This paper argues that the conformity-nonconformity dichotomy is a false dilemma.This study first critically reviews the basic philosophical,ethical,social psychological,and pedagogical literature related to the two c...This paper argues that the conformity-nonconformity dichotomy is a false dilemma.This study first critically reviews the basic philosophical,ethical,social psychological,and pedagogical literature related to the two concepts.It then outlines the way to overcome the phenomena of conformism and nonconformism together.The description of conformity and nonconformity as deprivation of freedom becomes stronger in 20th century philosophy and special literature from Heidegger through Fischer’s definition up to Cooley,and Crutchfield.Conformity is the sinking of the Self into the Anyone,the unprincipled alignment to the opinion of group mates,and nonconformity is the unprincipled resistance to it.But what is beyond conformity and nonconformity together as a group?There is a real community,in it the transformation of our pedagogical culture in a both useful and reasonable manner to allow the youth to accept the world by denying it and to deny the world by accepting it.The real community involves the virtue of goodness.Educate for goodness,because we possibly are the honest and humane man,who disregards the sinking of the self into the anyone and the self-contained rebellion.展开更多
Individual decision-making processes are not solely driven by self-interest maximization but are also influenced by the pressure to conform to the group.In primary games like the prisoner's dilemma,the presence of...Individual decision-making processes are not solely driven by self-interest maximization but are also influenced by the pressure to conform to the group.In primary games like the prisoner's dilemma,the presence of conformity pressure may facilitate the constructive development of cooperative behavior.In this study,we investigate how conformity influences the growth of cooperation in complicated coordination games.Our findings reveal that,even in the presence of stringent game rules,conformity can promote cooperation.In fact,a certain level of conformity pressure can even eliminate the“defection basin”of deer hunting games played on regular networks.Additionally,we demonstrate that the effect of conformity on cooperative behavior is contingent upon the degree of conformity pressure,with different levels of conformity pressure producing opposite effects.These findings provide novel insights into the promotion of cooperative evolution.For instance,if increasing the reward for cooperation has proven ineffective,manipulating the proportion of initial strategy choices may be a more promising approach.展开更多
This paper has developed a single mathematical measure for the evaluation of the shape conformity of the curved garment objects such as moulded brassiere cups. The measurements are based on the sectional analysis of t...This paper has developed a single mathematical measure for the evaluation of the shape conformity of the curved garment objects such as moulded brassiere cups. The measurements are based on the sectional analysis of the fringe pattern generated by means of moire topography. They include the area ratio, shape ratio and root mean square (RMS) of the height deviation of the moulded cup from the standard shape profile. Ultimately, the RMS was found to be a satisfactory method of assessing the shape conformity and a guideline for determining a good fit from the RMS value was then derived.展开更多
Exchange rate functions under systems of centrallyplanned economy and market economy are quite different,and the mechanism to determine such exchange rate is alsodifferent. To adopt a socialist market economic system ...Exchange rate functions under systems of centrallyplanned economy and market economy are quite different,and the mechanism to determine such exchange rate is alsodifferent. To adopt a socialist market economic system inChina, the exchange rate mechanism of Renminbi must bethoroughly transformed. To accomplish this goal, I believethere are three problems that must be solved: first,展开更多
Background: Studies have shown that there are striking variations in knee morphology between Asian and Western population. However, most of the existing total knee arthroplasty (TKA) implants are designed to suit the ...Background: Studies have shown that there are striking variations in knee morphology between Asian and Western population. However, most of the existing total knee arthroplasty (TKA) implants are designed to suit the anatomy of Western population. Our study investigated anthropometry of Indian arthritic knees and compared them to international ethnic groups. Methods: Computed tomography was used to create 3D knee models and obtain anthropometric data of distal femur and proximal tibia of Indian arthritic knees. Femoral measurements included mediolateral length, medial and lateral anteroposterior length, medial and lateral condylar width and aspect ratio. Tibial measurements included mediolateral length, medial, lateral and central anteroposterior length and aspect ratio. A preoperative virtual implantation using Western TKAimplants was carried out to visualize anatomical conformity. Results: Statistical analysis results showed that Indian males had significantly larger femoral and tibial mediolateral and anteroposterior width than Indian females;however, femoral and tibial aspect ratio was similar for both. In case of females, significant difference was observed between medial and lateral condylar widths. When compared to knee anthropometry of other ethnic groups, femoral and tibial aspect ratio of Indian knees was found to be similar to the Asian population and different from the Western population. The virtual implantation showed overhang of the femoral component in both lateral and medial regions. Conclusion: Morphological mismatch between Western and Indian knees established the fact that Western implants have drawbacks when implanted in Indian patients. The study also provided a basis for designing gender-specific TKA implants for the Indian population.展开更多
