进与竞合(双C)文化模型的提出

本文对组织文化分类的研究进行了综述,对该领域研究发展的脉络进行了梳理,对文化特质理论、竞争性价值观模型、环境-战略-文化关系模型、反馈速度-风险程度模型、正式-集权程度模型、文化强度模型以及双S模型等主要研究成果进行了评价,结合作者多年对组织文化现象的研究成果提出竞合文化(双C)模型,并探讨了其在实践中的应用。

基于互信息和Chan-Vese模型的图像分割方法

针对多目标物体图像的分割问题,该文在Chan-Vese模型(C-V模型)的基础上,提出了基于互信息和Chan-Vese模型的图像分割方法。该方法结合多级分割的思想,引入了信息论中互信息的概念,替代多级分割中的灰度平均方差,将互信息量作为判断分割是否完成的标准。实验结果表明,该方法能够有效地解决多目标物体图像以及弱边界物体的分割问题。

基于NGM(1,1,k,c)模型和改进切线角的危岩变形预测

针对危岩变形预测问题,本文以非齐次指数序列的灰色模型(NGM)作为危岩变形预测的基本模型,通过对望霞危岩变形的分析结果显示,NGM(1,1,k,c)模型拟合效果明显优于GM(1,1)模型,说明危岩变形趋势更接近于非齐次指数序列。利用NGM(1,1,k,c)模型结合改进切线角可对危岩变形趋势进行分析预测,可作为危岩稳定性和发展趋势的评估依据。

一类离散事件动态系统Kalman模型参数矩阵A、B、C图论表示法

利用图论方法,将串行生产线一类离散事件动态系统的Kalman 模型参数矩阵A、B、C归结为三类型有向赋权网络的邻接矩阵,使得列写A、B、C的算法变得快速、准确而且直观。

基于Johnson-Cook模型构建M50NiL齿轮钢的流变应力本构方程

利用Gleeble-3500型热模拟试验机，研究了M50NiL齿轮钢在变形温度为1123．15～1423．15K、应变速率为0．005~10s^-1条件下的变形行为，并对实测流变曲线进行了摩擦修正；基于应变速率和变形温度对金属高温变形的耦合效应，建立了基于Johnson-Cook（J—C）模型的耦合流变应力本构方程并进行了验证。结果表明：对试验钢流变曲线摩擦修正后，得到的流变应力比实测值小；经变形参数耦合修正后的J—C耦合本构方程计算得到的流变应力与摩擦修正后流变应力的平均相对误差为3．08％，其预测精度高于传统J—C本构方程（平均相对误差为14．31％）的。

基于灰模型白化响应的边缘检测算法

为获得更好的图像边缘,提高机器视觉的检测精度,提出一种新的基于GM(1,1,C)模型白化响应的图像边缘检测算法.该算法用原图相邻的若干像素点值构建GM(1,1,C)模型,计算出相应像素点的白化值,得到原图像素点的像素值与相应白化值之间的误差.依据边缘像素点的像素值与非边缘像素点的像素值相差大而不满足GM(1,1,C)建模条件,从而导致边缘像素点白化值出现较大误差的特点,实现图像的边缘检测.实验证明:该算法在无噪声和有噪声的情况下均有效;建模像素数量越少,抗噪能力越强,但对边缘的检测能力会下降;建模像素数量越多,边缘的检测能力越强,但抗噪能力下降.

Helicobacter Pylori-induced Gastritis Model in BALB/c Mice Infected With Fresh Isolates from a Human Complex Ulcer Patient

A useful helicobacter pylori-induced gastritis model using BALB/c mice was established for mimicking of human gastritis induced by Helicobacter pylori (H. pylori). The H. pylori isolates were obtained freshly from a human complex ulcer patient. BALB/c mice were fasted for 24 h and then 0.25 mL of 0.2 mol·L -1 NaHCO 3 was administered after by gavage to each mouse and 0.5 mL of 10 9 colonies formation unit per milliliter (CFU/mL) of H. pylori was administered 15 min. On the 3 rd day and 5 th day, the H. pylori inoculations were repeated. The inoculated mice were sacrificed in batch on the 5 th day, in the 2 nd week, 3 rd week and 4 th week. The gastric mucous membrane near pyloric portion was removed, treated and then cultured under microaerobic condition for detection of H.pylori. The remainders of the gastric membrane were fixed by 10% formaldehyde solution for pathological detection. The results showed that the H. pylori could be separated from the gastric membranes of inoculated mice. Obvious invasion of inflammatory cells in the gastric membranes of inoculated mice could be observed from pathological sections. It can be concluded that the inoculating fresh human H. pylori isolates can produce mouse gastritis. This model of BALB/c mice can be used for evaluating the therapeutic agents for the treatment of gastritis induced by H. pylori.

