Nowadays,incorporating cooperative groups and group activities are very common in oral English classroom.By using group dy namics teachers can provide students with large blocks of time for authentic communication,whi...Nowadays,incorporating cooperative groups and group activities are very common in oral English classroom.By using group dy namics teachers can provide students with large blocks of time for authentic communication,while keeping the class focused in English.This paper discusses the importance of group dynamics in the oral English classroom and gives teachers some ideas about group dynamics in language classrooms.展开更多
AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was c...AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation Kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time PCR.RESULTS: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAK-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral proteins.CONCLUSION: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.展开更多
Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollu...Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollution emergencies:by pollutant type,it falls into organic pollution emergencies and inorganic pollution emergencies;by the approach of entering agricultural environment,it falls into water resource agricultural environmental pollution emergencies and non-water resource agricultural environmental pollution emergencies.Hazards of agricultural environmental pollution emergencies are analyzed from 4 perspectives:personal security,indirect loss,ecological environment and social stability.In view of the hazards,countermeasures are given to deal with the pollution emergencies as(i)establishing a risk evaluation mechanism for agricultural environment;(ii)enhancing the capacity of handling agricultural environmental pollution emergencies;(iii)introducing new management concepts for environmental emergencies,and cultivating keen emergency management consciousness.展开更多
Dialogue is frequently employed as role-play in the classroom activities.Students are encouraged to practice speaking skill in the context of a certain conversation.Conversation tasks in listening exercises also attra...Dialogue is frequently employed as role-play in the classroom activities.Students are encouraged to practice speaking skill in the context of a certain conversation.Conversation tasks in listening exercises also attract various interests in English lessons.This essay aims to analyze the functions of dialogues,followed with the discussion on how to apply the proper dialogues into English classroom,and ending up with the suggestions of some possible activities adopted in English language class.A dialogue cited from Dellar and Walkley(2003,p.125)is used as a sample to interpret in detail.展开更多
After the 21st century,high school history learning will focus on teachers promoting the twelve-year state education.In recent years,in line with the changes in the new 108-year social curriculum,supporting strategies...After the 21st century,high school history learning will focus on teachers promoting the twelve-year state education.In recent years,in line with the changes in the new 108-year social curriculum,supporting strategies have been proposed:such as literacy orientation,inquiry and practice,learning process archives,and the structural direction of the controversial Chinese history into East Asian history.Historical learning has indeed had a great impact on the people’s national spiritual education and the development of historical consciousness in Taiwan’s education policy.This is the reason Taiwan’s Ministry of Education strives to improve students’historical literacy and connotation application abilities.When developing a learning policy,both external and internal learning factors need to be considered.The external aspect deals with the reasons for learning:Is learning for the purpose of using or accumulating historical wisdom in daily life to learn from the past and the present,on the other hand,to test the content of the course and the degree of absorption;or is it specifically for exams or other enlightenment purposes.The internal aspect involves those most affected by the policy:students and teachers.After studying and observing high school history learning policies for decades,some alternative future visions for history learning were found in the method of reflection on future research-the conclusion is that history is interestingly revitalized,and the preferred future is thematic history.According to the famous futurology scholar Sohail Inayatuallah’s proposal:the causal layering model.It helps understand how Taiwan’s historical policies operate.And how teachers and students on the front line respond to changes and take future actions.The key is to change the future:in the process of building an alternative future,whether the internal and external mix has changed or whether you want to try new things and expand your horizons.In fact,the difficulty of teaching lies in students’cooperation and conscious learning.Therefore,in the analysis of learning through alternative futures,is it possible to distinguish between internal and external situations and methods such as:1.Internal:Is education centered on teachers?Or is it student-centered?2.External:Does the Ministry of Education prioritize testing,or encourage teachers to adopt interactive communication and integrate education into the curriculum?Therefore,what is the function and inspiration of studying high school history and life?If thematic history teaching is used:teachers can use thematic learning methods to help students focus on causal relationships,the causes of turning points,or the evolution process of the beginning and end of events.This is more advantageous for testing based on the application