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基于第一性原理C-Cd掺杂ZnO的电子结构和光学性质的研究
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作者 张善祥 李海侠 +2 位作者 于镇 吴浩伟 张巍钟 《原子与分子物理学报》 CAS 北大核心 2025年第2期135-142,共8页
借助于计算材料科学和化学的计算机模拟软件Materials Studio,利用密度泛函理论下的第一性原理的计算方法,系统的计算研究了C、Cd单掺杂以及C和Cd共掺杂(不同浓度)ZnO的形成能、电子结构和光学性质.计算结果表明:单掺杂体系当中,C掺杂... 借助于计算材料科学和化学的计算机模拟软件Materials Studio,利用密度泛函理论下的第一性原理的计算方法,系统的计算研究了C、Cd单掺杂以及C和Cd共掺杂(不同浓度)ZnO的形成能、电子结构和光学性质.计算结果表明:单掺杂体系当中,C掺杂时形成能是正的,说明掺杂体系不易形成;共掺杂体系当中,所有掺杂体系的形成能均为负的,C-2Cd掺杂时形成能最低;与本征ZnO相比,所有掺杂体系的禁带宽度均有所降低,由于C元素的掺杂,禁带中产生杂质能级,减小电子跃迁所需要的能量;在光学性质方面,所有掺杂体系在低能区域的吸收图谱、介电函数虚部的峰值与本征ZnO相比均有所增大,且在低能区均发生红移,其中C-2Cd掺杂体系的红移程度最为明显且峰值最大.由此说明C和Cd共掺杂有望提高ZnO的光吸收率和光电转化效率,可以扩展其在光电器件领域中的应用. 展开更多
关键词 c-cd共掺杂 第一性原理 密度泛函理论 电子结构 光学性质
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C MEX S-function在导弹/弹丸动态仿真中的应用 被引量:1
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作者 黄志彦 王有豪 《电光与控制》 2003年第3期61-63,共3页
介绍了在导弹 /弹丸动态数字仿真中如何运用CMEXS function开发软件 ,更有效地利用C语言和MATLAB语言各自优势进行仿真软件的开发 ,从而大大提高仿真软件的开发效率。
关键词 cMEXS-function MATLAB 仿真
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The quantified analysis of China's GM cotton yield capacity by C-D function and stochastic frontier model
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作者 张涛 薛宝娣 《Hunan Agricultural Science & Technology Newsletter》 2004年第1期11-13,共3页
Using a modified C D function and stochastic frontier model, the paper analyzed China's cotton yield capacity and found that the yield and technical efficiency of China's cotton planting system can be increas... Using a modified C D function and stochastic frontier model, the paper analyzed China's cotton yield capacity and found that the yield and technical efficiency of China's cotton planting system can be increased by the use of genetically modified (GM) varieties. 展开更多
关键词 GM cotton yield capacity c D function stochastic frontier model
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血清超敏C反应蛋白、胱抑素C与脓毒性休克患者心功能、肾功能损伤的关系 被引量:1
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作者 王波 苏勇 +2 位作者 刘述平 谢敏 朱姝姮 《保健医学研究与实践》 2024年第3期38-42,共5页
目的检测脓毒性休克患者血清超敏C反应蛋白(hs-CRP)、胱抑素C(Cys C)水平,探讨其与脓毒性休克患者心功能、肾功能损伤的关系。方法选取2020年5月—2023年12月我院收治的脓毒性休克患者50例,纳入休克组。另选取同期健康体检者48名,纳入... 目的检测脓毒性休克患者血清超敏C反应蛋白(hs-CRP)、胱抑素C(Cys C)水平,探讨其与脓毒性休克患者心功能、肾功能损伤的关系。方法选取2020年5月—2023年12月我院收治的脓毒性休克患者50例,纳入休克组。另选取同期健康体检者48名,纳入参照组。比较2组研究对象hs-CRP、Cys C水平,分析脓毒性休克患者血清hs-CRP、Cys C水平与患者左室射血分数(LVEF)、二尖瓣舒张早期血流峰速(E)/二尖瓣环舒张早期速度(E’)、血浆脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(c TnⅠ)、肾小球滤过率(GFR)及急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分的关系。结果2组研究对象年龄、性别分布、身体质量指数(BMI)及基础疾病患病情况等方面的差异均无统计学意义(P>0.05)。休克组患者的血清hs-CRP水平[(181.01±37.39)mg/L]和血清Cys C水平[(2.62±0.25)mg/L]显著高于参照组[(38.78±10.55)mg/L、(0.96±0.15)mg/L],差异均有统计学意义(P<0.05)。休克组患者的血清hs-CRP水平与LVEF、E/E’、BNP、c TnⅠ水平、APACHEⅡ评分有关(P<0.05),与GFR无相关性(P>0.05);休克组患者的血清Cys C水平与GFR水平、APACHEⅡ评分有关(P<0.05),与LVEF、E/E’、BNP及c TnⅠ水平均无相关性(P>0.05)。结论脓毒性休克患者血清hs-CRP、Cys C水平均显著高于健康体验者,推测其可能与心肌细胞受损、炎症因子水平升高、肾血流量降低等因素有关,可作为评估脓毒性休克患者心、肾功能损伤的参考指标。 展开更多
