In this paper, we design and create the novel multivariate optimization theory based approach for building the paradigm. From the seller, web sites, the external environment, the respect such as online trust building ...In this paper, we design and create the novel multivariate optimization theory based approach for building the paradigm. From the seller, web sites, the external environment, the respect such as online trust building credibility evaluation index system. To factors affecting online trust as input will trust composite scores as the output, and then, using BP neural network technology, from the perspective of buyers and build a C2C e-commerce trust evaluation model. The multivariate optimization theory helps us modify the current pattern to be more feasible and robust. In the near future, we have scheduled to polish the neural network part to obtain better performance.展开更多
High ce rvical spinal co rd injuries induce permanent neuromotor and autonomic deficits.These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system....High ce rvical spinal co rd injuries induce permanent neuromotor and autonomic deficits.These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system.So far,cardiovascular studies have focused on models of complete contusion or transection at the lower cervical and thoracic levels and diaphragm activity evaluations using invasive methods.The present study aimed to evaluate the impact of C2 hemisection on different parameters representing vital functions(i.e.,respiratory function,cardiovascular,and renal filtration parameters)at the moment of injury and 7 days post-injury in rats.No ventilatory parameters evaluated by plethys mography were impacted during quiet breathing after 7 days post-injury,whereas permanent diaphragm hemiplegia was observed by ultrasound and confirmed by diaphragmatic electromyography in anesthetized rats.Interestingly,the mean arterial pressure was reduced immediately after C2 hemisection,with complete compensation at 7 days post-injury.Renal filtration was unaffected at 7 days post-injury;however,remnant systolic dysfunction chara cterized by a reduced left ventricular ejection fraction persisted at 7 days post-injury.Taken together,these results demonstrated that following C2 hemisection,diaphragm activity and systolic function are impa cted up to 7 days post-injury,whereas the respiratory and cardiovascular systems display vast ada ptation to maintain ventilatory parameters and blood pressure homeostasis,with the latter likely sustained by the remaining descending sympathetic inputs spared by the initial injury.A better broad characterization of the physiopathology of high cervical spinal cord injuries covering a longer time period post-injury could be beneficial for understanding evaluations of putative therapeutics to further increase cardiorespiratory recovery.展开更多
In-depth understanding of interactions between crude oil and CO2 provides insight into the CO2-based enhanced oil recovery（EOR） process design and simulation. When CO2 contacts crude oil, the dissolution process tak...In-depth understanding of interactions between crude oil and CO2 provides insight into the CO2-based enhanced oil recovery（EOR） process design and simulation. When CO2 contacts crude oil, the dissolution process takes place. This phenomenon results in the oil swelling, which depends on the temperature, pressure, and composition of the oil. The residual oil saturation in a CO2-based EOR process is inversely proportional to the oil swelling factor. Hence, it is important to estimate this influential parameter with high precision. The current study suggests the predictive model based on the least-squares support vector machine（LS-SVM） to calculate the CO2–oil swelling factor. A genetic algorithm is used to optimize hyperparameters（у and б^2） of the LS-SVM model. This model showed a high coefficient of determination（R^2= 0.9953） and a low value for the mean-squared error（MSE = 0.0003） based on the available experimental data while estimating the CO2–oil swelling factor. It was found that LS-SVM is a straightforward and accurate method to determine the CO2–oil swelling factor with negligible uncertainty. This method can be incorporated in commercial reservoir simulators to include the effect of the CO2–oil swelling factor when adequate experimental data are not available.展开更多
