Let R ＊θ G be the skew group ring with a F.C group G and the group homomrphism 8 from G to Aut（R）, the group of automorphisms of the ring R. In this paper,the necessary and sufficient condition such that R ＊θ G ...Let R ＊θ G be the skew group ring with a F.C group G and the group homomrphism 8 from G to Aut（R）, the group of automorphisms of the ring R. In this paper,the necessary and sufficient condition such that R ＊θ G will be Noetherian is given, which generalizes the results of LG. connel.展开更多
目的ATP结合盒B亚家族成员1(ATP binding cassette subfamily B member 1,ABCB1)的异常表达在多种癌症的发生发展中发挥关键作用。然而,G蛋白偶联受体C家族5组A型(G protein coupled receptor family C group5 type A,GPRC5A)调控的ABCB...目的ATP结合盒B亚家族成员1(ATP binding cassette subfamily B member 1,ABCB1)的异常表达在多种癌症的发生发展中发挥关键作用。然而,G蛋白偶联受体C家族5组A型(G protein coupled receptor family C group5 type A,GPRC5A)调控的ABCB1表达对肺腺癌增殖的影响仍不清楚。本研究探讨了GPRC5A调控的ABCB1表达对肺腺癌增殖的影响。方法我们采用RT-PCR、Western-blot或免疫组化实验,分析ABCB1在肺腺癌细胞系、人肺腺癌组织以及GPRC5A基因敲除小鼠和野生型小鼠的气管上皮细胞和肺组织中的表达。采用细胞计数试剂盒-8(CCK-8)分析GPRC5A基因敲除小鼠气管上皮细胞对化疗药物的敏感性。采用皮下肿瘤形成实验探讨下调ABCB1表达是否可抑制体内肺腺癌增殖。采用免疫荧光和免疫沉淀实验研究GPRC5A和ABCB1之间潜在的调控关系。结果ABCB1在肺腺癌细胞系和人类肺腺癌组织中表达上调。GPRC5A基因敲除小鼠的气管上皮细胞及肺组织的ABCB1表达高于野生型小鼠。与GPRC5A野生型小鼠的气管上皮细胞相比,GPRC5A基因敲除小鼠的气管上皮细胞对塔立奇达和多柔比星更敏感。注射移植细胞28天后,接受ABCB1基因敲除细胞移植的GPRC5A-/-C57BL/6小鼠的肺肿瘤的体积和重量均明显低于野生型细胞移植小鼠(P=0.0043,P=0.0060)。此外,免疫荧光和免疫沉淀实验表明,GPRC5A通过直接结合方式调控ABCB1的表达。结论GPRC5A通过抑制ABCB1表达降低肺腺癌增殖。GPRC5A调节ABCB1表达的途径有待研究。展开更多
For a repairable redundant system consisting of two same components with exponential lifetime and general repair time distribution, the probability densities of the system in some state at time t were determined b...For a repairable redundant system consisting of two same components with exponential lifetime and general repair time distribution, the probability densities of the system in some state at time t were determined by a group of ordinary and partial differential equations, called density evolution equations. It was proved that the time dependent solution of the density evolution equations uniquely exists and strongly converges to its steady state density solution by a semi group method. In this proof, it is not necessary to suppose that the repair rate function is bounded. The technique of the proof is valuable for many density evolution equations.展开更多
Chevkinite specimen from a rare-earth mineral deposit in Sichuan, southwest of China have been studied in detail by means of transmission electron microscope (TEM).The selected area electron diffraction (SAED)and conv...Chevkinite specimen from a rare-earth mineral deposit in Sichuan, southwest of China have been studied in detail by means of transmission electron microscope (TEM).The selected area electron diffraction (SAED)and convergent beam electron diffraction (CBED) patterns , obtained from different crystal zone axis direction , proved coincidently that the space group of chevkinite is C2/m . Fringe lattice image observation showed the mineral crystal is structurally uniform in microscale , and it is an ideal specimen for electron diffraction analysis . The mineral studied here is similar to the one from Bayan Obo , Inner Mongolia , China , in chemical composition and REE distribution . The chemical formula of the crystal is (Ce , La ,… , Ca) 4 Fe2+ (Fe, Ti, Nb) 2 O8 (Si2O7)2 From our study , we come to the conclusion that the space group of the natural chevkinite is C2/m , instead of P21/a as synthetic one . Up to now , chevkinite compositionally similar to the synthetic one , in which the complete replacements of Ce , La by Nd and Fe by Mg or Co occur , has not been discovered in nature . So we suggest that the name for synthesized chevkinite should be further discussed .展开更多
Tricyclic compound 6 was synthesized form compound 1 through sis steps, thus preblem of the stereochemistry of C2α-H being solved. The stereochemistry for introducing hydroxy groups at C3β and C4α positions in com...Tricyclic compound 6 was synthesized form compound 1 through sis steps, thus preblem of the stereochemistry of C2α-H being solved. The stereochemistry for introducing hydroxy groups at C3β and C4α positions in compound 1 was also described.展开更多
基金Supported by the NSF of Educational Department of Henan Province(20025100003)
文摘Let R ＊θ G be the skew group ring with a F.C group G and the group homomrphism 8 from G to Aut（R）, the group of automorphisms of the ring R. In this paper,the necessary and sufficient condition such that R ＊θ G will be Noetherian is given, which generalizes the results of LG. connel.
