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Assessment of C-Reactive Protein/Serum Albumin Ratio in Relation to Acute Presentation and Early Outcome of Patients with Acute Coronary Syndrome
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作者 Waseem F. Al Tameemi Noor Alaa Alkhazraji 《Journal of Biosciences and Medicines》 CAS 2023年第2期239-253,共15页
Background: Acute coronary syndrome (ACS) is the leading cardiovascular (CV) cause of mortality. C reactive protein (CRP) has linked with long-term risk of recurrent cardiovascular events or death. Albumin, in contras... Background: Acute coronary syndrome (ACS) is the leading cardiovascular (CV) cause of mortality. C reactive protein (CRP) has linked with long-term risk of recurrent cardiovascular events or death. Albumin, in contrast to CRP known as a negative acute-phase protein. Thus a newly introduced marker assessed relation of CRP to albumin ratio (CAR), which may provide better results than the use of either marker alone. The aim of the study is to assess the association of C-reactive protein to albumin ratio (CAR) with in-hospital short-term major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. Patients & Methods: A multi-centers prospective cohort study was conducted at coronary intensive care units (CICU) in Baghdad during the period from March to October 2021 that included a total of 132 patients who were diagnosed as a case of ACS. They were assessed for major adverse cardiac events (MACEs) like cardiogenic shock, arrhythmias, post-MI angina, and acute heart failure while inside the ward, in addition to need for early interventional therapeutic approach in relation to (CAR) immediately at time of admission to hospital. Results: High values of CAR, whether using hs-CRP or CRP, were identified as an independent predictor for in-hospital MACEs (P value Conclusion: The CAR was independently correlated with in-hospital short-term MACEs and can be used for risk stratification in patients with ACS. 展开更多
关键词 Acute coronary Syndrome cardiac Events c reactive protein ALBUMIN
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Elevated levels of inflammatory cytokines and high-sensitivity C-reactive protein in periodontitis patients in Kosovo: A pilot study 被引量:7
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作者 Zana Sllamniku-Dalipi Hasan Mehmeti +5 位作者 Fatmir Dragidella Ferit Ko?ani Metush Disha Kastriot Meqa Luljeta Begolli Gramos Begolli 《Open Journal of Stomatology》 2013年第1期32-38,共7页
The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that the same contents have been published in another journal at the same time. The scient... The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that the same contents have been published in another journal at the same time. The scientific community takes a very strong view on this matter, and the Open Journal of Stomatology treats all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No.1 32-38, 2013 has been removed from this site. Title: Elevated levels of inflammatory cytokines and high-sensitivity C-reactive protein in periodontitis patients in Kosovo: A pilot study Authors: Zana Sllamniku-Dalipi, Hasan Mehmeti, Fatmir Dragidella, Ferit Kocani, Metush Disha, Kastriot Meqa, Luljeta Begolli, Gramos 展开更多
关键词 Periodontal Disease Interleukin-1beta INTERLEUKIN-6 Tumour Necrosis Factor Alpha High-Sensitivity c reactive protein
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Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China 被引量:2
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作者 ZHU Zheng Bao HUANGFU Xin Feng +8 位作者 ZHONG Chong Ke ZHOU Yi Peng TIAN Yun Fan BUREN Batu XU Tian WANG Ai Li LI Hong Mei ZHANG Ming Zhi ZHANG Yong Hong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第9期632-640,共9页
Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease(CVD) and high serum C‐reactive protein(CRP) on the stroke incidence in an Inner Mongolian population in China. Meth... Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease(CVD) and high serum C‐reactive protein(CRP) on the stroke incidence in an Inner Mongolian population in China. Methods A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels. Results We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio(HR) of 1.78 [95% confidence interval(CI), 1.03‐3.07; P = 0.039] of stroke, and an HR of 2.14(95% CI, 1.09‐4.20; P = 0.027) of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant(all P 〉 0.05). Conclusion Participants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD. 展开更多
