目的探讨^(11)C-CFT脑多巴胺转运体显像对帕金森病(PD)进展及病情严重程度的评估价值。方法回顾性分析30例临床确诊的PD病人临床和^(11)C-CFT DAT PET显像资料,将30例PD患者按Hoehn-Yahr(H-Y)分级分为早期PD组和中晚期PD组两组,分别比...目的探讨^(11)C-CFT脑多巴胺转运体显像对帕金森病(PD)进展及病情严重程度的评估价值。方法回顾性分析30例临床确诊的PD病人临床和^(11)C-CFT DAT PET显像资料,将30例PD患者按Hoehn-Yahr(H-Y)分级分为早期PD组和中晚期PD组两组,分别比较两组组内及组间的起病侧及起病对侧尾状核、前壳核、后壳核DAT摄取指数的差异。并分析摄取指数与发病年龄、病程、H-Y分级、临床运动症状评分(UPDRSⅢ)、非运动症状评分(NMSS)、日常生活活动量表评分(ADL)的相关性。结果中晚期PD组与早期PD组比较,除起病对侧后壳核外各区域DAT摄取指数均降低。早期PD组双侧壳核比较,起病对侧DAT摄取指数减少,差异有统计学意义。其余各组起病侧及对侧比较,差异无统计学意义。纹状体内部分脑区DAT摄取指数与PD患者发病年龄、病程、H-Y分级、UPDRSⅢ呈显著负相关,均与NMSS、ADL无相关性。结论 ^(11)C-CFT PET显像能为不同严重程度PD病人分期提供影像学依据,有助于PD的病情严重程度评估。展开更多
Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders.In the present study,we investigated the ro...Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders.In the present study,we investigated the role of CFTR variations,poly-T,TG-repeats,and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province,China.A total of 72 bronchial asthma patients,68 chronic bronchitis patients,and 117 healthy subjects were included in this study.The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism(RFLP).We found that the frequency of T5-TG12-V470 in chronic bronchitis patients was 0.07%,which was notably higher than that in healthy subjects(0.01%) and bronchial asthma patients(0.04%).Thus,the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions,such as chronic bronchitis.展开更多
文摘目的探讨^(11)C-CFT脑多巴胺转运体显像对帕金森病(PD)进展及病情严重程度的评估价值。方法回顾性分析30例临床确诊的PD病人临床和^(11)C-CFT DAT PET显像资料,将30例PD患者按Hoehn-Yahr(H-Y)分级分为早期PD组和中晚期PD组两组,分别比较两组组内及组间的起病侧及起病对侧尾状核、前壳核、后壳核DAT摄取指数的差异。并分析摄取指数与发病年龄、病程、H-Y分级、临床运动症状评分(UPDRSⅢ)、非运动症状评分(NMSS)、日常生活活动量表评分(ADL)的相关性。结果中晚期PD组与早期PD组比较,除起病对侧后壳核外各区域DAT摄取指数均降低。早期PD组双侧壳核比较,起病对侧DAT摄取指数减少,差异有统计学意义。其余各组起病侧及对侧比较,差异无统计学意义。纹状体内部分脑区DAT摄取指数与PD患者发病年龄、病程、H-Y分级、UPDRSⅢ呈显著负相关,均与NMSS、ADL无相关性。结论 ^(11)C-CFT PET显像能为不同严重程度PD病人分期提供影像学依据,有助于PD的病情严重程度评估。
基金supported by the Key Talent's Subsidy Project in Science and Education of the Jiangsu Province (No. 2007158)
文摘Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders.In the present study,we investigated the role of CFTR variations,poly-T,TG-repeats,and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province,China.A total of 72 bronchial asthma patients,68 chronic bronchitis patients,and 117 healthy subjects were included in this study.The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism(RFLP).We found that the frequency of T5-TG12-V470 in chronic bronchitis patients was 0.07%,which was notably higher than that in healthy subjects(0.01%) and bronchial asthma patients(0.04%).Thus,the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions,such as chronic bronchitis.
