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Effects of Radix Puerariae, Radix Rehmanniae and Their Compatibility on Blood Glucose and Blood Lipids in Mice
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作者 Yumei ZHANG Yulin ZHAO +3 位作者 Yanmei QIN Jialing WEI Xiang QIN Suoyi HUANG 《Medicinal Plant》 2024年第1期45-47,共3页
[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fa... [Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly. 展开更多
关键词 Radix Puerariae Radix Rehmanniae compatibility Hypoglycemic effect Blood lipids
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Rapid evolution of T2/S-RNase genes in Fragaria linked to multiple transitions from self-incompatibility to self-compatibility 被引量:1
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作者 Wu Chen Hong Wan +4 位作者 Fang Liu Haiyuan Du Chengjun Zhang Weishu Fan Andan Zhu 《Plant Diversity》 SCIE CAS CSCD 2023年第2期219-228,共10页
The T2/RNase gene family is widespread in eukaryotes,and particular members of this family play critical roles in the gametophytic self-incompatibility(GSI) system in plants.Wild diploid strawberry(Fragaria)species ha... The T2/RNase gene family is widespread in eukaryotes,and particular members of this family play critical roles in the gametophytic self-incompatibility(GSI) system in plants.Wild diploid strawberry(Fragaria)species have diversified their sexual systems via self-incompatible and self-compatible traits,yet how these traits evolved in Fragaria remains elusive.By integrating the published and de novo assembled genomes and the newly generated RNA-seq data,members of the RNase T2 gene family were systematically identified in six Fragaria species,including three self-incompatible species(Fragaria nipponica,Fragaria nubicola,and Fragaria viridis) and three self-compatible species(Fragaria nilgerrensis,Fragaria vesca,and Fragaria iinumae).In total,115 RNase T2 genes were identified in the six Fragaria genomes and can be classified into three classes(Ⅰ-Ⅲ) according to phylogenetic analysis.The identified RNase T2 genes could be divided into 22 homologous gene sets according to amino acid sequence similarity and phylogenetic and syntenic relationships.We found that extensive gene loss and pseudogenization coupled with small-scale duplications mainly accounted for variations in the RNase T2 gene numbers in Fragaria.Multiple copies of homologous genes were mainly generated from tandem and segmental duplication events.Furthermore,we newly identified five S-RNase genes in three self-incompatible Fragaria genomes,including two in F.nipponica,two in F.viridis,and one in F.nubicola,which fit for typical features of a pistil determinant,including highly pistil-specific expression,highly polymorphic proteins and alkaline isoelectric point(pI),while no S-RNase genes were found in all three selfcompatible Fragaria species.Surprisingly,these T2/S-RNase genes contain at least one large intron(>10 kb).This study revealed that the rapid evolution of T2/S-RNase genes within the Fragaria genus could be associated with its sexual mode,and repeated evolution of the self-compatible traits in Fragaria was convergent via losses of S-RNase. 展开更多
关键词 FRAGARIA RNase T2 Self-(in)compatibility S-RNASE
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Epidemiological Investigation of Brucellosis Spondylitis and Optimal Selection of Clinical Drug Compatibility, Treatment Course and Treatment Plan
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作者 Xinming Yang Fei Liu Yanlin Yin 《Open Journal of Preventive Medicine》 CAS 2023年第5期129-138,共10页