关键词 Family history of cardiovascular disease creactive protein STROKE Prospective study
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Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial
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作者 Banothu Vinod Kumar Kajal Kamboj +3 位作者 Ashok Kumar Pannu Ashok Kumar Yadav Mandip Bhatia Atul Saroch 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第4期160-165,共6页
Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue infection.Methods:A single-centre,open-label,parallel-group randomi... Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue infection.Methods:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER Chandigarh from June 2021 to October 2022.Patients were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard treatment.The objective was to measure the effect of doxycycline on inflammatory markers in dengue infection.Results:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and CRP in cases compared to the control group(ferritin:P=0.006 and CRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.Conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection. 展开更多
关键词 DENGUE cYTOKINE DOXYcYcLINE Serum ferritin c reactive protein
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Correlation between serum C1q tumor necrosis factor-related protein 4 and high-sensitivity C-reactive protein levels and coronary heart disease
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作者 Xiang-Wen Hu Xian-Lin Zhang +2 位作者 Ling Xuan Meng-Meng Chen Heng Zhang 《Journal of Hainan Medical University》 2021年第5期18-22,共5页
Objective:To investigate the relationship between serum levels of C1q tumor necrosis factorrelated protein 4(CTRP4)and hypersensitive C reactive protein(hs-CRP)and coronary heart disease(CHD)and its clinical value.Met... Objective:To investigate the relationship between serum levels of C1q tumor necrosis factorrelated protein 4(CTRP4)and hypersensitive C reactive protein(hs-CRP)and coronary heart disease(CHD)and its clinical value.Methods:128 patients underwent coronary angiography in our hospital,63 males,65 women,Based on blood sugar levels and coronary angiography,Divided into pure coronary heart disease(CHD)group 62 cases,Coronary heart disease with diabetes(DM+CHD)group 66 cases,A total of 126 patients were selected as control group,65 men,61 women,CTRP4 and hs-CRP levels in serum,Using Pearson correlation analysis to assess the correlation between Gennisi score and CTRP4、hs-CRP,Analysis of three groups of biochemical indicators,CTRP4、hs-CRP level changes and clinical significance.Results:The CTRP4、hs-CRP level of DM+CHD group was significantly higher than that of control group and CHD group(P DM+CHD 0.05).The CTRP4、hs-CRP level of the three-vessel coronary artery lesion group in the experimental group was higher than that in the two-vessel lesion group(P﹤0.05),Double branch lesion group was higher than single branch lesion group(P﹤0.05);Correlation analysis shows,There was a significant positive correlation between the CTRP4、hs-CRP level of CHD group and DM+CHD group and the Gennisi score(P DM+CHD 0.05).ROC curves show,CTRP4 and hs-CRP levels had predictive value(CHD group,AUC=0.940,0.934,DM+CHD group,AUC=0.980,0.964),Two associations(CHD:AUC=0.961,P﹤0.001,DM+CHD group:AUCDM+CHD 0.982,P﹤0.001)the predictive value is high.Conclusion:Serum CTRP4 and hs-CRP are positively related to the severity of coronary heart disease,and the sensitivity and specificity of predicting coronary heart disease are high,which is helpful for the identification and early prevention of coronary heart disease,and has certain clinical reference value. 展开更多
关键词 coronary heart disease Diabetes Serum c1q tumor necrosis factorrelated protein 4 Hypersensitive c reactive protein
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Effects of XUEZHIKANG on Oxidized Low Density Lipoprotein,C - Reactive Protein, Fibrinogen in Unstable Angina Pectoris Patients
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作者 姚青海 崔长琮 +1 位作者 王军奎 姚晓伟 《South China Journal of Cardiology》 CAS 2003年第1期28-30,共3页