topic,and it is easy to test how much understanding and understanding of history?Has an activating effect.By studying history in high school,using the“CLA(Causal layered analysis)”method of future studies,you can enter the stage of worldview exploration with the goal of improving professional depth and emotional level,and use it in your own understanding and utilization of history.Based on research,some insights into the prospects and thinking of learning history in high schools are provided:1.Facing the impact of declining birthrate,Taiwan needs a macro perspective to improve its future competitiveness and look forward to a new perspective on world history,using futuristic cause-and-effect level analysis to combine world changes with daily life applications.2.The study of history in high schools should go into a systematic construction:understand its cause-and-effect relationships and global trends,so teachers play a professional and future role in controlling the use of new information and technology.3.In the future,humans may develop more“intelligent”needs.As a reference from history or to explore the preferred path for the future,there will also be a greater need to innovate and meet challenges.4.Studying high school history has entered the professional field.Through self-exploration,it can be transformed into life affairs and establish the concept and value of lifelong learning.5.In studying the“history of high school learning”,have new prospects for the future of education.Through professional knowledge such as“trend theory and causal hierarchy analysis”of futurology,pursue new horizons and visions,making future education full of hope and possibility.展开更多
This study examines the impact of the digital revolution on the job quality of workers with a specific focus on those at the lowest end of the spectrum in China's domestic labor market. Leveraging exogenous timing...This study examines the impact of the digital revolution on the job quality of workers with a specific focus on those at the lowest end of the spectrum in China's domestic labor market. Leveraging exogenous timing variations that result from the implementation of the Broadband China Program across different cities, it provides quasi-experimental evidence concerning the effects of the digital revolution on the job quality of lower class workers, particularly rural–urban migrant workers. Using data from China Migrants Dynamic Survey, this study reveals that migrants' comprehensive job quality index increased by 0.0138 (5.33 percent), and its component indices experienced positive effects after the Broadband China Program was implemented. This study also investigates heterogeneous policy treatment effects among workers with diverse demographic and occupational characteristics. Underlying mechanisms are considered, including positive macroeconomic shocks, increased social interactions, and Internet use. In particular, migrants' attitudes toward local settlement became more positive, suggesting that the positive effects of the digital revolution on livelihood lasted for some time. Taking China as an example, this study contributes valuable empirical evidence of how the digital revolution can affect lower class workers' employment or living conditions in a developing country. Related policy implications are also considered.展开更多
文摘Nowadays,incorporating cooperative groups and group activities are very common in oral English classroom.By using group dy namics teachers can provide students with large blocks of time for authentic communication,while keeping the class focused in English.This paper discusses the importance of group dynamics in the oral English classroom and gives teachers some ideas about group dynamics in language classrooms.
基金Supported by Council of Scientific and Industrial Research,No.27(0262)12/EMR-II
文摘AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation Kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time PCR.RESULTS: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAK-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral proteins.CONCLUSION: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.
基金Supported by Humanities and Social Science Fund of Henan Provincial Department of Education(2013-QN-027)Doctoral Fund of Henan Polytechnic University(B2012-008)
文摘Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollution emergencies:by pollutant type,it falls into organic pollution emergencies and inorganic pollution emergencies;by the approach of entering agricultural environment,it falls into water resource agricultural environmental pollution emergencies and non-water resource agricultural environmental pollution emergencies.Hazards of agricultural environmental pollution emergencies are analyzed from 4 perspectives:personal security,indirect loss,ecological environment and social stability.In view of the hazards,countermeasures are given to deal with the pollution emergencies as(i)establishing a risk evaluation mechanism for agricultural environment;(ii)enhancing the capacity of handling agricultural environmental pollution emergencies;(iii)introducing new management concepts for environmental emergencies,and cultivating keen emergency management consciousness.
文摘Dialogue is frequently employed as role-play in the classroom activities.Students are encouraged to practice speaking skill in the context of a certain conversation.Conversation tasks in listening exercises also attract various interests in English lessons.This essay aims to analyze the functions of dialogues,followed with the discussion on how to apply the proper dialogues into English classroom,and ending up with the suggestions of some possible activities adopted in English language class.A dialogue cited from Dellar and Walkley(2003,p.125)is used as a sample to interpret in detail.