This paper presents an approach for extending the constraint model defined for conformity testing of a given method of class to its overriding method in subclass using inheritance principle. The first objective of the...This paper presents an approach for extending the constraint model defined for conformity testing of a given method of class to its overriding method in subclass using inheritance principle. The first objective of the proposed work is to find the relationship between the test model of an overriding method and its overridden method using the constraint propagation. In this context the approach shows that the test cases developed for testing an original method can be used for testing its overriding method in a subclass and then the number of test cases can be reduced considerably. The second objective is the use of invalid data which do not satisfy the precondition constraint and induce valid output values for introducing a new concept of test called secure testing. The implementation of this approach is based on a random generation of test data and analysis by formal proof.展开更多
From birth to adulthood,we often align our behaviors,attitudes,and opinions with a majority,a phenomenon known as social conformity.A seminal framework has proposed that conformity behaviors are mainly driven by three...From birth to adulthood,we often align our behaviors,attitudes,and opinions with a majority,a phenomenon known as social conformity.A seminal framework has proposed that conformity behaviors are mainly driven by three fundamental motives:a desire to gain more information to be accurate,to obtain social approval from others,and to maintain a favorable self-concept.Despite extensive interest in neuroimaging investigation of social conformity,the relationship between brain systems and these fundamental motivations has yet to be established.Here,we reviewed brain imaging findings of social conformity with a componential framework,aiming to reveal the neuropsychological substrates underlying different conformity motivations.First,information-seeking engages the evaluation of social information,information integration,and modification of task-related activity,corresponding to brain networks implicated in reward,cognitive control,and tasks at hand.Second,social acceptance involves the anticipation of social acceptance or rejection and mental state attribution,mediated by networks of reward,punishment,and mentalizing.Third,self-enhancement entails the excessive representation of positive self-related information and suppression of negative self-related information,ingroup favoritism and/or outgroup derogation,and elaborated mentalizing processes to the ingroup,supported by brain systems of reward,punishment,and mentalizing.Therefore,recent brain imaging studies have provided important insights into the fundamental motivations of social conformity in terms of component processes and brain mechanisms.展开更多
A popular explicit analytic Borowy 2C PV module model is proposed for power generation prediction.The maximum power point and the open-circuit point which are calculated in this model cannot be equal to the data given...A popular explicit analytic Borowy 2C PV module model is proposed for power generation prediction.The maximum power point and the open-circuit point which are calculated in this model cannot be equal to the data given by manufacturers under standard test condition(STC).The derivation of this model has never been mentioned in any literatures.The parameter forms of 2C model in this paper are more simplified,and the model is decomposed into a STC sub-model and an incremental sub-model.The STC model is derived successfully from an ideal single-diode circuit model.Relative error estimations are developed to do the conformity error measurements.The analysis results showed that though the biases at those critical points are very small,the conformity will depend on both of the two ratio values I_(m)/I_(sc) and V_(m)/V_(oc),which can be used to verify whether 2C model is applicable for the PV module produced by a particular manufacturer.展开更多
