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Impacts of the COVID-19 pandemic on vegetable production and countermeasures from an agricultural insurance perspective 被引量:3
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作者 GU Hai-ying WANG Chang-wei 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2020年第12期2866-2876,共11页
In the face of the corona virus disease 2019(COVID-19)pandemic,it is essential to stabilize the security of urban“shopping baskets”.Through a survey and interviews with 46 agricultural cooperatives in Shanghai,this ... In the face of the corona virus disease 2019(COVID-19)pandemic,it is essential to stabilize the security of urban“shopping baskets”.Through a survey and interviews with 46 agricultural cooperatives in Shanghai,this paper analyzes the impact of the pandemic on vegetable production and offers suggestions on agricultural insurance.The research results show that:(1)the pandemic has impacted almost all stages of the vegetable supply chain but has had a greater impact on the sales stage;(2)the market risks of vegetable production have increased significantly,and the gap between the field price and the market price has widened.The sales price difference between traditional channels and e-commerce is notable;(3)farmers’incomes have generally declined due to the COVID-19 pandemic,and traditional small-scale farmers have suffered more losses;and(4)agricultural insurance plays an important role in stabilizing the supply of vegetables to the city.To minimize the impact of the pandemic on vegetable production and to stabilize both urban“shopping baskets”and farmers’incomes,it is necessary to further improve agricultural insurance,especially to provide insurance against market risks. 展开更多
关键词 covid-19 vegetable supply chain agricultural insurance market risks
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Impact of COVID-19 Epidemic on the International Food Supply Chain and Countermeasures of Shandong Province 被引量:1
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作者 Fangyao YUAN Ping YANG +1 位作者 Feng XU Tongkai HAN 《Asian Agricultural Research》 2020年第8期1-5,16,共6页
The COVID-19 epidemic has exerted an impact on the global food supply chain,and also has contributed to the tendency of food hoarding and short supply;strong food demand has led to a rapid rise in international food p... The COVID-19 epidemic has exerted an impact on the global food supply chain,and also has contributed to the tendency of food hoarding and short supply;strong food demand has led to a rapid rise in international food prices,which has put enormous pressure on China's food import,and domestic food price showed a rise trend accordingly.In order to ensure sufficient and stable supply of China's food market,it is necessary to adhere to the food security strategy of"food self-sufficiency"for a long term.In the spring agricultural production,Shandong Province has taken effective measures to stabilize food production and achieved good results.It has not been greatly affected by the COVID-19 epidemic;however,under the continuous spread of foreign epidemics,we must adhere to the dual hard core operation of epidemic prevention and production,and explore the establishment of technical specifications for agricultural production under normal conditions for epidemic prevention and control to ensure the food security. 展开更多
关键词 covid-19 epidemic Food supply chain Food price Food security
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COVID-19 countermeasures of Chinese national athletes:Prevention,treatment,and return to play 被引量:1
