High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic performance.Herein,we investigated the transposed Paternò-B...High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic performance.Herein,we investigated the transposed Paternò-Büchi reaction of biomass cyclic ketone and cyclic alkene to synthesize a new kind of alkyl-substituted polycyclic hydrocarbon fuel with high energy density and good cryogenic performance.The triplet-energy-quenching results and phosphorescent emission spectra reveal the sensitization mechanism of the reaction,including photosensitizer excitation,triplettriplet energy transfer,cyclization,and relaxation,and the possible reaction path was revealed by the density functional theory(DFT)calculations.The reaction conditions of photosensitizer type and addition,molar ratio of substrates,reaction temperature,and incident light intensity were optimized,with the target product yield achieving 65.5%.Moreover,the reaction dynamics of the reaction rate versus the light intensity are established.After the hydrogenation-deoxygenation reaction,three fuels with a high density of 0.864-0.938 g·ml^(-1) and a low freezing point of<-55℃ are obtained.This work provides a benign and effective approach to synthesize high-performance fuels.展开更多
Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionna...Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionnaire on exercise compliance for patients with Parkinson’s disease was developed, and its reliability and validity were tested. Then, a survey was conducted to investigate the current status of exercise compliance among Parkinson’s disease patients, including general information, scoring status, and single and multiple factor analyses of influencing factors [1]. The results of the study show that through qualitative research, the dimensions and item pools of the questionnaire were initially constructed, and the reliability analysis of the questionnaire was conducted through Delphi expert consultation, with favorable results in terms of its reliability and validity [2]. Regarding the current status of exercise compliance among Parkinson’s disease patients, the study found that the level of exercise compliance needs improvement, and there are significant differences in exercise compliance levels among patients under different circumstances. Finally, the research results were discussed and conclusions were drawn. The innovation of this study lies in the development of a questionnaire on exercise compliance for patients with Parkinson’s disease and the preliminary qualitative research and Delphi expert consultation conducted on it, providing new ideas and methods for the study of exercise compliance. However, the study also has limitations as it did not examine the effects of other interventions on Parkinson’s disease, so further research should be conducted [3].展开更多
Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health benefits.The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing.This editor...Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health benefits.The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing.This editorial aims to provide a concise summary of the current state of evidence for Tai Chi's effects on individuals with type 2 diabetes(T2D).The review includes 3 randomized controlled trials(RCTs)and 5 systematic reviews and meta-analyses,all of which investigate the effectiveness of Tai Chi on various health outcomes in individuals with T2D.Tai Chi demonstrates a significant effect to enhance glycemic control,lower blood pressure,improve serum lipid profiles,reduce insulin resistance,positively influence obesity-related indices,and improve overall quality of life in individuals with T2D.However,it is noteworthy that recent RCTs have reported inconsistent findings regarding the effects of Tai Chi on glycemic control and insulin resistance.The author also delves into potential mechanisms by which Tai Chi may exert its influence on the human body.Finally,the editorial highlights the critical issues that warrant further exploration in the future.展开更多
目的:观察川黄方治疗3~4期慢性肾脏病(CKD)患者的临床疗效,及对急性肾损伤(AKI)标志物尿L-FABP、CHI3L1的影响。方法:将3~4期CKD患者92例,按照1∶1的比例随机分到治疗组或对照组,即每组46例。对照组给予内科基础治疗;治疗组在对照组基...目的:观察川黄方治疗3~4期慢性肾脏病(CKD)患者的临床疗效,及对急性肾损伤(AKI)标志物尿L-FABP、CHI3L1的影响。方法:将3~4期CKD患者92例,按照1∶1的比例随机分到治疗组或对照组,即每组46例。对照组给予内科基础治疗;治疗组在对照组基础上加服川黄方。疗程为12周。进行临床疗效评价,并观察中医证候积分变化。检测治疗前后肾功能(Scr、BUN、UA、eGFR),24 h U-pro,尿L-FABP、尿CHI3L1变化。结果:(1)治疗组总有效率为73.9%,对照组43.5%,治疗组高于对照组(P<0.05)。(2)用药后,两组患者肾Scr、BUN、UA均有一定程度的降低,eGFR均有一定程度的升高,肾功能得到了改善。治疗组更明显(P<0.01)。两组患者UA差异无统计学意义(P>0.05)。(3)治疗后两组患者24 h U-pro均有降低,治疗组更显著(P<0.01)。(4)两组患者尿L-FABP、CHI3L1治疗前后比较,差异均有统计学意义(P<0.01)。治疗组降低更明显。(5)治疗后,两组患者中医证候积分均显著降低(P<0.01),说明两种治疗方法均有利于改善患者临床症状。结论:川黄方联合内科基础治疗的临床疗效优于单纯内科基础治疗,能更好地促进3~4期CKD患者肾功能恢复、延缓CKD进展,并能显著降低患者尿L-FABP和尿CHI3L1。展开更多