Ovalbumin(OVA)is the major allergenic protein that can induce T helper 2(Th2)-allergic reactions,for which current treatment options are inadequate.In this study,we developed a polymerized hypoallergenic OVA product v...Ovalbumin(OVA)is the major allergenic protein that can induce T helper 2(Th2)-allergic reactions,for which current treatment options are inadequate.In this study,we developed a polymerized hypoallergenic OVA product via laccase/caffeic acid(Lac/CA)-catalyzed crosslinking in conjunction with galactomannan(Man).The formation of high molecular weight crosslinked polymers and the Ig G-binding were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE)and Western blotting.The study indicated that Lac/CA-catalyzed crosslinking plus Man conjugation substantially altered secondary and tertiary structures of OVA along with the variation in surface hydrophobicity.Gastrointestinal digestion stability assay indicated that crosslinked OVA exhibited less resistance in simulated gastric fluid(SGF)and simulated intestinal fluid(SIF).Mouse model study indicated that Lac-Man/OVA ameliorated eosinophilic airway inflammatory response and efficiently downregulated the expression of Th2-related cytokines(interleukin(IL)-4,IL-5,and IL-13),and upregulated IFN-γand IL-10 expression.Stimulation of bone marrow-derived dendritic cells with Lac-Man/OVA suppressed the expression of phenotypic maturation markers(CD80 and CD86)and MHC class II molecules,and suppressed the expression levels of proinflammatory cytokines.The knowledge obtained in the present study offers an effective way to acquire a hypoallergenic OVA product that can have a therapeutic effect in alleviating OVA-induced allergic asthma.展开更多
The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation measures.The literature reports various successful applications of machine learning(ML)models for rockburst asses...The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation measures.The literature reports various successful applications of machine learning(ML)models for rockburst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rockburst grade even in the face of intricate and out-of-distribution samples,without any associated confidence value.Given the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential failures.To address this issue,we propose a conformal prediction(CP)framework built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rockburst while producing a measure of confidence for its output.The proposed framework guarantees marginal coverage and,in most cases,conditional coverage on the test dataset.The CP was evaluated on a rockburst case in the Sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence levels.Significantly,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed decision-making.The proposed framework improves the reliability and accuracy of rockburst assessments,with the potential to bolster user confidence.展开更多
Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant chal...Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for IHB.Gelatin is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most tissues.This study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical programmability.The regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to 0.52.The negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological interfaces.The GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high conformability.Notably,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue restoration.The GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.展开更多
Herein,binary mixed brushes consisting of poly(2-methyl-2-oxazoline)(PMOXA)and poly(2-(dimethylamine)ethyl methacrylate)(PDMAEMA)with different chain lengths were fabricated by successive grafting of NH_(2)-terminated...Herein,binary mixed brushes consisting of poly(2-methyl-2-oxazoline)(PMOXA)and poly(2-(dimethylamine)ethyl methacrylate)(PDMAEMA)with different chain lengths were fabricated by successive grafting of NH_(2)-terminated PMOXA and SH-terminated PDMAEMA onto polydopamine-anchored substrates.The mixed-brush coating was characterized by variable-angle spectroscopic ellipsometry,X-ray photoelectron spectroscopy,Fourier transform infrared spectroscopy,zeta potential measurements,water contact angle,and atomic force microscopy.The mixed brushes showed tunable surface charge,wettability,and surface roughness,depending on the degree of PDMAEMA swelling under varying pH and ionic strength(Ⅰ).Then the adsorption behaviors of pepsin,bovine serum albumin(BSA),γ-globulin,and lysozyme,four very different proteins with regard to isoelectric point,on the mixed brushes coating were studied by using fluorescence microscopy and surface plasmon resonance.When the chain length of PDMAEMA was about twice as long as PMOXA,the mixed brushes not only had high adsorption capacity for pepsin,BSA,and y-globulin but also had a desorption efficiency of 86.9%,87.1%,and 93.5%,respectively.It is explained that electrostatic attraction between the protonated PDMAEMA and positively charged acidic proteins(pepsin and BSA,whose isoelectric points were below the pK_(a) of PDMAEMA)would drive the intensive adsorption(at pH 3,I=10^(-3)mol·L^(-1)for pepsin,and pH 5,I=10^(-5)mol·L^(-1)for BSA),while desorption was dominated by the hydrophilic PMOXA when PDMAEMA was shrinking(at pH 7,I=10^(-1)mol·L^(-1)for pepsin,and pH 9,I=10^(-1)mol·L^(-1)for BSA).Furthermore,the isoelectric precipitation led to the adsorption of neutral protein(γ-globulin,whose isoelectric point was near the pK_a of PDMAEMA)at pH 7,I=10^(-5)mol·L^(-1),while electrostatic repulsion and antifouling PMOXA triggered the desorption of y-globulin at pH 3,I-10^(-1)mol·L^(-1).However,alkaline protein(lysozyme,whose isoelectric point was higher than the pK_(a) of PDMAEMA)exhibited slight adsorption on PMOXA/PDMAEMA mixed brushes under test conditions,regardless of whether PMOXA or PDMAEMA occupied the outermost layer.The antibacterial property of the mixed brushes against Escherichia coli was investigated.PMOXA/PDMAEMA mixed brushes showed significant bactericidal activity at pH 3,I=10^(-3)mol·L^(-1),while the rinse of pH 9,I=10^(-1)mol·L^(-1)solution could remove most of the residual bacteria.This work not only enables controlled adsorption of proteins with different isoelectric points but also ensures that the surface of the coating is minimized from bacterial contamination.展开更多