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作者 Hui Zhan Feng Gao +3 位作者 Minhao Xie Guoping Li Jing Li Jingbin Zhou 《Sports Medicine and Health Science》 2022年第1期61-69,共9页
Under the condition of normalized epidemic,how athletes train and compete well has been in the spotlight.This article reported the symptom,hospitalization and training situation of seven confirmed cases of coronavirus... Under the condition of normalized epidemic,how athletes train and compete well has been in the spotlight.This article reported the symptom,hospitalization and training situation of seven confirmed cases of coronavirusdisease-2019(COVID-19)among Chinese national teams.Moreover,the paper summarized the experience of Chinese national teams in terms of epidemic prevention and control,treatment of infection,and safe return to play.Through a scientific combination of medication and non-medical treatment,seven athletes were all discharged from the hospital.These discharged athletes underwent strict isolation and scientific training before returning to sports teams.Before returning to play,continuous monitoring of physical and mental condition was required.All seven athletes returned to play safely and performed excellently.As for hosting large-scale sporting events,the entire enclosed-loop management from immigration to competition was proposed in this paper.This study could serve as a standard of epidemic prevention and control,treatment for infection and safe return to play during competition and training around the world. 展开更多
关键词 covid-19 ATHLETE Epidemic prevention and control TREATMENT Return to play
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Impact of COVID-19 on Agriculture,Countryside and Farmers and Countermeasures
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作者 Wanyu ZHANG 《Asian Agricultural Research》 2021年第6期25-28,共4页
COVID-19 outbreak has great impact on agricultural and rural farmers.In order to effectively cope with the impact of COVID-19 epidemic and promote agricultural and rural development,this paper expounds the impact of t... COVID-19 outbreak has great impact on agricultural and rural farmers.In order to effectively cope with the impact of COVID-19 epidemic and promote agricultural and rural development,this paper expounds the impact of the epidemic from three aspects of agricultural production,farmers and rural development,and puts forward corresponding countermeasures:building development platform for rural electric business,implementing the development mode of"Internet plus agriculture",strengthening the input and publicity of agricultural insurance to benefit farmers,and increasing support for local employment and entrepreneurship of migrant workers. 展开更多
关键词 covid-19 AGRICULTURE Rural areas and farmers countermeasures
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Investigation and analysis of 14034 college students on COVID-19 and its countermeasures and suggestions
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作者 Jia-Jia Zhang Di Ma +3 位作者 Lu Chen Shi-Xue Chen Hai-Yang Peng Dong-Xian Zhang 《Journal of Hainan Medical University》 2020年第15期12-17,共6页