Objective:To assess the quality of systematic reviews assessing the effects of traditional Chinese exercises on controlling blood indices,anthropometric indices,psychological indices,and quality of life in patients wi...Objective:To assess the quality of systematic reviews assessing the effects of traditional Chinese exercises on controlling blood indices,anthropometric indices,psychological indices,and quality of life in patients with diabetes.Methods:Systematic studies/meta-analyses of intervention with traditional Chinese exercises on diabetes mellitus were searched in the Pub Med,Web of Science,the China National Knowledge Infrastructure Databases(CNKI),Wan Fang Database,and Chinese Scientific Journal Database(VIP).Two researchers independently screened the studies and extracted the data.The methodology and quality of evidence of the included studies were assessed using A Measurement Tool to Assess Systematic Reviews2(AMSTAR-2)and Grading of Recommendations Assessment,Development and Evaluation(GRADE)criteria,respectively.Results:A total of 32 systematic reviews/meta-analyses were included in the present study.Of them,the methodological quality of 4 studies was graded as low,while that of the other 28 was graded as extremely low.The most common quality flaws in key items included a lack of preliminary proposals for systematic reviews,failure to explain the reasons for the inclusion criteria,failure to provide a list of excluded studies and reasons for exclusion,failure to report potential conflicts of interest,and inadequate assessment of publication bias.The quality of evidence for most of the 18 outcomes was subsequently graded as medium or low.Overall,the results of these studies indicated that Tai Chi,health qigong,and other traditional Chinese exercises lowered fasting blood glucose(FBG),2-h postprandial blood glucose(2hPBG),hemoglobin A_(1c)(HbA_(1c)),and body mass index,and relieved anxiety and depression in patients with diabetes.Conclusion:Our findings indicate that the methodological quality of systematic reviews related to traditional Chinese exercises in the diabetic population is generally low,and the quality of evidence is also relatively poor.Therefore,we suggest that the quality of systematic reviews and meta-analyses on traditional Chinese exercises for controlling diabetes mellitus needs to be improved.In the future,researchers should conduct higher-quality clinical studies with reference to the AMSTAR2 checklist and GRADE system.展开更多
Chi Zijian’s novel White Snow Crow is about the pestis in Northeast China from the autumn and winter of 1910 to the spring of 1911,focusing on the living conditions of people in Fujiadian,Harbin,under the shadow of t...Chi Zijian’s novel White Snow Crow is about the pestis in Northeast China from the autumn and winter of 1910 to the spring of 1911,focusing on the living conditions of people in Fujiadian,Harbin,under the shadow of the pestis,and thus connects the vicissitudes of Harbin in the development of modern Chinese history.Re-reading this novel in the context of the post-epidemic era not only allows us to immerse ourselves in the specific temporal and spatial fields described in the text with an immersive reading mindset,feel the heavy impact that the disaster has brought to the people of Northeast China,but also provide us with a different perspective to observe the current social reality.In particular,the social problems shown by the novel through the pestis and the description of ordinary people’s life experience under the plague still deserve further discussion.展开更多
基金support from National Key Research and Development Program of China(2021YFC2103704)the National Natural Science Foundation of China(22222808,21978200)the Haihe Laboratory of Sustainable Chemical Transformations.
文摘High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic performance.Herein,we investigated the transposed Paternò-Büchi reaction of biomass cyclic ketone and cyclic alkene to synthesize a new kind of alkyl-substituted polycyclic hydrocarbon fuel with high energy density and good cryogenic performance.The triplet-energy-quenching results and phosphorescent emission spectra reveal the sensitization mechanism of the reaction,including photosensitizer excitation,triplettriplet energy transfer,cyclization,and relaxation,and the possible reaction path was revealed by the density functional theory(DFT)calculations.The reaction conditions of photosensitizer type and addition,molar ratio of substrates,reaction temperature,and incident light intensity were optimized,with the target product yield achieving 65.5%.Moreover,the reaction dynamics of the reaction rate versus the light intensity are established.After the hydrogenation-deoxygenation reaction,three fuels with a high density of 0.864-0.938 g·ml^(-1) and a low freezing point of<-55℃ are obtained.This work provides a benign and effective approach to synthesize high-performance fuels.
文摘Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionnaire on exercise compliance for patients with Parkinson’s disease was developed, and its reliability and validity were tested. Then, a survey was conducted to investigate the current status of exercise compliance among Parkinson’s disease patients, including general information, scoring status, and single and multiple factor analyses of influencing factors [1]. The results of the study show that through qualitative research, the dimensions and item pools of the questionnaire were initially constructed, and the reliability analysis of the questionnaire was conducted through Delphi expert consultation, with favorable results in terms of its reliability and validity [2]. Regarding the current status of exercise compliance among Parkinson’s disease patients, the study found that the level of exercise compliance needs improvement, and there are significant differences in exercise compliance levels among patients under different circumstances. Finally, the research results were discussed and conclusions were drawn. The innovation of this study lies in the development of a questionnaire on exercise compliance for patients with Parkinson’s disease and the preliminary qualitative research and Delphi expert consultation conducted on it, providing new ideas and methods for the study of exercise compliance. However, the study also has limitations as it did not examine the effects of other interventions on Parkinson’s disease, so further research should be conducted [3].