An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the...An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the substrate medium,we design a circular microstrip antenna,which can achieve a bandwidth of 140 MHz at Zeeman splitting frequency of 2.87 GHz,specifically suitable for NV center experiments.Subsequently,this antenna is seamlessly fixed at a three-dimensional-printed cylindrical support,allowing the optical fiber tip to extend out of a dedicated aperture.To mitigate errors originating from processing,precise tuning within a narrow range can be achieved by adjusting the conformal amplitude.Finally,we image the microwave magnetic field around the integrated probe with high resolution,and determine the suitable area for placing the fiber tip(SAP).展开更多
The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with...The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with molecular simulations to improve the sampling efficiency of the vast conformational space of large biomolecules.This review focuses on recent studies that utilize ML-based techniques in the exploration of protein conformational landscape.We first highlight the recent development of ML-aided enhanced sampling methods,including heuristic algorithms and neural networks that are designed to refine the selection of reaction coordinates for the construction of bias potential,or facilitate the exploration of the unsampled region of the energy landscape.Further,we review the development of autoencoder based methods that combine molecular simulations and deep learning to expand the search for protein conformations.Lastly,we discuss the cutting-edge methodologies for the one-shot generation of protein conformations with precise Boltzmann weights.Collectively,this review demonstrates the promising potential of machine learning in revolutionizing our insight into the complex conformational ensembles of proteins.展开更多
Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electroni...Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.展开更多
文摘This paper argues that the conformity-nonconformity dichotomy is a false dilemma.This study first critically reviews the basic philosophical,ethical,social psychological,and pedagogical literature related to the two concepts.It then outlines the way to overcome the phenomena of conformism and nonconformism together.The description of conformity and nonconformity as deprivation of freedom becomes stronger in 20th century philosophy and special literature from Heidegger through Fischer’s definition up to Cooley,and Crutchfield.Conformity is the sinking of the Self into the Anyone,the unprincipled alignment to the opinion of group mates,and nonconformity is the unprincipled resistance to it.But what is beyond conformity and nonconformity together as a group?There is a real community,in it the transformation of our pedagogical culture in a both useful and reasonable manner to allow the youth to accept the world by denying it and to deny the world by accepting it.The real community involves the virtue of goodness.Educate for goodness,because we possibly are the honest and humane man,who disregards the sinking of the self into the anyone and the self-contained rebellion.
基金supported by the National Natural Science Foundation of China(Grant No.72031009)the National Social Science Foundation of China(Grant No.20&ZD058)the National Natural Science Foundation of China(Grant No.72101189)。
文摘Individual decision-making processes are not solely driven by self-interest maximization but are also influenced by the pressure to conform to the group.In primary games like the prisoner's dilemma,the presence of conformity pressure may facilitate the constructive development of cooperative behavior.In this study,we investigate how conformity influences the growth of cooperation in complicated coordination games.Our findings reveal that,even in the presence of stringent game rules,conformity can promote cooperation.In fact,a certain level of conformity pressure can even eliminate the“defection basin”of deer hunting games played on regular networks.Additionally,we demonstrate that the effect of conformity on cooperative behavior is contingent upon the degree of conformity pressure,with different levels of conformity pressure producing opposite effects.These findings provide novel insights into the promotion of cooperative evolution.For instance,if increasing the reward for cooperation has proven ineffective,manipulating the proportion of initial strategy choices may be a more promising approach.
文摘This paper has developed a single mathematical measure for the evaluation of the shape conformity of the curved garment objects such as moulded brassiere cups. The measurements are based on the sectional analysis of the fringe pattern generated by means of moire topography. They include the area ratio, shape ratio and root mean square (RMS) of the height deviation of the moulded cup from the standard shape profile. Ultimately, the RMS was found to be a satisfactory method of assessing the shape conformity and a guideline for determining a good fit from the RMS value was then derived.
