目的分析动态双C疗法对2型糖尿病(T2DM)患者的效果。方法选取2017年2月至2020年2月平煤神马医疗集团总医院收治的92例T2DM患者。对所有患者使用胰岛素控制血糖。将45例采用血糖仪进行血糖监测的患者纳入对照组。将47例使用动态血糖监测...目的分析动态双C疗法对2型糖尿病(T2DM)患者的效果。方法选取2017年2月至2020年2月平煤神马医疗集团总医院收治的92例T2DM患者。对所有患者使用胰岛素控制血糖。将45例采用血糖仪进行血糖监测的患者纳入对照组。将47例使用动态血糖监测系统(CGM)联合胰岛素泵(CSII)强化治疗(动态双C疗法)的患者纳入观察组。比较两组治疗前后血糖水平[空腹血糖(FPG)、餐后2小时血糖(2 h PG)、平均血糖波动幅度(MAGE)]、血糖达标时间、低血糖发生率、C反应蛋白(CRP)、尿微量白蛋白(UAE)、胰岛功能(Homa-β指数、空腹C肽、餐后2小时C肽)。结果治疗后,两组FPG、2 h PG、MAGE水平低于治疗前,观察组FPG、2 h PG、MAGE水平低于对照组(P<0.05)。观察组血糖达标时间较对照组短(P<0.05)。观察组低血糖发生率[6.38%(3/47)]较对照组[22.22%(10/45)]低(P<0.05)。治疗后,两组CRP、UAE水平均低于治疗前,观察组CRP、UAE水平均低于对照组(P<0.05)。治疗后,两组Homa-β指数、空腹C肽、餐后2小时C肽水平高于治疗前(P<0.05);治疗后,观察组Homa-β指数、空腹C肽、餐后2小时C肽与对照组比较,差异无统计学意义(P>0.05)。结论动态双C疗法治疗T2DM患者可平稳降低血糖,缩短血糖达标时间,减少低血糖发生,降低CRP、UAE水平,改善胰岛功能。展开更多
AIM:To investigate the relationship between the expression of pepsinogen C (PGC) and gastric cancer, precancerous diseases, and Helicobacter pylori (H pylori) infection. METHODS: The expression of PGC was determined b...AIM:To investigate the relationship between the expression of pepsinogen C (PGC) and gastric cancer, precancerous diseases, and Helicobacter pylori (H pylori) infection. METHODS: The expression of PGC was determined by immunohistochemistry method in 430 cases of gastric mucosa. H3 Pylori infection was determined by HE staining, PCR and ELISA in 318 specimens. RESULTS: The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100%. The positive rates of PGC expression in superficial gastritis or gastric ulcer or erosion, atrophic gastritis or gastric dysplasia and gastric cancer decreased significantly in sequence (P<0.05; 100%/89.2% vs 14.3%/15.2% vs 2.4%). The over-expression rate of PGC in group of superficial gastritis with H pyloriinfection was higher than that in group without H pylori infection (P<0.05; x2= 0.032 28/33 vs 15/25). The positive rate of PGC expression in group of atrophic gastritis with H pylori infection was lower than that in group without H pylori infection (P<0.01; x2 = 0.003 4/61 vs9/30), and in dysplasia and gastric cancer. CONCLUSION: The level of PGC expression has a close relationship with the degree of malignancy of gastric mucosa and development of gastric lesions. There is a relationship between H pylori infection and expression of antigen PGC in gastric mucosa, the positive rate of PGC expression increases in early stage of gastric lesions with H pylori infection such as gastric inflammation and decreases during the late stage such as precancerous diseases and gastric cancer. PGC-negative cases with H py/ori-positive gastric lesions should be given special attention.展开更多
文摘目的分析动态双C疗法对2型糖尿病(T2DM)患者的效果。方法选取2017年2月至2020年2月平煤神马医疗集团总医院收治的92例T2DM患者。对所有患者使用胰岛素控制血糖。将45例采用血糖仪进行血糖监测的患者纳入对照组。将47例使用动态血糖监测系统(CGM)联合胰岛素泵(CSII)强化治疗(动态双C疗法)的患者纳入观察组。比较两组治疗前后血糖水平[空腹血糖(FPG)、餐后2小时血糖(2 h PG)、平均血糖波动幅度(MAGE)]、血糖达标时间、低血糖发生率、C反应蛋白(CRP)、尿微量白蛋白(UAE)、胰岛功能(Homa-β指数、空腹C肽、餐后2小时C肽)。结果治疗后,两组FPG、2 h PG、MAGE水平低于治疗前,观察组FPG、2 h PG、MAGE水平低于对照组(P<0.05)。观察组血糖达标时间较对照组短(P<0.05)。观察组低血糖发生率[6.38%(3/47)]较对照组[22.22%(10/45)]低(P<0.05)。治疗后,两组CRP、UAE水平均低于治疗前,观察组CRP、UAE水平均低于对照组(P<0.05)。治疗后,两组Homa-β指数、空腹C肽、餐后2小时C肽水平高于治疗前(P<0.05);治疗后,观察组Homa-β指数、空腹C肽、餐后2小时C肽与对照组比较,差异无统计学意义(P>0.05)。结论动态双C疗法治疗T2DM患者可平稳降低血糖,缩短血糖达标时间,减少低血糖发生,降低CRP、UAE水平,改善胰岛功能。
基金Supported by the National High Technology R and D Program of China, No. 2001BA703B06 (B) National Natural Science Foundation of China, No. 30171054
文摘AIM:To investigate the relationship between the expression of pepsinogen C (PGC) and gastric cancer, precancerous diseases, and Helicobacter pylori (H pylori) infection. METHODS: The expression of PGC was determined by immunohistochemistry method in 430 cases of gastric mucosa. H3 Pylori infection was determined by HE staining, PCR and ELISA in 318 specimens. RESULTS: The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100%. The positive rates of PGC expression in superficial gastritis or gastric ulcer or erosion, atrophic gastritis or gastric dysplasia and gastric cancer decreased significantly in sequence (P<0.05; 100%/89.2% vs 14.3%/15.2% vs 2.4%). The over-expression rate of PGC in group of superficial gastritis with H pyloriinfection was higher than that in group without H pylori infection (P<0.05; x2= 0.032 28/33 vs 15/25). The positive rate of PGC expression in group of atrophic gastritis with H pylori infection was lower than that in group without H pylori infection (P<0.01; x2 = 0.003 4/61 vs9/30), and in dysplasia and gastric cancer. CONCLUSION: The level of PGC expression has a close relationship with the degree of malignancy of gastric mucosa and development of gastric lesions. There is a relationship between H pylori infection and expression of antigen PGC in gastric mucosa, the positive rate of PGC expression increases in early stage of gastric lesions with H pylori infection such as gastric inflammation and decreases during the late stage such as precancerous diseases and gastric cancer. PGC-negative cases with H py/ori-positive gastric lesions should be given special attention.
