“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL2024)将于2024年7月25-29日在山西太原举行,会议由中国中文信息学会计算语言学专业委员会主办,山西大学承办。中国计...“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL2024)将于2024年7月25-29日在山西太原举行,会议由中国中文信息学会计算语言学专业委员会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会主办。经过30余年的发展,中国计算语言学大会已成为国内自然语言处理领域权威性最高、规模和影响最大的学术会议。作为中国中文信息学会(全国一级学会)的旗舰会议,CCL聚焦于中国境内各类语言的智能计算和信息处理,为研讨和传播计算语言学最新学术和技术成果提供了最广泛的高层次交流平台。展开更多
“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25-28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于199...“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25-28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。经过30余年的发展,中国计算语言学大会已成为国内自然语言处理领域权威性最高、规模和影响最大的学术会议。展开更多
“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25—28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1...“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25—28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。展开更多
Spinal cord injury causes accumulation of a large number of leukocytes at the lesion site where they contribute to excessive inflammation.Overproduced chemokines are responsible for the migratory process of the leukoc...Spinal cord injury causes accumulation of a large number of leukocytes at the lesion site where they contribute to excessive inflammation.Overproduced chemokines are responsible for the migratory process of the leukocytes,but the regulatory mechanism underlying the production of chemokines from resident cells of the spinal cord has not been fully elucidated.We examined the protein levels of macrophage migration inhibitory factor and chemokine C-C motif chemokine ligand 2 in a spinal cord contusion model at different time points following spinal cord injury.The elevation of macrophage migration inhibitory factor at the lesion site coincided with the increase of chemokine C-C motif chemokine ligand 2 abundance in astrocytes.Stimulation of primary cultured astrocytes with different concentrations of macrophage migration inhibitory factor recombinant protein induced chemokine C-C motif chemokine ligand 2 production from the cells,and the macrophage migration inhibitory factor inhibitor 4-iodo-6-phenylpyrimidine attenuated the stimulatory effect.Further investigation into the underlying mechanism on macrophage migration inhibitory factor-mediated astrocytic production of chemokine C-C motif chemokine ligand 2 revealed that macrophage migration inhibitory factor activated intracellular JNK signaling through binding with CD74 receptor.Administration of the macrophage migration inhibitory factor inhibitor 4-iodo-6-phenylpyrimidine following spinal cord injury resulted in the reduction of chemokine C-C motif chemokine ligand 2-recruited microglia/macrophages at the lesion site and remarkably improved the hindlimb locomotor function of rats.Our results have provided insights into the functions of astrocyte-activated chemokines in the recruitment of leukocytes and may be beneficial to develop interventions targeting chemokine C-C motif chemokine ligand 2 for neuroinflammation after spinal cord injury.展开更多
文摘“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL2024)将于2024年7月25-29日在山西太原举行,会议由中国中文信息学会计算语言学专业委员会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会主办。经过30余年的发展,中国计算语言学大会已成为国内自然语言处理领域权威性最高、规模和影响最大的学术会议。作为中国中文信息学会(全国一级学会)的旗舰会议,CCL聚焦于中国境内各类语言的智能计算和信息处理,为研讨和传播计算语言学最新学术和技术成果提供了最广泛的高层次交流平台。
文摘“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25-28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。经过30余年的发展,中国计算语言学大会已成为国内自然语言处理领域权威性最高、规模和影响最大的学术会议。
文摘“第二十三届中国计算语言学大会”(The Twenty-third China National Conference on Computational Linguistics,CCL 2024)将于2024年7月25—28日在山西太原举行,会议由中国中文信息学会主办,山西大学承办。中国计算语言学大会创办于1991年,由中国中文信息学会计算语言学专业委员会负责组织。
基金supported by the China Postdoctoral Science Foundation,No.2020M681689(to YMH)the Basic Scientific Research Projects of Nantong,Nos.JC2020015(to HX)and JC2020041(to YMH)。
文摘Spinal cord injury causes accumulation of a large number of leukocytes at the lesion site where they contribute to excessive inflammation.Overproduced chemokines are responsible for the migratory process of the leukocytes,but the regulatory mechanism underlying the production of chemokines from resident cells of the spinal cord has not been fully elucidated.We examined the protein levels of macrophage migration inhibitory factor and chemokine C-C motif chemokine ligand 2 in a spinal cord contusion model at different time points following spinal cord injury.The elevation of macrophage migration inhibitory factor at the lesion site coincided with the increase of chemokine C-C motif chemokine ligand 2 abundance in astrocytes.Stimulation of primary cultured astrocytes with different concentrations of macrophage migration inhibitory factor recombinant protein induced chemokine C-C motif chemokine ligand 2 production from the cells,and the macrophage migration inhibitory factor inhibitor 4-iodo-6-phenylpyrimidine attenuated the stimulatory effect.Further investigation into the underlying mechanism on macrophage migration inhibitory factor-mediated astrocytic production of chemokine C-C motif chemokine ligand 2 revealed that macrophage migration inhibitory factor activated intracellular JNK signaling through binding with CD74 receptor.Administration of the macrophage migration inhibitory factor inhibitor 4-iodo-6-phenylpyrimidine following spinal cord injury resulted in the reduction of chemokine C-C motif chemokine ligand 2-recruited microglia/macrophages at the lesion site and remarkably improved the hindlimb locomotor function of rats.Our results have provided insights into the functions of astrocyte-activated chemokines in the recruitment of leukocytes and may be beneficial to develop interventions targeting chemokine C-C motif chemokine ligand 2 for neuroinflammation after spinal cord injury.