Background: Brucellosis is a zoonotic endemic disease, the main source of infection is infected cattle, sheep, pigs and their products. In recent years, the global incidence of brucellosis spondylitis has increased ye... Background: Brucellosis is a zoonotic endemic disease, the main source of infection is infected cattle, sheep, pigs and their products. In recent years, the global incidence of brucellosis spondylitis has increased year by year, and it has spread from pastoral areas to semi-agricultural and semi-pastoral areas, agricultural areas and cities. It has changed from a mainly occupational disease to a mainly food-borne disease, and it is also a zoonotic specific spinal infectious disease that WHO and governments around the world pay great attention to. Due to the low cure rate and high recurrence rate of traditional drug therapy regimen. Therefore, to carry out epidemiological investigation and Related research on clinical drug therapy of brucellosis spondylitis has practical significance for improving diagnosis rate, cure rate and reducing recurrence rate. Objective: To analyze the epidemiological characteristics of Brucellosis spondylitis and explore the choice of drugs and the best drug treatment plan, so as to provide scientific basis for improving the prevention and control of the disease and treatment effect. Methods: Clinical epidemiodogical materials were collected from 113 patients with brucellar spondylitis. All these patients were divided into 5 different groups according to 5 kinds of drugs adopted respectively, and then the patients were given different course of treatment. Results: In the 113 patients, brucellar spondylitis morbility of female patients were higher than that of male ones, and the morbility of Bashang were higher than that of Baxia. These patients were infected mainly through browsing and breeding beasts. Lumbars were the major focus of infection. It was very comnlon that two adjacent lumbars were involved in concurrently. L4 was the most common infection location and its demolishment was most serious. The curative effect of group treated with doxycycline was better than that of group treated without doxycycline. If the course of treatment Was increased, the curative effect Was not increased obviously. Conclusions: There are characteristic features in clinical epidemiology of brucell spondylitis. Doxycycline + Rifampicin + Sulfamethoxazole was used as the preferred antibiotic. Using antibiotics adequately and jointly by two courses of treatment for a long time is the most reasonable way to treat the disease and prevent the disease from recurrence. 展开更多
关键词 BRUCELLOSIS SPONDYLITIS EPIDEMIOLOGY Drug compatibility Treatment Course PHARMACOTHERAPY Optimize Treatment
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Enhancing the compatibility of the amyloid-dye hybrid nanostructure for improved photo-biocatalysis
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作者 Zhen Dong Yanying Wang +2 位作者 Qin Yang Dan Li Peng Wu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第3期430-437,I0012,共9页
Artificial photosynthesis is significant for renewable energy generation,sustainable development,and environmental protection.Dye-protein hybrids are promising for developing photosynthesis mimics(e.g.,photo-biocataly... Artificial photosynthesis is significant for renewable energy generation,sustainable development,and environmental protection.Dye-protein hybrids are promising for developing photosynthesis mimics(e.g.,photo-biocatalysis),but their performances are far lower than the plant photosystems,partially because of the incompatibility between dye and the protein matrix that limits excited state electron transfer of the included dyes.Here,using ThT-insulin amyloid assembly as a model system,we proposed that increasing the dye-protein compatibility could lead to the improved photo-biocatalytic performance.A ThT derivative,ThTPD,was designed with the same electron acceptor but extended π-conjugated donor structure.When integrated into the insulin amyloid,the extended