文摘Exchange rate functions under systems of centrallyplanned economy and market economy are quite different,and the mechanism to determine such exchange rate is alsodifferent. To adopt a socialist market economic system inChina, the exchange rate mechanism of Renminbi must bethoroughly transformed. To accomplish this goal, I believethere are three problems that must be solved: first,
文摘Background: Studies have shown that there are striking variations in knee morphology between Asian and Western population. However, most of the existing total knee arthroplasty (TKA) implants are designed to suit the anatomy of Western population. Our study investigated anthropometry of Indian arthritic knees and compared them to international ethnic groups. Methods: Computed tomography was used to create 3D knee models and obtain anthropometric data of distal femur and proximal tibia of Indian arthritic knees. Femoral measurements included mediolateral length, medial and lateral anteroposterior length, medial and lateral condylar width and aspect ratio. Tibial measurements included mediolateral length, medial, lateral and central anteroposterior length and aspect ratio. A preoperative virtual implantation using Western TKAimplants was carried out to visualize anatomical conformity. Results: Statistical analysis results showed that Indian males had significantly larger femoral and tibial mediolateral and anteroposterior width than Indian females;however, femoral and tibial aspect ratio was similar for both. In case of females, significant difference was observed between medial and lateral condylar widths. When compared to knee anthropometry of other ethnic groups, femoral and tibial aspect ratio of Indian knees was found to be similar to the Asian population and different from the Western population. The virtual implantation showed overhang of the femoral component in both lateral and medial regions. Conclusion: Morphological mismatch between Western and Indian knees established the fact that Western implants have drawbacks when implanted in Indian patients. The study also provided a basis for designing gender-specific TKA implants for the Indian population.
文摘This paper presents an approach for extending the constraint model defined for conformity testing of a given method of class to its overriding method in subclass using inheritance principle. The first objective of the proposed work is to find the relationship between the test model of an overriding method and its overridden method using the constraint propagation. In this context the approach shows that the test cases developed for testing an original method can be used for testing its overriding method in a subclass and then the number of test cases can be reduced considerably. The second objective is the use of invalid data which do not satisfy the precondition constraint and induce valid output values for introducing a new concept of test called secure testing. The implementation of this approach is based on a random generation of test data and analysis by formal proof.
基金supported by the National Natural Science Foundation of China(32271126,31900757,32020103008,31920103009)Natural Science Foundation of Guangdong Province(2021A1515010746)+1 种基金the Major Project of National Social Science Foundation(20&ZD153)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2019SHIBS0003).
文摘From birth to adulthood,we often align our behaviors,attitudes,and opinions with a majority,a phenomenon known as social conformity.A seminal framework has proposed that conformity behaviors are mainly driven by three fundamental motives:a desire to gain more information to be accurate,to obtain social approval from others,and to maintain a favorable self-concept.Despite extensive interest in neuroimaging investigation of social conformity,the relationship between brain systems and these fundamental motivations has yet to be established.Here,we reviewed brain imaging findings of social conformity with a componential framework,aiming to reveal the neuropsychological substrates underlying different conformity motivations.First,information-seeking engages the evaluation of social information,information integration,and modification of task-related activity,corresponding to brain networks implicated in reward,cognitive control,and tasks at hand.Second,social acceptance involves the anticipation of social acceptance or rejection and mental state attribution,mediated by networks of reward,punishment,and mentalizing.Third,self-enhancement entails the excessive representation of positive self-related information and suppression of negative self-related information,ingroup favoritism and/or outgroup derogation,and elaborated mentalizing processes to the ingroup,supported by brain systems of reward,punishment,and mentalizing.Therefore,recent brain imaging studies have provided important insights into the fundamental motivations of social conformity in terms of component processes and brain mechanisms.
基金This work was partially supported by Key Science,Technology Project of Zhejiang Province(LZ12E07001)National Natural Science Foundation of China(51307038).