文摘Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health benefits.The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing.This editorial aims to provide a concise summary of the current state of evidence for Tai Chi's effects on individuals with type 2 diabetes(T2D).The review includes 3 randomized controlled trials(RCTs)and 5 systematic reviews and meta-analyses,all of which investigate the effectiveness of Tai Chi on various health outcomes in individuals with T2D.Tai Chi demonstrates a significant effect to enhance glycemic control,lower blood pressure,improve serum lipid profiles,reduce insulin resistance,positively influence obesity-related indices,and improve overall quality of life in individuals with T2D.However,it is noteworthy that recent RCTs have reported inconsistent findings regarding the effects of Tai Chi on glycemic control and insulin resistance.The author also delves into potential mechanisms by which Tai Chi may exert its influence on the human body.Finally,the editorial highlights the critical issues that warrant further exploration in the future.
文摘目的:观察川黄方治疗3~4期慢性肾脏病(CKD)患者的临床疗效,及对急性肾损伤(AKI)标志物尿L-FABP、CHI3L1的影响。方法:将3~4期CKD患者92例,按照1∶1的比例随机分到治疗组或对照组,即每组46例。对照组给予内科基础治疗;治疗组在对照组基础上加服川黄方。疗程为12周。进行临床疗效评价,并观察中医证候积分变化。检测治疗前后肾功能(Scr、BUN、UA、eGFR),24 h U-pro,尿L-FABP、尿CHI3L1变化。结果:(1)治疗组总有效率为73.9%,对照组43.5%,治疗组高于对照组(P<0.05)。(2)用药后,两组患者肾Scr、BUN、UA均有一定程度的降低,eGFR均有一定程度的升高,肾功能得到了改善。治疗组更明显(P<0.01)。两组患者UA差异无统计学意义(P>0.05)。(3)治疗后两组患者24 h U-pro均有降低,治疗组更显著(P<0.01)。(4)两组患者尿L-FABP、CHI3L1治疗前后比较,差异均有统计学意义(P<0.01)。治疗组降低更明显。(5)治疗后,两组患者中医证候积分均显著降低(P<0.01),说明两种治疗方法均有利于改善患者临床症状。结论:川黄方联合内科基础治疗的临床疗效优于单纯内科基础治疗,能更好地促进3~4期CKD患者肾功能恢复、延缓CKD进展,并能显著降低患者尿L-FABP和尿CHI3L1。
基金supported by the Fundamental Research Funds for the Central Universities(2022-JYB-JBZR-026)the National Natural Science Foundation of China(81873211)。
文摘Objective:To assess the quality of systematic reviews assessing the effects of traditional Chinese exercises on controlling blood indices,anthropometric indices,psychological indices,and quality of life in patients with diabetes.Methods:Systematic studies/meta-analyses of intervention with traditional Chinese exercises on diabetes mellitus were searched in the Pub Med,Web of Science,the China National Knowledge Infrastructure Databases(CNKI),Wan Fang Database,and Chinese Scientific Journal Database(VIP).Two researchers independently screened the studies and extracted the data.The methodology and quality of evidence of the included studies were assessed using A Measurement Tool to Assess Systematic Reviews2(AMSTAR-2)and Grading of Recommendations Assessment,Development and Evaluation(GRADE)criteria,respectively.Results:A total of 32 systematic reviews/meta-analyses were included in the present study.Of them,the methodological quality of 4 studies was graded as low,while that of the other 28 was graded as extremely low.The most common quality flaws in key items included a lack of preliminary proposals for systematic reviews,failure to explain the reasons for the inclusion criteria,failure to provide a list of excluded studies and reasons for exclusion,failure to report potential conflicts of interest,and inadequate assessment of publication bias.The quality of evidence for most of the 18 outcomes was subsequently graded as medium or low.Overall,the results of these studies indicated that Tai Chi,health qigong,and other traditional Chinese exercises lowered fasting blood glucose(FBG),2-h postprandial blood glucose(2hPBG),hemoglobin A_(1c)(HbA_(1c)),and body mass index,and relieved anxiety and depression in patients with diabetes.Conclusion:Our findings indicate that the methodological quality of systematic reviews related to traditional Chinese exercises in the diabetic population is generally low,and the quality of evidence is also relatively poor.Therefore,we suggest that the quality of systematic reviews and meta-analyses on traditional Chinese exercises for controlling diabetes mellitus needs to be improved.In the future,researchers should conduct higher-quality clinical studies with reference to the AMSTAR2 checklist and GRADE system.
文摘Chi Zijian’s novel White Snow Crow is about the pestis in Northeast China from the autumn and winter of 1910 to the spring of 1911,focusing on the living conditions of people in Fujiadian,Harbin,under the shadow of the pestis,and thus connects the vicissitudes of Harbin in the development of modern Chinese history.Re-reading this novel in the context of the post-epidemic era not only allows us to immerse ourselves in the specific temporal and spatial fields described in the text with an immersive reading mindset,feel the heavy impact that the disaster has brought to the people of Northeast China,but also provide us with a different perspective to observe the current social reality.In particular,the social problems shown by the novel through the pestis and the description of ordinary people’s life experience under the plague still deserve further discussion.
