多囊卵巢综合征(Polycystic ovary syndrome,PCOS)是一组生殖内分泌代谢紊乱的综合征,临床以稀发排卵、高雄激素体征、胰岛素抵抗为主要特征,其中育龄期发病率高,对女性生育力造成严重不良影响。PCOS的发生发展涉及多种信号通路,腺苷酸...多囊卵巢综合征(Polycystic ovary syndrome,PCOS)是一组生殖内分泌代谢紊乱的综合征,临床以稀发排卵、高雄激素体征、胰岛素抵抗为主要特征,其中育龄期发病率高,对女性生育力造成严重不良影响。PCOS的发生发展涉及多种信号通路,腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)及哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)作为细胞能量感受器是其中两个关键靶点。二者在PCOS各个发病部位包括下丘脑-垂体-卵巢轴、子宫内膜、脂肪与骨骼肌中发挥重要的调节作用,通过影响细胞自噬、氧化应激、炎症、线粒体功能、葡萄糖摄取等,促进卵泡的发育和成熟,改善胰岛素抵抗。近年来,中医药因其成分多样、靶点众多等优势广泛应用于临床,研究人员已对PCOS的发病以及中药治疗及改善PCOS的机制进行了大量研究,结果提示AMPK与mTOR相关通路在其中发挥关键作用。通过总结中药干预AMPK与mTOR及其相关通路治疗PCOS的研究结果,为临床治疗及基础研究提供参考。展开更多
We first design and analyze the contour surface of the globoidal indexing cam with the aid of computer, and then do optimum design according to the requirements of dynamics. Finally, we discuss the problem of the pres...We first design and analyze the contour surface of the globoidal indexing cam with the aid of computer, and then do optimum design according to the requirements of dynamics. Finally, we discuss the problem of the pressure angle of the globoidal indexing cam mechanism in detail and put forward a new concept of equivalent pressure angle.展开更多
A new type of rapier drive for flexible rapier loom through conjugate cams with five-bar linkage mechanism is raised and analyzed. Two designs suitable for the conversion of 1515-190.5 shuttle looms are given as examp...A new type of rapier drive for flexible rapier loom through conjugate cams with five-bar linkage mechanism is raised and analyzed. Two designs suitable for the conversion of 1515-190.5 shuttle looms are given as examples. This mechanism can be applied to traditional shuttle looms as well as to new flexible rapier loom design.展开更多
A new type of parallel indexing cam mechanism is discovered.The composition of the cam profile is proposed and the formulas of the mechanism parameters are established by synthesis of its configuration and size.The eq...A new type of parallel indexing cam mechanism is discovered.The composition of the cam profile is proposed and the formulas of the mechanism parameters are established by synthesis of its configuration and size.The equations for working pro- file and pressure angle of the cam are derived based on the inverse model and the derivative of pitch curve of cams.An example is given and demonstrates that it is available to design the new mechanism using the derived expressions.展开更多
In order to realize the parametric design of the conjugate cam weft insertion mechanism,according to the necessary parameters of weft insertion process,ideal kinematic curves of the weft insertion mechanism were given...In order to realize the parametric design of the conjugate cam weft insertion mechanism,according to the necessary parameters of weft insertion process,ideal kinematic curves of the weft insertion mechanism were given,and the mathematical model of reverse solution for this mechanism was established.The parameters of this mechanism were obtained by reverse solution on the basis of the given ideal kinematic curves and kinematic requirements.The parametric design platform which was integrated with the functions of parametric reverse solution,motion simulation,three-dimensional modeling and virtual assembly was developed based on VB.NET and Unigraphics(UG) NX.After entering the technological parameters of weft insertion process and essential structural parameters by users,three-dimensional drawing of the main parts such as the conjugate cam and shaft,can be obtained by this platform,also the processing data of the cam can be calculated.This platform provides a rapid approach for parametric design of weft insertion mechanism.展开更多
This paper is aimed to propose an approach to predict the dynamic characteristics of ring-plate planetary indexing cam mechanism, which is a novel type of indexing mechanism that employs internal planetary transmissio...This paper is aimed to propose an approach to predict the dynamic characteristics of ring-plate planetary indexing cam mechanism, which is a novel type of indexing mechanism that employs internal planetary transmission structure. Firstly, the geometry and structure of the mechanism are discussed and the kinematic practicability is simulated with virtual prototype design. Then a 3D finite element model of the ring-plate planetary indexing cam mechanism is developed with the commercial software of MATLAB and ANSYS. Through the finite element analysis, the natural frequencies and the corresponding mode shapes are predicted in one motion cycle. On the basis of the virtual prototype design and finite element analysis, an experimental prototype is made and tested to validate the prediction of the dynamic characteristics. The agreement between experimental results and the finite element analysis testifies that the finite element model developed is applicable to the prediction of the dynamic characteristics of this type of mechanism.展开更多
In the usual shedding mechanism of a weaving loom, the conjugate type of cams can be designed precisely according to any regular pattern sequence of heald frame motion to suit the weaving technological requirements. A...In the usual shedding mechanism of a weaving loom, the conjugate type of cams can be designed precisely according to any regular pattern sequence of heald frame motion to suit the weaving technological requirements. As this mechanism is also quite simple, with smaller cam size and better technological function, it is therefore very important and worthwhile to study this type of conjugate cams. In this paper, we try to analyze the defects of the traditional and some abroad type outside conjugate cams shedding mechanism, and propose a new improved design of this type of conjugate cams and then work it out finally.展开更多