π-conjugated donor structure allowed increased binding affinity and energy with the amyloid matrix,thus better electron transport to the mediator to drive the photocatalytic reaction.Meanwhile,compared with ThT, ThTPD exhibited improved light absorption and longer excited state lifetime.The photo-biocatalytic performance of ThTPD-insulin amyloid was greatly improved as compared with that of ThT in reduced nicotinamide adenine dinucleotide(NADH) regeneration.When integrating with NADH-dependent L-glutamate reductase,the efficiency of the ThTPD-insulin amyloid hybrid was 2.8-fold higher than that of ThT in glutamate generation,showing promising feature in biocatalytic solar-to-chemical conversion. 展开更多
关键词 Photo-biocatalysis Dye-protein assembly Insulin amyloid ThT compatibility
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Exploring the compatibility theory of traditional Chinese medicine formulae:the disassembled prescriptions study
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作者 Xue Yang Xin-Yuan Luan 《Traditional Medicine Research》 2023年第5期38-43,共6页
Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their ... Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review. 展开更多
关键词 compatibility theory of formulae traditional Chinese medicine disassembled prescriptions study systems pharmacology
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Compatibility Rules of Prescriptions of Tibetan Medicine Polygonatum cirrhifolium Based on Data Mining
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作者 Nianggecairang Zhuomacuomao +2 位作者 Gelacuo Gongbajia Cairangnanjia 《Medicinal Plant》 CAS 2023年第3期9-14,共6页
[Objectives]To study the prescription compatibility rules of the Tibetan medicine Polygonatum cirrhifolium(Polygonati Rhizoma,Huangjing)based on data mining,so as to provide data support for clinical application and n... [Objectives]To study the prescription compatibility rules of the Tibetan medicine Polygonatum cirrhifolium(Polygonati Rhizoma,Huangjing)based on data mining,so as to provide data support for clinical application and new drug development.[Methods]Prescriptions containing Tibetan medicine Huangjing were collected from Tibetan Medicine Prescriptions Encyclopedia and Tibetan Medicine Classic Literature Collection.The Traditional Chinese Medicine Inheritance Computing System(TCMICS 3.0)and R version 4.1.3 were used to mine and analyze the compatibility rules of prescriptions containing Tibetan medicinal material Huangjing,the rules of medication for high-frequency diseases,and the association rules of various medicinal materials.[Results]A total of 124 prescriptions were collected from the classic literature of Tibetan medicine,and the frequency statistical analysis showed that drugs compatible with Huangjing(≥15)included Tianmendong(Root of Cochinchinese Asparagus)(80),Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)(72),Jili(Tribuli Fructus)(70),Tibetan Aoruqin(Vicatia coniifolia)(58),Baidoukou(Round Cardamom Fruit)(47),Hezi(Chebulae Fructus)(45),Shouzhangshen(Rhizome of Conic Gymnadenia)(28),Yuganzi(Phyllanthi Fructus)(26),Pomegranate(25),Maohezi(Terminaliae Belliricae Fructus)(24),Zicaorong(Lacca)(23),Rougui(Cinnamomi Cortex)(15).The main diseases were yellow water disease(20),gynecological diseases(19),kidney cold disease(17),and other Tibetan medicine diseases.Association rule analysis showed that the drug combinations with the highest frequency were Huangjing—Tianmendong,Huangjing—Himalayan purple jasmine,and Huangjing—Jili.[Conclusions]The frequency of combined use of Tibetan medicine Huangjing with dry yellow water,tonifying kidney and diuresis,nourishing health,and treating gynecological diseases is relatively high. 展开更多
关键词 Tibetan medicinal material Polygonatum cirrhifolium(Polygonati Rhizoma Huangjing) PRESCRIPTIONS compatibility Rules
