The photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones has emerged as a promising and powerful approach for post-synthetic modification of quinoxalin-2(1H)-ones.This review provides an overview of rece...The photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones has emerged as a promising and powerful approach for post-synthetic modification of quinoxalin-2(1H)-ones.This review provides an overview of recent developments in photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones including arylation,alkylation,fluoroalkylation,amination,phosphorylation,acylation,alkoxylation,thiolation,silylation,and annulation.The reaction scope and the related mechanism are also well discussed.展开更多
Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,th...Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,the directing group-assisted activation of non-aromatic vinylic C–H bonds still remains challenging.During the recent years,significant progress has been made in this fascinating field with various functionalized alkenes,heterocycles and carbocycles being obtained.This article will focus on the recent achievements in the field of directing-group-assisted vinylic C–H bond functionalization.展开更多
During the past decade, there was increased interest in the functionalization of the allylic C-H bond of alkenes. As opposed to traditional Trost-Tsuji reactions, this strategy avoids the prefunctionalization of the a...During the past decade, there was increased interest in the functionalization of the allylic C-H bond of alkenes. As opposed to traditional Trost-Tsuji reactions, this strategy avoids the prefunctionalization of the alkene. Many transi- tion metals have been used to promote such processes, and palladium has proved to be one of the best catalysts as it offers great advantages from the point of view of substrate scope and selectivity. Therefore, many groundbreaking re- suits obtained with Pd-catalyzed processes have been re- ported, including allylic C-H oxygenation, amination, al- kylation, and other transformations, which have been well documented in reviews [1].展开更多
Transition metal catalyzed C-H Functionalization is one of the most important and challenging research fields in or- ganic chemistry and has rapidly evolved in recent decades. Some recent achievements in the field inc...Transition metal catalyzed C-H Functionalization is one of the most important and challenging research fields in or- ganic chemistry and has rapidly evolved in recent decades. Some recent achievements in the field include i） minimizing the pre-activation procedures of substrates, ii） reducing waste production, and iii） shortening synthetic steps by de- veloping direct activations and straightforward transfor- mations of C-H bonds. With the rapid developments in chemistry and the continuous support of the Chinese gov- ernment, Chinese chemists have played important roles in this emerging field in the past two decades. To stimulate the continued success of Chinese chemists, this work provides an intensive account of the current status of this important field in China's Mainland.展开更多
In recent years,transition-metal-catalyzed inert C–H bond activation has developed rapidly and is a powerful protocol for the construction of new C–C or C–X bonds and the introduction of new functional groups.Our g...In recent years,transition-metal-catalyzed inert C–H bond activation has developed rapidly and is a powerful protocol for the construction of new C–C or C–X bonds and the introduction of new functional groups.Our group has also developed a series of R2(O)P-directed Pd-catalyzed C–H functionalizations involving olefination,hydroxylation,acetoxylation,arylation,and acylation through an uncommon seven-membered cyclo-palladium pretransition state.Unlike previously used directing groups,the R2(O)P group acts as a directing group and is also involved in the construction of P,-hetero-ligands.展开更多
文摘The photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones has emerged as a promising and powerful approach for post-synthetic modification of quinoxalin-2(1H)-ones.This review provides an overview of recent developments in photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones including arylation,alkylation,fluoroalkylation,amination,phosphorylation,acylation,alkoxylation,thiolation,silylation,and annulation.The reaction scope and the related mechanism are also well discussed.
基金supported by the National Basic Research Program of China(2015CB856600)the National Natural Science Foundation of China(21332002,21272010)
文摘Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,the directing group-assisted activation of non-aromatic vinylic C–H bonds still remains challenging.During the recent years,significant progress has been made in this fascinating field with various functionalized alkenes,heterocycles and carbocycles being obtained.This article will focus on the recent achievements in the field of directing-group-assisted vinylic C–H bond functionalization.
文摘During the past decade, there was increased interest in the functionalization of the allylic C-H bond of alkenes. As opposed to traditional Trost-Tsuji reactions, this strategy avoids the prefunctionalization of the alkene. Many transi- tion metals have been used to promote such processes, and palladium has proved to be one of the best catalysts as it offers great advantages from the point of view of substrate scope and selectivity. Therefore, many groundbreaking re- suits obtained with Pd-catalyzed processes have been re- ported, including allylic C-H oxygenation, amination, al- kylation, and other transformations, which have been well documented in reviews [1].
文摘Transition metal catalyzed C-H Functionalization is one of the most important and challenging research fields in or- ganic chemistry and has rapidly evolved in recent decades. Some recent achievements in the field include i） minimizing the pre-activation procedures of substrates, ii） reducing waste production, and iii） shortening synthetic steps by de- veloping direct activations and straightforward transfor- mations of C-H bonds. With the rapid developments in chemistry and the continuous support of the Chinese gov- ernment, Chinese chemists have played important roles in this emerging field in the past two decades. To stimulate the continued success of Chinese chemists, this work provides an intensive account of the current status of this important field in China's Mainland.
基金supported by the Natural Science Foundation of Gansu Province(1208RJZA216)
文摘In recent years,transition-metal-catalyzed inert C–H bond activation has developed rapidly and is a powerful protocol for the construction of new C–C or C–X bonds and the introduction of new functional groups.Our group has also developed a series of R2(O)P-directed Pd-catalyzed C–H functionalizations involving olefination,hydroxylation,acetoxylation,arylation,and acylation through an uncommon seven-membered cyclo-palladium pretransition state.Unlike previously used directing groups,the R2(O)P group acts as a directing group and is also involved in the construction of P,-hetero-ligands.
