研究了基于CLTC(China light-duty test cycle)工况下的纯电动汽车匹配单踏板再生制动系AVL_CURISE平台搭建虚拟仿真模型,建立配置单踏板制动能量回收控制系统的纯电动汽车模型;对比了不同工况下配置单踏板系统和原并联制动再生系统效...研究了基于CLTC(China light-duty test cycle)工况下的纯电动汽车匹配单踏板再生制动系AVL_CURISE平台搭建虚拟仿真模型,建立配置单踏板制动能量回收控制系统的纯电动汽车模型;对比了不同工况下配置单踏板系统和原并联制动再生系统效果经济性能差异。仿真结果表明,单踏板再生制动系统能量回收效果优于原并联再生制动系统,纯电动汽车NEDC切换为CLTC工况续驶里程差异较为有限。展开更多
BACKGROUND The aberrant expression of the anaplastic lymphoma kinase(ALK)gene in ALKpositive(ALK+)anaplastic large cell lymphoma(ALCL)is usually due to t(2;5)/NPM-ALK.However,rarely,aberrant ALK expression can also re...BACKGROUND The aberrant expression of the anaplastic lymphoma kinase(ALK)gene in ALKpositive(ALK+)anaplastic large cell lymphoma(ALCL)is usually due to t(2;5)/NPM-ALK.However,rarely,aberrant ALK expression can also result from a rearrangement of the ALK gene with various partner genes.Central nervous system(CNS)metastasis is very rare in ALK+ALCL.Patients with CNS involvement show an inferior prognosis.CASE SUMMARY Here,we present the case of an 8-year-old girl diagnosed with ALK+ALCL.She presented with fever,skin nodules,leg swelling,and abdominal pain over the preceding 6 mo.She had extensive involvement and showed an extraordinary rare translocation,t(2;17)/CLTC-ALK,as demonstrated by RNA-seq.She underwent chemotherapy as per ALCL99,followed by vinblastine(VBL)maintenance treatment,and achieved complete remission.However,she developed CNS relapse during VBL monotherapy.The patient achieved a durable second remission with high-dose chemotherapy(including methotrexate 8 g/m2)and continuous treatment with alectinib and VBL.CONCLUSION Alectinib showed significant and durable CNS effects in this patient.However,more cases are needed to prove the efficacy and safety of alectinib for pediatric ALK+ALCL patients.展开更多
文摘研究了基于CLTC(China light-duty test cycle)工况下的纯电动汽车匹配单踏板再生制动系AVL_CURISE平台搭建虚拟仿真模型,建立配置单踏板制动能量回收控制系统的纯电动汽车模型;对比了不同工况下配置单踏板系统和原并联制动再生系统效果经济性能差异。仿真结果表明,单踏板再生制动系统能量回收效果优于原并联再生制动系统,纯电动汽车NEDC切换为CLTC工况续驶里程差异较为有限。
基金Supported by the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority,No.XTZD20180204。
文摘BACKGROUND The aberrant expression of the anaplastic lymphoma kinase(ALK)gene in ALKpositive(ALK+)anaplastic large cell lymphoma(ALCL)is usually due to t(2;5)/NPM-ALK.However,rarely,aberrant ALK expression can also result from a rearrangement of the ALK gene with various partner genes.Central nervous system(CNS)metastasis is very rare in ALK+ALCL.Patients with CNS involvement show an inferior prognosis.CASE SUMMARY Here,we present the case of an 8-year-old girl diagnosed with ALK+ALCL.She presented with fever,skin nodules,leg swelling,and abdominal pain over the preceding 6 mo.She had extensive involvement and showed an extraordinary rare translocation,t(2;17)/CLTC-ALK,as demonstrated by RNA-seq.She underwent chemotherapy as per ALCL99,followed by vinblastine(VBL)maintenance treatment,and achieved complete remission.However,she developed CNS relapse during VBL monotherapy.The patient achieved a durable second remission with high-dose chemotherapy(including methotrexate 8 g/m2)and continuous treatment with alectinib and VBL.CONCLUSION Alectinib showed significant and durable CNS effects in this patient.However,more cases are needed to prove the efficacy and safety of alectinib for pediatric ALK+ALCL patients.