关键词 脓毒性休克 血清超敏c反应蛋白 胱抑素c 心功能 肾功能
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Effect of Shengmai Injection(生脉注射液) on Cardiac Function and Inflammatory Reaction in Patients with Acute Coronary Syndrome 被引量:14
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作者 张亚臣 陈瑞明 +1 位作者 吕宝经 荣烨之 《Chinese Journal of Integrative Medicine》 SCIE CAS 2008年第2期107-110,共4页
Objective: To confirm the effect of Shengmai Injection (生脉注射液, SMI) in improving cardiac function in patients with acute coronary syndrome (ACS) and to explore its influence on inflammatory reaction in patie... Objective: To confirm the effect of Shengmai Injection (生脉注射液, SMI) in improving cardiac function in patients with acute coronary syndrome (ACS) and to explore its influence on inflammatory reaction in patients. Methods: Ninety ACS patients were randomized into two groups, the control group treated with conventional therapy and the SMI group treated with SMI. The patients' cardiac function was noted and the content of high sensitive C-reactive protein (hs-CRP) in venous blood was measured before treatment and 1 week and 3 weeks after treatment, so as to observe and compare their changes between the two groups. Results: The cardiac output, stroke volume and ejection fraction in the SMI group after 3 weeks of treatment were all higher than those in the control group (P〈0.05). The serum content of hs-CRP was reduced in both groups (P〈0.05), but the reduction in the SMI group was more significant than that in the control group (P〈0.05). Conclusion: SMI could improve the cardiac function and further inhibit the inflammatory reaction in patients with ACS. 展开更多
关键词 Shengmai Injection acute coronary syndrome c-reactive protein inflammatory reaction cardiac function
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通督调神针法治疗阴虚动风型脑梗死偏瘫疗效及对患者血清Hcy、CRP水平的影响 被引量:1
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作者 齐涛 张闻东 +1 位作者 李佩芳 刘辉 《陕西中医》 CAS 2024年第5期696-699,共4页
目的:探讨通督调神针法治疗阴虚动风型脑梗死偏瘫患者疗效及对患者血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)水平的影响。方法:选取脑梗死偏瘫患者76例,1∶1随机分为观察组(西医治疗+通督调神针法)与对照组(常规西医治疗)各38例。持续治疗... 目的:探讨通督调神针法治疗阴虚动风型脑梗死偏瘫患者疗效及对患者血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)水平的影响。方法:选取脑梗死偏瘫患者76例,1∶1随机分为观察组(西医治疗+通督调神针法)与对照组(常规西医治疗)各38例。持续治疗1个月后,评估两组临床疗效,比较两组治疗前后中医证候积分、血清炎症因子(Hcy、CRP)水平、运动功能[Fugl-Meyer评定量表(FMA)]、平衡功能[Berg平衡量表(BBS)]和移动功能[功能性步态评价表(FGA)]变化情况,并记录两组不良事件发生率。结果:观察组总有效率更高(P<0.05);观察组治疗后中医证候积分降低程度比对照组更明显(P<0.05)。观察组治疗后FMA、FGA和BBS评分升高水平均比对照组更明显(P<0.05),观察组治疗后Hcy、CRP水平下降程度均比对照组更明显(P<0.05)。治疗期间两组均无不良事件发生。结论:阴虚动风型脑梗死偏瘫患者应用通督调神针法联合常规西医治疗具有较好的增益效果,可有效提高临床疗效,缓解患者临床症状,提高运动、平衡和移动能力,降低炎症反应。 展开更多
关键词 脑梗死偏瘫 通督调神针法 阴虚动风型 血清同型半胱氨酸 c反应蛋白 运动功能
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基于C++的金属丝线屈服曲线的设计与实现
