目的 探究利妥昔单抗联合化疗对高龄弥漫大B细胞性非霍奇金淋巴瘤（diffuse large B cell lymphoma,DLBCL）的疗效.方法 2005年1月～2009年8月厦门大学附属第一医院接收的高龄DLBCL患者34例,其中10例采用单纯的CEOP化疗方案,24例采用利...目的 探究利妥昔单抗联合化疗对高龄弥漫大B细胞性非霍奇金淋巴瘤（diffuse large B cell lymphoma,DLBCL）的疗效.方法 2005年1月～2009年8月厦门大学附属第一医院接收的高龄DLBCL患者34例,其中10例采用单纯的CEOP化疗方案,24例采用利妥昔单联合化疗的R-CEOP治疗方案.比较2种治疗方案下患者近期疗效、长期随访生存率、不良反应和血清中免疫球蛋白的变化.结果 采用R-CEOP治疗方案的患者近期总有效率为66.7％ （16/24）、长期随访生存率第1、2、3年为87.5％、75.0％、54.0％,显著高于CEOP组[近期总有效率50.0％ （5/10）,第1、2、3年长期随访生存率为81.8％、60.0％、40.0％],差异有统计学意义（P＜0.05）;不良反应发生率（66.7％）及严重程度低于CEOP组（80.0％）,血清中IgG、IgA、IgM发生降低变化的百分比（72.7％、77.3％、72.7％）高于CEOP组（20.0％、30.0％、30.0％）,两两比较差异有统计学意义（P＜0.05）.结论 利妥昔单抗联合化疗对高龄DLBCL疗效确切,高龄DLBCL患者对大部分不良反应可以耐受,但利妥昔单抗易使高龄DLBCL患者血清中免疫球蛋白降低而发生感染.展开更多
The water and energy cycle in the Tibetan Plateau is an important component of Monsoon Asia and the global energy and water cycle. Using data at a CEOP （Coordinated Enhanced Observing Period）-Tibet site, this study ...The water and energy cycle in the Tibetan Plateau is an important component of Monsoon Asia and the global energy and water cycle. Using data at a CEOP （Coordinated Enhanced Observing Period）-Tibet site, this study presents a first-order evaluation on the skill of weather forecasting from GCMs and satellites in producing precipitation and radiation estimates. The satellite data, together with the satellite leaf area index, are then integrated into a land data assimilation system （LDAS-UT） to estimate the soil moisture and surface energy budget on the Plateau. The system directly assimilates the satellite microwave brightness temperature, which is strongly affected by soil moisture but not by cloud layers, into a simple biosphere model. A major feature of this system is a dual-pass assimilation technique, which can auto-calibrate model parameters in one pass and estimate the soil moisture and energy budget in the other pass. The system outputs, including soil moisture, surface temperature, surface energy partition, and the Bowen ratio, are compared with observations, land surface models, the Global Land Data Assimilation System, and four general circulation models. The results show that this satellite data-based system has a high potential for a reliable estimation of the regional surface energy budget on the Plateau.展开更多
基金the "100-Talent" Project of Chinese Academy of Sciences
文摘The water and energy cycle in the Tibetan Plateau is an important component of Monsoon Asia and the global energy and water cycle. Using data at a CEOP （Coordinated Enhanced Observing Period）-Tibet site, this study presents a first-order evaluation on the skill of weather forecasting from GCMs and satellites in producing precipitation and radiation estimates. The satellite data, together with the satellite leaf area index, are then integrated into a land data assimilation system （LDAS-UT） to estimate the soil moisture and surface energy budget on the Plateau. The system directly assimilates the satellite microwave brightness temperature, which is strongly affected by soil moisture but not by cloud layers, into a simple biosphere model. A major feature of this system is a dual-pass assimilation technique, which can auto-calibrate model parameters in one pass and estimate the soil moisture and energy budget in the other pass. The system outputs, including soil moisture, surface temperature, surface energy partition, and the Bowen ratio, are compared with observations, land surface models, the Global Land Data Assimilation System, and four general circulation models. The results show that this satellite data-based system has a high potential for a reliable estimation of the regional surface energy budget on the Plateau.
