Recent research has highlighted the potential of Codonopsis Radix to modulate the immune system,making it a promising candidate for treating chronic inflammatory and cardiovascular diseases,tumors,and aging.However,be...Recent research has highlighted the potential of Codonopsis Radix to modulate the immune system,making it a promising candidate for treating chronic inflammatory and cardiovascular diseases,tumors,and aging.However,because of the complex immune activities of its various components,a comprehensive understanding of Codonopsis Radix immune-regulating properties is still lacking.This knowledge gap hinders its widespread utilization in clinical practice.Therefore,this review aimed to assess the impact of Codonopsis Radix on the immune system and elucidate its underlying mechanisms.Additionally,we compared the immunomodulatory effects of different active ingredients derived from Codonopsis Radix to provide a theoretical basis for future investigations on immunomodulation.展开更多
Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medici...Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medicine and traditional Chinese medicine(TCM).To date,TCM has developed a substantial foundational theoretical understanding and accumulated significant clinical experience in combating tumors.According to TCM foundational theories,"Qi deficiency"is a critical symptom associated with cancer,and"fortifying the body's vitality while expelling pathogens"is the cornerstone of TCM's approach to tumor treatment and bodily balance.Codonopsis pilosula(CP),a Qi-invigorating herb,is known to invigorat the spleen,benefit the lungs,nourish the blood,and promote bodily fluids.It is often employed as a substitute for ginseng in clinical settings.Prolonged clinical observations have identified key active constituents of CP,such as Codonopsis polysaccharides,isoimperatorin,saponins,lobetyolin,sesquiterpene lactones,and muscone.These ingredients exhibit various therapeutic properties,including anti-tumor,immunomodulatory,anti-infective,antioxidant,and hematopoiesis-enhancing effects.Additionally,when CP is combined with other TCM herbs like Astragalus and Atractylodes macrocephala,it bolsters the body's vital energy and rejuvenates both Qi and blood.CP can be used in combination with chemotherapy agents to mitigate the adverse effects of radiotherapy and chemotherapy.Moreover,CP demonstrates potential in preventing precancerous lesions.This review summarizes recent research findings on the anti-tumor properties of CP,elucidates the anti-tumor effects and molecular mechanisms of its active components,provides a basis for promoting the utilization of CP resources and its active constituents,and offers insights for the research and development of new anti-tumor drugs.展开更多
In this paper, the resources of Codonopsis convolvulacea subsp. Vinciflora in 13 counties of Tibet were investigated and analyzed by field investigation, sample point-sample set-sample survey, market investigation and...In this paper, the resources of Codonopsis convolvulacea subsp. Vinciflora in 13 counties of Tibet were investigated and analyzed by field investigation, sample point-sample set-sample survey, market investigation and expert visit. The results showed that among the 13 counties, the distribution area of C. convolvulacea ranked as Gongbujiangda County 〉 Zuogong County 〉 Milin County 〉 Mozhugongka County 〉 Lang County 〉 Duilongdeqing County 〉 Chayu County=Jiali County= Mangkang County=Dingqing County=Baqing County=Suo County=Nimu County. The Gongbujiangda County showed the largest distribution, while Zuogong County and Milin County showed relatively small distribution. Chayu County, Jiali County, Mangkang County, Dingqing County, Baqing County, Suo County and Nimu County showed no distribution. The average plant dry weight C. convolvulacea ranked as Duilongdeqing County 〉 Lang County, Gongbujiangda County 〉Milin County 〉Chayu County =Jiali County =Zuogong County =Mangkang County =Dingqing County =Baqing County=Suo County=Mozhugongka County=Nimu County. Among them, Duilongdeqing County showed the largest average plant dry weight. The average plant dry weight of C. convolvulacea in Chayu County, Jiali County, Zuogong County, Mangkang County, Dingqing County, Baqing County, Suo County, Mozhugongka County and Nimu County was all 0 g. The order of biomass of C. convolvulacea in the 13 counties was Mozhugongka County 〉Duilongdeqing County 〉 Lang County 〉 Gongbujiangda County 〉Milin County 〉Zuogong County 〉Dingqing County =Jiali County=Mangkang County=Chayu County=Nimu County=Suo County=Baqing County. Mozhugongka County showed the largest biomass, while the biomass of C. convolvulacea in Dingqing County, Jiali County, Mangkang County, Chayu County, Nimu County, Suo County and Baqing County was all 0 t. The reserve of C. convolvulacea is determined by distribution area habitat and its own growth. In the 13 counties, the reserve of C. convolvulacea ranked as Gongbujiangda County 〉Mozhugongka County 〉 Lang County 〉Zuogong County 〉Milin County 〉Duilongdeqing County 〉Dingqing County=Jiali County=Mangkang County=Chayu County=Nimu County=Suo County=Baqing County. The reserve of C. convolvulacea was biggest in Gongbujiangda County and was relatively small in Dingqing County, Jiali County, Mangkang County, Chayu County, Nimu County, Suo County and Baqing County. Targeting at the problems existing in the utilization of C. convolvulacea, some suggestions are put forward, such as establishment of reserve for medicinal plant ecological industry, artificial cultivation, renewing concept and rational exploitation and utilization. In this paper, the resource characteristics and sustainable utilization of Tibetan medicinal plants were studied so as to provide a theoretical basis for the rational development and utilization of C. convolvulacea in the region.展开更多
基金funded by Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine(24HHZYSS00002)the National Key Research and Development Program of China(2022YFC3501800)the National Natural Science Foundation of China(82204878).