As an alternative power source for hybrid electrical vehicle(HEV), electric generating system(EGS) driven by sphere cam engine(SCE) is said to own higher power density and integration. In this work, the structure and ...As an alternative power source for hybrid electrical vehicle(HEV), electric generating system(EGS) driven by sphere cam engine(SCE) is said to own higher power density and integration. In this work, the structure and working principle of EGS were introduced, based on which the advantages of EGS were displayed. The profile of sphere cam was achieved after the desired motion of piston was given. After establishing the dynamic model of power transmission mechanism, the characteristics of cam-roller mechanism were studied. The results show that the optimal cam profile of SCE is a sinusoid curve which has two peaks and two valleys and a mean pressure angle of 47.19°. Because of the special cam shape, the trace of end surface center of piston is an eight-shape curve on a specific sphere surface. SCE running at speed of 3000 r/min can generate the power of 33.81 kW, which could satisfy the need of HEVs. However, the force between cylinder and piston skirt caused by Coriolis acceleration can reach up to 1182 N, which leads to serious wear between cylinder liner and piston skirt and may shorten the lifespan of SCE.展开更多
Background: Recently, high efficacy of the chemotherapeutic regimen combining clarithromycin (CAM) with lenalidomide (Len) and dexamethasone (Dex) (BiRD) in treating multiple myeloma (MM) patients has been reported. H...Background: Recently, high efficacy of the chemotherapeutic regimen combining clarithromycin (CAM) with lenalidomide (Len) and dexamethasone (Dex) (BiRD) in treating multiple myeloma (MM) patients has been reported. However, the exact mechanism of added CAM has not been fully elucidated. This case report will provide helpful information for understanding the significance and the mechanism of action of CAM as an add-on therapy. Patient: A 78-year-old female patient with IgA-λ type MM was treated with low-dose Len coupled with low-dose Dex (low Rd), and excellent response was achieved for long term, but she later became refractory to this treatment. Then, CAM was added to low Rd (low Rd-CAM, i.e., modified BiRD therapy). This add-on-therapy was found to be effective, but later suspended because of pneumonitis. Then, low-dose Len coupled with CAM (low R-CAM) treatment was applied;but effect of this Dex-free treatment was insufficient. Thus, low Rd-CAM was reapplied and satisfactory reduction of IgA was achieved. This fact suggests that low Rd-CAM is the favorable combination, Dex is requisite and CAM might have enhanced the effect of Dex. In this case, various serum cytokines were examined during the course of illness. Only interleukin-6 showed apparent increase, and tumor necrosis factor-α, transforming growth factor-β, soluble IL-2 receptors and C-reactive protein showed the slight increase during low Rd-CAM treatment. The results seem somewhat conflicting, but it seems that intricate cytokine response due to immune activation might have occurred during low Rd-CAM treatment.展开更多
Palletizing robot technology has been applied more and more extensively in logistics automation field.But there are some limitations in the current single-arm palletizing robot that it cannot do effective work in the ...Palletizing robot technology has been applied more and more extensively in logistics automation field.But there are some limitations in the current single-arm palletizing robot that it cannot do effective work in the process of moving back to the taking-end and the mechanical arm has so many freedoms that its control system is relatively complex.Based on the translating cam principle,a novel palletizing robot is designed.The horizontal movement of the palletizing mechanical arm is controlled by changeable outer slides,and the vertical movement is controlled by partitioned up-and-down spindles.To improve palletizing efficiency,the single palletizing mechanical arm is changed into multi-arm.Moreover,to improve its kinematic properties,the acceleration operating performance,joint driving force and palletizing trajectory are optimized through the multi-objective delaminating sequence method.According to the optimization results,the 3D model of the multi-arm palletizing robot is built in Pro/E,and the kinematic simulation is made.The simulation results show that the novel mechanism and optimization parameters are rational and feasible.This novel palletizing robot has the advantages of cam mechanism,so it simplifies the driving mode of palletizing movement and can lower the requirements for controlling system.At the same time,it can increase palletizing efficiency further by adding mechanical arms.展开更多
The principle of conjugate cam shedding mechanism forthe outside tappets with dual driving shafts is discussed,and its design conditions and parameters are studied,giving the results of practical calculations finally.
