Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

Background:L-dopa(Levodopa)is well known for managing PD(Parkinson’s disease);however,its prolonged use caused dyskinesia(LID).Due to the varied presentation of LID,effective treatment options are scarce.Flavonoids reported their neuroprotective activity by ameliorating acetylcholinesterase,monoamine oxidase,and neuroinflammation.Kaempferol is anotherflavonoid bearing these potentials.Aim:To evaluate neuroprotective activity of kaempferol in dyskinetic rats.Methods:PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid(10µL)+6-OHDA(12µg)in medial forebrain bundle to induce neuronal damage in substantial nigra(SNr).LID was induced by administrating combination of L-dopa(20 mg/kg)+benserazide HCl(5 mg/kg)for 42 days.Rats were concomitantly treated with amantadine(40 mg/kg)or kaempferol(25,50,and 100 mg/kg,p.o.).Results:Kaempferol(50 and 100 mg/kg)markedly(p<0.05)inhibited LID-induced abnormal involuntary movements(AIMs)and alternation in motor function.Kaempferol administration considerably(p<0.05)inhibited reduced mitochondrial complex activities,serotonin and dopamine levels,Bcl-2,and Tyrosine hydroxylase protein expressions in SNr.Additionally,kaempferol considerably(p<0.05)attenuated increased cFOS,FosB,Parkin,and Pdyn mRNAs expressions,Bax,cleaved caspase-3,caspase-3,and pJNK proteins levels;DOPAC and 5-HIAA levels in SNr.A positive correlation was reported between cFOS,FosB,Parkin,Pdyn,apoptosis,and TH with AIMs.Conclusion:Kaempferol effectively attenuated L-dopa-induced AIMs and dyskinesia via amelioration of alterations in cFOS,FosB,Parkin,Pdyn,Tyrosine hydroxylase,and apoptosis in the brain SNr.

氧化应激与cfos和cjun转录和AP－1激活

激活剂蛋白－１（ａｃｔｉｖａｔｏｒｐｒｏｔｅｉｎ－１，ＡＰ－１）是近年来受到关注的与氧化应激基因表达调控有关的转录因子．文章就氧化应激与ｃｆｏｓ和ｃｊｕｎ基因表达，ＡＰ－１的激活，ＡＰ－１对氧化应激反应的调控，ＡＰ－１与亲电子反应元件等有关内容作了简要的综述．

肺癌与转录因子cJun、cFos、AP-1

cJun、cFos、AP－1作为转录因子，与细胞的增殖与分化密切相关。在肿瘤的促癌和演进过程中起关键的调节作用。深入研究AP－1、cJun、cFos在肺癌中的表达，有助于探索肺癌的诊断和防治都有极大的进步，但效果不能令人满意，因此，进一步探索肺癌的发病机理，为肺癌的防治提供一些科学依据。

肺癌发生发展中cJun、cFos的表达

目的 :探讨肺癌发生发展过程中cJun、cFos表达水平。方法 :收集 42例人肺癌标本 ,其中 10例可观察到肺癌癌前病变组织 ,运用免疫组织化学的方法 ,研究cJun、cFos在上述组织中的表达水平。结果 :42例肺癌组织中cJun、cFos的阳性表达率分别为 83.2 %和 5 9.5 % ,其中鳞癌为 88.0 %和 5 6 .0 % ,腺癌为 6 9.2 %和 5 3.8% ,小细胞肺癌均为 10 0 .0 %。正常肺组织cJun、cFos表达阴性。在 4例癌前组织中 ,cJun表达为 75 % ;9例癌前病变组织中 ,cFos表达为 77.8%。结论 :在肺癌组织中 ,有cJun、cFos的高表达 ,同时 。

NADH regulates the expression of cFos and Npas4 through modulating NMDARs activity