文摘A popular explicit analytic Borowy 2C PV module model is proposed for power generation prediction.The maximum power point and the open-circuit point which are calculated in this model cannot be equal to the data given by manufacturers under standard test condition(STC).The derivation of this model has never been mentioned in any literatures.The parameter forms of 2C model in this paper are more simplified,and the model is decomposed into a STC sub-model and an incremental sub-model.The STC model is derived successfully from an ideal single-diode circuit model.Relative error estimations are developed to do the conformity error measurements.The analysis results showed that though the biases at those critical points are very small,the conformity will depend on both of the two ratio values I_(m)/I_(sc) and V_(m)/V_(oc),which can be used to verify whether 2C model is applicable for the PV module produced by a particular manufacturer.
基金supported by the Guangdong Basic and Applied Basic Research Foundation(2021B15151300042021B1515140021)+2 种基金the Scientific Research Start-up Funding of Guangdong Medical University(1026/4SG21229G)China Postdoctoral Science Foundation(2021M702781)Guangdong Medical University Post-doctoral Research Funding(2BH19006P)。
文摘Ovalbumin(OVA)is the major allergenic protein that can induce T helper 2(Th2)-allergic reactions,for which current treatment options are inadequate.In this study,we developed a polymerized hypoallergenic OVA product via laccase/caffeic acid(Lac/CA)-catalyzed crosslinking in conjunction with galactomannan(Man).The formation of high molecular weight crosslinked polymers and the Ig G-binding were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE)and Western blotting.The study indicated that Lac/CA-catalyzed crosslinking plus Man conjugation substantially altered secondary and tertiary structures of OVA along with the variation in surface hydrophobicity.Gastrointestinal digestion stability assay indicated that crosslinked OVA exhibited less resistance in simulated gastric fluid(SGF)and simulated intestinal fluid(SIF).Mouse model study indicated that Lac-Man/OVA ameliorated eosinophilic airway inflammatory response and efficiently downregulated the expression of Th2-related cytokines(interleukin(IL)-4,IL-5,and IL-13),and upregulated IFN-γand IL-10 expression.Stimulation of bone marrow-derived dendritic cells with Lac-Man/OVA suppressed the expression of phenotypic maturation markers(CD80 and CD86)and MHC class II molecules,and suppressed the expression levels of proinflammatory cytokines.The knowledge obtained in the present study offers an effective way to acquire a hypoallergenic OVA product that can have a therapeutic effect in alleviating OVA-induced allergic asthma.
文摘The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation measures.The literature reports various successful applications of machine learning(ML)models for rockburst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rockburst grade even in the face of intricate and out-of-distribution samples,without any associated confidence value.Given the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential failures.To address this issue,we propose a conformal prediction(CP)framework built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rockburst while producing a measure of confidence for its output.The proposed framework guarantees marginal coverage and,in most cases,conditional coverage on the test dataset.The CP was evaluated on a rockburst case in the Sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence levels.Significantly,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed decision-making.The proposed framework improves the reliability and accuracy of rockburst assessments,with the potential to bolster user confidence.
基金This work was sponsored by the National Natural Science Foundation of China(No.52235007,52325504)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004).
文摘Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for IHB.Gelatin is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most tissues.This study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical programmability.The regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to 0.52.The negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological interfaces.The GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high conformability.Notably,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue restoration.The GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.
