CHRYSANTHEME (1)

Après un hiver rigoureux, la terre commena  se réveiller. Le vent printanier soufflait sur les papiers brlés, devant les tombeaux du cimetière couverts de fleurs de chrysanthème flétries. A la tombée de la nuit, des lumières phosphoriques apparaissaient irrégulièrement au bord du Fleuve Jaune, berceau de la civilisation humaine.“Papa, dépêche-toi, le repas est déj refroidi.” Une voix douce et claire frappa le tympan de Vieux Li. Il termina sa prière devant le portrait de ses ancêtres et celui de sa femme, tourna la tête vers sa fille bien-aimée, et répondit :“Oui, oui, on va manger tout de suite.”Avec sa paire de baguettes en bambou, Vieux Li pina un gros morceau de viande pour le mettre dans le bol de sa fille. Il la regardait affectueusement. “Chrysanthème, tu as déj vingt ans. Il faut que tu trouves un homme. Il y a pas mal de garons qui demandent ta main. Tu ne dois pas être trop exigeante. Ta maman nous a quittés prématurément. Avant sa mort, elle m’a demandé de bien t’élever. Elle espérait que tu te marierais le plus tt possible pour nous donner un descendant.

Synthesis and Insecticidal Activity of Novel Camptothecin Derivatives Containing Analogs of Chrysanthemic Acid Moieties

Creating high-efifcient and environment-friendly pesticides is very important to produce the pollution free agriculture food and maintain the balance of the survival environmental of the human being. According to reports, camptothecin （CPT） and its derivatives are now being explored as a class of botanical insecticide in agriculture due to its novel mode of action. In order to improve the insecticidal activity of CPT, ten novel camptothecin （1） and 10-hydroxycamptothecin （2） derivatives （1a, 1b, 1c, 1d, 1e;2a, 2b, 2c, 2d, 2e） were designed and synthesized via esteriifcation with analogs of chrysanthemic acid, which have outstanding insecticidal activity. The results showed that compound 2a exhibited potent antifeeding effect and the best contact toxicity among the target compounds against the third-instar larvae of beet armyworm, Spodoptera exigua H＆#252;bner. Compound 2a was also found to be the most effective cytotoxic compound to the tested insect cell lines, IOZCAS-Spex-II, which were established from the fat bodies of S. exigua. It was proposed that the 10-hydroxyl group in the camptothecin derivatives is a key factor for the antifeeding activity of a compound. The nature of the substituents was considered the major factor in determining the insecticidal activity of these compounds.

Synthesis of Optically Active trans-2-Aminocyclopropane-carboxylic Esters

Two new optically active trans-2-atrfinocyclopropanecarboxylic esters （β-ACCs） of optical purity 91%-96% were concisely synthesized via ozonization, oxidation, Curtius rearrangement from commercial available optically active trans-chrysanthemate in total yield 36%.

SYNTHESIS OF CHIRAL MIXED-LICAND COMPLEXES AND THEIR USE IN ASYMMETRIC SYNTHESIS OF CHRYSANTHEMIC ACID

Several chiral mixed-ligand complexes have been synthesized and their efficiency as catalysts for the asymmetric synthesis of chrysanthemic acid tested.