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作者 张晓辉 《辽宁师范大学学报(自然科学版)》 CAS 2024年第2期197-202,共6页
在工业生产实践中,金属丝线折弯成型是常见的加工工艺过程.例如:弹簧机将钢丝压出弹簧,眼镜绕框机将框丝绕出眼镜框型等.该类设备都有一个送丝机构,将直的金属丝推入由动、静轮为主要部件构成的成型机构中挤压变形,从而加工出不同形状... 在工业生产实践中,金属丝线折弯成型是常见的加工工艺过程.例如:弹簧机将钢丝压出弹簧,眼镜绕框机将框丝绕出眼镜框型等.该类设备都有一个送丝机构,将直的金属丝推入由动、静轮为主要部件构成的成型机构中挤压变形,从而加工出不同形状、不同大小的框型产品.以自动眼镜绕框机系统为例,说明金属框丝形变与动轮压力角度之间函数关系的建立及使用C++语言实现过程. 展开更多
关键词 折弯原理 屈服曲线 幂函数 c++程序设计
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Pseudo S-Asymptotically(ω,c)-Periodic Solutions to Fractional Differential Equations of Sobolev Type
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作者 MAO Hang-ning CHANG Yong-kui 《Chinese Quarterly Journal of Mathematics》 2024年第3期295-306,共12页
In this paper,we firstly recall some basic results on pseudo S-asymptotically(ω,c)-periodic functions and Sobolev type fractional differential equation.We secondly investigate some existence of pseudo S-asymptotical... In this paper,we firstly recall some basic results on pseudo S-asymptotically(ω,c)-periodic functions and Sobolev type fractional differential equation.We secondly investigate some existence of pseudo S-asymptotically(ω,c)-periodic solutions for a semilinear fractional differential equations of Sobolev type.We finally present a simple example. 展开更多
关键词 Pseudo S-asymptotically(ω c)-periodic functions Evolution equations Sobolev type Fractional differential equations Existence and uniqueness
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维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎的疗效 被引量:2
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作者 何娜 郑光强 +3 位作者 黄娆 林科 陈耿浩 袁文霄 《川北医学院学报》 2024年第1期42-45,共4页
目的:探讨维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎(MPP)疗效及其对免疫功能的影响。方法:选取106例MPP患儿为研究对象,按照治疗方式不同分为观察组和对照组,每组各53例。观察组患者采用维生素C辅助阿奇霉素序贯疗法治疗;对... 目的:探讨维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎(MPP)疗效及其对免疫功能的影响。方法:选取106例MPP患儿为研究对象,按照治疗方式不同分为观察组和对照组,每组各53例。观察组患者采用维生素C辅助阿奇霉素序贯疗法治疗;对照组采用阿奇霉素治疗,疗程均为7 d。比较两组患儿临床疗效、症状缓解时间、肺功能、免疫功能及不良反应发生情况。结果:观察组患儿临床总有效率高于对照组(98.11%vs.86.79%,P<0.05)。治疗后,观察组患儿高热、咳嗽、肺啰音、胸片缓解时间短于对照组(P<0.05)。治疗前,两组患儿用力呼气肺活量占预计值百分比(FVC)、第1秒用力呼气肺活量(FEVl)、FEVl/FVC无统计学差异(P>0.05);治疗后,两组患儿FVC、FEVl、FEVl/FVC均升高,且观察组高于对照组(P<0.05)。治疗前,两组患儿外周血免疫球蛋白IgA、IgM、IgG水平无统计学差异(P>0.05);治疗后,两组患儿外周血IgA、IgG水平均升高,且观察组高于对照组(P<0.05);IgM水平均降低,且观察组低于对照组(P<0.05)。两组患儿治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿奇霉素序贯疗法联合维生素C治疗儿童肺炎支原体肺炎能够提高疗效和免疫功能,值得临床推广。 展开更多
关键词 维生素c 阿奇霉素序贯疗法 肺炎支原体肺炎 免疫功能
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LOCAL C-SEMIGROUPS AND LOCAL C-COSINE FUNCTIONS 被引量:1
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作者 高明杵 《Acta Mathematica Scientia》 SCIE CSCD 1999年第2期201-213,共13页
