目的:探讨基底细胞样乳腺癌(basal-like breast cancer,BLBC)的生物学特征及CD109、AR在BLBC中的表达意义。方法:对本院病理科2005年～2008年手术存档乳腺癌石蜡标本全部病例的HE组织切片进行形态学观察以确定诊断,同时采用免疫组化(S-P...目的:探讨基底细胞样乳腺癌(basal-like breast cancer,BLBC)的生物学特征及CD109、AR在BLBC中的表达意义。方法:对本院病理科2005年～2008年手术存档乳腺癌石蜡标本全部病例的HE组织切片进行形态学观察以确定诊断,同时采用免疫组化(S-P法)检测CD109、AR在86例BLBC和90例浸润性导管癌(invasive ductalcancer,IDC)中的表达情况。结果:BLBC具有独特的形态学特征,其癌组织异型性明显,组织学分级较高。在BLBC中CD109的阳性表达率明显高于IDC,而AR的阳性表达率则明显低于IDC;CD109在BLBC中的表达与患者年龄、肿瘤大小、肿瘤的组织学分级和淋巴结累及情况均无关,而AR在BLBC中的表达与肿瘤的组织学分级有关,与患者年龄、肿瘤大小和淋巴结累及情况无关。结论:BLBC是一组具有一定形态学特点的乳腺癌,CD109的高表达和AR的低表达在BLBC中具有明显特征,CD109不随肿瘤临床病理指标变化而具有稳定的高表达率说明了它可能是BLBC新的特异性标志物,而AR的阳性表达率随肿瘤分级升高而降低则可能与肿瘤的侵袭进展有关。展开更多
Transforming growth factor（TGF）-β signaling plays an important role in the pathogenesis of psoriasis. CD109, a novel TGF-β co-receptor, which inhibits TGF-β signaling by enhancing Smad7-dependent degradation of T...Transforming growth factor（TGF）-β signaling plays an important role in the pathogenesis of psoriasis. CD109, a novel TGF-β co-receptor, which inhibits TGF-β signaling by enhancing Smad7-dependent degradation of TGF-β type Ⅰ receptor（TGF-β RⅠ）, is abnormally expressed in psoriasis. To date, the expression of Smad7 and the correlation between CD109 and Smad7 expression in psoriasis have not been fully elucidated. This study was designed to investigate the expression and the correlation of CD109 and TGF-β signaling associated proteins in psoriasis and their roles in the pathogenesis of psoriasis. Thirty-two psoriasis specimens were subjected to immunohistochemical staining for CD109, Smad7, TGF-β RⅠ and Ki67. Ten normal skin（NS） specimens served as controls. The positive expression rate（% positive cells） of Smad7 and Ki67 in psoriasis was significantly higher than in NS（62.6%±19.9% vs. 17.2%±4.4%, and 50.7%±14.3% vs. 19.5%±3.2%, respectively, P〈0.001）, and the expression levels of CD109 and TGF-β RⅠ were reduced significantly in psoriasis as compared with NS（8.1%±6.7% vs. 35.8%±6.7% and 27.3%±3.4% vs. 3.0%±3.4%, respectively, P〈0.001）. There were significantly negative correlations between CD109 and Smad7（r=-0.831, P〈0.01）. These findings indicated that CD109 might play a certain role in the pathogenesis of psoriasis. Lower expression of CD109 and TGF-β RⅠ was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-β RⅠ, and lead to the termination of TGF-β signaling.展开更多
文摘目的:探讨基底细胞样乳腺癌(basal-like breast cancer,BLBC)的生物学特征及CD109、AR在BLBC中的表达意义。方法:对本院病理科2005年～2008年手术存档乳腺癌石蜡标本全部病例的HE组织切片进行形态学观察以确定诊断,同时采用免疫组化(S-P法)检测CD109、AR在86例BLBC和90例浸润性导管癌(invasive ductalcancer,IDC)中的表达情况。结果:BLBC具有独特的形态学特征,其癌组织异型性明显,组织学分级较高。在BLBC中CD109的阳性表达率明显高于IDC,而AR的阳性表达率则明显低于IDC;CD109在BLBC中的表达与患者年龄、肿瘤大小、肿瘤的组织学分级和淋巴结累及情况均无关,而AR在BLBC中的表达与肿瘤的组织学分级有关,与患者年龄、肿瘤大小和淋巴结累及情况无关。结论:BLBC是一组具有一定形态学特点的乳腺癌,CD109的高表达和AR的低表达在BLBC中具有明显特征,CD109不随肿瘤临床病理指标变化而具有稳定的高表达率说明了它可能是BLBC新的特异性标志物,而AR的阳性表达率随肿瘤分级升高而降低则可能与肿瘤的侵袭进展有关。
基金supported by the National Natural Science Foundation of China(No.81101191and No.30972654)
文摘Transforming growth factor（TGF）-β signaling plays an important role in the pathogenesis of psoriasis. CD109, a novel TGF-β co-receptor, which inhibits TGF-β signaling by enhancing Smad7-dependent degradation of TGF-β type Ⅰ receptor（TGF-β RⅠ）, is abnormally expressed in psoriasis. To date, the expression of Smad7 and the correlation between CD109 and Smad7 expression in psoriasis have not been fully elucidated. This study was designed to investigate the expression and the correlation of CD109 and TGF-β signaling associated proteins in psoriasis and their roles in the pathogenesis of psoriasis. Thirty-two psoriasis specimens were subjected to immunohistochemical staining for CD109, Smad7, TGF-β RⅠ and Ki67. Ten normal skin（NS） specimens served as controls. The positive expression rate（% positive cells） of Smad7 and Ki67 in psoriasis was significantly higher than in NS（62.6%±19.9% vs. 17.2%±4.4%, and 50.7%±14.3% vs. 19.5%±3.2%, respectively, P〈0.001）, and the expression levels of CD109 and TGF-β RⅠ were reduced significantly in psoriasis as compared with NS（8.1%±6.7% vs. 35.8%±6.7% and 27.3%±3.4% vs. 3.0%±3.4%, respectively, P〈0.001）. There were significantly negative correlations between CD109 and Smad7（r=-0.831, P〈0.01）. These findings indicated that CD109 might play a certain role in the pathogenesis of psoriasis. Lower expression of CD109 and TGF-β RⅠ was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-β RⅠ, and lead to the termination of TGF-β signaling.