文摘Recent research has highlighted the potential of Codonopsis Radix to modulate the immune system,making it a promising candidate for treating chronic inflammatory and cardiovascular diseases,tumors,and aging.However,because of the complex immune activities of its various components,a comprehensive understanding of Codonopsis Radix immune-regulating properties is still lacking.This knowledge gap hinders its widespread utilization in clinical practice.Therefore,this review aimed to assess the impact of Codonopsis Radix on the immune system and elucidate its underlying mechanisms.Additionally,we compared the immunomodulatory effects of different active ingredients derived from Codonopsis Radix to provide a theoretical basis for future investigations on immunomodulation.
基金support of the National Natural Science Foundation of China(Grant No.82204696)the Natural Science Foundation project of Nanjing University of Chinese Medicine(Grant No.XPT82204696).
文摘Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medicine and traditional Chinese medicine(TCM).To date,TCM has developed a substantial foundational theoretical understanding and accumulated significant clinical experience in combating tumors.According to TCM foundational theories,"Qi deficiency"is a critical symptom associated with cancer,and"fortifying the body's vitality while expelling pathogens"is the cornerstone of TCM's approach to tumor treatment and bodily balance.Codonopsis pilosula(CP),a Qi-invigorating herb,is known to invigorat the spleen,benefit the lungs,nourish the blood,and promote bodily fluids.It is often employed as a substitute for ginseng in clinical settings.Prolonged clinical observations have identified key active constituents of CP,such as Codonopsis polysaccharides,isoimperatorin,saponins,lobetyolin,sesquiterpene lactones,and muscone.These ingredients exhibit various therapeutic properties,including anti-tumor,immunomodulatory,anti-infective,antioxidant,and hematopoiesis-enhancing effects.Additionally,when CP is combined with other TCM herbs like Astragalus and Atractylodes macrocephala,it bolsters the body's vital energy and rejuvenates both Qi and blood.CP can be used in combination with chemotherapy agents to mitigate the adverse effects of radiotherapy and chemotherapy.Moreover,CP demonstrates potential in preventing precancerous lesions.This review summarizes recent research findings on the anti-tumor properties of CP,elucidates the anti-tumor effects and molecular mechanisms of its active components,provides a basis for promoting the utilization of CP resources and its active constituents,and offers insights for the research and development of new anti-tumor drugs.
基金Supported by the Fourth National Census of Traditional Chinese Medicine Resources(20120716-540000)Program for Research on Humanities and Social Sciences in Colleges and Universities of Tibet Autonomous Region(sk2015-34)Construction Project for Tibet Characteristic Agriculture and Animal Husbandry Resources R&D Collaborative Innovation Center(2014-2015)~~
文摘In this paper, the resources of Codonopsis convolvulacea subsp. Vinciflora in 13 counties of Tibet were investigated and analyzed by field investigation, sample point-sample set-sample survey, market investigation and expert visit. The results showed that among the 13 counties, the distribution area of C. convolvulacea ranked as Gongbujiangda County 〉 Zuogong County 〉 Milin County 〉 Mozhugongka County 〉 Lang County 〉 Duilongdeqing County 〉 Chayu County=Jiali County= Mangkang County=Dingqing County=Baqing County=Suo County=Nimu County. The Gongbujiangda County showed the largest distribution, while Zuogong County and Milin County showed relatively small distribution. Chayu County, Jiali County, Mangkang County, Dingqing County, Baqing County, Suo County and Nimu County showed no distribution. The average plant dry weight C. convolvulacea ranked as Duilongdeqing County 〉 Lang County, Gongbujiangda County 〉Milin County 〉Chayu County =Jiali County =Zuogong County =Mangkang County =Dingqing County =Baqing County=Suo County=Mozhugongka County=Nimu County. Among them, Duilongdeqing County showed the largest average plant dry weight. The average plant dry weight of C. convolvulacea in Chayu County, Jiali County, Zuogong County, Mangkang County, Dingqing County, Baqing County, Suo County, Mozhugongka County and Nimu County was all 0 g. The order of biomass of C. convolvulacea in the 13 counties was Mozhugongka County 〉Duilongdeqing County 〉 Lang County 〉 Gongbujiangda County 〉Milin County 〉Zuogong County 〉Dingqing County =Jiali County=Mangkang County=Chayu County=Nimu County=Suo County=Baqing County. Mozhugongka County showed the largest biomass, while the biomass of C. convolvulacea in Dingqing County, Jiali County, Mangkang County, Chayu County, Nimu County, Suo County and Baqing County was all 0 t. The reserve of C. convolvulacea is determined by distribution area habitat and its own growth. In the 13 counties, the reserve of C. convolvulacea ranked as Gongbujiangda County 〉Mozhugongka County 〉 Lang County 〉Zuogong County 〉Milin County 〉Duilongdeqing County 〉Dingqing County=Jiali County=Mangkang County=Chayu County=Nimu County=Suo County=Baqing County. The reserve of C. convolvulacea was biggest in Gongbujiangda County and was relatively small in Dingqing County, Jiali County, Mangkang County, Chayu County, Nimu County, Suo County and Baqing County. Targeting at the problems existing in the utilization of C. convolvulacea, some suggestions are put forward, such as establishment of reserve for medicinal plant ecological industry, artificial cultivation, renewing concept and rational exploitation and utilization. In this paper, the resource characteristics and sustainable utilization of Tibetan medicinal plants were studied so as to provide a theoretical basis for the rational development and utilization of C. convolvulacea in the region.