On basis of the computer a fuzzy design system is developed for the design of cam mechanisms. The system includes a fuzzy knowledge base, a virtual knowledge base,a fuzzy design mathematical model,a fuzzy design proce...On basis of the computer a fuzzy design system is developed for the design of cam mechanisms. The system includes a fuzzy knowledge base, a virtual knowledge base,a fuzzy design mathematical model,a fuzzy design procedure which can complete the conventional fuzzy design and the fuzzy design optimisation.It can draw on the designer's wisdom better,and enhance the design quality and efficiency.展开更多
文摘多囊卵巢综合征(Polycystic ovary syndrome,PCOS)是一组生殖内分泌代谢紊乱的综合征,临床以稀发排卵、高雄激素体征、胰岛素抵抗为主要特征,其中育龄期发病率高,对女性生育力造成严重不良影响。PCOS的发生发展涉及多种信号通路,腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)及哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)作为细胞能量感受器是其中两个关键靶点。二者在PCOS各个发病部位包括下丘脑-垂体-卵巢轴、子宫内膜、脂肪与骨骼肌中发挥重要的调节作用,通过影响细胞自噬、氧化应激、炎症、线粒体功能、葡萄糖摄取等,促进卵泡的发育和成熟,改善胰岛素抵抗。近年来,中医药因其成分多样、靶点众多等优势广泛应用于临床,研究人员已对PCOS的发病以及中药治疗及改善PCOS的机制进行了大量研究,结果提示AMPK与mTOR相关通路在其中发挥关键作用。通过总结中药干预AMPK与mTOR及其相关通路治疗PCOS的研究结果,为临床治疗及基础研究提供参考。
文摘We first design and analyze the contour surface of the globoidal indexing cam with the aid of computer, and then do optimum design according to the requirements of dynamics. Finally, we discuss the problem of the pressure angle of the globoidal indexing cam mechanism in detail and put forward a new concept of equivalent pressure angle.
文摘A new type of rapier drive for flexible rapier loom through conjugate cams with five-bar linkage mechanism is raised and analyzed. Two designs suitable for the conversion of 1515-190.5 shuttle looms are given as examples. This mechanism can be applied to traditional shuttle looms as well as to new flexible rapier loom design.
文摘A new type of parallel indexing cam mechanism is discovered.The composition of the cam profile is proposed and the formulas of the mechanism parameters are established by synthesis of its configuration and size.The equations for working pro- file and pressure angle of the cam are derived based on the inverse model and the derivative of pitch curve of cams.An example is given and demonstrates that it is available to design the new mechanism using the derived expressions.
基金National Natural Science Foundation of China (No.50875243)Natural Science Foundation of Zhejiang Province,China (No.Y1110100)
文摘In order to realize the parametric design of the conjugate cam weft insertion mechanism,according to the necessary parameters of weft insertion process,ideal kinematic curves of the weft insertion mechanism were given,and the mathematical model of reverse solution for this mechanism was established.The parameters of this mechanism were obtained by reverse solution on the basis of the given ideal kinematic curves and kinematic requirements.The parametric design platform which was integrated with the functions of parametric reverse solution,motion simulation,three-dimensional modeling and virtual assembly was developed based on VB.NET and Unigraphics(UG) NX.After entering the technological parameters of weft insertion process and essential structural parameters by users,three-dimensional drawing of the main parts such as the conjugate cam and shaft,can be obtained by this platform,also the processing data of the cam can be calculated.This platform provides a rapid approach for parametric design of weft insertion mechanism.
基金Supported by the Key Project of Ministry of Education of China
文摘This paper is aimed to propose an approach to predict the dynamic characteristics of ring-plate planetary indexing cam mechanism, which is a novel type of indexing mechanism that employs internal planetary transmission structure. Firstly, the geometry and structure of the mechanism are discussed and the kinematic practicability is simulated with virtual prototype design. Then a 3D finite element model of the ring-plate planetary indexing cam mechanism is developed with the commercial software of MATLAB and ANSYS. Through the finite element analysis, the natural frequencies and the corresponding mode shapes are predicted in one motion cycle. On the basis of the virtual prototype design and finite element analysis, an experimental prototype is made and tested to validate the prediction of the dynamic characteristics. The agreement between experimental results and the finite element analysis testifies that the finite element model developed is applicable to the prediction of the dynamic characteristics of this type of mechanism.
