BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metas...BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metastasis is unclear.AIM To evaluate predictive value of combined tests for CEA,CA125,and CA19-9 levels in patients with liver metastases of CRC.METHODS The retrospective study included patients with CRC alone(50 cases)and patients with CRC combined with liver metastases(50 cases)who were hospitalized between January 2021 and January 2023.Serum CEA,CA125 and CA19-9 levels were compared between the two groups,and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver metastasis.In addition,we performed receiver operating characteristic(ROC)curve analysis to assess its diagnostic accuracy.RESULTS The results showed that the serum CEA,CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone group.Specifically,the average serum CEA level in the CRC with liver metastasis group was 162.03±810.01 ng/mL,while that in the CRC alone group was 5.71±9.76 ng/mL;the average serum CA125 levels were 43.47±83.52 U/mL respectively.and 13.5±19.68 U/mL;the average serum CA19-9 levels were 184.46±473.13 U/mL and 26.55±43.96 U/mL respectively.In addition,binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis(P<0.05).ROC curve analysis results showed that the areas under the ROC curves of CEA,CA125 and CA19-9 were 0.607,0.692 and 0.586.CONCLUSION These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis,thereby improving patient prognosis.展开更多
目的：探讨血清糖类抗原125（CA125）及CA125联合CA199、CA153、癌胚抗原（CEA）检测在卵巢癌诊断中的意义。方法：采用化学发光微粒子免疫检测法测定71例卵巢癌患者、10例卵巢交界性肿瘤患者和42例卵巢良性肿瘤患者血清中CA125、CA199...目的：探讨血清糖类抗原125（CA125）及CA125联合CA199、CA153、癌胚抗原（CEA）检测在卵巢癌诊断中的意义。方法：采用化学发光微粒子免疫检测法测定71例卵巢癌患者、10例卵巢交界性肿瘤患者和42例卵巢良性肿瘤患者血清中CA125、CA199、CA153和CEA的含量,阳性诊断标准分别为：CA125〉35 k U/L,CA199〉37 k U/L,CA153〉30 k U/L,CEA〉5μg/L。结果：在单项肿瘤标记物中,CA125的阳性率最高（84.5%）,敏感度、特异度和准确度指标平稳。在不同的联合检测方案中CA199、CA153与CA125联合检测方案最优,较CA125单项检测敏感度和准确度均有提高。晚期卵巢癌（Ⅲ～Ⅳ期）患者的CA153、CA125含量高于早期卵巢癌（Ⅰ～Ⅱ期）患者（P〈0.001）。结论：CA199、CA153、CEA与CA125在卵巢癌鉴别诊断中均有一定价值,并可以根据CA153、CA125含量判断患者卵巢癌的分期,CA199、CA153与CA125联合检测是诊断卵巢癌较为理想的标记物组合。展开更多
文摘BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metastasis is unclear.AIM To evaluate predictive value of combined tests for CEA,CA125,and CA19-9 levels in patients with liver metastases of CRC.METHODS The retrospective study included patients with CRC alone(50 cases)and patients with CRC combined with liver metastases(50 cases)who were hospitalized between January 2021 and January 2023.Serum CEA,CA125 and CA19-9 levels were compared between the two groups,and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver metastasis.In addition,we performed receiver operating characteristic(ROC)curve analysis to assess its diagnostic accuracy.RESULTS The results showed that the serum CEA,CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone group.Specifically,the average serum CEA level in the CRC with liver metastasis group was 162.03±810.01 ng/mL,while that in the CRC alone group was 5.71±9.76 ng/mL;the average serum CA125 levels were 43.47±83.52 U/mL respectively.and 13.5±19.68 U/mL;the average serum CA19-9 levels were 184.46±473.13 U/mL and 26.55±43.96 U/mL respectively.In addition,binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis(P<0.05).ROC curve analysis results showed that the areas under the ROC curves of CEA,CA125 and CA19-9 were 0.607,0.692 and 0.586.CONCLUSION These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis,thereby improving patient prognosis.
文摘目的：探讨血清糖类抗原125（CA125）及CA125联合CA199、CA153、癌胚抗原（CEA）检测在卵巢癌诊断中的意义。方法：采用化学发光微粒子免疫检测法测定71例卵巢癌患者、10例卵巢交界性肿瘤患者和42例卵巢良性肿瘤患者血清中CA125、CA199、CA153和CEA的含量,阳性诊断标准分别为：CA125〉35 k U/L,CA199〉37 k U/L,CA153〉30 k U/L,CEA〉5μg/L。结果：在单项肿瘤标记物中,CA125的阳性率最高（84.5%）,敏感度、特异度和准确度指标平稳。在不同的联合检测方案中CA199、CA153与CA125联合检测方案最优,较CA125单项检测敏感度和准确度均有提高。晚期卵巢癌（Ⅲ～Ⅳ期）患者的CA153、CA125含量高于早期卵巢癌（Ⅰ～Ⅱ期）患者（P〈0.001）。结论：CA199、CA153、CEA与CA125在卵巢癌鉴别诊断中均有一定价值,并可以根据CA153、CA125含量判断患者卵巢癌的分期,CA199、CA153与CA125联合检测是诊断卵巢癌较为理想的标记物组合。
