THE chemistry of nitronic esters remains relatively unknown due to their conspicuous feature ofinstability. In the preceding papers, we described the late progress in the researchof nitronic esters: (i) nitronic ester...THE chemistry of nitronic esters remains relatively unknown due to their conspicuous feature ofinstability. In the preceding papers, we described the late progress in the researchof nitronic esters: (i) nitronic esters were first synthesized via O-alkylation of the alkali met-展开更多
A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as...A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as the solvent instead of the organic solvent in this catalytic system.Through mild reaction conditions gave a variety of corresponding alkylated heterocyclic compounds with good to excellent yields.More importantly,the gramscale C-alkylation reaction was successfully carried out with good yield using a common route with only a single purification by column chromatography.展开更多
文摘THE chemistry of nitronic esters remains relatively unknown due to their conspicuous feature ofinstability. In the preceding papers, we described the late progress in the researchof nitronic esters: (i) nitronic esters were first synthesized via O-alkylation of the alkali met-
基金support from the National Natural Science Foundation of China(No.22005179)the Natural Science Foundation of Shandong Province(Nos.ZR2020QB113,ZR2020MB018 and ZR2021QB049).
文摘A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as the solvent instead of the organic solvent in this catalytic system.Through mild reaction conditions gave a variety of corresponding alkylated heterocyclic compounds with good to excellent yields.More importantly,the gramscale C-alkylation reaction was successfully carried out with good yield using a common route with only a single purification by column chromatography.
