化工、纺织印染与农药化肥等产业的蓬勃发展推动着人类社会的进步,但同时也给环境治理带来了巨大难题。目前,光催化降解局限于在特定波长下针对单一有机污染物进行降解,然而现实中的情况往往更复杂。因此,开发一种多功能光催化材料用于...化工、纺织印染与农药化肥等产业的蓬勃发展推动着人类社会的进步,但同时也给环境治理带来了巨大难题。目前,光催化降解局限于在特定波长下针对单一有机污染物进行降解,然而现实中的情况往往更复杂。因此,开发一种多功能光催化材料用于光催化降解不同有机污染物显得尤为重要。采用一步无模板溶剂热法合成了核壳结构的C-TiO_(2)复合材料前驱体,并在氩气气氛下煅烧得到高结晶度的C-TiO_(2)复合光催化材料。运用SEM、TEM、XRD和TG等表征手段对材料进行表征,结论如下:550℃煅烧时的样品为包含少量碳的高结晶度的锐钛矿相TiO 2,且550℃煅烧时的样品依然保持了完整的核壳结构。此外,C-TiO_(2)复合材料的比表面积高达85.69 m 2·g^(-1),平均孔径为16.4 nm以及孔体积为0.423 m 3·g^(-1)。在UV-Vis光照射下,C-TiO_(2)复合材料分别对罗丹明B(RhB)、亚甲基蓝(MB)和刚果红(CR)3种染料显示出增强的光催化降解活性。展开更多
通过溶剂热法制备了球状C-TiO_(2)催化剂以及BiOCl/C-TiO_(2)复合光催化材料。与纯TiO_(2)相比,球状C-TiO_(2)和BiOCl/C-TiO_(2)的禁带宽度显著降低。以亚甲基蓝为降解目标,当染料质量浓度为25 mg/L、pH为7时,0.1 g BiOCl/CTiO_(2)对其...通过溶剂热法制备了球状C-TiO_(2)催化剂以及BiOCl/C-TiO_(2)复合光催化材料。与纯TiO_(2)相比,球状C-TiO_(2)和BiOCl/C-TiO_(2)的禁带宽度显著降低。以亚甲基蓝为降解目标,当染料质量浓度为25 mg/L、pH为7时,0.1 g BiOCl/CTiO_(2)对其的降解率在1 h可达到81.44%,催化效率达64.15%,其动力学过程符合一级动力学模型。展开更多
为获得一种具有理论容量高、循环性能佳、光催化性能优异的新型多功能材料,在石墨存在下,以钛酸四丁酯为钛源,利用简单的一步溶剂热法制备不同石墨含量的石墨@TiO_(2)复合材料并对其进行表征。将石墨@TiO_(2)复合材料作为锂离子电池负...为获得一种具有理论容量高、循环性能佳、光催化性能优异的新型多功能材料,在石墨存在下,以钛酸四丁酯为钛源,利用简单的一步溶剂热法制备不同石墨含量的石墨@TiO_(2)复合材料并对其进行表征。将石墨@TiO_(2)复合材料作为锂离子电池负极材料测试了其电化学性能,并将其用作降解甲基橙溶液的光催化剂测试了其光催化性能。结果表明:锐钛矿型TiO_(2)纳米线呈三维相互交织状包覆在石墨片表面,使复合材料具有较高的比表面积;复合材料中TiO_(2)含量越高,其初始放电比容量越大,在100 mA/g电流密度下的初始放电比容量最高可达到464.9 m A·h/g,在2 A/g电流密度下的初始放电比容量最高可达到120.3 mA·h/g;而复合材料中TiO_(2)含量越低,其可逆循环性能越好,在100 m A/g电流密度下循环100次后放电比容量为310.8 mA·h/g;石墨@TiO_(2)复合材料光催化性能随着TiO_(2)含量的增加而增强,在紫外光照射60 min后,甲基橙溶液的降解率最高可达98.72%。研究表明,石墨@TiO_(2)复合材料具有优异的电化学性能和光催化性能,有望替代传统的负极材料和光催化剂材料,具有广阔的应用前景。展开更多
The therapeutic efficiency of sonodynamic therapy(SDT)mainly depends on the presence of oxygen(O_(2))to generate harmful reactive oxygen species(ROS);thus,the hypoxic tumor microenvironment significantly limits the ef...The therapeutic efficiency of sonodynamic therapy(SDT)mainly depends on the presence of oxygen(O_(2))to generate harmful reactive oxygen species(ROS);thus,the hypoxic tumor microenvironment significantly limits the efficacy of SDT.Therefore,the development of oxygen-independent free radical generators and associated combination therapy tactics can be a promising field to facilitate the anticancer capability of SDT.In this study,a biomimetic drug delivery system(C-TiO_(2)/AIPH@PM)composed of an alkyl-radical generator(2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride,AIPH)-loaded C-TiO_(2) hollow nanoshells(HNSs)as the inner cores,and a platelet membrane(PM)as the outer shells is successfully prepared for synergistic SDT and oxygen-independent alkyl-radical therapy.The PM encapsulation can significantly prolong the blood circulation time of CTiO_(2)/AIPH@PM compared with C-TiO_(2)/AIPH while enabling C-TiO_(2)/AIPH@PM to achieve tumor targeting.C-TiO_(2)/AIPH@PM can efficiently produce ROS and alkyl radicals,which can achieve a more thorough tumor eradication regardless of the normoxic or hypoxic conditions.Furthermore,the generation of these radicals improves the efficiency of SDT.In addition,nitrogen(N_(2))produced due to the decomposition of AIPH enhances the acoustic cavitation effect and lowers the cavitation threshold,thereby enhancing the penetration of CTiO_(2)/AIPH@PM at the tumor sites.Both in vitro and in vivo experiments demonstrate that CTiO_(2)/AIPH@PM possesses good biosafety,ultrasound imaging performance,and excellent anticancer efficacy.This study provides a new strategy to achieve oxygen-independent free radical production and enhance therapeutic efficacy by combining SDT and free radical therapy.展开更多