OBJECTIVE CYP2 family including CYP2C and CYP2J is the predominant arachidonic acid(AA)epoxygenase,and the epoxidation of AA produces four regioisomeric cis-epoxyeicosatrienoic acids(5,6-,8,9-,11,12-,and 14,15-EET).Hu...OBJECTIVE CYP2 family including CYP2C and CYP2J is the predominant arachidonic acid(AA)epoxygenase,and the epoxidation of AA produces four regioisomeric cis-epoxyeicosatrienoic acids(5,6-,8,9-,11,12-,and 14,15-EET).Human CYP2J2 is one of the main CYP isoforms expressed in brain,but CYP2C8 was present at a low level.The aim of this study is to investigate the roles of brain CYP2J in Parkinson disease.METHODS Rats received the right-unilateral y injection with concentrated LV-CYP2J3 or LV-EGFP in the substantia nigra(SN)at 3 d before LPS or 6-OHDA treatment.The animals were tested for rotational behavior with the dopaminergic agonist apomorphine dissolved in sterile saline at 14 and 21 d after LPS injection.The influence of CYP2J-dependent derivative,14,15-EET,on the genes related with oxidative stress was assayed in SH-SY5Y cells.RESULTS CYP2J overexpression or 14,15-EET treatment significantly increased the levels of SOD1,CAT,GPX1,NRF2 and KEAP1 in neurons.TLR4-My D88 signaling pathway was involved the down-regulation of CYP2J by LPS.The binding of p-CREB with the promoter of CYP2J was inhibited by the LPS treatment.The loss of dopaminergic neurons in the right SN induced by LPS or 6-OHDA was significantly decreased by CYP2J3 transfection at 21 d after LPS injection.Compared with LPS or 6-OHDA group,the number of the rotation of rats was decreased by 42.6% and 60.7%by CYP2J3 transfection at 14 d after LPS or 6-OHDA injection;meanwhile,the rotation number was decreased by 12.7%and 21.3%at 21 d.The accumulation of alpha synuclein induced by LPS was significantly decreased by CYP2J3 transfection.The mR NA levels of SOD1,CAT,GPX1,NRF2 and KEAP1 in SN were decreased by LPS,which was attenuated by the injection of LV-CYP2J3.CONCLUSION Brain CYP2J can play a protective role in the damage of the inflammation and oxidative stress to the dopaminergic neurons.Brain CYP2J-dependent derivatives from AA may have therapeutic effects in Parkinson disease via the up-regulation of the antioxidant system in neurons.展开更多
Scientific and technical progress has been the driving forces of enterprises development.Milk productive enterprises are developing faster and growing better.It is very important to measure the contributive ratio of s...Scientific and technical progress has been the driving forces of enterprises development.Milk productive enterprises are developing faster and growing better.It is very important to measure the contributive ratio of scientific and technical progress in milk productive enterprises.And the appraisement could help to develop milk productive enterprises.The model C^2GS^2 was established to appraise the contributive ratio of scientific and technical progress in milk productive enterprises in the research.And the appraisement on the contributive ratio of scientific and technical progress in milk productive enterprises was made by the model.In the results of appraisement,science and technology play a main role in milk productive enterprises.It is shown that our milk productive enterprises are developed by scientific and technical progress while not by input of productive factors.展开更多
It has been widely believed that trust is the basis for on-line trading by both academia and practice. The process of f initial trust formation is a dynamic and repeated process. In the electric business environment, ...It has been widely believed that trust is the basis for on-line trading by both academia and practice. The process of f initial trust formation is a dynamic and repeated process. In the electric business environment, this work chose to research the first phase of the process, which is initial trust. The Writer established dynamic model of initial trust formation biased on theory of planned behavior with other theories, such as TAM and social exchange theory, after micro-analyzing this formation mechanism from. in order to confirming effectiveness of the dynamic model, the writer adopted empirical study, from which writer got an order of. From the result of empirical study, we got the strength order of main factors that can influence the establishment of initial trust.展开更多
In recent years, the Cavally River has been subject to multiple activities, <span style="font-family:;" "="">including the construction of diversion channels and a bridge that makes it v...In recent years, the Cavally River has been subject to multiple activities, <span style="font-family:;" "="">including the construction of diversion channels and a bridge that makes it vulnerable to flooding. In order to assess the impact of these hydraulic structures on the <span>river hydrodynamic functioning, a 1D-2D model was realized. The</span> implementation of the 1D-2D model consisted </span><span style="font-family:;" "="">of </span><span style="font-family:;" "="">first </span><span style="font-family:;" "="">running</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">the 1D model, then the 2D model, and finally in coupling them. The 1D-2D model was designed with <span>the 1988 flood hydrograph, a Manning’s coefficient of 0.052 m<sup>1/3</sup>/s for the </span>minor bed and 0.06 m<sup>1/3</sup>/s for the major bed. The results of the hydraulic model show that the velocities are almost identical to those of the Cavally in natural operation. The values of the velocities are included between 0.4 m/s and 1.3 m/s at the level of the minor bed of the river and between 0.06 m/s and 0.71 m/s at the level of the floodplains. The average water level for flood propagation is 262.37 ± 0.44 m before construction of the structures and 262.23 ± <span>0.85 m after construction of the structures. The 0.41 m reduction in water</span> level due to the diversion canal and bridge is negligible compared to the total fluctuations of the Cavally River, which vary from 6 to 7 m over the year.</span>展开更多
