The title compound (C14H12N2O2, Mr = 240.26) crystallizes in the monoclinic system, space group P21/a with a = 7.394(1), b = 21.334(3), c = 7.423(1) ? b = 89.82(1)? V = 1170.8(3) ?, Z = 4, Dc = 1.363 g/cm3, m(MoKa) = ...The title compound (C14H12N2O2, Mr = 240.26) crystallizes in the monoclinic system, space group P21/a with a = 7.394(1), b = 21.334(3), c = 7.423(1) ? b = 89.82(1)? V = 1170.8(3) ?, Z = 4, Dc = 1.363 g/cm3, m(MoKa) = 0.93 cm-1 and F(000) = 504.00. The final R and wR are 0.0440 and 0.1370 for 2153 observed reflections (I > 2s(I)), respectively. The dihedral angle between the two phenyl rings is 52.9 and that between the NO2 group and its attached ring is 3.0. In the crystal, molecules are stacked along [100] through p…p interactions. The CH…O hydrogen bond (3.403 ? 120.4? laterally connects the stacks along [010] to form networks (001) which are further anti- parallelly connected by CH…O (3.382 ? 142.9) and p…p interactions extending along [001]. Also presented here is a brief study on the CH…O hydrogen bonds in nitro-substituted benzyl-ideneanilines which can be classified into five types, namely, )5(12R, )4(21R, )8(22R, )6(12R and )7(22R, with the first three occurring more often.展开更多
The title complex [Cu（L1）（L2）（H2O）]·H2O（1,HL1 = N-（imino（pyridin-2-yl）me-thyl）picolinamidine）,HL2 = salicylic acid） has been obtained by volatilization method with L1 prepared from 2,4,6-tripyridyl-1...The title complex [Cu（L1）（L2）（H2O）]·H2O（1,HL1 = N-（imino（pyridin-2-yl）me-thyl）picolinamidine）,HL2 = salicylic acid） has been obtained by volatilization method with L1 prepared from 2,4,6-tripyridyl-1,3,5-triazine in situ.1 was fully characterized by single-crystal X-ray diffraction,elemental analysis and FT-IR.This complex exhibits a three-dimensional frame-work constructed through hydrogen bonding and C-H···π stacking interactions.The cyclic voltametric behavior of complex 1 was also investigated.1 belongs to the monoclinic system,space group P21/c with a = 15.112（5）,b = 7.115（2）,c = 19.899（6） ,β = 112.32°,V = 1979.4（11） 3,Mr = 460.94,Dc = 1.540 g/cm3,F（000） = 948,μ = 1.146 mm-1,Z = 4,the final R = 0.0612 and wR = 0.1813 for 2510 observed reflections with I 2σ（I）.展开更多
Two complexes, [Cu2（Htdb）4（H2O）2] （1） and [Cd（bipy）2（Hmcmbc）2] （2） （H2tdb = 2,2-thiodibenzoic acid, H2mcmbc = m-（carboxyl-methyloxy）-benzenecarboxylic acid, bipy = 4,4＇-bipyridine）, have been prepared...Two complexes, [Cu2（Htdb）4（H2O）2] （1） and [Cd（bipy）2（Hmcmbc）2] （2） （H2tdb = 2,2-thiodibenzoic acid, H2mcmbc = m-（carboxyl-methyloxy）-benzenecarboxylic acid, bipy = 4,4＇-bipyridine）, have been prepared, and were characterized by elemental analysis, FT-IR and single-crystal X-ray diffraction. Structures indicate that complex 1 is a single molecule, and 2 is a one-dimensional chain. Their two-and three-dimensional frameworks are constructed through hydrogen bonding, π…π or C–H…π stacking, and such other weak interactions. The cyclic voltametric behavior of complex 1 and luminescence property of complex 2 were investigated. 