Objective:To understand the current situation of college students'knowledge,cognitive attitude and behavior(KAP)towards the prevention and control of Corona Virus Disease 2019(Corona Virus Disease 2019,COVID-19)du... Objective:To understand the current situation of college students'knowledge,cognitive attitude and behavior(KAP)towards the prevention and control of Corona Virus Disease 2019(Corona Virus Disease 2019,COVID-19)during the epidemic,so as to provide theoretical basis for college students'resumption of study and campus prevention and control.Methods:A questionnaire survey was conducted among 16,410 college students by using the convenient sampling method of,One-Way ANOVA and Logistic regression analysis of the survey data.Results:The total awareness rate of college students on COVID-19 was 85%,the average knowledge score was(70.4±10.0),and the proportion of high cognition was 74.5%.The average attitude score of college students was(3.78±0.55),and only 3.9%of them held a positive attitude.The average score of college students'protective behaviors was(19.35±1.69),and 48.8%of them took good protective behaviors.Binary logistic regression analysis showed that the proportion of students with high cognition who adopt good protective behaviors is higher than that of students with low cognition(95%CI:0.621-0.752).The proportion of students with a positive attitude to adopt good behaviors was higher than that with a negative attitude(95%CI:1.398-2.009),Spearman rank correlation analysis results showed that there was a weak positive correlation between cognition and attitude(r=0.056,P<0.05),and a weak positive correlation between cognition and behavior(r=0.118,P<0.05),and a weak positive correlation between attitude and behavior(r=0.038,P<0.05).Conclusion:College students have a good overall cognition of COVID-19,but their attitudes and protective behaviors need to be further improved.Therefore,knowledge education,behavioral intervention and psychological counseling on COVID-19 epidemic prevention and control among college students should be strengthened to improve their prevention and control ability and physical quality. 展开更多
关键词 College students covid-19 KNOWLEDGE ATTITUDE BEHAVIORAL
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Evolution of COVID-19 in Relation to Public Health Countermeasures in Morocco
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作者 Majda Sebbani Latifa Adarmouch +1 位作者 Adil Mansouri Mohamed Amine 《Open Journal of Epidemiology》 2020年第2期187-194,共8页
The new coronavirus, officially responsible for COVID-19, has spread rapidly internationally despite multiple countermeasures to limit its transmission. Morocco recorded his first case of COVID-19 on March 02, 2020. T... The new coronavirus, officially responsible for COVID-19, has spread rapidly internationally despite multiple countermeasures to limit its transmission. Morocco recorded his first case of COVID-19 on March 02, 2020. The main data on the pandemic and its evolution come from the Moroccan Ministry of Health. This paper aims to describe the evolution of the pandemic in Morocco and to highlight the different measures taken to stem its progression between March 02 to April 07, 2020. The measures were taken very early since the declaration of the first case in Morocco on March 2, 2020. After 5 weeks of the epidemic, the number of confirmed cases in Morocco reached 1184 including 90 deaths and 93 recoveries. The evolution of the curve seems to be slowed down compared to neighboring countries like Spain. The wearing of a mandatory mask was implemented on April 7 by the Ministry of Health as an additional measure to flatten the curve and allow the health system to effectively cope with the pandemic. The impact of this measure could be assessed by analyzing the evolution of the curve in the coming weeks. Sharing these results can serve as an example to other countries, especially for low-income countries, in their fight against the COVID-19. 展开更多
关键词 COVID19 Morocco countermeasures
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The Crisis and the Countermeasures in the Growth of China’s Travel Agencies under the Influences of COVID-19