INFLUENCE OF VIRTUAL PHOTON FIELD ON COLLAPSE AND REVIVAL PHENOMENON IN TWO PHOTON J C MODEL WITHOUT RWA

The time evolution of system in two photon Jaynes Cummings (J C) model without rotating waves approximation (RWA) is obtained by using the theory of ordinary differential equations. Based on the evolution, the mean value of the atom inversion operator 〈 S 3(t)〉 is gi ven. The influence of the “counter rotating term” on the collapse and revival phenomenon is discussed from the comparison between the cases with RWA and without RWA. It shows that the influence of the virtual photon field makes the quantum fluctuations appear on the collapse and revival phenomenon.

Information Entropy Squeezing for a Atom in Mode-Mode Competition System

The entropy squeezing properties for a two-level atom interacting with a two-mode field via two differentcompeting transitions are investigated from a quantum information point of view.The influences of the initial state of thesystem and the relative coupling strength between the atom and the field on the atomic information entropy squeezingare discussed.Our results show that the squeezed direction and the frequency of the information entropy squeezing canbe controlled by choosing the phase of the atom dipole and the relative competing strength of atom-field,respectively.We find that,under the same condition,no atomic variance squeezing is predicted from the HUR while optimal entropysqueezing is obtained from the EUR,so the quantum information entropy is a remarkable precision measure for theatomic squeezing in the considered system.

＂Pseudo-invariant Eigen-operator＂ Method for Deriving Energy-Gap of an Atom-Cavity Jaynes-Cummings Hamiltonian with Atomic Centre-of-Mass Motion

Using the ＂pseudo-invariant eigen-operator＂ method we find the energy-gap of the Jaynes-Cummings Hamiltonian model of an atom-cavity system. This model takes the atomic centre-of-mass motion into account. The supersymmetric structure is involved in the Hamiltonian of an atom-cavity system. By selecting suitable supersymmettic generators and using supersymmetrie transformation the Hamiltonian is diagonalized and energy eigenvectors are obtained.

Converted-wave Seismology in Anisotropic Media Revisited, Part II: Application to Parameter Estimation

In transversely isotropic media with a vertical symmetry axis （VTI）, the converted-wave （C-wave） moveout over intermediate-to-far offsets is determined by four parameters. These are the C-wave stacking velocity Vc2 , the vertical and effective velocity ratios γ0 and γeff, and the anisotropic parameter χeff. We refer to the four parameters as the C-wave stacking velocity model. The purpose of C-wave velocity analysis is to determine this stacking velocity model. The C-wave stacking velocity model Vc2, γ0, γeff, and χeff can be determined from P-and C-wave reflection moveout data. However, error propagation is a severe problem in C-wave reflection-moveout inversion. The current short-spread stacking velocity as deduced from hyperbolic moveout does not provide sufficient accuracy to yield meaningful inverted values for the anisotropic parameters. The non-hyperbolic moveout over intermediate-offsets （x/z from 1.0 to 1.5） is no longer negligible and can be quantified using a background γ. Non-hyperbolic analysis with a γ correction over the intermediate offsets can yield Vc2 with errors less than 1% for noise free data. The procedure is very robust, allowing initial guesses of γ with up to 20% errors. It is also applicable for vertically inhomogeneous anisotropic media. This improved accuracy makes it possible to estimate anisotropic parameters using 4C seismic data. Two practical work flows are presented for this purpose： the double-scanning flow and the single-scanning flow. Applications to synthetic and real data show that the two flows yield results with similar accuracy but the single-scanning flow is more efficient than the double-scanning flow.