This paper is concerned with the local C-semigroups and local C-cosine functions without the assumption that the image of C is dense in a Banach space X, First, the sufficient and necessary conditions for a local C-se... This paper is concerned with the local C-semigroups and local C-cosine functions without the assumption that the image of C is dense in a Banach space X, First, the sufficient and necessary conditions for a local C-semigroup and a C-cosine function to be the restriction of a global C-semigroup and a global C-cosine function to an interval are given, respectively, Secondly, it is characterized for a closed operator to be the generator of a local C-semigroup and a local C-cosine function, respectively. 展开更多
关键词 local c-semigroups local c-cosine functions asymptotic c-resolvent
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An Empirical Study on Rural Economic Growth in Hubei Province Based on New C-D Production Function 被引量:2
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作者 Yi WEN Minghong CAO 《Asian Agricultural Research》 2016年第10期6-8,12,共4页
Human capital is becoming a major driving force of promoting economic growth and social development. Hubei Province as a large agricultural province is significantly affected by the human capital. The paper selects th... Human capital is becoming a major driving force of promoting economic growth and social development. Hubei Province as a large agricultural province is significantly affected by the human capital. The paper selects the correlation data about rural economic growth in Hubei Province as samples to analyze the contribution of physical capital and human capital to rural economic growth by the new C-D function and SPSS22. 0. The results show that the effect of the elasticity of human capital is greater than that of physical capital in rural economic development; the high quality rural human capital storage and the average years of schooling of rural labor force will increase the net income of rural household. Therefore,we should not only increase input of physical capital but also increase the input of human capital to raise the level of human capital in rural areas and promote sustainable development of rural economy. 展开更多
关键词 New c-D function Human capital Physical capital
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Serial Communications Programming in Windows95 with API Functions 被引量:3
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作者 Wang Cheng-hu Yang Zi-jie +1 位作者 Wen Bi-yang Cheng Feng 《Wuhan University Journal of Natural Sciences》 EI CAS 2000年第3期323-328,共6页
This paper introduces the usage of these functions. It presents the technique of how to program with them to perform the serial communications between a computer and other digital devices by the serial porst in Window... This paper introduces the usage of these functions. It presents the technique of how to program with them to perform the serial communications between a computer and other digital devices by the serial porst in Windows95. The related sample codes of the applications of this technique written in C++ programming language are also given. This technique is applied successfully to receive the data of the radio noise from a frequency monitor. 展开更多