Objectives To study the effects of XUEZHIKANG on lipid modulating and the level of oxidized low density lipoprotein(OX - LDL), C -reactive protein(CRP), fibrinogen(FIB) in serum. Methods XUEZHIKANG was given to patien... Objectives To study the effects of XUEZHIKANG on lipid modulating and the level of oxidized low density lipoprotein(OX - LDL), C -reactive protein(CRP), fibrinogen(FIB) in serum. Methods XUEZHIKANG was given to patients with unstable angina pectoris and hyperlipidemia at a dose of 0. 6 gram bid for 2 months and with half -dose for another 2 months. Vitamin E was given to unstable angina pectoris patients with normal lipid at the dose of 0. 1 gram bid for 4 months respectively. Then compared the level of lipid and OX - LDfL, CRP, FIB in serum at beginning, first - month and second -month. Results XUEZHIKANG can reduce the serum level of total cholesterol, low density lipoprotein in 1 month , and gained better effect in 2 months. It can also reduce triglyceride and increase high density lipoprotein in 2 months. Compared with vitamin E XUEZHIKANG can reduce the level of OX - LDL, CRP, FIB significantly after treatment for 2 months. Conclusions XUEZHIKANG has significant effect in lipid modulating , and it can also inhibit the development of inflammation in coronary plaque. 展开更多
关键词 XUEZHIKANG Unstable angina pectoris c - reactive protein OX - LDL Fibrinogen
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Protection of Salvianolate against Atherosclerosis via Regulating the Inflammation in Rats 被引量:16
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作者 孟春 卓晓青 +1 位作者 徐国红 刘建立 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2014年第5期646-651,共6页
Inflammation plays an essential role in the pathophysiology of atherosclerosis. Our study was aimed to investigate whether salvianolate, a novel water-soluble phenolic compound of Danshen, alleviates atherosclerosis v... Inflammation plays an essential role in the pathophysiology of atherosclerosis. Our study was aimed to investigate whether salvianolate, a novel water-soluble phenolic compound of Danshen, alleviates atherosclerosis via regulating the inflammation in rats. High fat diet feeding plus vitamin D3 injection was used to induce atherosclerosis in rats. Salvianolate (60, 120 or 240 mg/kg) or placebo was given to atherosclerotic rats. The plasma lipids, interleukin 6 (IL-6) and C reactive protein (CRP) were measured by ELISA. CD4+CD25+Foxp3+ cells were determined by flow cytometry. Histological changes were examined by hematoxylin and eosin staining. The results showed that the levels of plasma IL-6 and CRP were elevated in the rats fed on high fat diet, and the histological analysis demonstrated the successful establishment of atherosclerosis models. Treatment with salvianolate alleviated the atherosclerotic process and decreased the levels of plasma IL-6 and CRP. Also the number of CD4+CD25+Foxp3+ cells was increased in salvianolate-treated rats. It was concluded that salvianolate could treat atherosclerosis via modulating the inflammation at cytokine and cell levels. 展开更多
关键词 ATHEROScLEROSIS SALVIANOLATE interleukin 6 Tregulatory cells c reactive protein
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Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα 被引量:2
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作者 张莉莉 祝之明 +1 位作者 曹廷兵 王利娟 《Journal of Medical Colleges of PLA(China)》 CAS 2006年第2期77-81,共5页
Objective: To investigate the role of peroxisome proliferator-activated receptors δ (PPARδ) in inflammatory reaction and its possible mechanism in adipocyte. Methods:Lentivirus-mediated RNA interference (RNAi)... Objective: To investigate the role of peroxisome proliferator-activated receptors δ (PPARδ) in inflammatory reaction and its possible mechanism in adipocyte. Methods:Lentivirus-mediated RNA interference (RNAi) was used to block the expression of PPARδ in 3T3-L1 cells. In order to induce inflammation in 3T3-L1, cells were stimulated with tumor necrosis factor-α(TNFα, 20 ng/ml) for 4 h. The expression of PPARδ, nuclear factor κB (NFκB) and C reactive protein (CRP) were determined by Western blot analysis. Results:The expression of PPARδ was reduced by 80% after RNAi. Blockage of PPARδ promoted the expression of CRP and NFκB in cells stimulated with TNFα but had no effect on normal cells. Conclusion: PPARδ is involved in inflammatory reaction in adipocyte. Blockage of PPARδ can promote the inflammation mediated by inflammatory factors and increase the expression of NFκB and CRP in 3T3-L1 cells stimulated with TNFα. 展开更多