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作者 Jinxia Zhang 《管理科学与研究(中英文版)》 2020年第1期57-63,共7页
After more than 40 years of development,China's travel agency industry has grown rapidly,but the situation of scattered,small,weak and poor has not fundamentally changed.The unexpected the public health event cris... After more than 40 years of development,China's travel agency industry has grown rapidly,but the situation of scattered,small,weak and poor has not fundamentally changed.The unexpected the public health event crisis of COVID-19 in 2020 has brought great influence on China's travel agency industry,which makes China's travel agency industry face double challenges at home and abroad,but also breeds opportunities for development.In the face of the crisis,China's travel agency industry has responded to it,trying to restore confidence and revive the economy.This paper puts forward some idea from the aspects of crisis management,marketing and product development,including the establishment and implementation of the normalized tourism public crisis response mechanism;the reconstruction of the tourism image of the travel agency industry;the strengthening of marketing,with special attention to new media marketing;the emphasis on natural education,and the enhancement of the upgrading of tourism products. 展开更多
关键词 China Travel Agency covid-19 Crisis Management Coping Strategies
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Impact of COVID-19 on College Students’Non-intellectual Factors and Corresponding Countermeasures
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作者 HE Tong-tong HU Xin-yun +1 位作者 JIANG Dan ZHANG Shun-sheng 《Journal of Literature and Art Studies》 2023年第2期110-116,共7页
The outbreak of COVID-19 in December 2019 has exerted a wide and everlasting impact on the world,which has also influenced education enormously.The adjustment of objective learning environment during the COVID-19 pand... The outbreak of COVID-19 in December 2019 has exerted a wide and everlasting impact on the world,which has also influenced education enormously.The adjustment of objective learning environment during the COVID-19 pandemic makes the influence of non-intellectual factors on college students worthy of investigation,research and analysis.Based on this,we have launched a questionnaire survey on 500 college students who have witnessed the pandemic,and referred to related literature,network documents,news reports,contrast and analysis of college students’non-intelligence factors before and after the outbreak of the different levels of change,summing up some new measures to promote the development of college students’non-intelligence factors under the COVID-19 outbreak for online learning and autonomous learning. 展开更多
关键词 covid-19 college students’non-intellectual factors IMPACT learning enlightenment
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Opportunities,Challenges and Countermeasures proposed for the new retail industry in The COVID-19
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作者 Changli Lu Yingdong Xiang 《Journal of Economic Science Research》 2020年第4期47-56,共10页