Effect of discounting on estimation of benefits determined by hepatitis C treatment

The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis C. Since the benefit of these treatments takes place after years, simulation models are needed to predict long-term outcomes. In simulation models, the choice of different values of yearly discount rates (e.g., 6%, 3.5%, 2%, 1.5% or 0%) influences the results, but no studies have specifically addressed this issue. We examined this point by determining the long-term benefits under different conditions on the basis of standard modelling and using quality-adjusted life years (QALYs) to quantify the benefits. In our base case scenario, we compared the long-term benefit between patients given a treatment with a 40% sustained virologic response (SVR) (dual therapy) and patients given a treatment with a 70% SVR (triple therapy), and we then examined how these specific yearly discount rates influenced the incremental benefit. The gain between a 70% SVR and a 40% SVR decreased from 0.45 QA-LYs with a 0% discount rate to 0.22 QALYs with a 6% discount rate (ratio between the two values = 2.04).Testing the other discounting assumptions confirmed that the discount rate has a marked impact on the magnitude of the model-estimated incremental benefit. In conclusion, the results of our analysis can be helpful to better interpret cost-effectiveness studies evaluating new treatment for hepatitis C.

THRFuzzy:Tangential holoentropy-enabled rough fuzzy classifier to classification of evolving data streams

The rapid developments in the fields of telecommunication, sensor data, financial applications, analyzing of data streams, and so on, increase the rate of data arrival, among which the data mining technique is considered a vital process. The data analysis process consists of different tasks, among which the data stream classification approaches face more challenges than the other commonly used techniques. Even though the classification is a continuous process, it requires a design that can adapt the classification model so as to adjust the concept change or the boundary change between the classes. Hence, we design a novel fuzzy classifier known as THRFuzzy to classify new incoming data streams. Rough set theory along with tangential holoentropy function helps in the designing the dynamic classification model. The classification approach uses kernel fuzzy c-means(FCM) clustering for the generation of the rules and tangential holoentropy function to update the membership function. The performance of the proposed THRFuzzy method is verified using three datasets, namely skin segmentation, localization, and breast cancer datasets, and the evaluated metrics, accuracy and time, comparing its performance with HRFuzzy and adaptive k-NN classifiers. The experimental results conclude that THRFuzzy classifier shows better classification results providing a maximum accuracy consuming a minimal time than the existing classifiers.

Gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rat with ulcers and expressions of ras and c-erbB2 genes

Objective: To observe the series of pathological changes during the development of gastric adenocarcinoma in ulcerative rats induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), and the expression profile of related oncogenic protein.Methods: MNNG was administered in rats with ulcers due to acetic acid treatment to induce gastric cancer, and the protein expressions of ras and c-erbB2 genes in the ulcer were examined immunohistochemically along with pathological examination.Results: The incidence of gastric adenocarcinoma in the model group reaches 40% (6/15), while none of the rats developed cancer in the control group with ulcers.Positive expressions of the proteins of p21ras and c-erbB2 were observed in the tissues undergoing canceration in the 6 rats of model group, but were not observed in the 5 control rats; p53 protein expression, however, failed to be detected in both groups.Conclusion: A new animal model of gastric cancer has been established in rats with gastric ulcer after MNNG treatment, which may facilitate the pharmacological research of gastric cancer.

Indications of c-axis Charge Transport in Hole Doped Triangular Antiferromagnets

The c-axis charge transport of the hole doped triangular antiferromagnet is investigated within the t-J model by considering the incoherent interlayer hopping. It is shown that the c-axis charge transport of the hole doped triangular antiferromagnet is essentially determined by the scattering from the in-plane fluctuation. The c-axis conductivity spectrum shows a low-energy peak and the unusual high-energy broad band, while the c-axis resistivity is characterized by a crossover from the high temperature metallic-like behavior to the low temperature insulating-like behavior, which is qualitatively consistent with those of the hole doped square lattice antiferromagnet.

A New 3D Meso-mechanical Modeling Method of Coral Aggregate Concrete Considering Interface Characteristics

On the basis of the three-dimensional(3D)random aggregate&mortar two-phase mesoscale finite element model,C++programming was used to identify the node position information of the interface between the aggregate and mortar elements.The nodes were discretized at this position and the zero-thickness cohesive elements were inserted.After that,the crack energy release rate fracture criterion based on the fracture mechanics theory was assigned to the failure criterion of the interface transition zone(ITZ)elements.Finally,the three-phase mesomechanical model based on the combined finite discrete element method(FDEM)was constructed.Based on this model,the meso-crack extension and macro-mechanical behaviour of coral aggregate concrete(CAC)under uniaxial compression were successfully simulated.The results demonstrated that the meso-mechanical model based on FDEM has excellent applicability to simulate the compressive properties of CAC.

