Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that cita...Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.展开更多
Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Pe...Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such disorders.Objective: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious distress.Design, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h;patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 h.Main outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two groups.Results: Fifty-six participants with MDD and anxious distress were randomly assigned to two groups.Mean depression scores significantly decreased in citalopram and herbal groups at weeks three and six(time effect: P < 0.001), although the observed changes were not significantly different between the groups(intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three(P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group(intervention effect: P = 0.007).Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious distress.Trial registration number: IRCT2016102430459 N1 on Iranian Registry of Clinical Trials.展开更多
目的系统评价西酞普兰联合重复经颅磁刺激治疗脑卒中后抑郁的疗效及安全性。方法计算机检索Cochrane图书馆、PubMed、Web of Science、Embase、中国知网、万方数据服务平台、维普网、中国生物医学文献服务系统(SinoMed)等数据库,检索时...目的系统评价西酞普兰联合重复经颅磁刺激治疗脑卒中后抑郁的疗效及安全性。方法计算机检索Cochrane图书馆、PubMed、Web of Science、Embase、中国知网、万方数据服务平台、维普网、中国生物医学文献服务系统(SinoMed)等数据库,检索时限为自建库至2022年9月,检索西酞普兰联合重复经颅磁刺激治疗脑卒中后抑郁的随机对照试验。根据纳入和排除标准筛选出符合要求的随机对照研究,通过RevMan 5.4软件对结果进行系统分析。结果共纳入9篇文献,共729例患者。Meta分析结果显示,试验组患者汉密尔顿抑郁量表评分显著低于对照组(MD=-3.31,95%CI:-4.37~-2.25,P<0.001),试验组NIHSS评分显著低于对照组(MD=-1.96,95%CI:-2.73~-1.19,P<0.001),试验组Barthel指数显著高于对照组(MD=15.95,95%CI:6.14~25.76,P<0.001),试验组患者抑郁缓解有效率显著高于对照组(OR=2.69,95%CI:1.61~4.49,P<0.001)。两组用药后不良反应发生率比较,差异无统计学意义(RR=1.67,95%CI:0.54~5.14,P=0.37)。结论西酞普兰联合重复经颅磁刺激可改善脑卒中后抑郁的抑郁症状、神经功能、日常生活能力,不良反应相当。展开更多
基金funded by the Research Center for Science and Technology in Medicine(RCSTiM),Tehran University of Medical Sciences,Tehran(TUMS),Tehran,Iran
文摘Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.
基金a part of a PhD thesis by Dr. Toktam Sadat Firoozeei,supported by Tehran University of Medical Sciences,in order to fulfil the requirements of a PhD degree in Persian medicine。
文摘Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such disorders.Objective: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious distress.Design, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h;patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 h.Main outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two groups.Results: Fifty-six participants with MDD and anxious distress were randomly assigned to two groups.Mean depression scores significantly decreased in citalopram and herbal groups at weeks three and six(time effect: P < 0.001), although the observed changes were not significantly different between the groups(intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three(P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group(intervention effect: P = 0.007).Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious distress.Trial registration number: IRCT2016102430459 N1 on Iranian Registry of Clinical Trials.
文摘目的系统评价西酞普兰联合重复经颅磁刺激治疗脑卒中后抑郁的疗效及安全性。方法计算机检索Cochrane图书馆、PubMed、Web of Science、Embase、中国知网、万方数据服务平台、维普网、中国生物医学文献服务系统(SinoMed)等数据库,检索时限为自建库至2022年9月,检索西酞普兰联合重复经颅磁刺激治疗脑卒中后抑郁的随机对照试验。根据纳入和排除标准筛选出符合要求的随机对照研究,通过RevMan 5.4软件对结果进行系统分析。结果共纳入9篇文献,共729例患者。Meta分析结果显示,试验组患者汉密尔顿抑郁量表评分显著低于对照组(MD=-3.31,95%CI:-4.37~-2.25,P<0.001),试验组NIHSS评分显著低于对照组(MD=-1.96,95%CI:-2.73~-1.19,P<0.001),试验组Barthel指数显著高于对照组(MD=15.95,95%CI:6.14~25.76,P<0.001),试验组患者抑郁缓解有效率显著高于对照组(OR=2.69,95%CI:1.61~4.49,P<0.001)。两组用药后不良反应发生率比较,差异无统计学意义(RR=1.67,95%CI:0.54~5.14,P=0.37)。结论西酞普兰联合重复经颅磁刺激可改善脑卒中后抑郁的抑郁症状、神经功能、日常生活能力,不良反应相当。
