The synthesis of N-substituted amines is one of the key transformations in synthetic chemistry and chemical industry,because amines are ubiquitous in the syntheses of agrochemicals,pharmaceuticals,flavorings,fragrance...The synthesis of N-substituted amines is one of the key transformations in synthetic chemistry and chemical industry,because amines are ubiquitous in the syntheses of agrochemicals,pharmaceuticals,flavorings,fragrances,and advanced materials.In order to realize the clean and economic synthe-sis of N-substituted amines,several asperts should be concerned.1)The application of alkyl halides as alkylation reagents should be replaced by alcohol and alkane;2)the employment of amines as nitrogen sources can be replaced by nitrobenzene,nitrile and ammonia;3)the application of environmentally benign and low-cost starting materials,such as C0_(2),HCHO,biomass resources,for the nitrogen-containing chemicals synthesis should be established;and 4)economic,green and efficient catalyst should be developed for the above transformations.In this account,we describe our results in the clean and economic synthesis of N-substituted amines with amine,ammonia,nitrobenzene or nitrile as nitrogen sources and alcohol,alkane or C0_(2),HCHO,CO,and biomass resources as alkylation or carbonylation reagents.展开更多
基金The National Natural Science Foundation of China(21633013,21802147,and 21925207),National Key Research and Development Program of China(2017YFA0403103),the Youth Innovation Promotion Association(2019409),the'Light of West China'Program and Key Research Program of Frontier Sciences of CAS(QYZDJ-SSW-SLH051)for financial support.
文摘The synthesis of N-substituted amines is one of the key transformations in synthetic chemistry and chemical industry,because amines are ubiquitous in the syntheses of agrochemicals,pharmaceuticals,flavorings,fragrances,and advanced materials.In order to realize the clean and economic synthe-sis of N-substituted amines,several asperts should be concerned.1)The application of alkyl halides as alkylation reagents should be replaced by alcohol and alkane;2)the employment of amines as nitrogen sources can be replaced by nitrobenzene,nitrile and ammonia;3)the application of environmentally benign and low-cost starting materials,such as C0_(2),HCHO,biomass resources,for the nitrogen-containing chemicals synthesis should be established;and 4)economic,green and efficient catalyst should be developed for the above transformations.In this account,we describe our results in the clean and economic synthesis of N-substituted amines with amine,ammonia,nitrobenzene or nitrile as nitrogen sources and alcohol,alkane or C0_(2),HCHO,CO,and biomass resources as alkylation or carbonylation reagents.