It has been four years since the concept of“new retail”was proposed,and the layout of“new retail”of several major domestic enterprises has been intensified,which has a“unique landscape”compared to the foreign re... It has been four years since the concept of“new retail”was proposed,and the layout of“new retail”of several major domestic enterprises has been intensified,which has a“unique landscape”compared to the foreign retail landscape.The trend,however,the sudden outbreak and continued spread of the COVID-19 has dealt a serious blow to the global economic development,from the domestic point of view,the epidemic caused by the decline in GDP,leading to a negative year-on-year growth in the total retail sales of consumer goods,the new retail industry is still in the development stage suffered a blow.On the other hand,however,the sinking of the new retail market driven by the consumer economy,the surge of private domain traffic on platforms and the rise of the“house economy”prompted the new retail industry to create new development opportunities during the epidemic,clarifying the development of the new retail industry in the post-epidemic era and pointing out the direction. 展开更多
关键词 covid-19 New retail Consumer economy Supply chain People and goods yard
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基于CiteSpace及VOSviewer的COVID-19相关心律失常的文献计量学分析
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作者 李敏 马晓娟 +2 位作者 赵小晗 刘敏 陈子怡 《中西医结合心脑血管病杂志》 2024年第7期1163-1172,共10页
目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSvie... 目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSviewer软件生成知识图谱。结果:共鉴定出768篇文章,发文涉及美国、意大利和中国为首的319个国家/地区和4 366个机构,领先的研究机构是梅奥诊所和哈佛医学院。New England Journal of Medicine是该领域最常被引用的期刊。在6 687位作者中,Arbelo Elena撰写的研究最多,Guo T被共同引用的次数最多,心房纤颤是最常见的关键词。结论:随着COVID-19的暴发,对COVID-19所致新发/进行性心律失常事件的研究蓬勃发展,未来的研究者可能会对COVID-19感染后新发或遗留的快速性心律失常/缓慢性心律失常的发生机制进行进一步的探索。 展开更多
关键词 新型冠状病毒感染 covid-19 心律失常 CITESPACE VOSviewer 文献计量分析
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麻杏石甘汤干预COVID-19肺炎的网络药理学研究及分子对接分析
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作者 武燕 马啸 李春雨 《产业与科技论坛》 2024年第12期42-43,共2页
目的:运用网络药理学与分子对接研究方法探讨麻杏石甘汤干预COVID-19肺炎的作用机制。方法:经TCMSP、HTDocking数据库检索麻杏石甘汤所有药物的成分并进行ADME筛选得到活性成分,在Uniport数据库检索其发挥治疗作用可能的基因靶点;借助Ge... 目的:运用网络药理学与分子对接研究方法探讨麻杏石甘汤干预COVID-19肺炎的作用机制。方法:经TCMSP、HTDocking数据库检索麻杏石甘汤所有药物的成分并进行ADME筛选得到活性成分,在Uniport数据库检索其发挥治疗作用可能的基因靶点;借助GeneCards、PharmGKB等数据库检索COVID-19肺炎相关基因靶点,利用Cytoscape软件构建药物-活性成分-靶基因-疾病网络;借助String系统构建PPI网络,并进行拓扑学特征分析,筛选核心基因;利用R语言的clusterProfiler包对核心基因进行GO、KEGG富集分析;利用AutoDock Vina软件对疾病靶蛋白及药物活性成分进行分子对接验证。结果:共筛选出麻杏石甘汤与COVID-19肺炎交集基因靶点67个。PPI网络分析显示,其发挥治疗作用的核心基因靶点有MAPK1、MAPK3、STAT1、JUN等8个。GO富集分析显示,相关生物过程1863个,分子功能95个,细胞成分36个;KEGG富集分析显示,相关作用通路167条。分子对接结果显示,麻杏石甘汤活性成分槲皮素、山奈酚、熊果酸等与核心基因靶点JUN、MAK1、IL2等有较好的结合活性。结论:麻杏石甘汤可能以槲皮素、山奈酚等为物质基础,多成分、多靶点、多通路、相互协同发挥抑制病毒活性,降低炎症反应,保护肺部组织,从而对COVID-19肺炎起到积极的干预作用。 展开更多
关键词 麻杏石甘汤 covid-19肺炎 网络药理学 分子对接
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COVID-19诊疗信息、中医证型分布及组方用药规律的文献研究 被引量:1
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作者 刘鑫瑶 臧凝子 +7 位作者 王琳琳 王梅 邹吉宇 王亚勤 孙婉宁 彭成飞 吕晓东 庞立健 《中华中医药学刊》 CAS 北大核心 2024年第1期9-15,共7页
目的利用数据挖掘技术深入探究新型冠状病毒感染(COVID-19,简称新冠感染)患者的诊断、中医证型分布以及药物使用规律,以期为中医药治疗新冠感染提供有效的参考依据。方法通过搜索,可以获取来自国家卫生健康委员会和全国各地的《新型冠... 目的利用数据挖掘技术深入探究新型冠状病毒感染(COVID-19,简称新冠感染)患者的诊断、中医证型分布以及药物使用规律,以期为中医药治疗新冠感染提供有效的参考依据。方法通过搜索,可以获取来自国家卫生健康委员会和全国各地的《新型冠状病毒肺炎诊疗方案》内涉及的中医证型和中医药防治方案,以及中国生物医学文献服务系统、知网、维普、万方数据库收录的治疗新冠感染相关文献共249份。对文献通过筛选、整理和去重并建立中药复方数据库、诊疗信息数据库、证型数据库,运用频数分析、频率分析进行探究。结果新冠感染患者常见的症状频数较高的为咳嗽、咽干咽痛、发热、纳差、乏力;大多数患者呈淡红舌、红舌,脉象为滑脉、滑数脉;中医证型频数较高的有湿毒郁肺证、湿热蕴肺证、肺脾气虚证、寒湿郁肺证、气阴两伤证、兼夹瘀血证。此外,共纳入491首治疗新冠感染中药复方,涉及中药227味,得到高频中药共64个,药物类别以清热药、补益药、解表药、化痰止咳平喘药、化湿药为主;药性以温、平、寒为主,药味以甘、辛、苦为主,归经中归肺、脾、胃经中药居多;聚类分析结果根据中药性能将治疗新冠感染的高频药物聚为8类较好。结论中医药治疗新型冠状病毒感染用药具有以下特点:补益药用药次数较多体现攻邪不忘扶正;解表、清热、攻下、化湿、利湿、渗湿药物俱全体现多种逐邪之法;药类以清热药、补益药、化湿药、化痰止咳平喘药、解表药为主,彰显新冠感染基本治法为清热化湿、止咳平喘、补养气阴。可为指导临床用药及研发新药提供一定的参考与借鉴。 展开更多
关键词 covid-19 诊疗信息 中医证型 中药复方 数据挖掘 关联规则分析
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低频脉冲磁场诱导TRPC1改善COVID-19患者康复期下肢的肌肉无力症状 被引量:1