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Compatibility mechanism of Chinese medicine formula:state of the art and perspectives
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作者 Yi-Xuan Wang Yu-Xi Huang +3 位作者 Xu-Hui Wang Feng Xie Xiang-Long Duan Cui-Juan Li 《Drug Combination Therapy》 2023年第2期1-6,共6页
Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could pl... Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could play the key role of enhancing efficacy and reducing toxicity,which has significant therapeutic advantages in the treatment of complex diseases in clinical practice.While the TCM compatibility is not the simple addition of drugs.Under the appropriate dosage ratio,multiple TCMs can play a synergistic role to realize the overall regulation of TCM treatment.Therefore,it is of critical essential to study the compatibility of TCM formula to promote TCM modernization,new drug development and clinical application.Recently,under the guidance of TCM theory,many researches on the composition,pharmacodynamic activity and pharmacokinetic properties of TCM formula have emerged by integrating new technologies and new methods,revealing the scientific connotation of the compatibility of TCM formula from different perspectives and levels.This paper introduces the research progress of compatibility rules from different levels of compatibility,compatibility for synergistic enhancement and detoxification,and application of cutting-edge technology,with representative cases,in order to provide ideas and references for further study on TCM compatibility. 展开更多
关键词 traditional Chinese medicine compatibility rules FORMULA synergism DETOXIFICATION
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Compatibility Rules of Prescriptions of Tibetan Medicinal Material Mirabilis himalaica(Edgew.)Heimerl Based on Data Mining
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作者 Zhuomacuomao Duojierenqing Cairangnanjia 《Medicinal Plant》 CAS 2023年第1期5-11,共7页
[Objectives]To study the prescription compatibility rules of the Tibetan medicinal material Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)based on data mining,and to provide reference for clinical applic... [Objectives]To study the prescription compatibility rules of the Tibetan medicinal material Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)based on data mining,and to provide reference for clinical application and new drug development.[Methods]The literature data were collected and the prescriptions containing Himalayan purple jasmine were sorted and classified by Microsoft Excel 2019 software.The Traditional Chinese Medicine Inheritance Computing System(TCMICS 3.0)was used to statistically analyze the high-frequency drugs and core drug combinations,the frequency of disease treatment,and the rules of"tastes transforming flavors"of drugs.The FP-tree algorithm was used to analyze the association rules among various Tibetan medicinal materials in the prescriptions,and different supports were set to analyze the compatibility rules of the prescriptions.[Results]There were a total of 129 prescriptions containing Himalayan purple jasmine,297 medicinal materials used in combination with it,and 34 Tibetan medicinal materials with a frequency of≥15.The medicinal flavors were mostly sweet,bitter,and pungent.Among the three flavors,bitterness and sweetness were the majority.At the same time,the medicinal properties were blunt,soft,cool,and warm.A total of 130 kinds of diseases were involved,among which 8 kinds of diseases such as gynecology,kidney cold and yellow water disease had a high frequency.Through association rule analysis,33 commonly used core drug combinations were obtained.The support,confidence,and frequency of the five drug combinations[Jili(Tribuli Fructus),Huangjing(Polygonati