BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal cancer.AIM To investigate causal associations between blood metabolites and colon c...BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal cancer.AIM To investigate causal associations between blood metabolites and colon cancer.METHODS The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal cancer.The primary method of analysis used was the inverse variance weighted model.To further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile score.These additional analyses were conducted to ensure the reliability and robustness of the findings.RESULTS After rigorous selection for genetic variation,486 blood metabolites were included in the MR analysis.We found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the results.CONCLUSION This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk factors.The other five blood metabolites are protective factors.展开更多
This article reflects on the process of transcribing spoken interaction and makes a comparative analysis of two different varieties of spoken interaction(casual conver- sation and institutional talk). By doing so, it ...This article reflects on the process of transcribing spoken interaction and makes a comparative analysis of two different varieties of spoken interaction(casual conver- sation and institutional talk). By doing so, it reveals how the different purposes of speech result in their distinctive characteristics, and shows how language is struc- tured to construct ideational meanings(Field) and interpersonal meanings(Tenor) that define each context.展开更多
This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-...This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-vironment for the casual-wear chain stores in HongKong.Julie Baker’s Three-category framework onstore environments namely ambient,design and socialfactors was adopted for investigation.The results indi-cated that the store environment was important in affect-ing consumers’selection of store for shopping.It alsorevealed that social factor was perceived relatively im-portant than ambient and design factors.Nine store ex-pectation dimensions were categorised and the resultdemonstrated that most respondents were concerned onthe social aspect in their expectation of having a satisfy-ing store environment.展开更多
Background: The gap in the understanding of the context of the sexually transmitted infections (STIs) and risky behaviours among men who have sex with men (MSM) could lead to the development and implementation of inap...Background: The gap in the understanding of the context of the sexually transmitted infections (STIs) and risky behaviours among men who have sex with men (MSM) could lead to the development and implementation of inappropriate interventions, which could exacerbate the rapid spread of STIs, especially HIV, among MSM. The aim of the study was to qualitatively assess the understanding of the STIs and the risky sexual behaviours of men who have sex with men in the North-West region of Tshwane. Methods: An exploratory qualitative design was employed to assess the STIs and the risky sexual behaviour of the MSM population. The study participants were enrolled in an HPV clinical trial at MECRU, which is a clinical research unit at the Sefako Makgatho Health Sciences University. Data collection occurred from September 2016 to May 2017. A convenience sampling method was used and n = 30 participants were selected. Face-to-face in-depth interviews were conducted on MSM 18 years and older, using a semi-structured interview guide. Thematic content analysis was used for data analysis, using NVivo version 10 software. Results: The mean age of the sample was 26 years, and the age range was 18 to 44 years. All were unmarried, and all of them came from townships, rural villages and informal settlements in the vicinity of the clinical research unit. The high-risk behaviours noted among the majority of the MSM in this study were having multiple sexual partners and exchanging partners, alcohol abuse, inconsistent condom-use, having unprotected anal sex, and having transactional sex. There was a high level of knowledge of STIs in the heterosexual population with poor understanding of STIs affecting MSM through anal sex. Most of the MSM played a female or bottom role, which made them vulnerable because they could not successfully negotiate condom use, and they reported that they sometimes accepted gifts or money in exchange for anal sex. Conclusion: The study concludes that the MSM in this study had casual sex, and are involved in sex work without practising safe sex. There is a need for health promotion on STIs and risky behaviours among MSM in communities as well as in health facilities for MSM in the North-West region of Tshwane.展开更多
The Yi are the largest and most disadvantaged ethnic minority population in southwestern China. This region contains over eight million Yi, with approximately 2.4 million living in the Liangshan Yi Autonomous Prefectu...The Yi are the largest and most disadvantaged ethnic minority population in southwestern China. This region contains over eight million Yi, with approximately 2.4 million living in the Liangshan Yi Autonomous Prefecture （Liangshan） in Sichuan Province. Liangshan is located along one of the main drug trafficking routes from the ＇Golden Triangle＇ to northwest and central China, making it one of the largest illicit drug production and distribution centers in China.展开更多
The theory of "thick translation", put forward by American scholar Kwame Anthony Appiah, suggests understanding and translating source text with the help of its rich cultural and linguistic context. The noti...The theory of "thick translation", put forward by American scholar Kwame Anthony Appiah, suggests understanding and translating source text with the help of its rich cultural and linguistic context. The notion boasts a significant role in the translation of ancient Chinese classics which is the embodiment and condensation of traditional Chinese philosophical principles, such as Taoism, Confucianism. This paper mainly looks into the translation of culture-loaded words in Casual Expressions of Idle Feeling from the perspective of"thick translation"and wishes to contribute to the strategies of translating culture-loaded words in ancient Chinese classics.展开更多
In the year 1999,when the secretary of Shaxi town,Zhongshan,Guangdong planning the first China's Casual Wear Fair,"Casual Wear" hadn’t become a widly accepted conception yet. At the end of last century,...In the year 1999,when the secretary of Shaxi town,Zhongshan,Guangdong planning the first China's Casual Wear Fair,"Casual Wear" hadn’t become a widly accepted conception yet. At the end of last century,Chinese people,who have just come across with lots of new ideas and new fashions brought from outside world,didn’t realized that casual wear is one of the most important fashion elements in people's daily life.展开更多
Tan Jun. 30, can still feel the adrenalin rush he experi- enced last November when watching the world＇s premier competitive gaming event of the 2017 League of Legends World Championship （LLWC）.