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作者 厉中山 包义君 +6 位作者 刘洁 孔维签 李伟 陈琳 白石 杨铁黎 王春露 《中国组织工程研究》 CAS 北大核心 2024年第16期2605-2612,共8页
背景:肌肉无力是新型冠状病毒(COVID-19)感染后的常见症状,影响康复期人体日常活动能力。在强度1.5 mT,频率3300 Hz的低频脉冲磁场刺激下可通过诱导和激活经典瞬时感受器电位通1(classical transient receptor potential channel 1,TRPC... 背景:肌肉无力是新型冠状病毒(COVID-19)感染后的常见症状,影响康复期人体日常活动能力。在强度1.5 mT,频率3300 Hz的低频脉冲磁场刺激下可通过诱导和激活经典瞬时感受器电位通1(classical transient receptor potential channel 1,TRPC1),提升人体骨骼肌的最大自主收缩力与力量耐力,对肌肉组织产生一系列生理支持效应,该手段是否会改善新型冠状病毒肺炎患者康复期的肌无力症状尚无研究。目的:选用低频脉冲磁场对新型冠状病毒肺炎患者下肢肌群进行磁刺激,以观察该刺激对新型冠状病毒肺炎患者康复期下肢肌群肌无力改善的影响。方法:招募胶体金法抗原检测试剂(COVID-19)为阳性并伴有肌肉无力症状的新型冠状病毒(奥密克戎毒株)感染患者14例,将所有受试者随机分成2组,分别为接受磁场刺激的试验组和接受假治疗的对照组。试验总时长3周,试验组每隔48 h对腿部进行低频脉冲磁刺激,对照组与试验组干预流程一致但给予假刺激,两组患者均不被告知磁刺激仪器是否运行,两组患者共进行9次操作,随后观察两组患者下肢局部肌群最大自主收缩力、腿部爆发力与力量耐力的变化情况。结果与结论:①在采集的8个局部肌群中,试验组患者7个局部肌群在经过3周的低频脉冲磁场刺激,最大自主收缩力值均增长。对照组除3个肌群最大自主收缩力自行增长改善以外,其他肌群肌力无提升。②试验组的左腿前群与双腿后群提升率显著高于对照组。③两组的纵跳摸高高度与膝关节峰值角速度相比试验前测均提升,试验组摸高高度提升率高于对照组。④在疲劳状态下,试验组膝关节峰值角速度下降率显著下降,对照组膝关节峰值角速度下降率无显著性变化;试验组摸高高度下降率显著下降,而对照组摸高高度下降率无显著性变化。⑤上述数据证实,在强度1.5 mT,频率3300 Hz的低频脉冲磁场刺激方案下,新型冠状病毒肺炎患者在康复期经过3周的低频脉冲磁场刺激相比人体自愈过程可使更多的下肢局部肌群肌力获得提升,对基于腿部爆发力的全身协调发力能力及功能状态明显改善。因此,低频脉冲磁场刺激可作为一种改善新冠感染患者下肢肌肉无力症状的有效、非运动的康复手段。 展开更多
关键词 新型冠状病毒 covid-19 新型冠状病毒肺炎 脉冲磁场 经典瞬时感受器电位通道1 TRPC1 肌肉无力
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COVID-19疫情前后28个国家生育率变化及影响因素研究:线性模型和中断时间序列分析
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作者 陈益 陈卿 +2 位作者 刘涵 王大朋 曹佳 《陆军军医大学学报》 CAS CSCD 北大核心 2024年第17期2021-2028,F0003,共9页
目的分析COVID-19疫情暴发前后不同国家经季节和日历调整后的生育率(seasonally and calendar adjusted fertility rate,SAFR)趋势的变化及其影响因素。方法使用国际人类生育力数据库(Human Fertility Database,HFD)中28个国家自2012年... 目的分析COVID-19疫情暴发前后不同国家经季节和日历调整后的生育率(seasonally and calendar adjusted fertility rate,SAFR)趋势的变化及其影响因素。方法使用国际人类生育力数据库(Human Fertility Database,HFD)中28个国家自2012年1月至2022年12月的月度SAFR数据,以2020年12月(2020年3月疫情暴发起点加9个月妊娠过程)为节点划分为疫情前(2012.1-2020.11)和疫情后(2020.12-2022.12)进行比较,使用中断时间序列方法分析各国疫情前后的SAFR趋势(短期波动和长期趋势)是否发生变化,使用秩和检验分析疫情前SAFR、人均GDP、公共卫生和社会措施(public health and social measures,PHSM)和失业率是否与SAFR趋势变化有关。结果疫情后28个国家中19个国家的SAFR出现短期下降,随后反弹。对于长期趋势,2个国家由下降趋势转为上升趋势,8个国家由上升趋势转为下降趋势,6个国家的SAFR保持不变。SAFR变化率下降主要集中在部分中欧国家以及地中海西岸的国家,而SAFR变化率增加的国家主要分布在北欧以及西欧地区。SAFR无短期波动的国家疫情前的SAFR低于有短期波动的国家(P=0.041),SAFR变化率下降国家的疫情前SAFR(P=0.005)与人均GDP(P=0.027)均低于SAFR变化率上升国家。未发现SAFR短期波动或长期趋势与PHSM严重程度指数或失业率存在关联。结论COVID-19疫情对28个国家的SAFR造成了不同的短期和长期影响,特别是经济水平和疫情前SAFR相对较低的国家可能更易遭到进一步打击。COVID-19疫情对各国人口的更长期影响值得进一步关注。 展开更多
关键词 covid-19 生育率 中断时间序列分析 影响因素
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显微镜下多血管炎相关间质性肺病合并COVID-19患者疫苗保护作用初探
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作者 祁福敏 苏睿 +4 位作者 郝剑 苏丽 范倩 李昕 魏蔚 《天津医药》 CAS 2024年第7期683-686,共4页
目的分析显微镜下多血管炎(MPA)相关间质性肺病(ILD)患者合并新型冠状病毒肺炎(COVID-19)的临床特征,初步探究新型冠状病毒(SARS-CoV-2)疫苗的保护作用。方法纳入确诊的MPA-ILD患者,同时符合《新型冠状病毒感染诊疗方案(第十版)》制定的... 目的分析显微镜下多血管炎(MPA)相关间质性肺病(ILD)患者合并新型冠状病毒肺炎(COVID-19)的临床特征,初步探究新型冠状病毒(SARS-CoV-2)疫苗的保护作用。方法纳入确诊的MPA-ILD患者,同时符合《新型冠状病毒感染诊疗方案(第十版)》制定的COVID-19诊断标准,且均有明确SARS-CoV-2抗原或核酸检测阳性证据。收集并分析患者临床资料,ILD影像学分型,SARS-CoV-2疫苗接种情况、临床分型及预后。结果共纳入37例MPA-ILD患者,女14例,男23例。32例在并发COVID-19时MPA病情处于缓解期,31例同时维持免疫抑制剂或生物制剂治疗。ILD的影像学类型以寻常型间质性肺炎(15例)和非特异性间质性肺炎(14例)为主,剩余8例分型不确定。COVID-19分型中,27例为轻症,5例因COVID-19死亡。11例未接种疫苗,26例接种SARS-CoV-2灭活疫苗,其中11例完成3剂次加强免疫。接种疫苗患者COVID-19轻症比例高于未接种疫苗组(P=0.038)。多因素分析显示接种疫苗为MPA-ILD患者合并COVID-19住院(OR=0.045,95%CI:0.004~0.472,P=0.010)及非轻症感染(OR=0.049,95%CI:0.005~0.517,P=0.012)的独立保护因素。同时MPA处于缓解期为COVID-19非轻症感染的保护因素(OR=0.021,95%CI:0.001~0.459,P=0.014)。结论接种SARS-CoV-2疫苗及MPA病情处于缓解期有可能减轻MPA患者合并COVID-19的严重程度。 展开更多
关键词 显微镜下多血管炎 新型冠状病毒肺炎 covid-19疫苗
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全球COVID-19疫情主要预测模型比较分析