Rhizoma),Tianmendong(Root of Cochinchinese Asparagus),and Tibetan Aoruqin(Vicatia coniifolia)]→Himalayan purple jasmine were the basic prescription of Tibetan medicine Wudagen Powder.The drug combinations with higher confidence included Bibo(Piperis Longi Fructus)→Himalayan purple jasmine,Pomegranate(Punica granatum→Himalayan purple jasmine,Baidoukou(Round Cardamom Fruit)→Himalayan purple jasmine,Hezi(Chebulae Fructus)→Himalayan purple jasmine.Jili(Tribuli Fructus)→Himalayan purple jasmine,Huangjing(Polygonati Rhizoma)→Himalayan purple jasmine and Tianmendong(Root of Cochinchinese Asparagus)→Himalayan purple jasmine had highest frequency.[Conclusions]Through the TCMICS,this paper analyzed the compatibility rules of commonly used drugs containing Himalayan purple jasmine and the characteristics of the main diseases.It can be seen that Himalayan purple jasmine is sweet in taste and warm in nature.It assists sovereign drugs in the form of ministerial drugs,which enhances the effect of regulating"long"and nourishing,and plays the role of regulating"long",dispelling cold,and reconciling various drugs,which embodies the compatibility rules of sovereign and ministerial drugs of Tibetan medicines.The main diseases of Himalayan purple jasmine are related to"long"regulation,and it is mostly used in the treatment of gynecological diseases after being combined with other drugs to form a prescription.Most drugs in the prescriptions are sweet,which is the therapeutic principle of regulating"long"and nourishing,and verifies the scientific and rational principle of clinical use of Tibetan medicine.In the prescription,the medicinal properties include both warm and cool,and the medicinal taste is sweet and bitter,which is in line with the compatibility theory of"tastes transforming flavors"in traditional Tibetan medicine prescriptions. 展开更多
关键词 Tibetan medicine Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine) compatibility RULES Prescription
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超声联合TCD技术诊断颈部动脉粥样硬化性脑梗死的临床价值
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作者 李新勇 《现代医用影像学》 2024年第3期533-535,539,共4页
目的:探讨超声联合TCD技术诊断颈部动脉粥样硬化性脑梗死(CAEI)的临床价值。方法:以62例CAEI患者为对象,以同期62例健康人为对照组。均接受血管超声及TCD检查,分析二者诊断CAEI的价值。结果:观察组颈总动脉收缩期内径(Ds)、内中膜厚度(I... 目的:探讨超声联合TCD技术诊断颈部动脉粥样硬化性脑梗死(CAEI)的临床价值。方法:以62例CAEI患者为对象,以同期62例健康人为对照组。均接受血管超声及TCD检查,分析二者诊断CAEI的价值。结果:观察组颈总动脉收缩期内径(Ds)、内中膜厚度(IMT)值高于对照组(P<0.05)。观察组Vd、Vs低于对照组,RI、PI高于对照组(P<0.05)。观察组斑块检出率为85.48%,高于对照组(19.35%,P<0.05)。模型1(Ds+IMT)诊断CAEI的AUC、灵敏度、特异度分别为0.754(95%CI:0.669-0.827)、79.03%、74.19%;模型2(Vs+Vd+RI+PI)诊断CAEI的AUC、灵敏度、特异度分别为0.814(95%CI:0.735-0.878)、82.26%、70.97%;模型3(Ds+IMT+Vs+Vd+RI+PI)诊断CAEI的AUC、灵敏度、特异度分别为0.871(95%CI:0.799-0.924)、90.32%、74.19%。模型3诊断CAEI的AUC高于模型1、模型2(P<0.05)。结论:超声联合TCD检测可了解CAEI患者的颈动脉斑块及血流信息,有助于提高诊断的准确度。 展开更多
关键词 超声 tcd 颈部动脉粥样硬化性脑梗死
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TCD监测颅内血流动力学参数评估脑血管病患者颈动脉狭窄程度及神经功能恶化的风险 被引量:1
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作者 杨茹 王明玉 +3 位作者 任孝林 董青 籍牛 周芯羽 《中国老年学杂志》 CAS 北大核心 2023年第21期5135-5138,共4页
目的探讨经颅射绝超声多普勒系统(TCD)监测颅内血流动力学对脑血管病患者颈动脉狭窄严重程度和神经功能恶化风险的评估价值。方法前瞻性纳入122例脑血管病患者为病例组,根据患者颈动脉狭窄程度分为轻度狭窄组(n=43)、中度狭窄组(n=47)... 目的探讨经颅射绝超声多普勒系统(TCD)监测颅内血流动力学对脑血管病患者颈动脉狭窄严重程度和神经功能恶化风险的评估价值。方法前瞻性纳入122例脑血管病患者为病例组,根据患者颈动脉狭窄程度分为轻度狭窄组(n=43)、中度狭窄组(n=47)、重度狭窄组(n=32),并纳入同期健康体检者60例为对照组,比较4组颅内血流动力学指标,并采用Pearson分析其与患者颈动脉狭窄严重程度的相关性;根据患者神经功能恶化程度分为神经功能恶化组(n=55)和神经功能未恶化组(n=67),采用单因素和多因素Logistic回归分析明确影响患者发生神经功能恶化的高危因素,并采用受试者工作特征(ROC)曲线进一步分析独立危险因素对神经功能恶化的诊断效能。结果轻、中、重度狭窄组舒张期峰值血流速度(EDV)、收缩期峰值血流速度(PSV)及平均血流速度(MV)水平均较对照组偏低,搏动指数(PI)和阻力指数(RI)较对照组偏高,有统计学差异(P<0.05);重度狭窄组PSV、MV、EDV水平较轻、中度狭窄组显著偏低,PI及RI水平显著偏高(P<0.05)。Pearson相关性分析结果显示,PSV、EDV及MV与颈动脉狭窄程度呈显著正相关(r=0.541,0.763,0.822,均P<0.05),PI及RI与颈动脉狭窄程度呈显著负相关(r=-0.133,-0.375,均P<0.05)。神经功能恶化组平均年龄、入院GCS评分、ICU停留时间及住院时长等临床指标均明显高于神经功能未恶化组(P<0.05);两组大脑中动脉血流动力学参数对比,神经功能恶化组收缩期血流速度(FVs)、PI显著高于神经功能未恶化组,FVd、平均流速(FVm)明显低于神经功能未恶化组(P<0.05)。Logistic回归分析结果显示,ICU停留时间、住院时间、FVs、舒张期血流速度(FVd)、PI均是影响脑血管病患者神经功能恶化的独立危险因素(P<0.05)。ROC曲线分析结果显示,FVs、FVd、FVm及PI对预测脑血管病患者发生神经功能的ROC曲线下面积(AUC)分别为0.643、0.834、0.336、0.866(均P<0.05)。诊断效能:PI>FVd>FVs>FVm。结论应用TCD对脑血管病患者颅内血流动力学参数进行监测可辅助临床评估患者的颈动脉狭窄程度,对此类患者发生神经功能病变具有较高的预测价值。 展开更多