Since its establishment in 2000, the China’s Casual Wear Fair bears the hope and dreams of the casual wear industry, continuously integrates commercial channel, brand, market, media, and collects various superior res...Since its establishment in 2000, the China’s Casual Wear Fair bears the hope and dreams of the casual wear industry, continuously integrates commercial channel, brand, market, media, and collects various superior resources, builds up pleasant industrial chain and pushes forward the rapid development of casual wear industry.展开更多
Beijing﹒20th March,2009-THINK PINK announces the launch of the Spring/Summer 2009 collection which features a new Maritime theme. The collection draws inspirations from the delightful lifestyle of the East Coast to e...Beijing﹒20th March,2009-THINK PINK announces the launch of the Spring/Summer 2009 collection which features a new Maritime theme. The collection draws inspirations from the delightful lifestyle of the East Coast to enrich the brand’s original Italian designs with American flair.展开更多
With "Lead Casual Fashion Trend to Promote Development Together" as the theme, the 9th China Casual Wear Expo (CHCW 2008) was grandly held at Zhongshan Expo Center
Aiming to achieve market integration together with European classic style and Chinese business style 130 years ago,Hart brothers established a men's wear company-Hart Schaffner Marx,and accordingly,a classic Ameri...Aiming to achieve market integration together with European classic style and Chinese business style 130 years ago,Hart brothers established a men's wear company-Hart Schaffner Marx,and accordingly,a classic American brand was born in Chicago in the United States.For 130 years,it has enjoyed countless glory,always standing in the forefront of American fashion,and the 44th president of the United States Barack Obama展开更多
This article reflects on how to transcribe two audio recordings and conducts a comparative analysis on them,aiming at identifying the typical features of transcribing process and identifying the different features of ...This article reflects on how to transcribe two audio recordings and conducts a comparative analysis on them,aiming at identifying the typical features of transcribing process and identifying the different features of classroom and casual conversations.The first recording is an institutional conversation recorded in a module called"Communication skills for teachers"in an under graduate classroom in Singapore.The second is a casual conversation occurring among four MA classmates who met for their sec ond time.The first part of this article focuses on the issues met and the insights gained in transcribing.The second part is a com parative analysis that leads to the conclusion classroom and casual conversations are two different genres of spoken interactions with distinctive features shaped by field and tenor.展开更多
基金Supported by the General Project of Medical and Health Technology Plan of Zhejiang Province,No.2020KY845.
文摘BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal cancer.AIM To investigate causal associations between blood metabolites and colon cancer.METHODS The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal cancer.The primary method of analysis used was the inverse variance weighted model.To further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile score.These additional analyses were conducted to ensure the reliability and robustness of the findings.RESULTS After rigorous selection for genetic variation,486 blood metabolites were included in the MR analysis.We found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the results.CONCLUSION This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk factors.The other five blood metabolites are protective factors.
文摘This article reflects on the process of transcribing spoken interaction and makes a comparative analysis of two different varieties of spoken interaction(casual conver- sation and institutional talk). By doing so, it reveals how the different purposes of speech result in their distinctive characteristics, and shows how language is struc- tured to construct ideational meanings(Field) and interpersonal meanings(Tenor) that define each context.
文摘This study attempted to examine the importance of storeenvironment in affecting consumers’store choice deci-sion;the relative importance among the three environ-mental factors;and consumers’expectations on store en-vironment for the casual-wear chain stores in HongKong.Julie Baker’s Three-category framework onstore environments namely ambient,design and socialfactors was adopted for investigation.The results indi-cated that the store environment was important in affect-ing consumers’selection of store for shopping.It alsorevealed that social factor was perceived relatively im-portant than ambient and design factors.Nine store ex-pectation dimensions were categorised and the resultdemonstrated that most respondents were concerned onthe social aspect in their expectation of having a satisfy-ing store environment.