文摘化工、纺织印染与农药化肥等产业的蓬勃发展推动着人类社会的进步,但同时也给环境治理带来了巨大难题。目前,光催化降解局限于在特定波长下针对单一有机污染物进行降解,然而现实中的情况往往更复杂。因此,开发一种多功能光催化材料用于光催化降解不同有机污染物显得尤为重要。采用一步无模板溶剂热法合成了核壳结构的C-TiO_(2)复合材料前驱体,并在氩气气氛下煅烧得到高结晶度的C-TiO_(2)复合光催化材料。运用SEM、TEM、XRD和TG等表征手段对材料进行表征,结论如下:550℃煅烧时的样品为包含少量碳的高结晶度的锐钛矿相TiO 2,且550℃煅烧时的样品依然保持了完整的核壳结构。此外,C-TiO_(2)复合材料的比表面积高达85.69 m 2·g^(-1),平均孔径为16.4 nm以及孔体积为0.423 m 3·g^(-1)。在UV-Vis光照射下,C-TiO_(2)复合材料分别对罗丹明B(RhB)、亚甲基蓝(MB)和刚果红(CR)3种染料显示出增强的光催化降解活性。
文摘通过溶剂热法制备了球状C-TiO_(2)催化剂以及BiOCl/C-TiO_(2)复合光催化材料。与纯TiO_(2)相比,球状C-TiO_(2)和BiOCl/C-TiO_(2)的禁带宽度显著降低。以亚甲基蓝为降解目标,当染料质量浓度为25 mg/L、pH为7时,0.1 g BiOCl/CTiO_(2)对其的降解率在1 h可达到81.44%,催化效率达64.15%,其动力学过程符合一级动力学模型。
文摘为获得一种具有理论容量高、循环性能佳、光催化性能优异的新型多功能材料,在石墨存在下,以钛酸四丁酯为钛源,利用简单的一步溶剂热法制备不同石墨含量的石墨@TiO_(2)复合材料并对其进行表征。将石墨@TiO_(2)复合材料作为锂离子电池负极材料测试了其电化学性能,并将其用作降解甲基橙溶液的光催化剂测试了其光催化性能。结果表明:锐钛矿型TiO_(2)纳米线呈三维相互交织状包覆在石墨片表面,使复合材料具有较高的比表面积;复合材料中TiO_(2)含量越高,其初始放电比容量越大,在100 mA/g电流密度下的初始放电比容量最高可达到464.9 m A·h/g,在2 A/g电流密度下的初始放电比容量最高可达到120.3 mA·h/g;而复合材料中TiO_(2)含量越低,其可逆循环性能越好,在100 m A/g电流密度下循环100次后放电比容量为310.8 mA·h/g;石墨@TiO_(2)复合材料光催化性能随着TiO_(2)含量的增加而增强,在紫外光照射60 min后,甲基橙溶液的降解率最高可达98.72%。研究表明,石墨@TiO_(2)复合材料具有优异的电化学性能和光催化性能,有望替代传统的负极材料和光催化剂材料,具有广阔的应用前景。
基金This work was supported by the Research fund of Anhui Institute of Translation Medicine(No.2021zhyx-C49)the Foundation of Anhui Medical University(No.2021xkj030)+2 种基金the Anhui Provincial Natural Science Foundation(No.2208085QC81)the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(No.2021xkjT028)Grants for Scientific Research of BSKY from Anhui Medical University(No.1406012201).
文摘The therapeutic efficiency of sonodynamic therapy(SDT)mainly depends on the presence of oxygen(O_(2))to generate harmful reactive oxygen species(ROS);thus,the hypoxic tumor microenvironment significantly limits the efficacy of SDT.Therefore,the development of oxygen-independent free radical generators and associated combination therapy tactics can be a promising field to facilitate the anticancer capability of SDT.In this study,a biomimetic drug delivery system(C-TiO_(2)/AIPH@PM)composed of an alkyl-radical generator(2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride,AIPH)-loaded C-TiO_(2) hollow nanoshells(HNSs)as the inner cores,and a platelet membrane(PM)as the outer shells is successfully prepared for synergistic SDT and oxygen-independent alkyl-radical therapy.The PM encapsulation can significantly prolong the blood circulation time of CTiO_(2)/AIPH@PM compared with C-TiO_(2)/AIPH while enabling C-TiO_(2)/AIPH@PM to achieve tumor targeting.C-TiO_(2)/AIPH@PM can efficiently produce ROS and alkyl radicals,which can achieve a more thorough tumor eradication regardless of the normoxic or hypoxic conditions.Furthermore,the generation of these radicals improves the efficiency of SDT.In addition,nitrogen(N_(2))produced due to the decomposition of AIPH enhances the acoustic cavitation effect and lowers the cavitation threshold,thereby enhancing the penetration of CTiO_(2)/AIPH@PM at the tumor sites.Both in vitro and in vivo experiments demonstrate that CTiO_(2)/AIPH@PM possesses good biosafety,ultrasound imaging performance,and excellent anticancer efficacy.This study provides a new strategy to achieve oxygen-independent free radical production and enhance therapeutic efficacy by combining SDT and free radical therapy.