在对软件构架和B/S应用程序体系结构的研究过程中,提出了如何运用构架和构件组装技术,通过对可复用构件的组装进行B/S应用程序的设计和快速开发。文章拟以C2构架风格作为在整合应用系统的业务逻辑的基础设施,以B/S Model 2作为表示层的...在对软件构架和B/S应用程序体系结构的研究过程中,提出了如何运用构架和构件组装技术,通过对可复用构件的组装进行B/S应用程序的设计和快速开发。文章拟以C2构架风格作为在整合应用系统的业务逻辑的基础设施,以B/S Model 2作为表示层的框架原型,提出一种基于构架和构件的B/S结构模型,称为CB Model。并且介绍在研究过程中开发的组装支持工具BSAppBuilder。展开更多
目的制备类似人类2型糖尿病兔模型,观察C-反应蛋白(C R P)在糖尿病发病过程中的变化。方法 26只新西兰大白兔随机分成对照组6只,常规饲养;实验组20只,采用高脂高糖饲料加小剂量链脲佐菌素(STZ)60 m g/kg联合诱导的方法建立2型糖尿病动...目的制备类似人类2型糖尿病兔模型,观察C-反应蛋白(C R P)在糖尿病发病过程中的变化。方法 26只新西兰大白兔随机分成对照组6只,常规饲养;实验组20只,采用高脂高糖饲料加小剂量链脲佐菌素(STZ)60 m g/kg联合诱导的方法建立2型糖尿病动物模型,以空腹血糖(FBG)≥11.0 m m ol/L作为造模成功的标准。观察糖尿病发病过程中兔血清C R P水平的变化情况。结果实验组注射STZ后FBG升高达高峰,2周后平均FBG为14.3 m m ol/L,与对照组比较差异有统计学意义(t=3.47,P<0.01),无动物死亡,成模率75%。实验组在饲养过程中,C R P于第3周开始升高,与对照组比较差异有统计学意义(t=3.16,P<0.05)。结论高脂高糖饲料加小剂量STZ诱导可建立兔2型糖尿病模型,方法简便易行,成模率高。C R P水平在糖尿病发病早期即上升且显著,糖尿病的发病可能与其异常变化有关,据此可预测及早期诊断糖尿病。展开更多
Basic structure and algorithm of leaf mechanism photosynthesis model were described in first part of this study based on former researcher results. Then, considering some environmental factors influencing on leaf ph...Basic structure and algorithm of leaf mechanism photosynthesis model were described in first part of this study based on former researcher results. Then, considering some environmental factors influencing on leaf photosynthesis, three numerical sensitivity experiments were carried out. We simulated the sing le leaf net CO2 assimilation, which acts as a function of different light, carbo n dioxide and temperature conditions. The relationships between leaf net photosy nthetic rate of C3 and C4 plant with CO2 concentration intercellular, leaf tempe rature, and photosynthetic active radiation (PAR) were presented, respectively. The results show the numerical experiment may indicate the main characteristic o f plant photosynthesis in C3 and C4 plant, and further can be used to integrate with the regional climate model and act as land surface process scheme, and bett er understand the interaction between vegetation and atmosphere.展开更多
文摘In this paper, we design and create the novel multivariate optimization theory based approach for building the paradigm. From the seller, web sites, the external environment, the respect such as online trust building credibility evaluation index system. To factors affecting online trust as input will trust composite scores as the output, and then, using BP neural network technology, from the perspective of buyers and build a C2C e-commerce trust evaluation model. The multivariate optimization theory helps us modify the current pattern to be more feasible and robust. In the near future, we have scheduled to polish the neural network part to obtain better performance.
基金supported by funding from the Chancellerie des Universites de Paris(Legs Poix)(to SV)Fondation Medisite(to SV)+1 种基金INSERM(to SV,AM,AF)Universite de Versailles Saint-Quentin-en-Yvelines(to SV,AM,AF)。
文摘High ce rvical spinal co rd injuries induce permanent neuromotor and autonomic deficits.These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system.So far,cardiovascular studies have focused on models of complete contusion or transection at the lower cervical and thoracic levels and diaphragm activity evaluations using invasive methods.The present study aimed to evaluate the impact of C2 hemisection on different parameters representing vital functions(i.e.,respiratory function,cardiovascular,and renal filtration parameters)at the moment of injury and 7 days post-injury in rats.No ventilatory parameters evaluated by plethys mography were impacted during quiet breathing after 7 days post-injury,whereas permanent diaphragm hemiplegia was observed by ultrasound and confirmed by diaphragmatic electromyography in anesthetized rats.Interestingly,the mean arterial pressure was reduced immediately after C2 hemisection,with complete compensation at 7 days post-injury.Renal filtration was unaffected at 7 days post-injury;however,remnant systolic dysfunction chara cterized by a reduced left ventricular ejection fraction persisted at 7 days post-injury.Taken together,these results demonstrated that following C2 hemisection,diaphragm activity and systolic function are impa cted up to 7 days post-injury,whereas the respiratory and cardiovascular systems display vast ada ptation to maintain ventilatory parameters and blood pressure homeostasis,with the latter likely sustained by the remaining descending sympathetic inputs spared by the initial injury.A better broad characterization of the physiopathology of high cervical spinal cord injuries covering a longer time period post-injury could be beneficial for understanding evaluations of putative therapeutics to further increase cardiorespiratory recovery.