Effects of Shuang Dan Ming Mu Capsule on Expression of VEGF-a, VEGF-b, VEGF-c and the VEGF receptor, Flk-1, in Diabetic Retinopathy Rats

Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were randomized into Groups A(blank),B(model),C(Shuang Dan Ming Mu)and D(positive control)group,with each group containing10rats and20eyes.Rats from groups B,C and D were administered one dose of50mg/kg streptozotocin(STZ)by tail vein injection to establish a diabetic rat model.One week after model preparation,medication was continuously administered by gavage.After gavage for8weeks,the animals were sacrificed and retinal expression of VEGF-a,VEGF-b,VEGF-c and Flk-1was quantified by immunohistochemical analysis.Results At week8of drug administration after model preparation,the average protein expression grayscale values for VEGF-a,VEGF-b,VEGF-c and Flk-1in the rats model,Shuang Dan Ming Mu and positive control groups were all lower than those in the normal group,while the mean optical density values were higher than those in the normal group.When the model group was compared to the normal group,the difference was extremely significant(P<0.01).The mean grayscale values of VEGF-a,VEGF-b,VEGF-c and Flk-1in the Shuang Dan Ming Mu and positive control groups were all higher than those in the model group,while the mean optical density values were lower than those in the model group(P<0.05or0.01).Conclusion Shuang Dan Ming Mu capsule can significantly decrease the expression of VEGF-a,VEGF-b,VEGF-c and Flk-1in the retinas of diabetic model rats and exhibit some protective effects in their retinas.

Modification of Intensive Care Unit Data Using Analytical Hierarchy Process and Fuzzy C-Means Model

This paper proposes a proper methodology in data modification by using AHP （analytical hierarchy process） technique and FCM （fuzzy c-mean） model in the ICU （intensive care unit）. The binary data were created from continuous data using FCM model, while the continuous data were constructed from binary data using AHP technique. The models used in this study are FCRM （fuzzy c-regression model）. A case study in scale of health at the ICU ward using the AI-IP, FCM model and FCRM models was conducted. There are six independent variables in this study. There are four cases which are considered as the result of using AHP technique and FCM model against independent data. After comparing the four cases, it was found that case 4 appeared to be the best model, because it has the lowest MSE （mean square error） value. The original data have the MSE value of 97.33, while the data in case 4 have the MSE value of 82.75. This means that the use of AHP technique can reduce the MSE value, while the use of FCM model can not reduce the MSE value. In other words, it can be proved that the AHP technique can increase the accuracy of prediction in modeling scale of health which is associated with the mortality rate in the ICU.

Process Modeling for Batch Cooling Crystallization

The general mathematical model for batch cooling crystallization was established based on the population balance equation considering the change of slurry volume, and simulated with crystallization thermodynamics,kinetics and mass balance employing bed voidage. In the system of vitamin C-water-ethanol, reliability of this model was verified by comparison between simulation results and experimental data. The effects of operation parameters on product quality can be systematically investigated by modeling simulation.

BEHAVIOR AND ACTIVITIES IN THE CENTRAL NERVOUS SYSTEM AFTER ACTIVATION OF L-TYPE CALCIUM CHANNELS IN MICE

The distribution of the immediate early gene c-fos expression in the mouse central nervous system after subcutaneous injection of Bay K 8644 was observed immunohistochemically. Half an hour after injection, cfos protein (FOS) was expressed in the piriform cortex, sensorimotor cortex, caudate putamen, thalamic paraventricular nucleus and striate cortex,etc. Intense FOS immunoreactive (FOS-ir) cells were seen during 2 ～ 4 h after injection. The restllts suggested that the distribution of FOS-ir ce1ls after subcutaneous injection of Bay K 8644 was coincldent with that of L-type calcium channels in the different areas of the CNS. After Bay K 8644 injection, mice appeared seizure-like behavior. The percentage of cells double-labelled by FOS and CaBP immunoreactivities in the observed regions was about 60. 2～72. 8% in CaBP-ir cells. It suggested that most CaBP-lr cells may have L-type calcium channels.