文摘我国企业在信息化进程中 ,成功实施的信息系统相对较少 ,多数系统以失败告终 ,其中缺乏一种比较系统全面的战略思想是重要原因。文章详细介绍了 CAL S的产生、发展及应用现状 ,并就其在信息化进程中的重要作用进行了分析 ,指出应该把 CAL S放到国防信息化和国民经济信息化的战略地位 ,刻不容缓地启动 CA LS工程。
文摘After the 21st century,high school history learning will focus on teachers promoting the twelve-year state education.In recent years,in line with the changes in the new 108-year social curriculum,supporting strategies have been proposed:such as literacy orientation,inquiry and practice,learning process archives,and the structural direction of the controversial Chinese history into East Asian history.Historical learning has indeed had a great impact on the people’s national spiritual education and the development of historical consciousness in Taiwan’s education policy.This is the reason Taiwan’s Ministry of Education strives to improve students’historical literacy and connotation application abilities.When developing a learning policy,both external and internal learning factors need to be considered.The external aspect deals with the reasons for learning:Is learning for the purpose of using or accumulating historical wisdom in daily life to learn from the past and the present,on the other hand,to test the content of the course and the degree of absorption;or is it specifically for exams or other enlightenment purposes.The internal aspect involves those most affected by the policy:students and teachers.After studying and observing high school history learning policies for decades,some alternative future visions for history learning were found in the method of reflection on future research-the conclusion is that history is interestingly revitalized,and the preferred future is thematic history.According to the famous futurology scholar Sohail Inayatuallah’s proposal:the causal layering model.It helps understand how Taiwan’s historical policies operate.And how teachers and students on the front line respond to changes and take future actions.The key is to change the future:in the process of building an alternative future,whether the internal and external mix has changed or whether you want to try new things and expand your horizons.In fact,the difficulty of teaching lies in students’cooperation and conscious learning.Therefore,in the analysis of learning through alternative futures,is it possible to distinguish between internal and external situations and methods such as:1.Internal:Is education centered on teachers?Or is it student-centered?2.External:Does the Ministry of Education prioritize testing,or encourage teachers to adopt interactive communication and integrate education into the curriculum?Therefore,what is the function and inspiration of studying high school history and life?If thematic history teaching is used:teachers can use thematic learning methods to help students focus on causal relationships,the causes of turning points,or the evolution process of the beginning and end of events.This is more advantageous for testing based on the application topic,and it is easy to test how much understanding and understanding of history?Has an activating effect.By studying history in high school,using the“CLA(Causal layered analysis)”method of future studies,you can enter the stage of worldview exploration with the goal of improving professional depth and emotional level,and use it in your own understanding and utilization of history.Based on research,some insights into the prospects and thinking of learning history in high schools are provided:1.Facing the impact of declining birthrate,Taiwan needs a macro perspective to improve its future competitiveness and look forward to a new perspective on world history,using futuristic cause-and-effect level analysis to combine world changes with daily life applications.2.The study of history in high schools should go into a systematic construction:understand its cause-and-effect relationships and global trends,so teachers play a professional and future role in controlling the use of new information and technology.3.In the future,humans may develop more“intelligent”needs.As a reference from history or to explore the preferred path for the future,there will also be a greater need to innovate and meet challenges.4.Studying high school history has entered the professional field.Through self-exploration,it can be transformed into life affairs and establish the concept and value of lifelong learning.5.In studying the“history of high school learning”,have new prospects for the future of education.Through professional knowledge such as“trend theory and causal hierarchy analysis”of futurology,pursue new horizons and visions,making future education full of hope and possibility.
基金This research was supported financially by the National Social Science Foundation of China(No.19BGL256).
文摘This study examines the impact of the digital revolution on the job quality of workers with a specific focus on those at the lowest end of the spectrum in China's domestic labor market. Leveraging exogenous timing variations that result from the implementation of the Broadband China Program across different cities, it provides quasi-experimental evidence concerning the effects of the digital revolution on the job quality of lower class workers, particularly rural–urban migrant workers. Using data from China Migrants Dynamic Survey, this study reveals that migrants' comprehensive job quality index increased by 0.0138 (5.33 percent), and its component indices experienced positive effects after the Broadband China Program was implemented. This study also investigates heterogeneous policy treatment effects among workers with diverse demographic and occupational characteristics. Underlying mechanisms are considered, including positive macroeconomic shocks, increased social interactions, and Internet use. In particular, migrants' attitudes toward local settlement became more positive, suggesting that the positive effects of the digital revolution on livelihood lasted for some time. Taking China as an example, this study contributes valuable empirical evidence of how the digital revolution can affect lower class workers' employment or living conditions in a developing country. Related policy implications are also considered.