基金financial support from Natural Sciences and Engineering Research Council of Canada (NSERC), Innovate NL, and Statoil Canada
文摘In-depth understanding of interactions between crude oil and CO2 provides insight into the CO2-based enhanced oil recovery（EOR） process design and simulation. When CO2 contacts crude oil, the dissolution process takes place. This phenomenon results in the oil swelling, which depends on the temperature, pressure, and composition of the oil. The residual oil saturation in a CO2-based EOR process is inversely proportional to the oil swelling factor. Hence, it is important to estimate this influential parameter with high precision. The current study suggests the predictive model based on the least-squares support vector machine（LS-SVM） to calculate the CO2–oil swelling factor. A genetic algorithm is used to optimize hyperparameters（у and б^2） of the LS-SVM model. This model showed a high coefficient of determination（R^2= 0.9953） and a low value for the mean-squared error（MSE = 0.0003） based on the available experimental data while estimating the CO2–oil swelling factor. It was found that LS-SVM is a straightforward and accurate method to determine the CO2–oil swelling factor with negligible uncertainty. This method can be incorporated in commercial reservoir simulators to include the effect of the CO2–oil swelling factor when adequate experimental data are not available.
基金supported by New Century Excellent Talents in University(NCET-11-0399)National Natural Science Foundation of China(81673503)
文摘OBJECTIVE CYP2 family including CYP2C and CYP2J is the predominant arachidonic acid(AA)epoxygenase,and the epoxidation of AA produces four regioisomeric cis-epoxyeicosatrienoic acids(5,6-,8,9-,11,12-,and 14,15-EET).Human CYP2J2 is one of the main CYP isoforms expressed in brain,but CYP2C8 was present at a low level.The aim of this study is to investigate the roles of brain CYP2J in Parkinson disease.METHODS Rats received the right-unilateral y injection with concentrated LV-CYP2J3 or LV-EGFP in the substantia nigra(SN)at 3 d before LPS or 6-OHDA treatment.The animals were tested for rotational behavior with the dopaminergic agonist apomorphine dissolved in sterile saline at 14 and 21 d after LPS injection.The influence of CYP2J-dependent derivative,14,15-EET,on the genes related with oxidative stress was assayed in SH-SY5Y cells.RESULTS CYP2J overexpression or 14,15-EET treatment significantly increased the levels of SOD1,CAT,GPX1,NRF2 and KEAP1 in neurons.TLR4-My D88 signaling pathway was involved the down-regulation of CYP2J by LPS.The binding of p-CREB with the promoter of CYP2J was inhibited by the LPS treatment.The loss of dopaminergic neurons in the right SN induced by LPS or 6-OHDA was significantly decreased by CYP2J3 transfection at 21 d after LPS injection.Compared with LPS or 6-OHDA group,the number of the rotation of rats was decreased by 42.6% and 60.7%by CYP2J3 transfection at 14 d after LPS or 6-OHDA injection;meanwhile,the rotation number was decreased by 12.7%and 21.3%at 21 d.The accumulation of alpha synuclein induced by LPS was significantly decreased by CYP2J3 transfection.The mR NA levels of SOD1,CAT,GPX1,NRF2 and KEAP1 in SN were decreased by LPS,which was attenuated by the injection of LV-CYP2J3.CONCLUSION Brain CYP2J can play a protective role in the damage of the inflammation and oxidative stress to the dopaminergic neurons.Brain CYP2J-dependent derivatives from AA may have therapeutic effects in Parkinson disease via the up-regulation of the antioxidant system in neurons.
基金Supported by Fund of Post Doctoral Research in Heilongjiang Province(LSZH-04052)Fund of Scientific and Technical Research Projects(10551039)
文摘Scientific and technical progress has been the driving forces of enterprises development.Milk productive enterprises are developing faster and growing better.It is very important to measure the contributive ratio of scientific and technical progress in milk productive enterprises.And the appraisement could help to develop milk productive enterprises.The model C^2GS^2 was established to appraise the contributive ratio of scientific and technical progress in milk productive enterprises in the research.And the appraisement on the contributive ratio of scientific and technical progress in milk productive enterprises was made by the model.In the results of appraisement,science and technology play a main role in milk productive enterprises.It is shown that our milk productive enterprises are developed by scientific and technical progress while not by input of productive factors.