1 belongs to the triclinic system, space group P with a = 7.8607（6）, b = 11.7619（9）, c = 15.3481（12） , α = 109.3670（10）, β = 92.4420（10）, γ = 92.0450（10）°, V = 1335.65（18） 3, Mr = 1256.26, Dc = 1.5619（2） g/cm3, F（000） = 642, μ = 1.029 mm–1, Z = 1, the final R = 0.0289 and wR = 0.0763 for 5199 observed reflections with I 2σ（I）. Complex 2 crystallizes in triclinic, space group P with a = 9.6378（10）, b = 9.7508（10）, c = 19.055（2） , α = 88.7020（10）, β = 80.5260（10）, γ = 69.2000（10）o, V = 1649.9（3） 3, Mr = 815.07, Dc = 1.641 g/cm3, μ = 0.732 mm-1, F（000） = 828, Z = 2, the final R = 0.0511 and wR = 0.1149 for 4729 observed reflections （I 2σ（I））.展开更多
目的研究胰高血糖素样肽素-1(glucogon like pep tide-1,GLP-1)对晚期糖基化终产物(advanced glycation end products,AGEs)诱导H9C2心肌细胞凋亡的保护作用机制。方法体外培养H9C2细胞,实验分为4组:正常对照组、100 mg·L^(-1)AGE...目的研究胰高血糖素样肽素-1(glucogon like pep tide-1,GLP-1)对晚期糖基化终产物(advanced glycation end products,AGEs)诱导H9C2心肌细胞凋亡的保护作用机制。方法体外培养H9C2细胞,实验分为4组:正常对照组、100 mg·L^(-1)AGEs试验组、AGEs(100 mg·L^(-1))+GLP-1(10 nmol·L^(-1))组、AGEs(100 mg·L^(-1))+NAC(5 mmol·L^(-1))组,处理24 h。通过CCK-8比色法检测细胞存活率,相差显微镜观察细胞形态,双氯荧光素(DCFH-DA)染色荧光显微镜摄片观察细胞内活性氧(ROS)水平;RT-PCR法测定Bax、Bcl-2 mRNA基因的表达;运用Hoechst 33258检测试剂盒及流式细胞术检测心肌细胞的凋亡率,Western blot检测凋亡相关蛋白Bax、Bcl-2的表达量。结果与正常组相比,100 mg·L^(-1)AGEs组降低H9C2细胞生存率,活性氧(ROS)生成量增加;与AGEs组相比,AGEs+GLP-1组细胞生成率提高,活性氧(ROS)生成量减少。与正常组相比,AGEs组促凋亡蛋白Bax表达增加,抑制凋亡蛋白Bcl-2减少,细胞凋亡率升高;AGEs+GLP-1组较AGEs组下调促凋亡蛋白Bax,上调凋亡抑制蛋白Bcl-2,细胞凋亡率减少。结论 GLP-1对AGEs诱导的心肌细胞凋亡具有保护作用,其保护机制与减少活性氧(ROS)有关。展开更多
Compound [Co 3(BTC)(HBTC)(H 2BTC)(C 2H 4O 2) 3]·3(DMF)·6(H 3O) was synthesized under mild conditions and its crystal structure was determined by using single crystal X-ray diffraction. The crystal structure ...Compound [Co 3(BTC)(HBTC)(H 2BTC)(C 2H 4O 2) 3]·3(DMF)·6(H 3O) was synthesized under mild conditions and its crystal structure was determined by using single crystal X-ray diffraction. The crystal structure was solved by direct method and refined by full-matrix least-square method. The crystal is monoclinic and belongs to space group Cc with a=2.645 3(5) nm, b= 1.670 4(3) nm, c=1\^821 6(4) nm, β=128.16(3) °, V=6.329(2) nm 3, Z=2 , D c=20.200 Mg/m 3, M r= 1 314.744, μ=10.274 mm -1, F(000) =38 226, GOF=0.99, R=0.094 1, ωR=0.257 3.展开更多
文摘The title compound (C14H12N2O2, Mr = 240.26) crystallizes in the monoclinic system, space group P21/a with a = 7.394(1), b = 21.334(3), c = 7.423(1) ? b = 89.82(1)? V = 1170.8(3) ?, Z = 4, Dc = 1.363 g/cm3, m(MoKa) = 0.93 cm-1 and F(000) = 504.00. The final R and wR are 0.0440 and 0.1370 for 2153 observed reflections (I > 2s(I)), respectively. The dihedral angle between the two phenyl rings is 52.9 and that between the NO2 group and its attached ring is 3.0. In the crystal, molecules are stacked along [100] through p…p interactions. The CH…O hydrogen bond (3.403 ? 120.4? laterally connects the stacks along [010] to form networks (001) which are further anti- parallelly connected by CH…O (3.382 ? 142.9) and p…p interactions extending along [001]. Also presented here is a brief study on the CH…O hydrogen bonds in nitro-substituted benzyl-ideneanilines which can be classified into five types, namely, )5(12R, )4(21R, )8(22R, )6(12R and )7(22R, with the first three occurring more often.