关键词 WINDOWS95 serial communications API function c++ cLc number TP 311. 1
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LOW-TEMPERATURE HEAT CAPACITY AND THERMODYNAMIC FUNCTIONS OF 2-CHLORO-6-(TRICHLOROMETHYL)PYRIDINE
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作者 谭志诚 徂徕道夫 菅宏 《Science China Chemistry》 SCIE EI CAS 1989年第10期1194-1207,共14页
The heat capacity of 2- chloro- 6- (trichloromethyl)pyridine has heen measured with anadiabatic calorimeter in the range from 13 to 316K. There is no indication of any phasetransition or thermal anomaly in this temper... The heat capacity of 2- chloro- 6- (trichloromethyl)pyridine has heen measured with anadiabatic calorimeter in the range from 13 to 316K. There is no indication of any phasetransition or thermal anomaly in this temperature region for the present compound. Theresults have been compared with those reported in [1] in the overlapping temperaturerange. The experimental heat capacity data have been fitted to a smoothed curve by the aidof the effective frequency distribution method, and the heat capacities below 13K have beenobtained by extrapolating the fitting curve down to 0K. The standard molar thermodynamicfunctions between 0 and 400 K have been derived by combining the present heat capacitymeasurements with the previous ones. The values of C_p^o (T), S^o(T) - S^o(0), [H^o(T) -H^o(0)]/T, and - [G^o(T) - H^o(0)]/T at T = 298.15 K are 189.35, 244.60, 112 .45 and 132.15J·K^(-1)·mol^(-1), respectively. 展开更多
关键词 heat capacity thermodynamic functions adiabatic calorimeter c_6H_3·cl_4N
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The Non-standard Characteristics of Functional SpacesK(X) and C_0(X) 被引量:1
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作者 陈东立 《Chinese Quarterly Journal of Mathematics》 CSCD 1998年第4期7-9, ,共3页
In this paper,the non standard characteristics of functional spaces K(X) and C 0(X) are presented and proved.
关键词 functional space K(X) functional space c 0(X) near standard points remote points
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MicroRNA-34c regulates porcine granulosa cell function by targeting forkhead box O3a 被引量:3
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作者 XU Yuan ZHANG Ai-ling +4 位作者 ZHANG Zhe YUAN Xiao-long CHEN Zan-mou ZHANG Hao LI Jia-qi 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第9期2019-2028,共10页