关键词 tcd监测 颅内血流动力学 脑血管病 颈动脉狭窄 神经功能恶化
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STUDY ON THE STARCH GRAFTED ACRYLATE MONOMERS AND ITS COMPATIBILITY FOR THE BLEND SYSTEM OF STARCH AND POLYETHYLENE
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作者 于九皋 李新蕊 《Transactions of Tianjin University》 EI CAS 1997年第1期56-61,共6页
研究采用高温和剪切力的作用直接引发淀粉与丙烯酸酯单体的接枝共聚合反应.讨论了各种反应条件对接枝反应的影响,并进一步研究了接枝物在淀粉聚乙烯共混体系中的增容作用.实验结果表明,高温和剪切作用力可以引发淀粉与丙烯酸酯单体... 研究采用高温和剪切力的作用直接引发淀粉与丙烯酸酯单体的接枝共聚合反应.讨论了各种反应条件对接枝反应的影响,并进一步研究了接枝物在淀粉聚乙烯共混体系中的增容作用.实验结果表明,高温和剪切作用力可以引发淀粉与丙烯酸酯单体的接枝共聚合反应。接枝物作为增容剂,对淀粉聚乙烯共混体系的力学性能和流变学性能均有所改善. 展开更多
关键词 淀粉 丙烯酸酯 接枝共聚 相容性
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改进的Pearson-Compatibility群决策算法在多属性协同过滤推荐中的应用研究
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作者 李岱峰 于长锐 +1 位作者 覃正 董添犀 《情报学报》 CSSCI 北大核心 2011年第2期121-130,共10页
目前个性化推荐领域的相关研究,很少考虑用户在资源属性上的兴趣差异,而资源属性往往是决定用户偏好的重要因素之一.针对这一问题,构建了基于资源多属性的用户评价模型和兴趣模型,并提出了一种改进的Pearson-Compatibility多属性群决策... 目前个性化推荐领域的相关研究,很少考虑用户在资源属性上的兴趣差异,而资源属性往往是决定用户偏好的重要因素之一.针对这一问题,构建了基于资源多属性的用户评价模型和兴趣模型,并提出了一种改进的Pearson-Compatibility多属性群决策算法,在k-临近相似用户的推荐问题中引入该算法,结合协同过滤推荐的特点,对相似用户偏好差异性、残缺值、算法可能出现的提前收敛等问题进行了充分考虑,进而实现多属性的协同过滤.最后通过实验对算法的有效性进行验证,实验结果表明:算法在目标用户属性偏好的预测上,具有较高的准确度,对偏差值、残缺值具有较强的抗干扰能力,具有较强的实用价值. 展开更多
关键词 改进 决策算法 多属性 协同过滤推荐 应用研究 COLLABORATIVE Filtering Based Decision Algorithm Improved 资源属性 用户偏好 问题 抗干扰能力 个性化推荐 重要因素 兴趣模型 兴趣差异 相似 相关研究 实用价值
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The Compatibility of Pragmatic Twist and Rhetoric
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作者 曾艳山 《海外英语》 2017年第8期213-215,共3页
It is universally believed that Rhetoric is an expressive way of language, while pragmatic twist(Deliberate misinterpretation) isthe understanding phenomenon, which is not a rhetorical device but a cognitive activity ... It is universally believed that Rhetoric is an expressive way of language, while pragmatic twist(Deliberate misinterpretation) isthe understanding phenomenon, which is not a rhetorical device but a cognitive activity in nature. The two can't be placed on a par witheach other. However, we find that the two aren't incompatible at all. The second speaker(S2) captures the rhetorical device in the firstspeaker(S1)'s utterance, and distorts the original meaning to achieve S2's communicative goal. 展开更多
关键词 PRAGMATIC RHETORIC compatibility
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The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis 被引量:49
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作者 Xin-Ming Yang Wei Shi +4 位作者 Xian-Yong Meng Ying Zhang Ya-Kun Du Lei Zhang Yao-Yi Wang 《Surgical Science》 2013年第1期92-99,共8页
Objective: To evaluate five drug treatment regimens in the treatment of Brucella spondylitis. Methods: Patients with clinical symptoms compatible and diagnostic test consistent with Brucella spondylitis were randomly ... Objective: To evaluate five drug treatment regimens in the treatment of Brucella spondylitis. Methods: Patients with clinical symptoms compatible and diagnostic test consistent with Brucella spondylitis were randomly assigned to five drug treatment regimens. Results: Combination therapy with doxycycline, rifampin and sulfamethoxazole for 56 consecutive days showed the highest cure rate of 20% after a single course and of 85% after a double course with affectivity rates of 55% and 95%. Cure rate and affectivity rate was significant better (P 0.05) than for patients receiving doxycycline, rifampin and streptomycin for the same period and regimens containing doxycycline were significant better than regimens without this drug. Conclusion: Combination therapy of doxycycline, rifampin and sulfamethoxazole for 8 weeks using one or two full courses should be recommended for Brucella spondylitis. 展开更多