文摘It has been widely believed that trust is the basis for on-line trading by both academia and practice. The process of f initial trust formation is a dynamic and repeated process. In the electric business environment, this work chose to research the first phase of the process, which is initial trust. The Writer established dynamic model of initial trust formation biased on theory of planned behavior with other theories, such as TAM and social exchange theory, after micro-analyzing this formation mechanism from. in order to confirming effectiveness of the dynamic model, the writer adopted empirical study, from which writer got an order of. From the result of empirical study, we got the strength order of main factors that can influence the establishment of initial trust.
文摘In recent years, the Cavally River has been subject to multiple activities, <span style="font-family:;" "="">including the construction of diversion channels and a bridge that makes it vulnerable to flooding. In order to assess the impact of these hydraulic structures on the <span>river hydrodynamic functioning, a 1D-2D model was realized. The</span> implementation of the 1D-2D model consisted </span><span style="font-family:;" "="">of </span><span style="font-family:;" "="">first </span><span style="font-family:;" "="">running</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">the 1D model, then the 2D model, and finally in coupling them. The 1D-2D model was designed with <span>the 1988 flood hydrograph, a Manning’s coefficient of 0.052 m<sup>1/3</sup>/s for the </span>minor bed and 0.06 m<sup>1/3</sup>/s for the major bed. The results of the hydraulic model show that the velocities are almost identical to those of the Cavally in natural operation. The values of the velocities are included between 0.4 m/s and 1.3 m/s at the level of the minor bed of the river and between 0.06 m/s and 0.71 m/s at the level of the floodplains. The average water level for flood propagation is 262.37 ± 0.44 m before construction of the structures and 262.23 ± <span>0.85 m after construction of the structures. The 0.41 m reduction in water</span> level due to the diversion canal and bridge is negligible compared to the total fluctuations of the Cavally River, which vary from 6 to 7 m over the year.</span>
文摘在对软件构架和B/S应用程序体系结构的研究过程中,提出了如何运用构架和构件组装技术,通过对可复用构件的组装进行B/S应用程序的设计和快速开发。文章拟以C2构架风格作为在整合应用系统的业务逻辑的基础设施,以B/S Model 2作为表示层的框架原型,提出一种基于构架和构件的B/S结构模型,称为CB Model。并且介绍在研究过程中开发的组装支持工具BSAppBuilder。
文摘目的制备类似人类2型糖尿病兔模型,观察C-反应蛋白(C R P)在糖尿病发病过程中的变化。方法 26只新西兰大白兔随机分成对照组6只,常规饲养;实验组20只,采用高脂高糖饲料加小剂量链脲佐菌素(STZ)60 m g/kg联合诱导的方法建立2型糖尿病动物模型,以空腹血糖(FBG)≥11.0 m m ol/L作为造模成功的标准。观察糖尿病发病过程中兔血清C R P水平的变化情况。结果实验组注射STZ后FBG升高达高峰,2周后平均FBG为14.3 m m ol/L,与对照组比较差异有统计学意义(t=3.47,P<0.01),无动物死亡,成模率75%。实验组在饲养过程中,C R P于第3周开始升高,与对照组比较差异有统计学意义(t=3.16,P<0.05)。结论高脂高糖饲料加小剂量STZ诱导可建立兔2型糖尿病模型,方法简便易行,成模率高。C R P水平在糖尿病发病早期即上升且显著,糖尿病的发病可能与其异常变化有关,据此可预测及早期诊断糖尿病。
基金Natural Science Foundation of China (Grant No. 39900084)
文摘Basic structure and algorithm of leaf mechanism photosynthesis model were described in first part of this study based on former researcher results. Then, considering some environmental factors influencing on leaf photosynthesis, three numerical sensitivity experiments were carried out. We simulated the sing le leaf net CO2 assimilation, which acts as a function of different light, carbo n dioxide and temperature conditions. The relationships between leaf net photosy nthetic rate of C3 and C4 plant with CO2 concentration intercellular, leaf tempe rature, and photosynthetic active radiation (PAR) were presented, respectively. The results show the numerical experiment may indicate the main characteristic o f plant photosynthesis in C3 and C4 plant, and further can be used to integrate with the regional climate model and act as land surface process scheme, and bett er understand the interaction between vegetation and atmosphere.
