Objective:To investigate the relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value.Methods: A total of 40 patients with cervical ca...Objective:To investigate the relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value.Methods: A total of 40 patients with cervical cancer underwent radical surgery, and the cervical cancer tissue samples and tissue samples adjacent to carcinoma were collected. The differences in CD24 and CD2β molecule expression in adjacent tissues and cervical cancer tissues were compared, and the correlation of CD24 and CD2β molecule expression in cervical cancer tissues with proliferation and apoptosis gene expression was further determined.Results: CD24 expression in cervical cancer tissues was higher than that in adjacent tissues whereas CD2β expression was lower than that in adjacent tissues. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD24 expression group were lower than those in low CD24 expression group whereas SCD-1, TLR4 and HERC4 mRNA expression were higher than those in low CD24 expression group;apoptosis genes OPCML, DAPK and TSLC1 mRNA expression were lower than those in low CD24 expression group whereas GRIM-19 mRNA was higher than that in low CD24 expression group. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD2β expression group were higher than those in low CD2β expression group whereas SCD-1, TLR4 and HERC4 mRNA expression were lower than those in low CD2β expression group;apoptosis genes OPCML, DAPK and TSLC1 mRNA expression were higher than those in low CD2β expression group whereas GRIM-19 mRNA was lower than that in low CD2β expression group.Conclusion: CD24 molecule expression abnormally increases whereas CD2β molecule expression abnormally decreases in cervical cancer tissues, and the specific expression levels can be used to evaluate cervical cancer cell proliferation and apoptosis, indirectly reflect the tumor condition and are expected to become the reference for long-term therapy development.展开更多
In this study,Ni_(2)P/CdS composites were constructed by depositing non-precious metal co-catalyst Ni_(2)P on a one-dimensional network of CdS using a simple in-situ photodeposition method.The prepared photocatalysts ...In this study,Ni_(2)P/CdS composites were constructed by depositing non-precious metal co-catalyst Ni_(2)P on a one-dimensional network of CdS using a simple in-situ photodeposition method.The prepared photocatalysts promoted the decomposition of ethanol into high-value-added products while generating hydrogen.The composite photoanodes loaded with the Ni_(2)P co-catalysts showed significantly higher ethanol conversion and hydrogen production in the visible light region,which was almost three times higher than that of pure CdS.The main products of photocatalytic ethanol production are acetaldehyde(AA)and 2,3-butanediol(2,3-BDA).Compared with CdS,the selectivity of the composite photocatalysts for converting ethanol to acetaldehyde was significantly improved(62% to 78%).Characterization of the prepared photocatalysts confirmed that the loading of Ni_(2)P co-catalysts on CdS not only broadened the optical region of the catalysts for trapping light but also effectively promoted the separation and transfer of charge carriers,which significantly improved the photocatalytic efficiency of ethanol conversion and hydrogen production in the catalysts.It has been proven through Electron Paramagnetic Resonance testing that loading a Ni_(2)P co-catalyst on CdS is beneficial for the adsorption of hydroxyethyl radicals(*CH(OH)CH_(3)),thereby further improving the selectivity of acetaldehyde.This study plays an important role in the rational design of composite catalyst structures and the introduction of co-catalysts to improve catalyst performance,promote green chemistry,advocate a low-carbon society,and promote sustainable development.展开更多
文摘Objective:To investigate the relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value.Methods: A total of 40 patients with cervical cancer underwent radical surgery, and the cervical cancer tissue samples and tissue samples adjacent to carcinoma were collected. The differences in CD24 and CD2β molecule expression in adjacent tissues and cervical cancer tissues were compared, and the correlation of CD24 and CD2β molecule expression in cervical cancer tissues with proliferation and apoptosis gene expression was further determined.Results: CD24 expression in cervical cancer tissues was higher than that in adjacent tissues whereas CD2β expression was lower than that in adjacent tissues. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD24 expression group were lower than those in low CD24 expression group whereas SCD-1, TLR4 and HERC4 mRNA expression were higher than those in low CD24 expression group;apoptosis genes OPCML, DAPK and TSLC1 mRNA expression were lower than those in low CD24 expression group whereas GRIM-19 mRNA was higher than that in low CD24 expression group. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD2β expression group were higher than those in low CD2β expression group whereas SCD-1, TLR4 and HERC4 mRNA expression were lower than those in low CD2β expression group;apoptosis genes OPCML, DAPK and TSLC1 mRNA expression were higher than those in low CD2β expression group whereas GRIM-19 mRNA was lower than that in low CD2β expression group.Conclusion: CD24 molecule expression abnormally increases whereas CD2β molecule expression abnormally decreases in cervical cancer tissues, and the specific expression levels can be used to evaluate cervical cancer cell proliferation and apoptosis, indirectly reflect the tumor condition and are expected to become the reference for long-term therapy development.
基金supported by the National Natural Science Foundation of China(22075197,22278290)the Shanxi Provincial Natural Science Foundation of China(202103021224079,201903D421081)the Research and Development Project of Key Core and Common Technology of Shanxi Province(20201102018)。
文摘In this study,Ni_(2)P/CdS composites were constructed by depositing non-precious metal co-catalyst Ni_(2)P on a one-dimensional network of CdS using a simple in-situ photodeposition method.The prepared photocatalysts promoted the decomposition of ethanol into high-value-added products while generating hydrogen.The composite photoanodes loaded with the Ni_(2)P co-catalysts showed significantly higher ethanol conversion and hydrogen production in the visible light region,which was almost three times higher than that of pure CdS.The main products of photocatalytic ethanol production are acetaldehyde(AA)and 2,3-butanediol(2,3-BDA).Compared with CdS,the selectivity of the composite photocatalysts for converting ethanol to acetaldehyde was significantly improved(62% to 78%).Characterization of the prepared photocatalysts confirmed that the loading of Ni_(2)P co-catalysts on CdS not only broadened the optical region of the catalysts for trapping light but also effectively promoted the separation and transfer of charge carriers,which significantly improved the photocatalytic efficiency of ethanol conversion and hydrogen production in the catalysts.It has been proven through Electron Paramagnetic Resonance testing that loading a Ni_(2)P co-catalyst on CdS is beneficial for the adsorption of hydroxyethyl radicals(*CH(OH)CH_(3)),thereby further improving the selectivity of acetaldehyde.This study plays an important role in the rational design of composite catalyst structures and the introduction of co-catalysts to improve catalyst performance,promote green chemistry,advocate a low-carbon society,and promote sustainable development.