关键词 BRUCELLOSIS SPONDYLITIS CLINIC Effect COURSE of Treatment DRUG compatibility
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Compatibility of rubber stoppers for recombinant antitumor-antivirus protein injection by gas chromatography-mass spectrometry 被引量:4
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作者 Zhaorui Meng Xun Gao +3 位作者 Haifeng Yu Lan Zhang Xiangyong Yu Longshan Zhao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2019年第3期178-184,共7页
A simple, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous determination of two fatty acids, methyl hexadecanoate (MH) and methyl stearate (MS),... A simple, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous determination of two fatty acids, methyl hexadecanoate (MH) and methyl stearate (MS), to allow the evaluation of packaging-drug compatibility. The two migrants were quantified in selective ion-monitoring (SIM) mode, with limits of detection (LOD) of 0.0030 μg/mL and 0.0121 μg/mL. Linear calibration curves for MH and MS were obtained in the concentration ranges of 0.1011–5.0570 μg/mL and 0.2015–10.0740 μg/mL, respectively. The developed method was successfully applied to estimate the safety of the injection of recombinant antitumor-antivirus protein (RAAP). The results showed that the possible maximum daily intake was 3.0 ng and 12.1 ng for MH and MS, respectively. As these values were both below the permitted daily exposure, the migrants can be considered as having low safety risk and do not affect the quality of the injection. 展开更多
关键词 compatibility RUBBER stoppers INJECTION FATTY ACIDS GC-MS
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EFFECT OF COMPATIBILITY ON PHASE MORPHOLOGY AND ORIENTATION OF ISOTACTIC POLYPROPYLENE (IPP) BLENDS OBTAINED BY DYNAMIC PACKING INJECTION MOLDING 被引量:3
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作者 傅强 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2006年第4期379-387,共9页
The effect of compatibility on phase morphology and orientation of isotactic polypropylene (iPP) blends under shear stress was investigated via dynamic packing injection molding (DPIM). The compatibility of iPP bl... The effect of compatibility on phase morphology and orientation of isotactic polypropylene (iPP) blends under shear stress was investigated via dynamic packing injection molding (DPIM). The compatibility of iPP blended with other polymers, namely, atactic polypropylene (aPP), octane-ethylene copolymer (POE), ethylene-propylene-diene rubber (EPDM) and poly(ethylene-co-vinyl acetate) (EVA), have first been studied using dynamic mechanical analysis (DMA). These blends were subjected to DPIM, which relies on the application of shear stress fields to the melt/solid interfaces during the packing stage by means of hydraulically actuated pistons. The phase morphology, orientation and mechanical properties of the injection-molded samples were characterized by SEM, 2D WAXS and Instron. For incompatible iPP/EVA blends, a much elongated and deformed EVA particles and a higher degree of iPP chain orientation were observed under the effect of shear. However, for compatible iPP/aPP blends, a less deformed and elongated aPP particles and less oriented iPP chains were deduced. It can be concluded that the compatibility between the components decreases the deformation and orientation in the polymer blends. This is most likely due to the hindering effect, resulting from the molecular entanglement and interaction in the compatible system. 展开更多
关键词 compatibility Phase morphology ORIENTATION Stress.