The transcription and translation of the immediate-early genes(IEGs),such as Arc,Zif268,eFos and Npas4,are considered to be molecular mechanisms underlying learning and memory.Recent studies have shown that application of NADH triggered the expression of Arc and Zif268 by activation of NMDA receptor(NMDAR)signaling.In this regard,we hypothesize that levels of Npas4 and c Fos,could be modulated by NMDAR activity-dependent NADH.To test our hypothesis,in primary cultured hippocampal neurons,we employed NADH to examine the effects of NADH on IEGs.Further more,NMDARs blocker MK801 were used to investigated the role of NMDAR in NADH's effects.The data of real-time PCR revealed that application of NADH promoted the transcription of Arc,cFos and Npas4.Similarly,Western blot analyses showed that the levels of Arc,c Fos and Npas4 were increased significantly after NADH treatment.

A time domain multiple-CFOs and CIRs estimation algorithm over wireless multimedia sensor networks

Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate local oscillator and every transmitter to receiver link has individual carrier frequency offset （CFO） and channel impulse response （CIR） parameters. In order to reduce the computational complexity for MD optimization, a time domain CFOs and CIRs estimation algorithm over the OFDMA based wireless multimedia sensor networks （WMSN） is proposed in this paper. In this algorithm, the receiver station can decouple the signal from every node by correlation based on specially designed training sequences, so that the MD optimization problem is simplified to an 1-D optimal problem. It is proved that the multiple CFOs can be identified from the correlation result using the phase shift of the consecutive training se- quences. Based on the CFOs estimation result, the CIRs can then he estimated according to the minimum mean square error （MMSE） criterion. The theoretic analysis and simulation results show that the proposed algorithm can effectively decouple the signal from different user nodes and the bit error rate （BER） per- formance curves are close to the ideal estimation when the user number is not large.

E^2KF Based Joint Multiple CFOs and Channel Estimate for MIMO-OFDM Systems over High Mobility Scenarios

An enhanced extended Kalman filtering （E2KF） algorithm is proposed in this paper to cope with the joint multiple carrier frequency offsets （CFOs） and time-variant channel estimate for MIMO-OFDM systems over high mobility scenarios. It is unveiled that, the auto-regressive （AR） model not only provides an effective method to capture the dynamics of the channel parameters, which enables the prediction capability in the EKF algorithm, but also suggests an method to incorporate multiple successive pilot symbols for the improved measurement update.

CFO变更与企业财务报告质量

在现代风险导向审计模式下,审计师会关注CFO变更这一信号以识别和评估财务报表重大错报风险,但鲜有文献探究财务报告质量是否因此而下降。以2010—2020年沪深两市A股上市公司为对象,研究CFO变更对企业财务报告质量的影响。研究表明,CFO变更提高了企业应计盈余管理的程度,增加了企业报告小额盈余、进行财务重述以及被出具非标审计意见的可能性,进而导致财务报告质量显著下降;当CFO未兼任内部董事、发生外部继任或非正常变更、任职于非央企时,上述负向作用更加明显。进一步研究表明,CFO变更通过提高企业的代理成本与信息不对称程度从而降低财务报告质量,并最终使企业面临更大的融资约束。