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作者 陈雅霖 洪秋棉 +3 位作者 温昊于 刘艳 喻勇 宇传华 《中国卫生统计》 CSCD 北大核心 2024年第3期382-386,共5页
目的新冠感染病死率预测对于深入理解新冠病毒严重性、合理配置医疗资源及开展针对性防疫策略有重大意义。方法本研究依据新冠病毒变异优势株,将疫情发展划分四个时期,选取美国、印度、巴西、墨西哥、秘鲁、中国六个国家以及全球平均水... 目的新冠感染病死率预测对于深入理解新冠病毒严重性、合理配置医疗资源及开展针对性防疫策略有重大意义。方法本研究依据新冠病毒变异优势株,将疫情发展划分四个时期,选取美国、印度、巴西、墨西哥、秘鲁、中国六个国家以及全球平均水平的病死率为研究对象。运用灰色模型、指数平滑模型、ARIMA模型、支持向量机、Prophet和LSTM模型六个模型进行拟合预测,探讨各模型的优缺点和适用性,选取效果最优的模型对全球和重点国家的病死率进行预测。结果模型比较显示多种模型各有优缺点,经预测,多数国家的累计确诊人数和累计死亡人数增长速度减缓,发展趋势逐渐平稳。结论传统时间序列模型适于发展趋势平稳、有限样本的预测;而机器学习模型更适用于波动型变化数据,可进行大样本预测,进一步外推,运用到其他卫生领域的研究。 展开更多
关键词 covid-19 预测模型 病死率
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系统性红斑狼疮合并COVID-19住院患者的临床特征分析
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作者 刘鹏程 张敏 +2 位作者 李建斌 余淑娇 吴锐 《中华临床免疫和变态反应杂志》 CAS 2024年第3期245-250,共6页
目的探讨系统性红斑狼疮(SLE)合并新型冠状病毒(SARS-CoV-2)感染住院患者的临床特点。方法选取2022年12月—2023年2月于南昌大学第一附属医院风湿免疫科就诊且确诊为COVID-19的SLE患者为研究对象,根据是否住院治疗将其分为未住院组和住... 目的探讨系统性红斑狼疮(SLE)合并新型冠状病毒(SARS-CoV-2)感染住院患者的临床特点。方法选取2022年12月—2023年2月于南昌大学第一附属医院风湿免疫科就诊且确诊为COVID-19的SLE患者为研究对象,根据是否住院治疗将其分为未住院组和住院组,比较两组患者的人口学数据、临床症状和实验室检查结果。评估淋巴细胞/单核细胞(LMR)、中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)、系统性免疫炎症指数(SⅡ)、SⅡ/白蛋白、红细胞沉降率/淋巴细胞(ELR)和C反应蛋白/淋巴细胞(CLR)等指标对SLE合并COVID-19患者住院的影响。结果两组患者在年龄、糖皮质激素剂量、SLEDAI评分、红细胞沉降率、C反应蛋白、血小板、淋巴细胞、白蛋白、NLR、PLR、LMR、CLR、ELR、SⅡ和SⅡ/ALB等方面存在统计学差异(P<0.05)。多因素Logistic回归分析显示,CLR(OR=1.16)、糖皮质激素剂量(OR=1.11)及SLEDAI评分(OR=1.23)为SLE合并COVID-19住院患者的临床特点。ROC曲线分析显示,CLR曲线下面积(AUC)为0.751,其灵敏度为50.0%,特异度为94.0%;糖皮质激素剂量的AUC为0.778,其灵敏度为76.9%,特异度为75.9%;SLEDAI的AUC为0.754,其灵敏度为50.0%,特异度为91.6%。结论对于SLE合并COVID-19住院患者而言,较高的CLR、糖皮质激素剂量及SLEDAI评分为其临床特点。 展开更多
关键词 系统性红斑狼疮 covid-19 住院患者 临床特点
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Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionnaire study 被引量:2
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作者 Abdullah M Alhammad Namareq F Aldardeer +10 位作者 Abdulaziz Alqahtani Mohammad H Aljawadi Bushra Alnefaie Raghad Alonazi Mansour Almuqbil Abdulrahman Alsaadon Rakan M Alqahtani Rashid Alballaa Bader Alshehri Mohammed I Alarifi Fahad D Alosaimi 《World Journal of Clinical Cases》 SCIE 2024年第15期2560-2567,共8页
BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological well-being.However,few studies have examined those who recovered from... BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological well-being.However,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the Middle East assessing the post-ICU discharge mental health status of patients who had COVID-19.AIM To evaluate anxiety and depression among patients who had severe COVID-19.METHODS This is a prospective single-center follow-up questionnaire-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for COVID-19.Eligible patients were contacted via telephone.The patient’s anxiety and depression six months after ICU discharge were assessed using the Hospital Anxiety and Depression Scale(HADS).The primary outcome was the mean HADS score.The secondary outcomes were risk factors of anxiety and/or depression.RESULTS Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the questionnaires.The mean age was 56.3±17.2 years.Thirty patients(62.5%)were male.The main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)diseases.The mean overall HADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A HADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),respectively.Results from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;P<0.05].CONCLUSION Six months after ICU discharge,30% of patients who had COVID-19 demonstrated a HADS score that confirmed anxiety and depression.To compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are warranted. 展开更多
