This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroam...This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide derivatives.The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.展开更多
Carbon dioxide(CO_(2))is an attractive C1 building block in chemical synthesis due to its abundance,availability and sustainability.However,the low reactivity and high stability generally limits its transformations un...Carbon dioxide(CO_(2))is an attractive C1 building block in chemical synthesis due to its abundance,availability and sustainability.However,the low reactivity and high stability generally limits its transformations under mild conditions to value added chemicals.Recent advances in flow chemistry provide effective means for the chemical transformation of CO_(2),and many new methods and techniques that fully utilized the advantages of continuous flow platforms for the chemical fixation of CO_(2)have been realized.In view of the rapid development and the urgent need for continuous transformation of CO_(2),herein we wish to present an update of the recent advances in this research area.展开更多
基金We gratefully acknowledge the financial support from the Start-up Grant in Nanjing Tech University(Nos.39837118,39837146)the National Natural Science Foundation of China(No.22001121).
文摘This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide derivatives.The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.
基金The financial support from the National Key Research and Development Program of China(No.2020YFA0710200)National Natural Science Foundation of China(No.22171090)+1 种基金the Shanghai Science and Technology Innovation Action Plan(No.20JC1416900)the Fundamental Research Funds for the Central Universities is highly appreciated。
文摘Carbon dioxide(CO_(2))is an attractive C1 building block in chemical synthesis due to its abundance,availability and sustainability.However,the low reactivity and high stability generally limits its transformations under mild conditions to value added chemicals.Recent advances in flow chemistry provide effective means for the chemical transformation of CO_(2),and many new methods and techniques that fully utilized the advantages of continuous flow platforms for the chemical fixation of CO_(2)have been realized.In view of the rapid development and the urgent need for continuous transformation of CO_(2),herein we wish to present an update of the recent advances in this research area.
