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CD4^+CD25^+T regs与CCL17和CCL22在头颈鳞状细胞癌发病机制中的初步研究 被引量:6
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作者 龚单春 张海东 +1 位作者 于振坤 邢光前 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2017年第20期1557-1560,共4页
目的:探讨CD4^+CD25^+T regs与CCL17、CCL22在头颈部鳞状细胞癌(HNSCC)发病分子机制中的关系。方法:选取HNSCC手术患者20例,均为初发或治疗后(放化疗、手术)复发的患者。取术后大体标本的部分肿瘤原发灶作为试验组,同时取距肿瘤原发灶1~... 目的:探讨CD4^+CD25^+T regs与CCL17、CCL22在头颈部鳞状细胞癌(HNSCC)发病分子机制中的关系。方法:选取HNSCC手术患者20例,均为初发或治疗后(放化疗、手术)复发的患者。取术后大体标本的部分肿瘤原发灶作为试验组,同时取距肿瘤原发灶1~3cm的部分癌旁正常组织作为对照组。利用免疫荧光检测CD4^+/Foxp3及CD25^+/Foxp3,利用ELISA检测CCL17、CCL22。比较两组之间CD4^+、CD25^+以及CCL17、CCL22的差别,分析CD4^+、CD25^+与CCL17、CCL22之间的相关性。结果:试验组与对照组之间CD4^+/Foxp3、CD25^+/Foxp3平均光密度值差异有统计学意义(均P<0.05)。试验组与对照组之间CCL17、CCL22检测浓度值差异有统计学意义(均P<0.01)。试验组中CD25^+与CCL17、CCL22之间具有明显正相关(r=0.595、0.720,P<0.01)。结论:CD4^+CD25^+T regs与CCL17、CCL22在HNSCC发病的免疫机制中具有重要作用,两者相互影响,共同促进了HNSCC的复发和转移。 展开更多
关键词 头颈部肿瘤 鳞状细胞 CD4^+CD25^+调节性T细胞 趋化因子CCLl7 趋化因子CCL22
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Cubic metric improvement of aggregated carriers for downlink transmission in LTE-advanced 被引量:2
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作者 ZHANG Shao-xin ZHOU Jun ZHU Hong-bo ZHU Qi 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2011年第1期60-63,90,共5页
To meet long term evolution-advanced (LTE-A) requirements of wider bandwidth and maintain backwards compatibility with LTE release 8 (Rel-8) simultaneously, carrier aggregation has been agreed by the third generat... To meet long term evolution-advanced (LTE-A) requirements of wider bandwidth and maintain backwards compatibility with LTE release 8 (Rel-8) simultaneously, carrier aggregation has been agreed by the third generation partnership project (3GPP). High cubic metric (CM) values and peak-to-average power ratio (PAPR) of aggregated component carriers (CCs) exists as an unpleasant issue for both uplink and downlink (DL) transmission. For DL transmission, to use distinct cell ID per DL CC to generate DL reference signal (RS) sequence can mitigate this problem but will cause some other issues on the corresponding uplink carrier. This article proposes two approaches to solve the problem of high CM/PAPR by introducing new variables to change the cell-specific DL RS sequence. In both methods, same cell identifier (cell ID) is allocated to all DL CCs. Simulation results show the performance improvements and prove the effectivity of our proposed approaches. 展开更多
关键词 LTE-A CC CM/PAPR DL RS ccll ID CC ID total numbcr of aggregatcd CCs
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