Granulosa cells(GCs) are somatic cells of ovary, the behaviors of GCs are important for ovarian function. MicroRNAs(miRNAs) are a class of endogenous 18–24 nucleotide(nt) non-coding RNAs, some of which have bee... Granulosa cells(GCs) are somatic cells of ovary, the behaviors of GCs are important for ovarian function. MicroRNAs(miRNAs) are a class of endogenous 18–24 nucleotide(nt) non-coding RNAs, some of which have been shown to be important regulators of GCs function. miR-34c involved in the regulation of various biological processes and was identified to be a pro-apoptotic and anti-proliferative factor in many cell types. However, the roles of miR-34c in GCs function remain unknown. In this study, we used Annexin V-FITC and Ed U assays to demonstrate that miR-34c exerted pro-apoptotic and anti-proliferative effects in porcine GCs. Dual-luciferase reporter assays, quantitative real-time PCR(q RT-PCR) and Western blotting identified Forkhead box O3a(Fox O3a) as a direct target gene of miR-34c. The overexpression of FoxO3a rescued the phenotypic change caused by miR-34c in porcine GCs. In conclusion, miR-34c regulate the function of porcine GCs by targeting FoxO3a. 展开更多
关键词 porcine microRNA-34c FoxO3a granulosa cell function
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Density Functional Study of the C Atom Adsorption on the α-Fe_2O_3 (001) Surface 被引量:2
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作者 董长青 张晓磊 杨勇平 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2011年第1期17-24,共8页
The adsorption of C atoms on the α-Fe2O3(001) surface was studied based on density function theory(DFT) ,in which the exchange-correlation potential was chosen as the PBE(Perdew,Burke and Ernzerhof) generalized... The adsorption of C atoms on the α-Fe2O3(001) surface was studied based on density function theory(DFT) ,in which the exchange-correlation potential was chosen as the PBE(Perdew,Burke and Ernzerhof) generalized gradient approximation(GGA) with a plane wave basis set. Upon the optimization on different adsorption sites with coverage of 1/20 and 1/5 ML,it was found that the adsorption of C atoms on the α-Fe2O3(001) surface was chemical adsorption. The coverage can affect the adsorption behavior greatly. Under low coverage,the most stable adsorption geometry lied on the bridged site with the adsorption energy of about 3.22 eV; however,under high coverage,it located at the top site with the energy change of 8.79 eV. Strong chemical reaction has occurred between the C and O atoms at this site. The density of states and population analysis showed that the s,p orbitals of C and p orbital of O give the most contribution to the adsorption bonding. During the adsorption process,O atom shares the electrons with C,and C can only affect the outermost and subsurface layers of α-Fe2O3; the third layer can not be affected obviously. 展开更多
关键词 α-Fe2O3 (001) c atom density functional theory ADSORPTION chemical looping combustion
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非血红素铁酶中动态配位变化对C-H键选择性胺化反应的调控机制
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作者 张璇 刘佳 +2 位作者 廖浪星 王子宽 王斌举 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第7期131-144,共14页