腺病毒介导的HSV-TK/GCV系统在Cfos启动子调控下对胶质瘤细胞的杀伤作用

目的 构建人Cfos启动子调控的单纯疱疹病毒（HSV）-胸苷激酶（TK）自杀基因重组腺病毒载体,观察其介导的HSV-TK/更昔洛韦（GCV）系统对胶质瘤细胞的杀伤作用. 方法 构建重组腺病毒载体Ad-Cfos-TK-IRES-hr绿色荧光蛋白（GFP）、Ad-CMV-TK-IRES-hrGFP,转染至HEK293细胞获得重组腺病毒Ad-Cfos-TK-IRES-hrGFP、Ad-CMV-TK-IRES-hrGFP,荧光计数法检测病毒滴度;将病毒感染U251、U87细胞,荧光显微镜下观察GFP的表达.将病毒感染U251、U87细胞,24 h后加入1000、100、10、1、0.1、0.01、0μmol/L GCV作用48 h,CCK-8法检测各组细胞抑制率. 结果 成功构建重组腺病毒载体pDC315-CMV-TK-IRES-hrGFP、pDC315-CFOS-TK-IRES-hrGFP.荧光计数法检测显示2种腺病毒滴度均达1＆#215;1010 PFU/mL.在病毒感染复数（MOI）为100、GCV浓度为1、10、100、1000 μmol/L时,转染Ad-Cfos-TK-IRES-hrGFP组U251细胞抑制率分别为（24.18±6.01）％、（30.39±9.67）％、（57.07±9.29）％、（94.50±3.48）％,转染Ad-Cfos-TK-IRES-hrGFP组U87细胞细胞抑制率分别为（9.78±2.24）％、（86.33±5.06）％、（98.48±0.79）％、（98.76±0.93）％. 结论 腺病毒介导的HSV-TK/GCV系统在Cfos启动子调控下在体外可以有效杀伤胶质瘤细胞.

CFO兼任董秘、异常审计费用与审计质量

注册制的全面实施使得企业上市的门槛降低,从而倒逼独立审计质量提升,而多部门的持续监管也在改变着上市公司的治理格局。本文采用2007~2022年我国A股上市公司数据,就CFO兼任董秘这一特殊治理机制对审计质量的影响进行实证考察。研究发现:CFO兼任董秘与审计质量显著正相关,其中异常审计费用发挥了部分中介作用,同时当CFO兼董秘年龄分布、盈余管理和异常审计费用方向、代理成本等不同时,CFO兼任董秘对审计质量的影响也不同。本文丰富了公司治理和审计质量研究领域的文献,并为政策制定部门和监管部门决策提供了参考依据。

世界一流财务管理体系建设下的企业财务领导角色定位思考

世界一流财务管理体系建设对企业财务工作及财务领导人员提出了更高要求。而现实中,财务领导却有不同的称谓,扮演了不同角色,在企业治理中的作用与地位也有所不同。笼统使用“CFO”可能会误导人们对财务领导的认识。文章以2022年上市公司数据为基础,从财务领导主体职位角色和财务领导兼任角色两个维度分析了财务领导的角色现状、存在问题与治理对策,为新时代完善财务领导角色和治理功能提出了参考建议。

移动OFDM CFOs估计的步长算法实现

为了保持移动中正交频分复用（OFDM）技术子载波间的正交性,避免载波间的干扰（ICI）引起的系统性能退化,建立了载波频率偏移（CFOs）的步长估计模型,对模型的稳定性、步长参数和CFOs的估计误差等进行研究,并进行了MATLAB仿真。VHDL程序在电路板上运行的实验结果表明：在±3σ估计变化区间内,移动速度为400和800 km/h时,CFOs的误差分别近似为0.010和0.017,符合CFOs估计误差必须精确的在子载波空间1-2%范围内的衡量标准,同时程序在电路板上能够正确执行。

CFO任期与会计稳健性关系的实证研究

本文以2010~2021年沪深A股上市公司为样本,利用改进后的BASU模型:C-SCORE稳健性指数计量法,实证检验了我国主要资本市场CFO任期和会计稳健性之间的关系。研究结果表明,CFO任期与会计稳健性之间呈倒U型关系,即CFO任职初期,任期和会计稳健性之间正相关。但这种关系存在一个拐点,到达拐点之后,CFO任期越长,会计稳健性逐渐下降。本文结果显示拐点为任期3年左右,这与现有研究关于CFO最佳任期的结果相同。区分性别和学历背景,进一步分析发现,在男性和本科及其以上的组中,CFO任期和会计稳健性之间的倒U型关系更显著。文章丰富了高管背景与会计稳健性领域内的研究,并对企业未来招聘及公司治理等方面提出可能的建议。