文摘目的ATP结合盒B亚家族成员1(ATP binding cassette subfamily B member 1,ABCB1)的异常表达在多种癌症的发生发展中发挥关键作用。然而,G蛋白偶联受体C家族5组A型(G protein coupled receptor family C group5 type A,GPRC5A)调控的ABCB1表达对肺腺癌增殖的影响仍不清楚。本研究探讨了GPRC5A调控的ABCB1表达对肺腺癌增殖的影响。方法我们采用RT-PCR、Western-blot或免疫组化实验,分析ABCB1在肺腺癌细胞系、人肺腺癌组织以及GPRC5A基因敲除小鼠和野生型小鼠的气管上皮细胞和肺组织中的表达。采用细胞计数试剂盒-8(CCK-8)分析GPRC5A基因敲除小鼠气管上皮细胞对化疗药物的敏感性。采用皮下肿瘤形成实验探讨下调ABCB1表达是否可抑制体内肺腺癌增殖。采用免疫荧光和免疫沉淀实验研究GPRC5A和ABCB1之间潜在的调控关系。结果ABCB1在肺腺癌细胞系和人类肺腺癌组织中表达上调。GPRC5A基因敲除小鼠的气管上皮细胞及肺组织的ABCB1表达高于野生型小鼠。与GPRC5A野生型小鼠的气管上皮细胞相比,GPRC5A基因敲除小鼠的气管上皮细胞对塔立奇达和多柔比星更敏感。注射移植细胞28天后,接受ABCB1基因敲除细胞移植的GPRC5A-/-C57BL/6小鼠的肺肿瘤的体积和重量均明显低于野生型细胞移植小鼠(P=0.0043,P=0.0060)。此外,免疫荧光和免疫沉淀实验表明,GPRC5A通过直接结合方式调控ABCB1的表达。结论GPRC5A通过抑制ABCB1表达降低肺腺癌增殖。GPRC5A调节ABCB1表达的途径有待研究。
文摘For a repairable redundant system consisting of two same components with exponential lifetime and general repair time distribution, the probability densities of the system in some state at time t were determined by a group of ordinary and partial differential equations, called density evolution equations. It was proved that the time dependent solution of the density evolution equations uniquely exists and strongly converges to its steady state density solution by a semi group method. In this proof, it is not necessary to suppose that the repair rate function is bounded. The technique of the proof is valuable for many density evolution equations.
基金Financial support for this study was provided by the Scicnce Foundation of Doctorate Program 8849104-11 from the National Committce of Education
文摘Chevkinite specimen from a rare-earth mineral deposit in Sichuan, southwest of China have been studied in detail by means of transmission electron microscope (TEM).The selected area electron diffraction (SAED)and convergent beam electron diffraction (CBED) patterns , obtained from different crystal zone axis direction , proved coincidently that the space group of chevkinite is C2/m . Fringe lattice image observation showed the mineral crystal is structurally uniform in microscale , and it is an ideal specimen for electron diffraction analysis . The mineral studied here is similar to the one from Bayan Obo , Inner Mongolia , China , in chemical composition and REE distribution . The chemical formula of the crystal is (Ce , La ,… , Ca) 4 Fe2+ (Fe, Ti, Nb) 2 O8 (Si2O7)2 From our study , we come to the conclusion that the space group of the natural chevkinite is C2/m , instead of P21/a as synthetic one . Up to now , chevkinite compositionally similar to the synthetic one , in which the complete replacements of Ce , La by Nd and Fe by Mg or Co occur , has not been discovered in nature . So we suggest that the name for synthesized chevkinite should be further discussed .
文摘Tricyclic compound 6 was synthesized form compound 1 through sis steps, thus preblem of the stereochemistry of C2α-H being solved. The stereochemistry for introducing hydroxy groups at C3β and C4α positions in compound 1 was also described.