关键词 RNA interference 3T3-L1 cells peroxisome proliferator-activated receptors 8 nuclear factor κB c reactive protein
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~rognostic value of baseline C-reactive protein levels in patients mdergoing coronary revascularization 被引量:4
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作者 LI Xu LIU Xiao-hui +11 位作者 NIE Shao-ping DU Xin Lu Qiang KANG Jun-ping DONG Jian-zeng GU Cheng-xiong HUANG Fang-jiong ZHOU Yu-jie CHEN Fang Lu Shu-zheng WU Xue-si MA Chang-sheng 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第13期1628-1632,共5页
Background C-reactive protein (CRP) is a lowly expressed marker for inflammatory response. This study aimed to evaluate the prognostic value of baseline CRP levels in patients undergoing coronary revascularization i... Background C-reactive protein (CRP) is a lowly expressed marker for inflammatory response. This study aimed to evaluate the prognostic value of baseline CRP levels in patients undergoing coronary revascularization in the context of modern medical treatment. Methods This was a retrospective study in a single center. Four hundred and fourteen patients were enrolled, who underwent coronary revascularization and received adequate medication for secondary prevention of coronary heart disease. The study compared the follow-up clinical outcomes between high level CRP group (CRP 〉5 mg/L) and low level one. The median follow-up time was 551 days. Results Compared with low CRP group, the relative risk (RR) of the major adverse cardiovascular and cerebral events (MACCE) in high CRP group was 5.131 (95% CI: 1.864-14.123, P=0.002). There were no significant differences in death myocardial infarction and stroke during the follow-up between two groups, but a higher risk of re-revascularization was found in high CRP group (RR 6.008, 95% CI: 1.667-21.665, P=0.006). Cox regression analysis showed that only CRP level could contribute to MACCE during the follow-up. MACCE-free rate was much lower in high CRP group (Kaplan-Meier log-rank P 〈0.001). Conclusion In the context of modern medical treatment, the baseline level of CRP is an independent predictor for long-term prognosis in patients with coronary revascularization. 展开更多
关键词 c reactive protein coronary heart disease REVAScULARIZATION PROGNOSIS
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Interaction of C-reactive Protein with Artificial Lipid Containing Monolayers Studied by Ellipsometric Microscope
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作者 童晶 周悦 +1 位作者 毛佳 隋森芳 《Tsinghua Science and Technology》 SCIE EI CAS 1998年第3期50-54,共5页
In order to study the interaction between C reactive protein (CRP) and a biomembrane, an artificial phospholipid with a long spacer, DS8PC, was synthesized. Also, a new microscope, ellipsometric microscope (EMM), wa... In order to study the interaction between C reactive protein (CRP) and a biomembrane, an artificial phospholipid with a long spacer, DS8PC, was synthesized. Also, a new microscope, ellipsometric microscope (EMM), was designed and constructed for studying film surfaces. Using the self made EMM specific interaction of rabbit C reactive protein (rCRP) with DS8PC containing monolayers was studied. 展开更多
关键词 c reactive protein lipid monolayer ELLIPSOMETRY
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Interaction of Rabbit C-reactive Protein with Phospholipid Monolayers at Air/Water Interface
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作者 肖才德 隋森芳 《Tsinghua Science and Technology》 SCIE EI CAS 1997年第1期61-63,共3页
C reactive protein (CRP) is a major acute phase reactant in most mammalian species. The recognition and the binding principles of CRP to its substrates are not well known. In this paper the interaction of rabbit ... C reactive protein (CRP) is a major acute phase reactant in most mammalian species. The recognition and the binding principles of CRP to its substrates are not well known. In this paper the interaction of rabbit CRP (rCRP) with lipid monolayers at the air/water interface was studied. From the experiments it was concluded that rCRP molecules were amphipathic, and rCRP molecules might interact with phospholipid monolayers by hydrophobic force. The critical surface pressure of rCRP interacting with phospholipid monolayers is about 34 5 mN/m. 展开更多
关键词 c reactive protein phospholipid monolayer critical pressure
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