环境不确定条件下CFO执行力强度对信息披露质量的影响研究

当前,数字化转型加快推进,企业面临的环境不确定性因素愈发凸显,企业内外环境不确定性会影响企业的经营决策,特别是财务决策。CFO作为上市公司财务报告的主要负责人,其财务的执行力强度对信息披露质量具有重要影响。文章选取沪深A股上市公司2017—2021年的数据,探讨环境不确定性条件下CFO执行力强度对信息披露质量的影响。研究结果表明,CFO执行力越强,越能积极影响信息披露质量,相比于国有企业,在非国有企业中的积极影响效果更加明显。环境不确定性越高,越会负向影响企业信息披露质量,相比于国有企业,在非国有企业中的负向影响效果更明显。进一步研究发现,增强CFO权力会削弱环境不确定性与信息披露质量的负向效果,相比于国有企业,在非国有企业中的削弱作用更明显。文章研究对于完善上市公司治理结构以及加强信息披露制度建设具有重要的现实意义。

Female CFOs and loan contracting: Financial conservatism or gender discrimination? – An empirical test based on collateral clauses

Based on signaling and gender discrimination theory, we examine whether chief financial officer(CFO) gender matters to bank–firm relationships and the designing of collateral clauses in bank loan contracting, and explore the potential path of influence. Data taken from Chinese listed companies between2009 and 2012 indicate that(1) female-CFO-led firms are less likely to obtain credit loans than male-CFO-led firms;(2) female-CFO-led borrowers are more likely to be required to provide collateral for loans than male-CFO-led borrowers; and(3) banks are more inclined to claim mortgaging collateral when lending to female-CFO-led firms and prefer to guarantee collateral when lending to male-CFO-led firms. Female-CFO-led borrowers seem to be granted more unfavorable loan terms than male-CFO-led borrowers, supporting the hypothesis that female CFOs experience credit discrimination. Further analysis reveals that regional financial development helps to alleviate lending discrimination against female CFOs. Furthermore, female CFOs in SOEs are less likely than their non-SOE counterparts to experience gender discrimination in the credit market.

CFO兼任董事的影响因素研究——基于董事会对内部财务专家需求的视角

文章基于2014—2021年我国沪深两市A股上市公司数据,从董事会对内部财务专家需求的视角,探讨了CFO兼任董事的影响因素。研究发现:公司本年融资需求越高或上年业绩表现越差,董事会对公司财务管理越重视,从而CFO兼任董事的概率越大;当董事会成员CEO缺少财务背景时,CFO兼任董事的概率将增大;公司所处行业异质性越高或竞争度越低,董事会外部财务专家的可用性越差,从而CFO兼任董事的概率越大;公司所在地金融机构越集中,董事会外部财务专家的可得性越高,从而CFO兼任董事的概率越小。

基于价值创造CFO应具有的专业视野

在实务中,财务履职情况在不同企业存在较大差异,大部分企业财务条线未能贡献应有价值。文章通过分析财务现状,试图指出财务价值创造容易被忽视的几大板块,期待引起财务总监们重视。通过扩展财务总监的专业视野,企业可提升财务的价值贡献力度,即在合法前提下,基于价值视角处理“权、钱、账、税”和设计经济合同,将核算型财务阶段提升至价值型财务阶段。

cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors

cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net.

CFO职能与胜任能力框架设计

随着经济转型的加速,CFO在财务管理中的职责和角色变得更加关键。论文从财务管理视角出发,旨在探讨我国CFO的胜任能力框架设计及其推广应用。首先,论文总结了CFO的职责定位,强调其在财务管理中的重要性;其次,从职业知识、职业技能、职业道德、商业能力4个方面分类说明CFO的胜任能力要素,并根据胜任能力要素设计CFO胜任能力框架;最后,提出对CFO胜任能力框架的推广应用建议。