氮杂环丙烷结构广泛存在于天然生物碱中,具有杀菌、抗癌等作用.然而,目前关于生物体系在合成氮杂环丙烷结构过程中如何克服氮杂环丙烷高环张力带来的热力学不利因素,以及如何避免形成热力学更稳定的羟基化副产物的报道较少.TqaL_(NC)酶... 氮杂环丙烷结构广泛存在于天然生物碱中,具有杀菌、抗癌等作用.然而,目前关于生物体系在合成氮杂环丙烷结构过程中如何克服氮杂环丙烷高环张力带来的热力学不利因素,以及如何避免形成热力学更稳定的羟基化副产物的报道较少.TqaL_(NC)酶是目前非血红素酶家族中唯一一种能够依赖α-酮戊二酸活化C-H键,进而生成氮杂环丙烷结构的酶.深入探究TqaL_(NC)酶选择性生成氮杂环丙烷结构并避免羟基化副产物的机制,有助于深入理解非血红素铁酶家族在C-H键活化及官能化过程中的选择性调控机理.本文以TqaL_(NC)酶的晶体结构为基础,采用分子动力学(MD)模拟以及量子力学-分子力学(QM/MM)等多尺度模拟方法对TqaL_(NC)酶与L-缬氨酸(L-Val)、TqaL_(NC)酶与L-异亮氨酸(L-Ile)和F345A-TqaL_(NC)酶与L-异亮氨酸(L-Ile)三个反应过程进行了详细的机理研究.结果表明,TqaL_(NC)酶在反应过程中生成的直立式构象的Fe(Ⅳ)=O物种会通过构象异构化获得赤道面式构象,为底物(L-Val、L-Ile、L-homoalaine)上NH_(3)^(+)与Fe的配位提供结构基础.在水和关键酸性残基的介导下,底物NH_(3)^(+)两次脱去质子与Fe(Ⅳ)=O物种配位,生成HN-Fe(Ⅳ)=O结构.随后,Fe(Ⅳ)=O物种攫取底物H原子,生成HN-Fe(Ⅲ)-OH中间体.此时NH回弹反应比传统的OH回弹反应在动力学上更有优势,因此选择性地生成了氮杂环丙烷产物.在反应过程中,底物侧链与周围氨基酸的位阻效应是影响NH回弹反应能垒的重要因素.通过改变底物侧链大小(L-Val→L-Ile)以及附近氨基酸的突变(F345A)实验,证实了该结论.本文还通过理论计算预测了TqaL_(NC)酶与L-高丙氨酸的反应产物为羟基化产物,并通过新的实验证据进一步支持了理论预测的机理.此外,在HN-Fe(Ⅲ)-OH结构中,通过前线轨道理论分析发现,dπ*Fe-N,dπ*Fe-OH轨道的能量差是影响NH/OH回弹反应能垒的另一重要因素.当底物NH与Fe配位时,其配位作用能够使得dπ*Fe-N以及dπ*Fe-OH轨道有效分裂,这种分裂进而影响了反应路径的选择性,确保氮杂环丙烷产物的生成.综上,本文提出了依赖α-酮戊二酸酶催化合成氮杂环丙烷结构的新机理.研究发现,Fe中心的动态配位效应在实现C-H键选择性胺化反应并避免C-H键羟基化反应中起到了关键作用.该理论为非血红素Fe酶催化的非羟基化反应提供了新的见解,并为探索包括C-N/C-S/C-O等重要生物合成反应新机理的探究提供了新思路. 展开更多
关键词 联合量子力学-分子力学方法 c-H键活化 非血红素酶 胺化反应 羟基化反应
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一类新的单参数F-C函数及其应用
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作者 李硕 尚有林 屈德强 《工程数学学报》 CSCD 北大核心 2024年第3期494-506,共13页
填充函数法作为可以有效求解多变量、多极值函数的全局最优化方法,通过交替求解目标函数和填充函数找到问题的全局最优解或近似全局最优解,其寻优能力与所采用的填充函数性质有直接关系。因此,构造具有良好数学性质的填充函数新形式一... 填充函数法作为可以有效求解多变量、多极值函数的全局最优化方法,通过交替求解目标函数和填充函数找到问题的全局最优解或近似全局最优解,其寻优能力与所采用的填充函数性质有直接关系。因此,构造具有良好数学性质的填充函数新形式一直都是填充函数法的重要研究领域。然而,当前已有的填充函数存在以下问题:填充函数不连续不可微;参数过多难以控制和调整;包含指数项或对数项。为解决上述不足,将填充函数和跨越函数相结合,引入求解无约束全局优化问题的F-C函数定义。根据此定义,构造一类新的单参数F-C函数,此参数在迭代过程中易于调节。在分析该函数理论性质的基础上,提出新的全局优化F-C函数方法,该算法打破传统填充函数算法的求解框架,成功减少求解目标函数的次数,提高计算效率。通过数值计算验证F-C函数算法的有效性和可行性。最后,用F-C函数算法对切削温度实验中的参数进行优化,并与已有结果进行比较,数值试验结果表明该算法具有更好的拟合效果。 展开更多
关键词 全局最优化 填充函数 跨越函数 F-c函数 切削温度
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Axonotmesis-evoked plantar vasodilatation as a novel assessment of C-fiber afferent function after sciatic nerve injury in rats 被引量:1
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作者 Xue-Song Wang Xue Chen +3 位作者 Tian-Wen Gu Ya-Xian Wang Da-Guo Mi Wen Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第12期2164-2172,共9页
Quantitative assessment of the recovery of nerve function, especially sensory and autonomic nerve function, remains a challenge in the field of nerve regeneration research. We previously found that neural control of v... Quantitative assessment of the recovery of nerve function, especially sensory and autonomic nerve function, remains a challenge in the field of nerve regeneration research. We previously found that neural control of vasomotor activity could be potentially harnessed to evaluate nerve function. In the present study, five