基金the financial support of the National Natural Science Foundation of China(21674102)。
文摘Herein,binary mixed brushes consisting of poly(2-methyl-2-oxazoline)(PMOXA)and poly(2-(dimethylamine)ethyl methacrylate)(PDMAEMA)with different chain lengths were fabricated by successive grafting of NH_(2)-terminated PMOXA and SH-terminated PDMAEMA onto polydopamine-anchored substrates.The mixed-brush coating was characterized by variable-angle spectroscopic ellipsometry,X-ray photoelectron spectroscopy,Fourier transform infrared spectroscopy,zeta potential measurements,water contact angle,and atomic force microscopy.The mixed brushes showed tunable surface charge,wettability,and surface roughness,depending on the degree of PDMAEMA swelling under varying pH and ionic strength(Ⅰ).Then the adsorption behaviors of pepsin,bovine serum albumin(BSA),γ-globulin,and lysozyme,four very different proteins with regard to isoelectric point,on the mixed brushes coating were studied by using fluorescence microscopy and surface plasmon resonance.When the chain length of PDMAEMA was about twice as long as PMOXA,the mixed brushes not only had high adsorption capacity for pepsin,BSA,and y-globulin but also had a desorption efficiency of 86.9%,87.1%,and 93.5%,respectively.It is explained that electrostatic attraction between the protonated PDMAEMA and positively charged acidic proteins(pepsin and BSA,whose isoelectric points were below the pK_(a) of PDMAEMA)would drive the intensive adsorption(at pH 3,I=10^(-3)mol·L^(-1)for pepsin,and pH 5,I=10^(-5)mol·L^(-1)for BSA),while desorption was dominated by the hydrophilic PMOXA when PDMAEMA was shrinking(at pH 7,I=10^(-1)mol·L^(-1)for pepsin,and pH 9,I=10^(-1)mol·L^(-1)for BSA).Furthermore,the isoelectric precipitation led to the adsorption of neutral protein(γ-globulin,whose isoelectric point was near the pK_a of PDMAEMA)at pH 7,I=10^(-5)mol·L^(-1),while electrostatic repulsion and antifouling PMOXA triggered the desorption of y-globulin at pH 3,I-10^(-1)mol·L^(-1).However,alkaline protein(lysozyme,whose isoelectric point was higher than the pK_(a) of PDMAEMA)exhibited slight adsorption on PMOXA/PDMAEMA mixed brushes under test conditions,regardless of whether PMOXA or PDMAEMA occupied the outermost layer.The antibacterial property of the mixed brushes against Escherichia coli was investigated.PMOXA/PDMAEMA mixed brushes showed significant bactericidal activity at pH 3,I=10^(-3)mol·L^(-1),while the rinse of pH 9,I=10^(-1)mol·L^(-1)solution could remove most of the residual bacteria.This work not only enables controlled adsorption of proteins with different isoelectric points but also ensures that the surface of the coating is minimized from bacterial contamination.
基金Project supported by the National Key Research and Development Program of China(Grant No.2021YFB2012600)the Science and Technology Plan Project of State Administration of Market Regulation,China(Grant No.2021MK039)。
文摘An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the substrate medium,we design a circular microstrip antenna,which can achieve a bandwidth of 140 MHz at Zeeman splitting frequency of 2.87 GHz,specifically suitable for NV center experiments.Subsequently,this antenna is seamlessly fixed at a three-dimensional-printed cylindrical support,allowing the optical fiber tip to extend out of a dedicated aperture.To mitigate errors originating from processing,precise tuning within a narrow range can be achieved by adjusting the conformal amplitude.Finally,we image the microwave magnetic field around the integrated probe with high resolution,and determine the suitable area for placing the fiber tip(SAP).
基金Project supported by the National Key Research and Development Program of China(Grant No.2023YFF1204402)the National Natural Science Foundation of China(Grant Nos.12074079 and 12374208)+1 种基金the Natural Science Foundation of Shanghai(Grant No.22ZR1406800)the China Postdoctoral Science Foundation(Grant No.2022M720815).
文摘The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with molecular simulations to improve the sampling efficiency of the vast conformational space of large biomolecules.This review focuses on recent studies that utilize ML-based techniques in the exploration of protein conformational landscape.We first highlight the recent development of ML-aided enhanced sampling methods,including heuristic algorithms and neural networks that are designed to refine the selection of reaction coordinates for the construction of bias potential,or facilitate the exploration of the unsampled region of the energy landscape.Further,we review the development of autoencoder based methods that combine molecular simulations and deep learning to expand the search for protein conformations.Lastly,we discuss the cutting-edge methodologies for the one-shot generation of protein conformations with precise Boltzmann weights.Collectively,this review demonstrates the promising potential of machine learning in revolutionizing our insight into the complex conformational ensembles of proteins.
基金This work is financially supported by the National Natural Science Foundation of China(52303036)the Natural Science Foundation of Guangxi Province(2020GXNSFAA297028)+4 种基金the Guangxi Science and Technology Base and Talent Special Project(GUIKE AD23026179)the International Science&Technology Cooperation Project of Chengdu(2021-GH03-00009-HZ)the Program of Innovative Research Team for Young Scientists of Sichuan Province(22CXTD0019)the Natural Science Foundation of Sichuan Province(2023NSFSC0986)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(Sklpme2023-3-18).
文摘Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.