文摘In the usual shedding mechanism of a weaving loom, the conjugate type of cams can be designed precisely according to any regular pattern sequence of heald frame motion to suit the weaving technological requirements. As this mechanism is also quite simple, with smaller cam size and better technological function, it is therefore very important and worthwhile to study this type of conjugate cams. In this paper, we try to analyze the defects of the traditional and some abroad type outside conjugate cams shedding mechanism, and propose a new improved design of this type of conjugate cams and then work it out finally.
基金Projects(51475464,51175500,51575519)supported by the National Natural Science Foundation of China
文摘As an alternative power source for hybrid electrical vehicle(HEV), electric generating system(EGS) driven by sphere cam engine(SCE) is said to own higher power density and integration. In this work, the structure and working principle of EGS were introduced, based on which the advantages of EGS were displayed. The profile of sphere cam was achieved after the desired motion of piston was given. After establishing the dynamic model of power transmission mechanism, the characteristics of cam-roller mechanism were studied. The results show that the optimal cam profile of SCE is a sinusoid curve which has two peaks and two valleys and a mean pressure angle of 47.19°. Because of the special cam shape, the trace of end surface center of piston is an eight-shape curve on a specific sphere surface. SCE running at speed of 3000 r/min can generate the power of 33.81 kW, which could satisfy the need of HEVs. However, the force between cylinder and piston skirt caused by Coriolis acceleration can reach up to 1182 N, which leads to serious wear between cylinder liner and piston skirt and may shorten the lifespan of SCE.
文摘Background: Recently, high efficacy of the chemotherapeutic regimen combining clarithromycin (CAM) with lenalidomide (Len) and dexamethasone (Dex) (BiRD) in treating multiple myeloma (MM) patients has been reported. However, the exact mechanism of added CAM has not been fully elucidated. This case report will provide helpful information for understanding the significance and the mechanism of action of CAM as an add-on therapy. Patient: A 78-year-old female patient with IgA-λ type MM was treated with low-dose Len coupled with low-dose Dex (low Rd), and excellent response was achieved for long term, but she later became refractory to this treatment. Then, CAM was added to low Rd (low Rd-CAM, i.e., modified BiRD therapy). This add-on-therapy was found to be effective, but later suspended because of pneumonitis. Then, low-dose Len coupled with CAM (low R-CAM) treatment was applied;but effect of this Dex-free treatment was insufficient. Thus, low Rd-CAM was reapplied and satisfactory reduction of IgA was achieved. This fact suggests that low Rd-CAM is the favorable combination, Dex is requisite and CAM might have enhanced the effect of Dex. In this case, various serum cytokines were examined during the course of illness. Only interleukin-6 showed apparent increase, and tumor necrosis factor-α, transforming growth factor-β, soluble IL-2 receptors and C-reactive protein showed the slight increase during low Rd-CAM treatment. The results seem somewhat conflicting, but it seems that intricate cytokine response due to immune activation might have occurred during low Rd-CAM treatment.
基金Supported by Natural Science Foundation of Shandong Province,China(No.ZR2010EM007)Shandong Province Science and Technology Development Plan(No.2010GGX10402)
文摘Palletizing robot technology has been applied more and more extensively in logistics automation field.But there are some limitations in the current single-arm palletizing robot that it cannot do effective work in the process of moving back to the taking-end and the mechanical arm has so many freedoms that its control system is relatively complex.Based on the translating cam principle,a novel palletizing robot is designed.The horizontal movement of the palletizing mechanical arm is controlled by changeable outer slides,and the vertical movement is controlled by partitioned up-and-down spindles.To improve palletizing efficiency,the single palletizing mechanical arm is changed into multi-arm.Moreover,to improve its kinematic properties,the acceleration operating performance,joint driving force and palletizing trajectory are optimized through the multi-objective delaminating sequence method.According to the optimization results,the 3D model of the multi-arm palletizing robot is built in Pro/E,and the kinematic simulation is made.The simulation results show that the novel mechanism and optimization parameters are rational and feasible.This novel palletizing robot has the advantages of cam mechanism,so it simplifies the driving mode of palletizing movement and can lower the requirements for controlling system.At the same time,it can increase palletizing efficiency further by adding mechanical arms.
文摘The principle of conjugate cam shedding mechanism forthe outside tappets with dual driving shafts is discussed,and its design conditions and parameters are studied,giving the results of practical calculations finally.
文摘On basis of the computer a fuzzy design system is developed for the design of cam mechanisms. The system includes a fuzzy knowledge base, a virtual knowledge base,a fuzzy design mathematical model,a fuzzy design procedure which can complete the conventional fuzzy design and the fuzzy design optimisation.It can draw on the designer's wisdom better,and enhance the design quality and efficiency.