different models of left sciatic nerve injury in rats were established: nerve crush injury, nerve transection/ suturing, nerve defect/autografting, nerve defect/conduit repair, and nerve defect/non-regeneration. Laser Doppler perfusion imaging was used to analyze blood perfusion of the hind feet. The toe pinch test and walking track analysis were used to assess sensory and motor functions of the rat hind limb, respectively. Transmission electron microscopy was used to observe the density of unmyelinated axons in the injured sciatic nerve. Our results showed that axonotmesis-evoked vasodilatation in the foot 6 months after nerve injury/repair recovered to normal levels in the nerve crush injury group and partially in the other three repair groups;whereas the nerve defect/non-regeneration group exhibited no recovery in vasodilatation. Furthermore, the recovery index of axonotmesis-evoked vasodilatation was positively correlated with toe pinch reflex scores and the density of unmyelinated nerve fibers in the regenerated nerve. As C-fiber afferents are predominantly responsible for dilatation of the superficial vasculature in the glabrous skin in rats, the present findings indicate that axonotmesis-evoked vasodilatation can be used as a novel way to assess C-afferent function recovery after peripheral nerve injury. This study was approved by the Ethics Committee for Laboratory Animals of Nantong University of China (approval No. 20130410-006) on April 10, 2013. 展开更多
关键词 NERVE REGENERATION axonotmesis-evoked VASODILATATION laser Doppler perfusion imaging NERVE function autonomic NERVE c-FIBER AFFERENT function peripheral NERVE injury unmyelinated AFFERENT fiber REGENERATION neural REGENERATION
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2型糖尿病患者维生素D水平与血清CRP、自身免疫抗体及甲状腺功能的相关性
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作者 姚莉敏 付士玲 郎少磊 《河南医学研究》 CAS 2024年第16期2988-2992,共5页
目的研究2型糖尿病患者维生素D水平与血清C反应蛋白(CRP)、自身免疫抗体及甲状腺功能的相关性。方法选取2018年1月至2019年1月于信阳职业技术学院附属医院就诊的150例2型糖尿病患者为研究组,同期选取50例健康体检者作为对照组。检测血清... 目的研究2型糖尿病患者维生素D水平与血清C反应蛋白(CRP)、自身免疫抗体及甲状腺功能的相关性。方法选取2018年1月至2019年1月于信阳职业技术学院附属医院就诊的150例2型糖尿病患者为研究组,同期选取50例健康体检者作为对照组。检测血清CRP、血清25-羟维生素D[25(OH)D]、胰岛自身免疫抗体和甲状腺功能指标水平并比较两组差异;按血清25(OH)D水平将研究组分为正常组(34例)、不足组(37例)、缺乏组(39例)和严重缺乏组(40例)4个亚组,比较组间血清CRP、胰岛自身免疫抗体阳性率和甲状腺功能指标水平差异;对血清25(OH)D与CRP、胰岛自身免疫抗体阳性率及甲状腺功能指标水平的相关性进行Pearson和Spearman相关性分析;随访3 a,统计甲状腺功能障碍发生率,并绘制受试者工作特征(ROC)曲线分析2型糖尿病患者血清25(OH)D对甲状腺功能障碍的预测效能。结果与对照组比较,研究组血清25(OH)D、TSH水平较低,CRP水平和胰岛自身免疫抗体阳性率较高(P<0.05)。正常组、不足组、缺乏组和严重缺乏组的血清CRP、胰岛自身免疫抗体阳性率和TSH水平比较差异有统计学意义,其中血清CRP、TSH水平逐渐上升(P<0.05)。2型糖尿病患者血清25(OH)D水平与CRP(r=-0.714)、胰岛自身免疫抗体阳性率(r=-0.397)和TSH(r=-0.410)水平均呈负相关(P<0.001)。2型糖尿病患者甲状腺功能障碍发生率为25.33%(38/150),绘制ROC曲线分析血清25(OH)D预测甲状腺功能障碍发生的AUC为0.916。结论2型糖尿病患者血清维生素D与CRP、自身免疫抗体阳性率以及甲状腺功能指标水平存在负相关关系,且对甲状腺功能障碍的发生有一定预测价值。 展开更多
关键词 2型糖尿病 c反应蛋白 维生素D 自身免疫抗体 甲状腺功能
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