关键词 covid-19 Critically ill ANXIETY DEPRESSION HADS Saudi Arabia
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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19 被引量:1
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作者 Angus K Jacobs Steven D Morley +7 位作者 Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter C Hayes John N Plevris 《World Journal of Gastroenterology》 SCIE CAS 2024年第31期3705-3716,共12页
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and fibrosis.Liver injury(LI)i... BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and fibrosis.Liver injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated cholangiopathy.Mechanisms of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell invasion.AIM To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe COVID-19.METHODS ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel classifiers.RESULTS ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct cholangiocytes.Strikingly,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in cirrhosis.ACE2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD spectrum.Hepatic ACE2 levels are also increased in COVID-19 patients,especially those showing evidence of LI,but are not correlated with the presence of SARS-CoV-2 virus in the liver.However,there is a clear association between the hepatic lipid droplet content and the presence of the virus,suggesting a possible functional link.CONCLUSION Hepatic ACE2 levels were elevated in nonfibrotic MASH and COVID-19 patients with LI,while lipid accumulation may promote intra-hepatic SARS-CoV-2 replication,accelerating MASLD progression and COVID-19-mediated liver damage. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 IMMUNOHISTOCHEMISTRY covid-19 covid-19-associated cholangiopathy
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Clinical application of COVID-19 vaccine in liver transplant recipients 被引量:1
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作者 Feng-Chao Liu Man Xie Wei Rao 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第4期339-343,共5页
Background:Solid organ transplant(SOT)activities,such as liver transplant,have been greatly influenced by the pandemic of coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome corona... Background:Solid organ transplant(SOT)activities,such as liver transplant,have been greatly influenced by the pandemic of coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Immunosuppressed individuals of liver transplant recipients(LTRs)tend to have a high risk of COVID-19 infection and related complications.Therefore,COVID-19 vaccination has been recommended to be administered as early as possible in LTRs.Data sources:The keywords“liver transplant”,“SARS-CoV-2”,and“vaccine”were used to retrieve articles published in PubMed.Results:The antibody response following the 1st and 2nd doses of vaccination was disappointingly low,and the immune responses among LTRs remarkably improved after the 3rd or 4th dose of vaccination.Although the 3rd or 4th dose of COVID-19 vaccine increased the antibody titer,a proportion of patients remained unresponsive.Furthermore,recent studies showed that SARS-CoV-2 vaccine could trigger adverse events in LTRs,including allograft rejection and liver injury.Conclusions:This review provides the recently reported data on the antibody response of LTRs following various doses of vaccine,risk factors for poor serological response and adverse events after vaccination. 展开更多
关键词 Liver transplant covid-19 SARS-CoV-2 VACCINE Antibody response
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