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The Compatibility of Polycarboxylate-Type Superplasticizers with Cement 被引量:3
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作者 李崇智 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2005年第3期95-98,共4页
Four polycarboxylate- type ( PC ) superplasticizers of different functional groups were used ; their dispersing and retaining behaviors were analyzed through ZETA potential measurement, mini-slump test of cement pas... Four polycarboxylate- type ( PC ) superplasticizers of different functional groups were used ; their dispersing and retaining behaviors were analyzed through ZETA potential measurement, mini-slump test of cement paste and performance test of concrete. The experimental results show that the dispersing and flow-retaining ability of PC was determined by two factors of anionic groups and nonionic groups : the density of anionic groups - COO^- or - SO3^- acted on the electronic repulsive force. and the length and proportion of nonionic graft groups of PEO in PC chemical stracture affected the steric effect. The compatibility between PC superplasticizers and cement mainly depended on the type of PEO groups ; furtlwrmore, adding mineral powders is good to the compatibility for high performance concretes ( HPCs ). 展开更多
关键词 PC superplasticizers CEMENT compatibility
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Purification and characterization of the kinetic parameters of cellulase produced from wheat straw by Trichoderma viride under SSF and its detergent compatibility 被引量:9
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作者 Hafiz Muhammad Nasir Iqbal Ishtiaq Ahmed +1 位作者 Muhammad Anjum Zia Muhammad Irfan 《Advances in Bioscience and Biotechnology》 2011年第3期149-156,共8页
This paper reports the purification and characterization of kinetic parameters of cellulase produced from Trichoderma viride under still culture solid state fermentation technique using cheap and an easily available a... This paper reports the purification and characterization of kinetic parameters of cellulase produced from Trichoderma viride under still culture solid state fermentation technique using cheap and an easily available agricultural waste material, wheat straw as growth supported substrate. Trichoderma viride was cultured in fermentation medium of wheat straw under some previously optimized growth conditions and maximum activity of 398±2.43U/mL obtained after stipulated fermentation time period. Cellulase was purified 2.33 fold with specific activity of 105U/mg in comparison to crude enzyme extract using ammonium sulfate precipitation, dialysis and Sephadex-G-100 column chromatography. The enzyme was shown to have a relative low molecular weight of 58kDa by sodium dodecyl sulphate poly-acrylamide gel electrophoresis. The purified enzyme displayed 6.5 and 55oC as an optimum pH and temperature respectively. Using carboxymethyl cellulose as substrate, the enzyme showed maximum activity (Vmax) of 148U/mL with its corresponding KM value of 68μM. Among activators/inhibitors SDS, EDTA, and Hg2+ showed inhibitory effect on purified cellulase whereas, the enzyme activated by Co2+ and Mn2+ at a concentration of 1mM. The purified cellulase was compatible with four local detergent brands with up to 20 days of shelf life at room temperature suggesting its potential as a detergent additive for improved washing therefore, it is concluded that it may be potentially useful for industrial purposes especially for detergent and laundry industry. 展开更多
关键词 CELLULASE TRICHODERMA viride Purification SDS-PAGE Characterization DETERGENT compatibility
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The Compatibility in Optic Fiber Smart Concrete and Structure 被引量:3
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作者 姜德生 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2003年第1期86-89,共4页
The compatibility between a fiber optical sensor and concrete structure in the optic fiber smart concrete is studied.The methods of improving the compatibility are proposed based on theory analysing, and a novel fiber... The compatibility between a fiber optical sensor and concrete structure in the optic fiber smart concrete is studied.The methods of improving the compatibility are proposed based on theory analysing, and a novel fiber optical sensor was developed. The experimental results show that the novel structure of fiber optical sensor and the scheme of the protecting layer of epoxy resin bed composite not only enable the sensor to be applied in strict environment, but also can monitor the beginning propagation and breaking of concrete cracks. The results also indicate that the sensor will maintain its properties in the case of large deformation and that it has the high compatibility with concrete structure and can meet special needs of the intelligent materials and structure. 展开更多
关键词 fiber optical sensor concrete structure compatibility
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Clustering of Virtual Network Function Instances Oriented to Compatibility in 5G Network 被引量:2
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作者 Xiaolei Wang Lijun Xie +1 位作者 Zhiqiang Qin Yunjie Chen 《China Communications》 SCIE CSCD 2017年第12期111-119,共9页
Network functions virtualization(NFV) increases network flexibility and scalability by virtualizing network functions running on the general servers and opens the network innovations by outsourcing VNF instances in 5G... Network functions virtualization(NFV) increases network flexibility and scalability by virtualizing network functions running on the general servers and opens the network innovations by outsourcing VNF instances in 5G networks.However,it leads to the incompatibility issue among different VNF instances,which makes operators difficult to determine which VNF instances to select for Service Function Chains(SFCs).In this paper,we divide VNF instances with high compatibility into clusters used for combining VNF instances in 5G networks.Firstly,we define compatibility among different VNF instances.Secondly,aiming to maximize compatibility of each cluster,we propose a novel hypergraph clustering model that divides the VNF instances into multiple clusters.Then,the hypergraph clustering model is transformed to an evolutionary game.Thus,the cluster establishing is transformed to the game equilibrium searching.Furthermore,we propose a discrete time high order replicator dynamic algorithm to find the game equilibrium.Finally,the simulation results show that the proposed approach can improve the quality of SFCs. 展开更多
关键词 5G wireless communication VNFinstances compatibility HYPERGRAPH cluster-ing EVOLUTIONARY GAME
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