基金supported by the University Science Foundation of Anhui Province (No.KJ2009B104)the Applied Chemistry Key Constructing Subject of Anhui Province (No.200802187C)
文摘The title complex [Cu（L1）（L2）（H2O）]·H2O（1,HL1 = N-（imino（pyridin-2-yl）me-thyl）picolinamidine）,HL2 = salicylic acid） has been obtained by volatilization method with L1 prepared from 2,4,6-tripyridyl-1,3,5-triazine in situ.1 was fully characterized by single-crystal X-ray diffraction,elemental analysis and FT-IR.This complex exhibits a three-dimensional frame-work constructed through hydrogen bonding and C-H···π stacking interactions.The cyclic voltametric behavior of complex 1 was also investigated.1 belongs to the monoclinic system,space group P21/c with a = 15.112（5）,b = 7.115（2）,c = 19.899（6） ,β = 112.32°,V = 1979.4（11） 3,Mr = 460.94,Dc = 1.540 g/cm3,F（000） = 948,μ = 1.146 mm-1,Z = 4,the final R = 0.0612 and wR = 0.1813 for 2510 observed reflections with I 2σ（I）.
基金supported by the University Science Foundation of Anhui Province (No. KJ2011Z271)the Applied Chemistry Key Constructing Subject of Anhui Province (No. 200802187C)
文摘Two complexes, [Cu2（Htdb）4（H2O）2] （1） and [Cd（bipy）2（Hmcmbc）2] （2） （H2tdb = 2,2-thiodibenzoic acid, H2mcmbc = m-（carboxyl-methyloxy）-benzenecarboxylic acid, bipy = 4,4＇-bipyridine）, have been prepared, and were characterized by elemental analysis, FT-IR and single-crystal X-ray diffraction. Structures indicate that complex 1 is a single molecule, and 2 is a one-dimensional chain. Their two-and three-dimensional frameworks are constructed through hydrogen bonding, π…π or C–H…π stacking, and such other weak interactions. The cyclic voltametric behavior of complex 1 and luminescence property of complex 2 were investigated. 1 belongs to the triclinic system, space group P with a = 7.8607（6）, b = 11.7619（9）, c = 15.3481（12） , α = 109.3670（10）, β = 92.4420（10）, γ = 92.0450（10）°, V = 1335.65（18） 3, Mr = 1256.26, Dc = 1.5619（2） g/cm3, F（000） = 642, μ = 1.029 mm–1, Z = 1, the final R = 0.0289 and wR = 0.0763 for 5199 observed reflections with I 2σ（I）. Complex 2 crystallizes in triclinic, space group P with a = 9.6378（10）, b = 9.7508（10）, c = 19.055（2） , α = 88.7020（10）, β = 80.5260（10）, γ = 69.2000（10）o, V = 1649.9（3） 3, Mr = 815.07, Dc = 1.641 g/cm3, μ = 0.732 mm-1, F（000） = 828, Z = 2, the final R = 0.0511 and wR = 0.1149 for 4729 observed reflections （I 2σ（I））.
文摘Compound [Co 3(BTC)(HBTC)(H 2BTC)(C 2H 4O 2) 3]·3(DMF)·6(H 3O) was synthesized under mild conditions and its crystal structure was determined by using single crystal X-ray diffraction. The crystal structure was solved by direct method and refined by full-matrix least-square method. The crystal is monoclinic and belongs to space group Cc with a=2.645 3(5) nm, b= 1.670 4(3) nm, c=1\^821 6(4) nm, β=128.16(3) °, V=6.329(2) nm 3, Z=2 , D c=20.200 Mg/m 3, M r= 1 314.744, μ=10.274 mm -1, F(000) =38 226, GOF=0.99, R=0.094 1, ωR=0.257 3.
