肿瘤凋亡抑制因子IAP(Inhibitor of apoptosis protein)蛋白参与细胞凋亡、细胞内信号传导、细胞周期多种细胞功能。IAP家族有8个成员,cIAP-1是其中的重要成员之一,其主要功能是介导肿瘤坏死因子受体家族以发挥凋亡抑制作用以及通过直...肿瘤凋亡抑制因子IAP(Inhibitor of apoptosis protein)蛋白参与细胞凋亡、细胞内信号传导、细胞周期多种细胞功能。IAP家族有8个成员,cIAP-1是其中的重要成员之一,其主要功能是介导肿瘤坏死因子受体家族以发挥凋亡抑制作用以及通过直接结合于caspas-3和caspase-7,降解其凋亡作用的内源性细胞凋亡作用。近年来笔者对食道癌、宫颈癌、头颈部癌、舌鳞状细胞癌cIAP-1(Cellular inhibitor of apop-tosis protein 1)表达进行了相关报道,现将cIAP-1研究进展予以综述。展开更多
Objective: To investigate whether several years after the diagnosis chronic idiopathic axonal polyneuropathy (CIAP), the cause of the neuropathy is still idiopathic. Methods: All outpatients were included in this stud...Objective: To investigate whether several years after the diagnosis chronic idiopathic axonal polyneuropathy (CIAP), the cause of the neuropathy is still idiopathic. Methods: All outpatients were included in this study in which, between 1993- 2000, with the same guideline for chronic neuropathy, the diagnosis CIAP wasmade. We checked whether the patients had been evaluated according to this guideline. We evaluated the clinical course in all patients and repeated questions on the family history. We also re- examined these patients. After recording these data, we decided whether or not the neuropathy remained idiopathic. Results A total of 478 outpatients had been evaluated, of these 53 were diagnosed as CIAP. Of these the diagnosis remained CIAP in 27 (51% ) patients. In 19 (36% ) of the patients a wrong diagnosis was made, explained by not following the diagnostic guideline, and by not recognising hereditary neuropathies. Conclusion: In half of the patients with the diagnosis CIAP, this diagnosis was changed after revision, including the family history of neuropathies. Therefore, in patients with the diagnosis CIAP, this diagnosis should be reconsidered. In addition the question should be whether the hereditary neuropathies have been excluded.展开更多
文摘肿瘤凋亡抑制因子IAP(Inhibitor of apoptosis protein)蛋白参与细胞凋亡、细胞内信号传导、细胞周期多种细胞功能。IAP家族有8个成员,cIAP-1是其中的重要成员之一,其主要功能是介导肿瘤坏死因子受体家族以发挥凋亡抑制作用以及通过直接结合于caspas-3和caspase-7,降解其凋亡作用的内源性细胞凋亡作用。近年来笔者对食道癌、宫颈癌、头颈部癌、舌鳞状细胞癌cIAP-1(Cellular inhibitor of apop-tosis protein 1)表达进行了相关报道,现将cIAP-1研究进展予以综述。
文摘Objective: To investigate whether several years after the diagnosis chronic idiopathic axonal polyneuropathy (CIAP), the cause of the neuropathy is still idiopathic. Methods: All outpatients were included in this study in which, between 1993- 2000, with the same guideline for chronic neuropathy, the diagnosis CIAP wasmade. We checked whether the patients had been evaluated according to this guideline. We evaluated the clinical course in all patients and repeated questions on the family history. We also re- examined these patients. After recording these data, we decided whether or not the neuropathy remained idiopathic. Results A total of 478 outpatients had been evaluated, of these 53 were diagnosed as CIAP. Of these the diagnosis remained CIAP in 27 (51% ) patients. In 19 (36% ) of the patients a wrong diagnosis was made, explained by not following the diagnostic guideline, and by not recognising hereditary neuropathies. Conclusion: In half of the patients with the diagnosis CIAP, this diagnosis was changed after revision, including the family history of neuropathies. Therefore, in patients with the diagnosis CIAP, this diagnosis should be reconsidered. In addition the question should be whether the hereditary neuropathies have been excluded.
