Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: A case report

AIM: An inherited deficiency of human lysosomal acid lipase (LAL)results in the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). We want to present the rare case of CESD in an adult.METHODS: We report about an adult female patient with severe chronic diarrhea and weight loss as a consequence of CESD. Clinical examination revealed signs of malabsorption and slightly elevated liver enzymes.RESULTS: Histopathologic changes in the liver tissue and DNA sequence analysis confirmed the diagnosis of CESD due to homozygosity for the most common CESD mutation,a G934A splice site defect encoded by exon 8 of the lysosomal acid lipase (LIPA) gene.CONCLUSION: It is the first case in the literature with diarrhea as a putative symptom of CESD in adult patients.

Association between Occupational Change Trajectories and Mental Health: Results from the Korean Longitudinal Study of Aging

Objectives:This study was to longitudinally investigate the association between occupational change trajectories and mental health in the Korean population aged 45 years and older from the Korean Longitudinal Study of Aging(KLo-SA).Methods:After excluding missing values,the data of 6,224 participants from thefirst to eighth waves of the KLo-SA were analyzed using t-test,Analysis of variance(ANOVA),Group-based Trajectory Model(GBTM)from 1–5th KLoSA and Time-Lagged Generalized estimating equation(GEE)model from 5–8th KLoSA to analyze the association between occupational change trajectories and mental health in the Korean population aged 45 years and older.Results:An analysis of the association between occupational change trajectories and mental health demonstrated that,among all age group,the“sustained in unemployment”group had a worse MMSE and CESD score compared to“sustained WC”group.unlike the under-54 age group,those aged≥55 years demonstrated reductions in the MMSE and CESD scores in the sustained unemployment and the changed working condition from Standard BC to Unemployment groups,whereas those who underwent a change from the Standard WC to unemployment group only demonstrated a reduction in MMSE scores.Conclusions:There was a close relationship between occupational change trajectories and mental health.Therefore,this study can serve as the foundation for policies and institutional measures to manage the deteriorate mental health in the late middle-aged and older population.

大学生抑郁情绪现状及影响因素分析

目的调查大学生抑郁情绪现状以及五态人格与抑郁的关系。方法以某大学的在校本科和硕士研究生为研究对象,发放一般调查资料、流调用抑郁自评量表(CES-D)和五态人格测试表。结果大学生抑郁的发生率为15.32%。二年级学生、医学专业学生、非独生子女的学生,农村学生的抑郁发生率较其他学生高。而性别与抑郁的发生无统计学意义。五态测试结果显示,少阴型人格与抑郁的发生成正相关,阴阳和平型人格与抑郁的发生成负相关。造成这个结果的原因是由于阴性人格的性格特征、生活方式等决定的。结论大学生抑郁的发生率处在很高的水平,教育机构应该加强对大学生心理健康问题的监测,提高大学生的心理健康水平。

60岁及以上老年体检人群共病率调查及与抑郁的关系分析

目的调查60岁及以上老年人群慢病共病患病率和抑郁情况,分析共病患病与抑郁的关联。方法以2019-02/08在川北医学院附属医院健康管理中心接受常规体检的老年人群为对象,调查7种常见慢病患病情况,采用流调用抑郁自评量表简化版(CESD-10)评估抑郁情况,采用SAS 9.3统计分析软件,对共病患病与抑郁的关系进行卡方趋势检验和Logistic回归分析。结果共获得有效问卷1358份,7种常见慢病共病患病率为15.54%;未患慢病,患1种、2种和3种及以上慢病的老年人群抑郁患病率分别为5.42%、14.50%、22.11%和41.38%,患病率随共病数目增加呈明显的增加趋势(χ^2trend=169.50,P<0.01);Logistic回归分析结果发现,与未患病人群比较,在经性别、婚姻状况和文化程度校正后,患1种、2种和3种及以上慢病的老年人群抑郁患病风险分别增加1.70(95%CI:1.04~2.77)、3.22(95%CI:1.77~5.86)和10.09(95%CI:6.12~16.62)倍,抑郁发生风险随慢病数目增多而明显增大。结论老年人群共病患病率高,共病患者抑郁风险大,应重视对多病种共患老年人群心理健康问题的识别和管理。