文摘Background: The gap in the understanding of the context of the sexually transmitted infections (STIs) and risky behaviours among men who have sex with men (MSM) could lead to the development and implementation of inappropriate interventions, which could exacerbate the rapid spread of STIs, especially HIV, among MSM. The aim of the study was to qualitatively assess the understanding of the STIs and the risky sexual behaviours of men who have sex with men in the North-West region of Tshwane. Methods: An exploratory qualitative design was employed to assess the STIs and the risky sexual behaviour of the MSM population. The study participants were enrolled in an HPV clinical trial at MECRU, which is a clinical research unit at the Sefako Makgatho Health Sciences University. Data collection occurred from September 2016 to May 2017. A convenience sampling method was used and n = 30 participants were selected. Face-to-face in-depth interviews were conducted on MSM 18 years and older, using a semi-structured interview guide. Thematic content analysis was used for data analysis, using NVivo version 10 software. Results: The mean age of the sample was 26 years, and the age range was 18 to 44 years. All were unmarried, and all of them came from townships, rural villages and informal settlements in the vicinity of the clinical research unit. The high-risk behaviours noted among the majority of the MSM in this study were having multiple sexual partners and exchanging partners, alcohol abuse, inconsistent condom-use, having unprotected anal sex, and having transactional sex. There was a high level of knowledge of STIs in the heterosexual population with poor understanding of STIs affecting MSM through anal sex. Most of the MSM played a female or bottom role, which made them vulnerable because they could not successfully negotiate condom use, and they reported that they sometimes accepted gifts or money in exchange for anal sex. Conclusion: The study concludes that the MSM in this study had casual sex, and are involved in sex work without practising safe sex. There is a need for health promotion on STIs and risky behaviours among MSM in communities as well as in health facilities for MSM in the North-West region of Tshwane.
基金supported by the Global Fund for AIDS program,China(Grant CSO-2012-YAN-39)
文摘The Yi are the largest and most disadvantaged ethnic minority population in southwestern China. This region contains over eight million Yi, with approximately 2.4 million living in the Liangshan Yi Autonomous Prefecture （Liangshan） in Sichuan Province. Liangshan is located along one of the main drug trafficking routes from the ＇Golden Triangle＇ to northwest and central China, making it one of the largest illicit drug production and distribution centers in China.
文摘The theory of "thick translation", put forward by American scholar Kwame Anthony Appiah, suggests understanding and translating source text with the help of its rich cultural and linguistic context. The notion boasts a significant role in the translation of ancient Chinese classics which is the embodiment and condensation of traditional Chinese philosophical principles, such as Taoism, Confucianism. This paper mainly looks into the translation of culture-loaded words in Casual Expressions of Idle Feeling from the perspective of"thick translation"and wishes to contribute to the strategies of translating culture-loaded words in ancient Chinese classics.
文摘In the year 1999,when the secretary of Shaxi town,Zhongshan,Guangdong planning the first China's Casual Wear Fair,"Casual Wear" hadn’t become a widly accepted conception yet. At the end of last century,Chinese people,who have just come across with lots of new ideas and new fashions brought from outside world,didn’t realized that casual wear is one of the most important fashion elements in people's daily life.
文摘Tan Jun. 30, can still feel the adrenalin rush he experi- enced last November when watching the world＇s premier competitive gaming event of the 2017 League of Legends World Championship （LLWC）.
文摘Since its establishment in 2000, the China’s Casual Wear Fair bears the hope and dreams of the casual wear industry, continuously integrates commercial channel, brand, market, media, and collects various superior resources, builds up pleasant industrial chain and pushes forward the rapid development of casual wear industry.
文摘Beijing﹒20th March,2009-THINK PINK announces the launch of the Spring/Summer 2009 collection which features a new Maritime theme. The collection draws inspirations from the delightful lifestyle of the East Coast to enrich the brand’s original Italian designs with American flair.
文摘With "Lead Casual Fashion Trend to Promote Development Together" as the theme, the 9th China Casual Wear Expo (CHCW 2008) was grandly held at Zhongshan Expo Center
文摘Aiming to achieve market integration together with European classic style and Chinese business style 130 years ago,Hart brothers established a men's wear company-Hart Schaffner Marx,and accordingly,a classic American brand was born in Chicago in the United States.For 130 years,it has enjoyed countless glory,always standing in the forefront of American fashion,and the 44th president of the United States Barack Obama
文摘This article reflects on how to transcribe two audio recordings and conducts a comparative analysis on them,aiming at identifying the typical features of transcribing process and identifying the different features of classroom and casual conversations.The first recording is an institutional conversation recorded in a module called"Communication skills for teachers"in an under graduate classroom in Singapore.The second is a casual conversation occurring among four MA classmates who met for their sec ond time.The first part of this article focuses on the issues met and the insights gained in transcribing.The second part is a com parative analysis that leads to the conclusion classroom and casual conversations are two different genres of spoken interactions with distinctive features shaped by field and tenor.
